PH12021550020A1 - High-affinity, isoform-selective tgf#1 inhibitors and use thereof - Google Patents
High-affinity, isoform-selective tgf#1 inhibitors and use thereofInfo
- Publication number
- PH12021550020A1 PH12021550020A1 PH12021550020A PH12021550020A PH12021550020A1 PH 12021550020 A1 PH12021550020 A1 PH 12021550020A1 PH 12021550020 A PH12021550020 A PH 12021550020A PH 12021550020 A PH12021550020 A PH 12021550020A PH 12021550020 A1 PH12021550020 A1 PH 12021550020A1
- Authority
- PH
- Philippines
- Prior art keywords
- isoform
- affinity
- inhibitors
- selective tgf
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18211—Henipavirus, e.g. hendra virus
- C12N2760/18234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696752P | 2018-07-11 | 2018-07-11 | |
| US201862718196P | 2018-08-13 | 2018-08-13 | |
| US201862737534P | 2018-09-27 | 2018-09-27 | |
| US201862758180P | 2018-11-09 | 2018-11-09 | |
| US201962810263P | 2019-02-25 | 2019-02-25 | |
| US201962827552P | 2019-04-01 | 2019-04-01 | |
| PCT/US2019/041373 WO2020014460A1 (en) | 2018-07-11 | 2019-07-11 | HIGH-AFFINITY, ISOFORM-SELECTIVE TGFβ1 INHIBITORS AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12021550020A1 true PH12021550020A1 (en) | 2021-09-13 |
Family
ID=67470735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12021550020A PH12021550020A1 (en) | 2018-07-11 | 2021-01-04 | High-affinity, isoform-selective tgf#1 inhibitors and use thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12252531B2 (enExample) |
| EP (1) | EP3820508A1 (enExample) |
| JP (2) | JP7540994B2 (enExample) |
| KR (1) | KR102891320B1 (enExample) |
| CN (1) | CN112996535B (enExample) |
| AU (1) | AU2019302679B2 (enExample) |
| BR (1) | BR112021000353A2 (enExample) |
| CL (1) | CL2021000073A1 (enExample) |
| CO (1) | CO2021000419A2 (enExample) |
| IL (1) | IL279914A (enExample) |
| MA (1) | MA53125A (enExample) |
| MX (1) | MX2021000347A (enExample) |
| PH (1) | PH12021550020A1 (enExample) |
| SG (1) | SG11202013231SA (enExample) |
| TW (1) | TWI923546B (enExample) |
| WO (1) | WO2020014460A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109153644B (zh) | 2016-03-16 | 2022-10-21 | H·李·莫菲特癌症中心研究有限公司 | 用以增强效应t细胞功能的针对cereblon的小分子 |
| EP3820532A4 (en) | 2018-07-11 | 2022-04-06 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | DIMERE IMMUNOMODULATORY COMPOUNDS AGAINST CEREBLON-BASED MECHANISMS |
| PT3677278T (pt) | 2018-07-11 | 2022-02-03 | Scholar Rock Inc | Inibidores seletivos da isoforma tgfbeta1 e sua utilização |
| KR102891320B1 (ko) | 2018-07-11 | 2025-11-28 | 스칼러 락, 인크. | 고친화도, 이소형-선택적 TGFβ1 억제제 및 그의 용도 |
| SG11202108099WA (en) | 2019-01-30 | 2021-08-30 | Scholar Rock Inc | LTBP COMPLEX-SPECIFIC INHIBITORS OF TGFβ AND USES THEREOF |
| CN120022360A (zh) | 2019-08-28 | 2025-05-23 | 中外制药株式会社 | 跨物种抗潜伏TGF-β1抗体和使用方法 |
| CA3166328A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| CA3167427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgfb inhibitors and use thereof |
| AU2021239667B2 (en) * | 2020-03-19 | 2026-05-07 | Chugai Seiyaku Kabushiki Kaisha | Biomarkers for predicting the response to checkpoint inhibitors |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| TW202317185A (zh) * | 2021-06-18 | 2023-05-01 | 美商健臻公司 | 抗ＴＧＦ－β抗體配製品及其用途 |
| EP4370148A1 (en) | 2021-07-14 | 2024-05-22 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgf beta1 and uses thereof |
| CN113604214B (zh) * | 2021-08-09 | 2023-07-14 | 青岛大学 | 一种高稳定性溶瘤肽荧光探针及其制备方法和应用 |
| CN116262137A (zh) * | 2021-12-14 | 2023-06-16 | 四川大学 | 一种同时杀伤肿瘤和改善免疫微环境的抗肿瘤联合用药物 |
| CN114236137A (zh) * | 2021-12-17 | 2022-03-25 | 中山大学·深圳 | 一种转化生长因子β的体外检测试剂盒及其应用 |
| CN115058440B (zh) * | 2022-06-08 | 2023-08-15 | 郑州轻工业大学 | 催化合成天然蔗糖酯的工程菌及其构建方法和应用 |
| CN120418286A (zh) | 2023-01-09 | 2025-08-01 | 北京拓界生物医药科技有限公司 | TGFβ1结合分子、GARP-TGFβ1结合分子及其医药用途 |
| EP4676954A1 (en) | 2023-03-07 | 2026-01-14 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
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| EP3820896A1 (en) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | TGFbeta1 INHIBITORS AND USE THEREOF |
| KR102891320B1 (ko) | 2018-07-11 | 2025-11-28 | 스칼러 락, 인크. | 고친화도, 이소형-선택적 TGFβ1 억제제 및 그의 용도 |
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-
2019
- 2019-07-11 KR KR1020217003926A patent/KR102891320B1/ko active Active
- 2019-07-11 SG SG11202013231SA patent/SG11202013231SA/en unknown
- 2019-07-11 EP EP19745926.6A patent/EP3820508A1/en active Pending
- 2019-07-11 AU AU2019302679A patent/AU2019302679B2/en active Active
- 2019-07-11 MX MX2021000347A patent/MX2021000347A/es unknown
- 2019-07-11 MA MA053125A patent/MA53125A/fr unknown
- 2019-07-11 TW TW108124516A patent/TWI923546B/zh active
- 2019-07-11 WO PCT/US2019/041373 patent/WO2020014460A1/en not_active Ceased
- 2019-07-11 JP JP2021500434A patent/JP7540994B2/ja active Active
- 2019-07-11 US US17/258,771 patent/US12252531B2/en active Active
- 2019-07-11 BR BR112021000353-3A patent/BR112021000353A2/pt unknown
- 2019-07-11 CN CN201980059305.0A patent/CN112996535B/zh active Active
-
2021
- 2021-01-03 IL IL279914A patent/IL279914A/en unknown
- 2021-01-04 PH PH12021550020A patent/PH12021550020A1/en unknown
- 2021-01-11 CL CL2021000073A patent/CL2021000073A1/es unknown
- 2021-01-18 CO CONC2021/0000419A patent/CO2021000419A2/es unknown
-
2024
- 2024-04-22 JP JP2024068880A patent/JP7858715B2/ja active Active
-
2025
- 2025-02-04 US US19/045,513 patent/US20250257125A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CO2021000419A2 (es) | 2021-01-29 |
| KR102891320B1 (ko) | 2025-11-28 |
| CN112996535A (zh) | 2021-06-18 |
| IL279914A (en) | 2021-03-01 |
| WO2020014460A1 (en) | 2020-01-16 |
| KR20210058811A (ko) | 2021-05-24 |
| EP3820508A1 (en) | 2021-05-19 |
| TW202005981A (zh) | 2020-02-01 |
| CN112996535B (zh) | 2026-04-24 |
| JP7540994B2 (ja) | 2024-08-27 |
| JP7858715B2 (ja) | 2026-05-14 |
| CL2021000073A1 (es) | 2021-07-30 |
| AU2019302679B2 (en) | 2026-04-23 |
| SG11202013231SA (en) | 2021-01-28 |
| US20210122814A1 (en) | 2021-04-29 |
| JP2024099673A (ja) | 2024-07-25 |
| TWI923546B (zh) | 2026-05-01 |
| MX2021000347A (es) | 2021-04-19 |
| JP2021531254A (ja) | 2021-11-18 |
| US12252531B2 (en) | 2025-03-18 |
| MA53125A (fr) | 2021-05-19 |
| US20250257125A1 (en) | 2025-08-14 |
| WO2020014460A8 (en) | 2020-02-13 |
| BR112021000353A2 (pt) | 2021-08-03 |
| CA3105988A1 (en) | 2020-01-16 |
| AU2019302679A1 (en) | 2021-02-11 |
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