CO2021000419A2 - Inhibidores de tgfβ1 selectivos de isoforma, de alta afinidad y usos de los mismos - Google Patents

Inhibidores de tgfβ1 selectivos de isoforma, de alta afinidad y usos de los mismos

Info

Publication number
CO2021000419A2
CO2021000419A2 CONC2021/0000419A CO2021000419A CO2021000419A2 CO 2021000419 A2 CO2021000419 A2 CO 2021000419A2 CO 2021000419 A CO2021000419 A CO 2021000419A CO 2021000419 A2 CO2021000419 A2 CO 2021000419A2
Authority
CO
Colombia
Prior art keywords
isoform
affinity
selective
tgfβ1 inhibitors
tgfβ1
Prior art date
Application number
CONC2021/0000419A
Other languages
English (en)
Inventor
Thomas Schurpf
Abhishek Datta
Gregory J Carven
Constance Martin
Alan Buckler
Allan Capili
Kevin B Dagbay
Christopher Chapron
Stefan Wawersik
Christopher Littlefield
Susan Lin
Justin W Jackson
Caitlin Stein
Andrew Avery
Anthony Cooper
Matthew Salotto
Original Assignee
Scholar Rock Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scholar Rock Inc filed Critical Scholar Rock Inc
Publication of CO2021000419A2 publication Critical patent/CO2021000419A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18211—Henipavirus, e.g. hendra virus
    • C12N2760/18234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se describen en la presente anticuerpos monoclonales y fragmentos de unión a antígeno de los mismos capaces de inhibir selectivamente ΤGFβ1 con alta potencia. También se describen composiciones, métodos y uso terapéutico relacionados.
CONC2021/0000419A 2018-07-11 2021-01-18 Inhibidores de tgfβ1 selectivos de isoforma, de alta afinidad y usos de los mismos CO2021000419A2 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862696752P 2018-07-11 2018-07-11
US201862718196P 2018-08-13 2018-08-13
US201862737534P 2018-09-27 2018-09-27
US201862758180P 2018-11-09 2018-11-09
US201962810263P 2019-02-25 2019-02-25
US201962827552P 2019-04-01 2019-04-01
PCT/US2019/041373 WO2020014460A1 (en) 2018-07-11 2019-07-11 HIGH-AFFINITY, ISOFORM-SELECTIVE TGFβ1 INHIBITORS AND USE THEREOF

Publications (1)

Publication Number Publication Date
CO2021000419A2 true CO2021000419A2 (es) 2021-01-29

Family

ID=67470735

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0000419A CO2021000419A2 (es) 2018-07-11 2021-01-18 Inhibidores de tgfβ1 selectivos de isoforma, de alta afinidad y usos de los mismos

Country Status (17)

Country Link
US (1) US20210122814A1 (es)
EP (1) EP3820508A1 (es)
JP (2) JP7540994B2 (es)
KR (1) KR20210058811A (es)
CN (1) CN112996535A (es)
AU (1) AU2019302679A1 (es)
BR (1) BR112021000353A2 (es)
CA (1) CA3105988A1 (es)
CL (1) CL2021000073A1 (es)
CO (1) CO2021000419A2 (es)
IL (1) IL279914A (es)
MA (1) MA53125A (es)
MX (1) MX2021000347A (es)
PH (1) PH12021550020A1 (es)
SG (1) SG11202013231SA (es)
TW (1) TW202005981A (es)
WO (1) WO2020014460A1 (es)

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BR112021015056A2 (pt) 2019-01-30 2022-01-11 Scholar Rock Inc Inibidores específicos de complexos ltbp de tgf-beta e usos dos mesmos
EP4021498A4 (en) 2019-08-28 2024-01-03 Chugai Seiyaku Kabushiki Kaisha CROSS-SPECIES ANTI-LATENT TGF-BETA-1 ANTIBODIES AND METHOD OF USE
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CN116262137A (zh) * 2021-12-14 2023-06-16 四川大学 一种同时杀伤肿瘤和改善免疫微环境的抗肿瘤联合用药物
CN114236137A (zh) * 2021-12-17 2022-03-25 中山大学·深圳 一种转化生长因子β的体外检测试剂盒及其应用
CN115058440B (zh) * 2022-06-08 2023-08-15 郑州轻工业大学 催化合成天然蔗糖酯的工程菌及其构建方法和应用
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Also Published As

Publication number Publication date
MA53125A (fr) 2021-05-19
JP2021531254A (ja) 2021-11-18
US20210122814A1 (en) 2021-04-29
EP3820508A1 (en) 2021-05-19
SG11202013231SA (en) 2021-01-28
KR20210058811A (ko) 2021-05-24
BR112021000353A2 (pt) 2021-08-03
CL2021000073A1 (es) 2021-07-30
CN112996535A (zh) 2021-06-18
PH12021550020A1 (en) 2021-09-13
WO2020014460A8 (en) 2020-02-13
IL279914A (en) 2021-03-01
JP2024099673A (ja) 2024-07-25
TW202005981A (zh) 2020-02-01
CA3105988A1 (en) 2020-01-16
WO2020014460A1 (en) 2020-01-16
AU2019302679A1 (en) 2021-02-11
JP7540994B2 (ja) 2024-08-27
MX2021000347A (es) 2021-04-19

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