JP2009502139A5 - - Google Patents

Info

Publication number

JP2009502139A5

JP2009502139A5 JP2008523043A JP2008523043A JP2009502139A5 JP 2009502139 A5 JP2009502139 A5 JP 2009502139A5 JP 2008523043 A JP2008523043 A JP 2008523043A JP 2008523043 A JP2008523043 A JP 2008523043A JP 2009502139 A5 JP2009502139 A5 JP 2009502139A5

Authority

JP

Japan

Prior art keywords

seq

sequence

light chain

amino acid

heavy chain

Prior art date

2006-07-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 35
• 125000003275 alpha amino acid group Chemical group 0.000 claims 27
• 102000004196 processed proteins & peptides Human genes 0.000 claims 27
• 229920001184 polypeptide Polymers 0.000 claims 26
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 101000908391 Homo sapiens Dipeptidyl peptidase 4 Proteins 0.000 claims 6
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 102000045598 human DPP4 Human genes 0.000 claims 2
• UDTXUDHDIVNHCL-AENUQYPBSA-N (2s)-2-[[(2s)-4-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpe Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O UDTXUDHDIVNHCL-AENUQYPBSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 206010066476 Haematological malignancy Diseases 0.000 claims 1
• 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 239000002257 antimetastatic agent Substances 0.000 claims 1
• 239000012830 cancer therapeutic Substances 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 238000001794 hormone therapy Methods 0.000 claims 1
• 238000009169 immunotherapy Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 108010056777 interleukin-2 (59-72) Proteins 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• CSHFHJNMIMPJST-HOTGVXAUSA-N methyl (2s)-2-[[(2s)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoate Chemical compound NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)OC)CC1=CC=CC=C1 CSHFHJNMIMPJST-HOTGVXAUSA-N 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1