HRP20151261T1 - Sastavi i postupci za lijeäśenje i dijagnosticiranje raka - Google Patents
Sastavi i postupci za lijeäśenje i dijagnosticiranje raka Download PDFInfo
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- HRP20151261T1 HRP20151261T1 HRP20151261TT HRP20151261T HRP20151261T1 HR P20151261 T1 HRP20151261 T1 HR P20151261T1 HR P20151261T T HRP20151261T T HR P20151261TT HR P20151261 T HRP20151261 T HR P20151261T HR P20151261 T1 HRP20151261 T1 HR P20151261T1
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- Prior art keywords
- protein
- antibody
- rspo
- lgr5
- lgr
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 14
- 201000011510 cancer Diseases 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 6
- 239000000203 mixture Substances 0.000 title 1
- 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 10
- 102000005962 receptors Human genes 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 3
- 102000047766 human LGR5 Human genes 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 1
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108091006332 Leucine-rich repeat-containing G-protein-coupled receptors Proteins 0.000 claims 1
- 102000037126 Leucine-rich repeat-containing G-protein-coupled receptors Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 102000052301 human GNAZ Human genes 0.000 claims 1
- 235000005772 leucine Nutrition 0.000 claims 1
- 150000002614 leucines Chemical class 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (19)
1. Izolirano monoklonalno protutijelo, naznačeno time, da se specifično veže na ljudski protein R-spondin (RSPO-protein) i inhibira rast čvrstog tumora koji obuhvaća matične stanice čvrstog tumora, čime protutijelo prekida vezanje RSPO-proteina na receptor proteina spojenog na G-protein, koji je bogat leukinima s ponavljanjem sadržaja (receptor LGR-proteina), pri čemu LGR-protein je LGR5; i/ili ono prekida aktiviranje RSPO-proteina od LGR5-signaliziranja.
2. Protutijelo prema zahtjevu 1, naznačeno time, da RSPO-protein je RSPO-1, RSPO-2 ili RSPO-3.
3. Protutijelo prema zahtjevu 2, naznačeno time, da RSPO-protein je RSPO-1.
4. Protutijelo prema zahtjevu 1, naznačeno time, da RSPO-protein je RSPO-4.
5. Izolirano monoklonalno protutijelo, naznačeno time, da se specifično veže na izvanstaničnu domenu od receptora LGR-proteina spojenog na G-protein, koji je bogat leukinima s ponavljanjem sadržaja, gdje LGR-protein je LGR5, i ono inhibira rast čvrstog tumora koji sadrži matične stanice čvrstog tumora, te pritom protutijelo prekida vezanje RSPO na LGR5; i/ili prekida RSPO-aktiviranje od LGR5-signaliziranja.
6. Protutijelo prema zahtjevu 5, naznačeno time, da izvanstanična domena obuhvaća aminokiseline od 22 do 564 od ljudskog LGR5 (SEQ ID NO:1).
7. Protutijelo prema zahtjevu 5, naznačeno time, da je protutijelo sljedeće:
(a) monoklonalno protutijelo 88M1 proizvedeno pomoću stanične linije hibridoma koji ima broj ATCC depozita pod oznakom PTA-9342; ili
(b) izolirano protutijelo koje sadrži CDR-ove jakog lanca i/ili CDR-ove slabog lanca od monoklonalnog protutijela 88M1 proizvedenog pomoću stanične linije hibridoma koji ima broj ATCC depozita pod oznakom PTA-9342; ili
(c) izolirano protutijelo koje se natječe u natjecateljskom ispitivanju vezanja, s monoklonalnim protutijelom 88M1 proizvedenim pomoću stanične linije hibridoma koji ima broj ATCC depozita pod oznakom PTA-9342.
8. Protutijelo prema bilo kojem od zahtjeva 1 do 6, naznačeno time, da je kimerno protutijelo, humanizirano ili ljudsko protutijelo, bispecifično protutijelo ili fragment protutijela.
9. Stanična linija, naznačena time, da proizvodi protutijelo prema bilo kojem od zahtjeva 1 do 8.
10. Farmaceutski sastav, naznačen time, da obuhvaća protutijelo prema bilo kojem od zahtjeva 1 do 8 i farmaceutski prikladan nosač.
11. Farmaceutski sastav prema zahtjevu 10, naznačen time, da nadalje obuhvaća drugo antitumorsko sredstvo.
12. Topivi receptor, naznačen time, da obuhvaća izvanstaničnu domenu ljudskog LGR5-proteina, za uporabu u postupku liječenja raka koji sadrži matične stanice raka.
13. Topivi receptor prema zahtjevu 12, naznačen time, da izvanstanična domena obuhvaća aminokiseline od 22 do 564 od ljudskog LGR5 (SEQ ID NO:1).
14. Topivi receptor prema zahtjevu 13, naznačen time, da on nadalje obuhvaća sekvencu ne-LGR-proteina.
15. Topivi receptor prema zahtjevu 14, naznačen time, da ne-LGR-proteinska sekvenca sadrži ljudski Fc.
16. Sredstvo, naznačeno time, da se upotrebljava u postupku liječenju raka koji sadrži matične stanice raka za čovjeka, ili u postupku inhibicije rasta tumora kod čovjeka, pri čemu taj postupak obuhvaća davanje terapeutski učinkovite količine sredstva koje vrši:
(a) prekidanje vezanja ljudskog proteina R-spondin (RSPO-proteina) i ljudskog receptora spojenog na G-protein, koji je bogat leukinima s ponavljanjem sadržaja (receptora LGR-proteina), pri čemu LGR-protein je LGR5; i/ili
(b) prekidanje RSPO-aktiviranja od LGR5-signaliziranja,
pri čemu sredstvo je protutijelo prema bilo kojem od zahtjeva 1 do 8, ili je topivi receptor prema bilo kojem od zahtjeva 12 do 15.
17. Sredstvo za uporabu prema zahtjevu 16, naznačeno time, da se radi o protutijelu prema bilo kojem od zahtjeva 1 do 8.
18. Sredstvo za uporabu prema zahtjevu 16 ili zahtjevu 17, naznačeno time, da čovjek ima tumor koji obuhvaća matične stanice raka ili je čovjeku odstranjen tumor koji je obuhvaćao matične stanice raka.
19. Sredstvo za uporabu prema bilo kojem od zahtjeva 16 do 18, naznačeno time, da postupak liječenja raka i/ili inhibiranja rasta tumora, nadalje obuhvaća davanje učinkovite količine drugog antitumorskog sredstva.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94761107P | 2007-07-02 | 2007-07-02 | |
| EP08779934.2A EP2173379B2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
| PCT/US2008/008210 WO2009005809A2 (en) | 2007-07-02 | 2008-07-02 | Compositions and methods for treating and diagnosing cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151261T1 true HRP20151261T1 (hr) | 2016-01-01 |
Family
ID=40226729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151261TT HRP20151261T1 (hr) | 2007-07-02 | 2015-11-24 | Sastavi i postupci za lijeäśenje i dijagnosticiranje raka |
Country Status (14)
| Country | Link |
|---|---|
| US (10) | US8158758B2 (hr) |
| EP (3) | EP2173379B2 (hr) |
| JP (3) | JP5931336B2 (hr) |
| AU (1) | AU2008270972B2 (hr) |
| CA (1) | CA2691378A1 (hr) |
| CY (1) | CY1116967T1 (hr) |
| DK (1) | DK2173379T3 (hr) |
| ES (2) | ES2553169T5 (hr) |
| HR (1) | HRP20151261T1 (hr) |
| HU (1) | HUE027154T2 (hr) |
| PL (2) | PL2173379T3 (hr) |
| PT (1) | PT2173379E (hr) |
| SI (1) | SI2173379T1 (hr) |
| WO (1) | WO2009005809A2 (hr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2157192T3 (pl) * | 2003-10-10 | 2014-01-31 | Deutsches Krebsforsch | Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin) |
| US8088374B2 (en) | 2006-10-20 | 2012-01-03 | Deutsches Krebsforschungszentrum Stiftung Des Offenlichen Rechts | Methods for inhibition of angiogenesis and vasculogenesis via rspondin antagonists |
| SI2173379T1 (sl) | 2007-07-02 | 2015-12-31 | Oncomed Pharmaceuticals, Inc. | Sestavki in postopki za zdravljenje in diagnosticiranje raka |
| JP5676107B2 (ja) * | 2007-11-14 | 2015-02-25 | 中外製薬株式会社 | 抗ｇｐｒ４９抗体を用いる癌の診断および治療 |
| WO2010016766A2 (en) * | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
| WO2010033553A2 (en) * | 2008-09-16 | 2010-03-25 | University Of Florida Research Foundation Inc. | Gene expression related to preeclampsia |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US8642339B2 (en) | 2009-02-03 | 2014-02-04 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
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| SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
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| US9057096B2 (en) | 2011-05-20 | 2015-06-16 | Board Of Regents Of The University Of Texas System | Regulation of Wnt/beta-catenin signaling |
| US8802097B2 (en) | 2011-07-15 | 2014-08-12 | Oncomed Pharmaceuticals, Inc. | Anti-RSPO1 antibodies |
| AU2013204484B2 (en) * | 2011-07-15 | 2016-05-12 | Oncomed Pharmaceuticals, Inc. | RSPO binding agents and uses thereof |
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| US9352039B2 (en) | 2012-02-09 | 2016-05-31 | The Regents Of The University Of Michigan | Method of reducing the number of EMT and MET type breast cancer stem cells |
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| AR090549A1 (es) * | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
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2013
- 2013-03-13 US US13/801,198 patent/US8883736B2/en active Active
- 2013-11-22 US US14/087,853 patent/US9040044B2/en active Active
-
2014
- 2014-05-19 JP JP2014103056A patent/JP2014144016A/ja not_active Withdrawn
- 2014-10-02 US US14/504,680 patent/US9610348B2/en active Active
-
2015
- 2015-04-22 US US14/693,648 patent/US9717794B2/en active Active
- 2015-11-24 HR HRP20151261TT patent/HRP20151261T1/hr unknown
- 2015-11-24 CY CY20151101056T patent/CY1116967T1/el unknown
-
2016
- 2016-07-28 JP JP2016148170A patent/JP2016187356A/ja active Pending
-
2017
- 2017-02-24 US US15/441,700 patent/US20170296658A1/en not_active Abandoned
- 2017-06-23 US US15/631,259 patent/US20180099047A1/en not_active Abandoned
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