JP2015509948A5 - - Google Patents
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- JP2015509948A5 JP2015509948A5 JP2014558901A JP2014558901A JP2015509948A5 JP 2015509948 A5 JP2015509948 A5 JP 2015509948A5 JP 2014558901 A JP2014558901 A JP 2014558901A JP 2014558901 A JP2014558901 A JP 2014558901A JP 2015509948 A5 JP2015509948 A5 JP 2015509948A5
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- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 39
- 101000864751 Homo sapiens Seizure protein 6 homolog Proteins 0.000 claims description 30
- 102100030057 Seizure protein 6 homolog Human genes 0.000 claims description 30
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
- 239000000611 antibody drug conjugate Substances 0.000 claims description 12
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 5
- 239000002254 cytotoxic agent Substances 0.000 claims description 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 201000005188 adrenal gland cancer Diseases 0.000 claims description 2
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 4
- 101100477420 Homo sapiens SEZ6 gene Proteins 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
- 229930195731 calicheamicin Natural products 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- -1 maytansinoid Chemical compound 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 description 5
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603203P | 2012-02-24 | 2012-02-24 | |
| US61/603,203 | 2012-02-24 | ||
| PCT/US2013/027476 WO2013126810A1 (en) | 2012-02-24 | 2013-02-22 | Anti sez6 antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018052506A Division JP2018127469A (ja) | 2012-02-24 | 2018-03-20 | 抗ｓｅｚ６抗体及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509948A JP2015509948A (ja) | 2015-04-02 |
| JP2015509948A5 true JP2015509948A5 (enExample) | 2016-04-14 |
| JP6401060B2 JP6401060B2 (ja) | 2018-10-03 |
Family
ID=47790548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558901A Expired - Fee Related JP6401060B2 (ja) | 2012-02-24 | 2013-02-22 | 抗ｓｅｚ６抗体及び使用方法 |
| JP2018052506A Pending JP2018127469A (ja) | 2012-02-24 | 2018-03-20 | 抗ｓｅｚ６抗体及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018052506A Pending JP2018127469A (ja) | 2012-02-24 | 2018-03-20 | 抗ｓｅｚ６抗体及び使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9676850B2 (enExample) |
| EP (2) | EP3539985A1 (enExample) |
| JP (2) | JP6401060B2 (enExample) |
| KR (1) | KR102099073B1 (enExample) |
| CN (2) | CN108383909B (enExample) |
| AU (3) | AU2013203506B2 (enExample) |
| CA (1) | CA2865415C (enExample) |
| CL (2) | CL2014002237A1 (enExample) |
| CO (1) | CO7151485A2 (enExample) |
| ES (1) | ES2741936T3 (enExample) |
| IL (1) | IL234208B (enExample) |
| MX (2) | MX373141B (enExample) |
| MY (1) | MY178120A (enExample) |
| NZ (1) | NZ631197A (enExample) |
| PE (1) | PE20150091A1 (enExample) |
| PH (2) | PH12020500604A1 (enExample) |
| RU (1) | RU2691698C2 (enExample) |
| SG (2) | SG10201801444WA (enExample) |
| WO (1) | WO2013126810A1 (enExample) |
| ZA (1) | ZA201406967B (enExample) |
Families Citing this family (41)
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|---|---|---|---|---|
| NZ631197A (en) * | 2012-02-24 | 2017-05-26 | Abbvie Stemcentrx Llc | Anti sez6 antibodies and methods of use |
| US11531028B2 (en) * | 2013-05-10 | 2022-12-20 | Nordic Bioscience A/S | Collagen type X alpha-1 assay |
| EP3038634A4 (en) * | 2013-08-28 | 2017-10-11 | AbbVie Stemcentrx LLC | Novel sez6 modulators and methods of use |
| BR112016004242A8 (pt) * | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Métodos para conjugação sítio-específica de anticorpos e composições |
| SG11201604191UA (en) * | 2013-11-04 | 2016-07-28 | Pfizer | Anti-efna4 antibody-drug conjugates |
| JP6594875B2 (ja) * | 2013-12-03 | 2019-10-23 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 細胞傷害性抗体 |
| PT3101131T (pt) * | 2014-01-29 | 2020-11-05 | Univ Kumamoto Nat Univ Corp | Anticorpo antitranstirretina humanizado |
| JP6517156B2 (ja) * | 2014-01-29 | 2019-05-22 | Ｋｍバイオロジクス株式会社 | 抗トランスサイレチンヒト抗体 |
| AU2015218633A1 (en) | 2014-02-21 | 2016-09-01 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
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| TW201617368A (zh) * | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| JP6574257B2 (ja) | 2014-10-07 | 2019-09-11 | アン アンド ロバート エイチ． ルーリー チルドレンズ ホスピタル オブ シカゴ | 新規の抗Ｎｏｄａｌ抗体及びその使用方法 |
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| TW202409084A (zh) | 2016-03-04 | 2024-03-01 | 美商Ｊｎ生物科學有限責任公司 | 針對tigit之抗體 |
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| US11066471B2 (en) * | 2016-10-19 | 2021-07-20 | Novelogics Biotechnology Inc. | Antibodies to MICA and MICB proteins |
| WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
| US11634486B2 (en) | 2016-12-23 | 2023-04-25 | Bluefin Biomedicine, Inc. | Anti-SEZ6L2 antibodies and antibody drug conjugates |
| EP3424527A1 (de) * | 2017-07-07 | 2019-01-09 | AVA Lifescience GmbH | Diagnostisches verfahren |
| JP7278623B2 (ja) * | 2018-04-13 | 2023-05-22 | ディンフー バイオターゲット カンパニー リミテッド | 抗ｃｄ２７抗体およびその使用 |
| KR20210018316A (ko) * | 2018-05-30 | 2021-02-17 | 애브비 스템센트알엑스 엘엘씨 | 항-sez6 항체 약물 접합체 및 사용 방법 |
| US12091453B2 (en) * | 2018-07-11 | 2024-09-17 | Hedgehog, Inc. | Epitope specific to SMO protein, antibody recognizing same, and composition comprising same |
| KR102894505B1 (ko) | 2018-07-31 | 2025-12-02 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 투여에 의한 전이성 뇌종양의 치료 |
| PL3808774T3 (pl) * | 2018-08-24 | 2025-06-23 | Jiangsu Hengrui Medicine Co., Ltd. | Przeciwciało wiążące ludzki il-4r, jego fragment wiążący antygen i ich zastosowanie medyczne |
| KR20230019152A (ko) | 2020-06-02 | 2023-02-07 | 아르커스 바이오사이언시즈 인코포레이티드 | Tigit에 대한 항체 |
| CN114106176B (zh) * | 2020-09-01 | 2024-04-09 | 深圳市菲鹏生物治疗股份有限公司 | Cd22抗体及其应用 |
| WO2022051223A1 (en) * | 2020-09-02 | 2022-03-10 | The Feinstein Institutes For Medical Research | Use of sars-cov-2 receptor binding motif (rbm)-reactive monoclonal antibodies to treat covid-19 |
| US20240269304A1 (en) | 2020-11-24 | 2024-08-15 | Novartis Ag | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| CN114790241B (zh) * | 2021-01-26 | 2024-12-13 | 北京免疫方舟医药科技有限公司 | 抗tigit抗体及其应用 |
| CN113307875B (zh) * | 2021-06-10 | 2022-09-02 | 福州迈新生物技术开发有限公司 | 抗TCRβF1蛋白单克隆抗体及其细胞株、制备方法和应用 |
| WO2023019174A2 (en) * | 2021-08-11 | 2023-02-16 | Apollos Diagnostics, Llc | Antibodies to sars-cov-2 |
| CR20240553A (es) | 2022-05-20 | 2025-05-02 | Servier Lab | Conjugados de anticuerpo-fármaco de compuestos antineoplásicos y métodos de uso de los mismos |
| AU2023270409A1 (en) | 2022-05-20 | 2024-11-21 | Novartis Ag | Antibody drug conjugates |
| CN115975036B (zh) * | 2022-08-18 | 2023-06-09 | 北京诺赛国际医学研究院 | 包含干细胞的药物组合物及其治疗癌症的用途 |
| CN121152805A (zh) * | 2023-05-08 | 2025-12-16 | 上海翰森生物医药科技有限公司 | 一种抗体或其抗原结合片段、抗体-药物偶联物及其应用 |
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| WO2025167503A1 (en) * | 2024-02-05 | 2025-08-14 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-sez6/b7h3 antibodies and uses thereof |
| CN119409821B (zh) * | 2024-10-18 | 2025-07-29 | 北京大学第一医院(北京大学第一临床医学院) | 一种抗sez6纳米抗体或抗原结合片段与应用 |
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