JP2015509948A5 - - Google Patents

Download PDF

Info

Publication number
JP2015509948A5
JP2015509948A5 JP2014558901A JP2014558901A JP2015509948A5 JP 2015509948 A5 JP2015509948 A5 JP 2015509948A5 JP 2014558901 A JP2014558901 A JP 2014558901A JP 2014558901 A JP2014558901 A JP 2014558901A JP 2015509948 A5 JP2015509948 A5 JP 2015509948A5
Authority
JP
Japan
Prior art keywords
seq
chain variable
variable region
antibody
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014558901A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015509948A (ja
JP6401060B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/027476 external-priority patent/WO2013126810A1/en
Publication of JP2015509948A publication Critical patent/JP2015509948A/ja
Publication of JP2015509948A5 publication Critical patent/JP2015509948A5/ja
Application granted granted Critical
Publication of JP6401060B2 publication Critical patent/JP6401060B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014558901A 2012-02-24 2013-02-22 抗sez6抗体及び使用方法 Expired - Fee Related JP6401060B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261603203P 2012-02-24 2012-02-24
US61/603,203 2012-02-24
PCT/US2013/027476 WO2013126810A1 (en) 2012-02-24 2013-02-22 Anti sez6 antibodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018052506A Division JP2018127469A (ja) 2012-02-24 2018-03-20 抗sez6抗体及び使用方法

Publications (3)

Publication Number Publication Date
JP2015509948A JP2015509948A (ja) 2015-04-02
JP2015509948A5 true JP2015509948A5 (enExample) 2016-04-14
JP6401060B2 JP6401060B2 (ja) 2018-10-03

Family

ID=47790548

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014558901A Expired - Fee Related JP6401060B2 (ja) 2012-02-24 2013-02-22 抗sez6抗体及び使用方法
JP2018052506A Pending JP2018127469A (ja) 2012-02-24 2018-03-20 抗sez6抗体及び使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018052506A Pending JP2018127469A (ja) 2012-02-24 2018-03-20 抗sez6抗体及び使用方法

Country Status (20)

Country Link
US (3) US9676850B2 (enExample)
EP (2) EP3539985A1 (enExample)
JP (2) JP6401060B2 (enExample)
KR (1) KR102099073B1 (enExample)
CN (2) CN104334580B (enExample)
AU (3) AU2013203506B2 (enExample)
CA (1) CA2865415C (enExample)
CL (2) CL2014002237A1 (enExample)
CO (1) CO7151485A2 (enExample)
ES (1) ES2741936T3 (enExample)
IL (1) IL234208B (enExample)
MX (2) MX373141B (enExample)
MY (1) MY178120A (enExample)
NZ (1) NZ631197A (enExample)
PE (1) PE20150091A1 (enExample)
PH (2) PH12020500604A1 (enExample)
RU (1) RU2691698C2 (enExample)
SG (2) SG10201801444WA (enExample)
WO (1) WO2013126810A1 (enExample)
ZA (1) ZA201406967B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201801444WA (en) * 2012-02-24 2018-04-27 Abbvie Stemcentrx Llc Anti sez6 antibodies and methods of use
US11531028B2 (en) * 2013-05-10 2022-12-20 Nordic Bioscience A/S Collagen type X alpha-1 assay
CA2922529A1 (en) 2013-08-28 2015-03-05 Stemcentrx, Inc. Novel sez6 modulators and methods of use
PE20160674A1 (es) * 2013-08-28 2016-07-21 Stemcentrx Inc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
BR112016010051A2 (pt) * 2013-11-04 2017-12-05 Pfizer ?conjugados de anticorpo-fármaco anti-efna4?
JP6594875B2 (ja) * 2013-12-03 2019-10-23 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ 細胞傷害性抗体
KR102240417B1 (ko) 2014-01-29 2021-04-13 케이엠 바이올로직스 가부시키가이샤 항-트랜스티레틴 인간 항체
CN106574258B (zh) * 2014-01-29 2021-03-30 Km生物医药股份公司 抗-运甲状腺素蛋白人源化抗体
WO2015127407A1 (en) 2014-02-21 2015-08-27 Stemcentrx, Inc. Anti-dll3 antibodies and drug conjugates for use in melanoma
EP3157634B1 (en) * 2014-06-23 2018-12-12 Bionomics, Inc. Antibodies that bind lgr4
TW201617368A (zh) 2014-09-05 2016-05-16 史坦森特瑞斯公司 新穎抗mfi2抗體及使用方法
EP3204414B1 (en) * 2014-10-07 2024-12-04 Ann and Robert H. Lurie Children's Hospital of Chicago Novel anti-nodal antibodies and methods of using same
MX2018002166A (es) * 2015-08-20 2018-09-12 Abbvie Stemcentrx Llc Conjugados anticuerpo anti-dll3-farmaco y metodos de uso.
CN108369269B (zh) 2015-10-06 2022-06-14 日本先锋公司 光控制装置、光控制方法和程序
WO2017087547A1 (en) * 2015-11-17 2017-05-26 Oncomed Pharmaceuticals, Inc. Pd-l1-binding agents and uses thereof
CN116514976A (zh) 2016-03-04 2023-08-01 Jn生物科学有限责任公司 针对tigit的抗体
EP3525814A4 (en) 2016-10-14 2020-09-23 Nima Labs, Inc. ANTI-GLIADINE ANTIBODY
CN110088137A (zh) * 2016-10-19 2019-08-02 诺瓦罗技科斯生物科技有限公司 针对mica和micb蛋白的抗体
WO2018107116A1 (en) * 2016-12-09 2018-06-14 Abbvie Stemcentrx Llc Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby
US11634486B2 (en) * 2016-12-23 2023-04-25 Bluefin Biomedicine, Inc. Anti-SEZ6L2 antibodies and antibody drug conjugates
EP3424527A1 (de) 2017-07-07 2019-01-09 AVA Lifescience GmbH Diagnostisches verfahren
EP3774898A4 (en) * 2018-04-13 2022-01-26 Dingfu Biotarget Co., Ltd. ANTI-CD27 ANTIBODIES AND USE THEREOF
BR112020024223A2 (pt) 2018-05-30 2021-03-16 Abbvie Stemcentrx Llc Conjugados anticorpo fármaco anti-sez6 e métodos de uso
US12091453B2 (en) * 2018-07-11 2024-09-17 Hedgehog, Inc. Epitope specific to SMO protein, antibody recognizing same, and composition comprising same
EP3831412A4 (en) 2018-07-31 2022-04-27 Daiichi Sankyo Company, Limited TREATMENT OF METASTATIC BRAIN TUMOR BY ADMINISTRATION OF AN ANTIBODY-DRUG CONJUGATE
BR112021002989A2 (pt) * 2018-08-24 2021-05-11 Jiangsu Hengrui Medicine Co., Ltd. anticorpo para ligação de il-4r de humano, fragmento para ligação de antígeno e uso médico do mesmo
US11820824B2 (en) 2020-06-02 2023-11-21 Arcus Biosciences, Inc. Antibodies to TIGIT
CN114106176B (zh) * 2020-09-01 2024-04-09 深圳市菲鹏生物治疗股份有限公司 Cd22抗体及其应用
WO2022051223A1 (en) * 2020-09-02 2022-03-10 The Feinstein Institutes For Medical Research Use of sars-cov-2 receptor binding motif (rbm)-reactive monoclonal antibodies to treat covid-19
AU2021386367A1 (en) 2020-11-24 2023-06-22 Les Laboratoires Servier Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
CN114790241B (zh) * 2021-01-26 2024-12-13 北京免疫方舟医药科技有限公司 抗tigit抗体及其应用
CN113307875B (zh) * 2021-06-10 2022-09-02 福州迈新生物技术开发有限公司 抗TCRβF1蛋白单克隆抗体及其细胞株、制备方法和应用
WO2023019174A2 (en) * 2021-08-11 2023-02-16 Apollos Diagnostics, Llc Antibodies to sars-cov-2
PE20251072A1 (es) 2022-05-20 2025-04-10 Novartis Ag Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos
KR20250011947A (ko) 2022-05-20 2025-01-22 노파르티스 아게 항체 약물 콘쥬게이트
CN115975036B (zh) * 2022-08-18 2023-06-09 北京诺赛国际医学研究院 包含干细胞的药物组合物及其治疗癌症的用途
KR20260008113A (ko) 2023-05-08 2026-01-15 상하이 한서 바이오메디컬 컴퍼니 리미티드 항체 또는 이의 항원 결합 단편, 항체-약물 접합체 및 이의 응용
CN117736331B (zh) * 2024-02-04 2024-05-07 南昌大学第一附属医院 一种特异性结合psma胞外段的单克隆抗体及其应用
WO2025167503A1 (en) * 2024-02-05 2025-08-14 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-sez6/b7h3 antibodies and uses thereof
CN120365421B (zh) * 2025-04-24 2025-11-04 成都古格尔生物技术有限公司 一种特异性抗sez6靶点的全人源抗体及其制备方法和应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
KR900005995A (ko) 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
WO1991006570A1 (en) 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
ATE145428T1 (de) 1990-12-14 1996-12-15 Cell Genesys Inc Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
DE69303494T2 (de) 1992-11-13 1997-01-16 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
HUT76369A (en) 1994-07-29 1997-08-28 Smithkline Beecham Corp Novel soluble protein compounds
WO1998052976A1 (en) 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
ES2375931T3 (es) 1997-12-05 2012-03-07 The Scripps Research Institute Humanización de anticuerpo murino.
PT1109812E (pt) 1998-08-27 2005-09-30 Spirogen Ltd Pirrolobenzodiazepinas
EP1051432B1 (en) 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
US20040067490A1 (en) * 2001-09-07 2004-04-08 Mei Zhong Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2001256977A1 (en) * 2000-04-28 2001-11-12 Eli Lilly And Company Human sez6 nucleic acids and polypeptides
US7608704B2 (en) 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
US20030211991A1 (en) * 2001-04-17 2003-11-13 Su Eric Wen Human sez6 nucleic acids and polypeptides
CN1343774A (zh) 2001-05-28 2002-04-10 复旦大学 一种癫痫相关蛋白编码序列,其编码的多肽、制法及用途
CA2478239A1 (en) 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
US20050008625A1 (en) 2003-02-13 2005-01-13 Kalobios, Inc. Antibody affinity engineering by serial epitope-guided complementarity replacement
WO2004101756A2 (en) 2003-05-09 2004-11-25 Diadexus, Inc. Ovr110 antibody compositions and methods of use
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
EP3434275A1 (en) 2003-11-06 2019-01-30 Seattle Genetics, Inc. Assay for cancer cells based on the use of auristatin conjugates with antibodies
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
CA2558195C (en) 2004-03-01 2012-11-06 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
US7189710B2 (en) 2004-03-30 2007-03-13 Council Of Scientific And Industrial Research C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
FR2869231B1 (fr) 2004-04-27 2008-03-14 Sod Conseils Rech Applic Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
US20070123448A1 (en) 2005-11-23 2007-05-31 The Hospital For Sick Children Novel chemical entities affecting neuroblastoma tumor-initiating cells
ATE527262T1 (de) 2006-01-25 2011-10-15 Sanofi Sa Neue tomaymycin derivate enhaltende zytotoxische mittel
CN101501187A (zh) 2006-06-06 2009-08-05 田纳西大学研究基金会 富含赘生干细胞的组合物及包含其的方法
CN101516912B (zh) 2006-06-07 2013-10-30 生物联合公司 识别癌细胞上表达的cd-43和cea的含糖表位的抗体及其使用方法
US7763242B2 (en) 2006-09-07 2010-07-27 Scott and White Memorial Hospital Methods for treating myelodysplastic syndrome with a human interleukin-3-diphtheria toxin conjugate
EP2109668A4 (en) 2007-01-22 2011-10-05 Macrogenics West Inc HUMAN CANCER STEM CELLS
KR101586617B1 (ko) * 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 pd-1에 대한 항체
WO2009012357A2 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
WO2009043051A2 (en) 2007-09-27 2009-04-02 Biogen Idec Ma Inc. Cd23 binding molecules and methods of use thereof
ES2613963T3 (es) 2008-01-18 2017-05-29 Medimmune, Llc Anticuerpos manipulados con cisteína para conjugación específica de sitio
JP5646457B2 (ja) 2008-04-29 2014-12-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
WO2010037134A2 (en) 2008-09-29 2010-04-01 Stemlifeline, Inc. Multi-stage stem cell carcinogenesis
WO2010081171A2 (en) 2009-01-12 2010-07-15 Cyntellect, Inc. Laser mediated sectioning and transfer of cell colonies
US20110020221A1 (en) 2009-04-09 2011-01-27 The Johns Hopkins University Cancer stem cell expression patterns and compounds to target cancer stem cells
AR078254A1 (es) 2009-09-01 2011-10-26 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
MX338932B (es) * 2010-03-12 2016-05-06 Immunogen Inc Moleculas de union cd37 y sus inmunoconjugados.
WO2011130598A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
JP5870400B2 (ja) 2010-04-15 2016-03-01 シアトル ジェネティクス,インコーポレーテッド 標的化ピロロベンゾジアゼピンコンジュゲート
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
US20120100560A1 (en) 2010-07-23 2012-04-26 The Johns Hopkins University Device for capture, enumeration, and profiling of circulating tumor cells
WO2012019060A1 (en) * 2010-08-05 2012-02-09 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications
US20130061342A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc. Identification and Enrichment of Cell Subpopulations
SG189212A1 (en) 2010-09-03 2013-05-31 Stem Centrx Inc Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US20130061340A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc. Identification and Enrichment of Cell Subpopulations
WO2013119964A2 (en) 2012-02-08 2013-08-15 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
EP2621526B1 (en) 2010-09-29 2018-06-06 Agensys, Inc. Antibody drug conjugates (adc) that bind to 191p4d12 proteins
SG10201801444WA (en) * 2012-02-24 2018-04-27 Abbvie Stemcentrx Llc Anti sez6 antibodies and methods of use
CA2922529A1 (en) * 2013-08-28 2015-03-05 Stemcentrx, Inc. Novel sez6 modulators and methods of use
PE20160674A1 (es) * 2013-08-28 2016-07-21 Stemcentrx Inc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
EP3209334A2 (en) 2014-10-20 2017-08-30 Igenica Biotherapeutics, Inc. Novel antibody-drug conjugates and related compounds, compositions, and methods of use
MA41645A (fr) * 2015-03-04 2018-01-09 Abbvie Stemcentrx Llc Anticorps issus de génie génétique spécifiques au site et méthodes d'utilisation
US11634486B2 (en) 2016-12-23 2023-04-25 Bluefin Biomedicine, Inc. Anti-SEZ6L2 antibodies and antibody drug conjugates

Similar Documents

Publication Publication Date Title
JP2015509947A5 (enExample)
JP2018127469A5 (enExample)
JP2016538318A5 (enExample)
ES2566602T3 (es) Anticuerpos anti-ErbB3
JP2016510002A5 (enExample)
JP2016536020A5 (enExample)
HRP20191169T1 (hr) Konjugati antidll3-protutijelo-pbd i njihove uporabe
JP2017518040A5 (enExample)
JP2016531915A5 (enExample)
JP2017500028A5 (enExample)
JP2021516973A5 (enExample)
JP2017535246A5 (enExample)
JP2016512551A5 (enExample)
JP2011046732A5 (enExample)
RU2016122041A (ru) Новые анти-клаудин антитела и способы их применения
JP2017512765A5 (enExample)
JP2021514973A5 (enExample)
RU2019118359A (ru) Антитело к cd73 человека
JP2019532056A5 (enExample)
EA202091590A1 (ru) Антитела против pd-l1 и варианты их применения
JP2010520290A5 (enExample)
JP2014530017A5 (enExample)
JP2015503909A5 (enExample)
JP2014502955A5 (enExample)
JP2016505546A5 (enExample)