JP2016510002A5 - - Google Patents
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- JP2016510002A5 JP2016510002A5 JP2015559019A JP2015559019A JP2016510002A5 JP 2016510002 A5 JP2016510002 A5 JP 2016510002A5 JP 2015559019 A JP2015559019 A JP 2015559019A JP 2015559019 A JP2015559019 A JP 2015559019A JP 2016510002 A5 JP2016510002 A5 JP 2016510002A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug conjugate
- antibody drug
- pharmaceutical composition
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940049595 antibody-drug conjugate Drugs 0.000 claims 37
- 239000000611 antibody drug conjugate Substances 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 5
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 239000000562 conjugate Substances 0.000 claims 2
- 229920002857 polybutadiene Polymers 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 102100036466 Delta-like protein 3 Human genes 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000053255 human DLL3 Human genes 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 230000000955 neuroendocrine Effects 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000005102 tumor initiating cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768368P | 2013-02-22 | 2013-02-22 | |
| US61/768,368 | 2013-02-22 | ||
| PCT/US2014/017810 WO2014130879A2 (en) | 2013-02-22 | 2014-02-21 | Novel antibody conjugates and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018242172A Division JP2019069983A (ja) | 2013-02-22 | 2018-12-26 | 新規抗体コンジュゲートおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510002A JP2016510002A (ja) | 2016-04-04 |
| JP2016510002A5 true JP2016510002A5 (enExample) | 2017-05-25 |
| JP6462591B2 JP6462591B2 (ja) | 2019-01-30 |
Family
ID=51391975
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559019A Expired - Fee Related JP6462591B2 (ja) | 2013-02-22 | 2014-02-21 | 新規抗体コンジュゲートおよびその使用 |
| JP2018242172A Pending JP2019069983A (ja) | 2013-02-22 | 2018-12-26 | 新規抗体コンジュゲートおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018242172A Pending JP2019069983A (ja) | 2013-02-22 | 2018-12-26 | 新規抗体コンジュゲートおよびその使用 |
Country Status (32)
Families Citing this family (108)
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| CN103997893B (zh) | 2011-10-14 | 2019-04-12 | 西雅图基因公司 | 吡咯并苯并二氮杂卓和靶向结合物 |
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| EP3489261B1 (en) | 2012-08-24 | 2020-10-21 | The Regents of The University of California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
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