HRP20201719T1 - Protutijela i imunokonjugati anti-her2 - Google Patents

Protutijela i imunokonjugati anti-her2 Download PDF

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Publication number
HRP20201719T1
HRP20201719T1 HRP20201719TT HRP20201719T HRP20201719T1 HR P20201719 T1 HRP20201719 T1 HR P20201719T1 HR P20201719T T HRP20201719T T HR P20201719TT HR P20201719 T HRP20201719 T HR P20201719T HR P20201719 T1 HRP20201719 T1 HR P20201719T1
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HR
Croatia
Prior art keywords
immunoconjugate
antibody
her2
image
seq
Prior art date
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HRP20201719TT
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English (en)
Inventor
Xiaocheng Chen
Mark Dennis
Jagath Reddy Junutula
Gail Lewis Phillips
Thomas Harden Pillow
Mark X. Sliwkowski
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Genentech, Inc.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54238547&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20201719(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HRP20201719T1 publication Critical patent/HRP20201719T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C—CHEMISTRY; METALLURGY
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Claims (51)

1. Izolirano protutijelo koje se veže na HER2, naznačeno time, da protutijelo obuhvaća: (i) (a) HVR-H1 koja sadrži aminokiselinski slijed od SEQ ID NO: 15; (b) HVR-H2 koja sadrži aminokiselinski slijed od SEQ ID NO: 16; (c) HVR-H3 koja sadrži aminokiselinski slijed od SEQ ID NO: 17; (d) HVR-L1 koja sadrži aminokiselinski slijed od SEQ ID NO: 12; (e) HVR-L2 koja sadrži aminokiselinski slijed od SEQ ID NO: 13; i (f) HVR-L3 koja sadrži aminokiselinski slijed od SEQ ID NO: 14; pri čemu se protutijelo veže na HER2 s konstantom disocijacije (KD) od ≤ 5nM kao što je određeno putem površinske plazmonske rezonancije; i/ili (ii) varijabilnu regiju teškog lanca koja sadrži slijed od SEQ ID NO: 11 i varijabilnu regiju lakog lanca koja sadrži slijed od SEQ ID NO: 10.
2. Protutijelo prema patentnom zahtjevu 1, naznačeno time, da protutijelo obuhvaća varijabilnu regiju teškog lanca koja sadrži slijed od SEQ ID NO: 11 i varijabilnu regiju lakog lanca koja sadrži slijed od SEQ ID NO: 10.
3. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je to monoklonsko protutijelo.
4. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je to humanizirano ili kimerno protutijelo.
5. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je to IgG1 protutijelo, IgG2a protutijelo ili IgG2b protutijelo.
6. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je to fragment protutijela koji se veže na HER2.
7. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da se protutijelo veže na izvanstaničnu domenu I od HER2, pri čemu izvanstanična domena I od HER2 ima slijed od SEQ ID NO: 35.
8. Protutijelo prema bilo kojem od prethodnih patentnih zahtjeva, naznačeno time, da je protutijelo obuhvaća najmanje jednu mutaciju u konstantnoj regiji teškog lanca, koja je odabrana od A118C i S400C i/ili obuhvaća najmanje jednu mutaciju u konstantnoj regiji lakog lanca, koja je odabrana od K149C i V205C, gdje su ostatci numerirani u skladu s EU sustavom numeriranja.
9. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 3, naznačeno time, da protutijelo obuhvaća: (a) teški lanac koji sadrži slijed od SEQ ID NO: 19 i laki lanac koji sadrži slijed od SEQ ID NO: 18; ili (b) teški lanac koji sadrži slijed od SEQ ID NO: 19 i laki lanac koji sadrži slijed od SEQ ID NO: 23; ili (c) teški lanac koji sadrži slijed od SEQ ID NO: 24 i laki lanac koji sadrži slijed od SEQ ID NO: 18.
10. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 3, naznačeno time, da protutijelo obuhvaća teški lanac koji sadrži slijed od SEQ ID NO: 19 i laki lanac koji sadrži slijed od SEQ ID NO: 23.
11. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 7, naznačeno time, da protutijelo obuhvaća konstantnu regiju teškog lanca od SEQ ID NO: 28, ili s time, da protutijelo obuhvaća konstantnu regiju lakog lanca od SEQ ID NO: 25.
12. Izolirana nukleinska kiselina, naznačena time, da kodira protutijelo prema bilo kojem od prethodnih patentnih zahtjeva.
13. Stanica domaćina, naznačena time, da obuhvaća nukleinsku kiselinu prema patentnom zahtjevu 12.
14. Postupak za proizvodnju protutijela, naznačen time, da obuhvaća kultiviranje stanice domaćina prema patentnom zahtjevu 13, tako, da se proizvede protutijelo.
15. Imunokonjugat, naznačen time, da obuhvaća protutijelo prema bilo kojem od patentnih zahtjeva 1 do 11 i jedno citotoksično sredstvo.
16. Imunokonjugat prema patentnom zahtjevu 15, naznačen time, da obuhvaća protutijelo prema patentnom zahtjevu 2 ili zahtjevu 10 i jedno citotoksično sredstvo.
17. Imunokonjugat prema patentnom zahtjevu 15 ili zahtjevu 16, naznačen time, da imunokonjugat ima formulu Ab-(L-D)p, u kojoj: (a) Ab je protutijelo; (b) L je povezivač; (c) D je citotoksično sredstvo; i (d) p iznosi u rasponu od 1 do 8.
18. Imunokonjugat prema patentnom zahtjevu 17, naznačen time, da p iznosi u rasponu od 1,3 do 2 ili od 2 do 5.
19. Imunokonjugat prema patentnom zahtjevu 17, naznačen time, da p iznosi oko 2.
20. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 19, naznačen time, da je citotoksično sredstvo odabrano od auristatina, majtanzinoida, kaliheamicina, pirolobenzodiazepina, derivata nemorubicina, i 1-(klorometil)-2,3-dihidro-1H-benzo[e]indola (CBI).
21. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 19, naznačen time, da citotoksično sredstvo je pirolobenzodiazepin formule A: [image] gdje crtkane linije označavaju opcijsku prisutnost dvostruke veze između C1 i C2 ili C2 i C3; R2 je neovisno odabran od H, OH, =O, =CH2, CN, R, OR, =CH-RD, =C(RD)2, O-SO2-R, CO2R i COR, te je opcijski dalje odabran od halo ili dihalo, pri čemu RD je neovisno odabran od R, CO2R, COR, CHO, CO2H i halo; R6 i R9 su neovisno odabrani od H, R, OH, OR, SH, SR, NH2, NHR, NRR', NO2, Me3Sn i halo; R7 je neovisno odabran od H, R, OH, SH, SR, NH2, NHR, NRR', NO2, Me3Sn i halo; Q je neovisno odabran od O, S i NH; R11 je ili H ili R; ili Q je O a R11 je SO3M, dok je M metalni kation; svaki od R i R' je neovisno odabran od opcijski supstituiranih sljedećih skupina: C1-8 alkil, C3-8 heterociklil i C5-20 aril, te opcijski u odnosu na skupinu NRR', R i R' zajedno s dušikovim atomom na kojega su priključeni, tvore opcijski supstituirani 4-člani, 5-člani, 6-člani ili 7-člani heterociklički prsten; R12, R16, R19 i R17 su definirani isto kao za pojedinačno R2, R6, R9 odnosno R7; R'' je C3-12 alkilen-skupina čiji lanac može biti prekinut s jednim ili više heteroatoma i/ili aromatičnih prstena koji su opcijski supstituirani; i X i X' su neovisno odabrani od O, S i N(H).
22. Imunokonjugat prema patentnom zahtjevu 21, naznačen time, da D ima strukturu: [image] gdje n je 0 ili 1.
23. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 19, naznačen time, da citotoksično sredstvo je derivat nemorubicina.
24. Imunokonjugat prema patentnom zahtjevu 23, naznačen time, da citotoksično sredstvo ima strukturu koja je odabrana od sljedećih: [image]
25. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 19, naznačen time, da citotoksično sredstvo sadrži 1-(klorometil)-2,3-dihidro-1H-benzo[e]indol (CBI).
26. Imunokonjugat prema patentnom zahtjevu 25, naznačen time, da citotoksično sredstvo ima formulu: [image] u kojoj R1je odabran od H, P(O)3H2, C(O)NRaRb, ili je veza s L; R2 je odabran od H, P(O)3H2, C(O)NRaRb, ili je veza s L; Rai Rb su neovisno odabrani od H i C1-C6 alkila koji je opcijski supstituiran s jednim ili više F, ili Rai Rb tvore peteročlanu ili šesteročlanu heterocikličku skupinu; T je privezana skupina odabrana od C3-C12 alkilena, Y, (C1-C6 alkilen)-Y-(C1-C6 alkilena), (C1-C6 alkilen)-Y-(C1-C6 alkilen)-Y- (C1-C6 alkilena), (C2-C6 alkenilen)-Y-(C2-C6 alkenilena), i (C2-C6 alkinilen)-Y-(C2-C6 alkinilena); gdje je Y neovisno odabran od O, S, NR1, arila i heteroarila; dok su alkilen, alkenilen, aril i heteroaril neovisno i opcijski supstituirani s F, OH, O(C1-C6 alkilom), NH2, NHCH3, N(CH3)2, OP(O)3H2 i C1-C6 alkilom, pri čemu je alkil opcijski supstituiran s jednim ili više F; ili su alkilen, alkenilen, aril i heteroaril neovisno i opcijski supstituirani s vezom na L; D' je dio supstance odabran od sljedećih: [image] [image] i [image] gdje valovita linija označava mjesto priključenja na T; X1 i X2 su neovisno odabrani od O i NR3, gdje je R3 odabran od H i C1-C6 alkila opcijski supstituiranog s jednim ili više F; R4 je H, CO2R, ili je veza s povezivačem (L), gdje R je C1-C6 alkil ili benzil; i R5 je H ili C1-C6 alkil.
27. Imunokonjugat prema patentnom zahtjevu 26, naznačen time, da citotoksično sredstvo ima strukturu koja je odabrana od sljedećih: [image] [image] [image] i [image]
28. Imunokonjugat prema bilo kojem od patentnih zahtjeva 17 do 27, naznačen time, da se povezivač može cijepati putem proteaze.
29. Imunokonjugat prema bilo kojem od patentnih zahtjeva 17 do 27, naznačen time, da je povezivač kiselinski labilan.
30. Imunokonjugat prema patentnom zahtjevu 29, naznačen time, da povezivač sadrži hidrazin.
31. Imunokonjugat prema bilo kojem od patentnih zahtjeva 17 do 29, naznačen time, da povezivač sadrži disulfid.
32. Imunokonjugat prema bilo kojem od patentnih zahtjeva 17 do 19, naznačen time, da ima stukturu koja je odabrana od sljedećih: [image] [image] [image] [image] [image] [image] [image] [image] [image] i [image]
33. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 19, naznačen time, da citotoksično sredstvo ima strukturu: [image]
34. Imunokonjugat prema bilo kojem od patentnih zahtjeva 15 do 33, naznačen time, da se upotrebljava u liječenju pojedinca koji ima HER2-pozitivan rak.
35. Imunokonjugat za uporabu prema patentnom zahtjevu 34, naznačen time, da HER2-pozitivan rak je rak dojke ili rak želuca.
36. Imunokonjugat za uporabu prema patentnom zahtjevu 35, naznačen time, da HER2-pozitivan rak dojke je rak dojke u ranom stadiju.
37. Imunokonjugat za uporabu prema patentnom zahtjevu 35, naznačen time, da HER2-pozitivan rak dojke je metastatski rak dojke.
38. Imunokonjugat za uporabu prema bilo kojem od patentnih zahtjeva 34 do 37, naznačen time, da se imunokonjugat upotrebljava u kombinaciji s jednim ili više dodatnih terapeutskih sredstava.
39. Imunokonjugat za uporabu prema patentnom zahtjevu 38, naznačen time, da se kod jednog ili više dodatnih terapeutskih sredstava radi o protutijelu ili imunokonjugatu koji se veže na HER2.
40. Imunokonjugat za uporabu prema patentnom zahtjevu 39, naznačen time, da se kod jednog ili više dodatnih terapeutskih sredstava radi o (i) protutijelu ili imunokonjugatu koje/koji se veže na domenu II od HER2, i/ili (ii) protutijelu ili imunokonjugatu koje/koji se veže na domenu IV od HER2.
41. Imunokonjugat za uporabu prema patentnom zahtjevu 39, naznačen time, da jedno ili više dodatnih terapeutskih sredstava je/su: (1) odabrano/i od trastuzumaba, trastuzumaba-MCC-DM1 (T-DM1) i pertuzumaba; (2) trastuzumab; (3) T-DM1; (4) pertuzumab; ili (5) trastuzumab i pertuzumab.
42. Imunokonjugat za uporabu prema patentnom zahtjevu 41, naznačen time, da HER2-pozitivan rak je metastatski rak dojke, i pritom dodatno terapeutsko sredstvo je T-DM1.
43. Imunokonjugat za uporabu prema patentnom zahtjevu 41, naznačen time, da HER2-pozitivan rak je metastatski rak dojke, i pritom je dodatno terapeutsko sredstvo trastuzumab, pertuzumab i kemoterapeutsko sredstvo.
44. Imunokonjugat za uporabu prema bilo kojem od patentnih zahtjeva 34 do 43, naznačen time, da HER2-pozitivan rak je rak koji se periodično ponavlja.
45. Imunokonjugat za uporabu prema patentnom zahtjevu 44, naznačen time, da rak koji se periodično ponavlja je rak koji se lokalno periodično ponavlja.
46. Imunokonjugat za uporabu prema bilo kojem od patentnih zahtjeva 34 do 43, naznačen time, da HER2-pozitivan rak je rak koji napreduje.
47. Imunokonjugat za uporabu prema bilo kojem od patentnih zahtjeva 34 do 46, naznačen time, da HER2-pozitivan rak je takav, da se ne može odrezati.
48. Imunokonjugat za uporabu prema patentnom zahtjevu 34 ili zahtjevu 35, naznačen time, da liječenje obuhvaća: a) podvrgavanje pojedinca neoadjuvantnoj obradi s imunokonjugatom, b) odstranjivanje raka putem definitivne operacije, i c) podvrgavanje pojedinca adjuvantnoj obradi s imunokonjugatom.
49. Protutijelo prema bilo kojem od patentnih zahtjeva 1 do 11, naznačeno time, da je konjugirano na oznaku, pri čemu je oznaka opcijski pozitronski emiter, gdje je pozitronski emiter opcijski 89Zr.
50. Postupak detektiranja ljudskog HER2 u biološkom uzorku, naznačen time, da obuhvaća stavljanje u doticaj biološkog uzorka s protutijelom anti-HER2 prema bilo kojem od patentnih zahtjeva 1 do 11 i 49, pod uvjetima koji dopuštaju vezivanje protutijela anti-HER2 na ljudski HER2 koji se prirodno pojavljuje, te otkrivanje stanja o tome, da li se je stvorio kompleks u biološkom uzorku između protutijela anti-HER2 i ljudskog HER2 koji se prirodno pojavljuje, dok je biološki uzorak opcijski uzorak raka dojke ili raka želuca.
51. Protutijelo prema patentnom zahtjevu 49, naznačeno time, da se upotrebljava kod detektiranja HER2-pozitivnog raka, pri čemu detektiranje obuhvaća (i) davanje protutijela pojedincu koji ima ili se sumnja da ima HER2-pozitivan rak, i (ii) otkrivanje protutijela kod pojedinca, pri čemu se detektiranjem protutijela indicira postojanje HER2-pozitivnog raka kod pojedinca.
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX336540B (es) * 2010-06-08 2016-01-22 Genentech Inc Conjugados y anticuerpos manipulados geneticamente con cisteina.
US10077318B2 (en) * 2014-09-12 2018-09-18 Genentech, Inc. Cysteine engineered antibodies and conjugates
AU2015314954B2 (en) 2014-09-12 2021-05-13 Genentech, Inc. Anti-HER2 antibodies and immunoconjugates
WO2016044396A1 (en) * 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
WO2016148674A1 (en) 2015-03-13 2016-09-22 Endocyte, Inc. Conjugates for treating diseases
GB201510010D0 (en) 2015-06-09 2015-07-22 King S College London PDD and BPD compounds
EP3307780A1 (en) * 2015-06-15 2018-04-18 Genentech, Inc. Antibodies and immunoconjugates
GB201514928D0 (en) 2015-08-21 2015-10-07 King S College London PDD compounds
US20180339985A1 (en) 2015-08-21 2018-11-29 Femtogenix Limited Pdd compounds
NZ741261A (en) 2015-10-02 2019-11-29 Genentech Inc Pyrrolobenzodiazepine antibody drug conjugates and methods of use
US20200323991A1 (en) * 2016-03-29 2020-10-15 Endocyte, Inc. Pbd conjugates for treating diseases
WO2017173359A2 (en) * 2016-03-31 2017-10-05 University Of Southern California Methods of constructing immunoglobulin fusion proteins inhibiting cathepsin b and compositions thereof
JP7049276B2 (ja) 2016-06-24 2022-04-06 メルサナ セラピューティクス インコーポレイテッド ピロロベンゾジアゼピンおよびその結合体
WO2018031662A1 (en) 2016-08-11 2018-02-15 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
FI3548515T3 (fi) 2016-12-01 2026-03-04 Regeneron Pharma Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen
AU2018219909B2 (en) 2017-02-10 2025-02-27 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-LAG3 antibodies for immuno-PET imaging
KR102697394B1 (ko) 2017-02-28 2024-08-20 씨젠 인크. 컨쥬게이션을 위한 시스테인 변이된 항체
AR111651A1 (es) * 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
WO2018227023A1 (en) * 2017-06-07 2018-12-13 Silverback Therapeutics, Inc. Antibody construct conjugates
JP7145891B2 (ja) * 2017-06-14 2022-10-03 アーデーセー セラピューティクス ソシエテ アノニム 抗ｃｄ１９ ａｄｃを投与するための投与レジメ
IL316355A (en) 2017-07-24 2024-12-01 Regeneron Pharma Anti-CD8 antibodies and their uses
HUE067109T2 (hu) * 2017-08-11 2024-09-28 Georg August Univ Goettingen Eljárás egyszeresen védett bifunkciós prodrugok elõállítására, az ezeken alapuló antitest hatóanyag konjugátumok, valamint eljárás az antitest hatóanyag konjugátumok elõállítására
CN118772287A (zh) 2018-02-08 2024-10-15 豪夫迈·罗氏有限公司 双特异性抗原结合分子和使用方法
WO2019197600A1 (en) 2018-04-13 2019-10-17 F. Hoffmann-La Roche Ag Her2-targeting antigen binding molecules comprising 4-1bbl
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
IL281344B2 (en) 2018-09-10 2025-09-01 Mirati Therapeutics Inc Combination of adagrasib and cetuximab for cancer treatment
US20200179500A1 (en) * 2018-12-05 2020-06-11 Wayne State University Methods and immunogenic compositions relating to her2 with selective sequence modifications
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
KR20210127714A (ko) * 2019-03-07 2021-10-22 에이비엘바이오 주식회사 항체-약물 접합체 및 이의 용도
AU2020381495A1 (en) 2019-11-15 2022-05-19 Seagen Inc. Methods of treating HER2 positive breast cancer with tucatinib in combination with an anti-HER2 antibody-drug conjugate
KR20220119445A (ko) * 2019-12-20 2022-08-29 화이자 인코포레이티드 부위 특이적 her2 항체-약물 접합체를 사용한 치료
CN111606996B (zh) * 2020-06-05 2020-12-25 北京鼎成肽源生物技术有限公司 一种靶向4d5的鼠源单克隆抗体及其制备方法和应用
IL297880A (en) 2020-06-23 2023-01-01 Hoffmann La Roche Agonistic cd28 antigen binding molecules targeting her2
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
EP4345113A1 (en) * 2022-09-30 2024-04-03 SDS Optic Spolka Akcyjna Anti-her2 antibody, a nucleic acid molecule encoding the variable region of said antibody, a method of detecting her2 in a biological sample, an immuno-enzymatic elisa assay and use of said anti-her2 antibody or fragments therefof
AU2023393382A1 (en) 2022-12-14 2025-06-19 Pheon Therapeutics Ltd Cytotoxic compounds
JP2026502860A (ja) 2022-12-23 2026-01-27 ジェネンテック， インコーポレイテッド セレブロン分解剤コンジュゲートおよびその使用
WO2026006689A2 (en) 2024-06-28 2026-01-02 Firefly Bio, Inc. Bcl-xl degrader antibody conjugates and uses thereof

Family Cites Families (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US633410A (en) 1898-09-22 1899-09-19 George A Ames Ice-cutter.
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4137230A (en) 1977-11-14 1979-01-30 Takeda Chemical Industries, Ltd. Method for the production of maytansinoids
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4265814A (en) 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
JPS5562090A (en) 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS5566585A (en) 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS55164685A (en) 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4309428A (en) 1979-07-30 1982-01-05 Takeda Chemical Industries, Ltd. Maytansinoids
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4427588A (en) 1982-11-08 1984-01-24 Bristol-Myers Company Process for conversion of oxotomaymycin to tomaymycin
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
IL106992A (en) 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
FI903489A0 (fi) 1988-11-11 1990-07-10 Medical Res Council Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna.
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
CA2026147C (en) 1989-10-25 2006-02-07 Ravi J. Chari Cytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
AU657961B2 (en) 1991-04-19 1995-03-30 Nexstar Pharmaceuticals, Inc. Pharmaceutical formulation and process
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
US5362852A (en) 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
EP1005870B1 (en) 1992-11-13 2009-01-21 Biogen Idec Inc. Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
WO1994029351A2 (en) 1993-06-16 1994-12-22 Celltech Limited Antibodies
CA2173150C (en) 1993-10-01 2004-11-30 Kyoichi Sakakibara Novel peptide derivatives
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
GB2315067B (en) 1996-07-11 2000-02-16 Pharmacia Spa Morpholinyl anthracycline derivatives
US7371376B1 (en) * 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
CA2269204C (en) 1996-10-18 2012-01-24 Genentech, Inc. Anti-erbb2 antibodies
DK0979281T3 (da) 1997-05-02 2005-11-21 Genentech Inc Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ES2244066T3 (es) 1997-06-24 2005-12-01 Genentech, Inc. Procedimiento y composiciones de glicoproteinas galactosiladas.
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
EP1028751B1 (en) 1997-10-31 2008-12-31 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
AU760562B2 (en) 1997-12-05 2003-05-15 Scripps Research Institute, The Humanization of murine antibody
WO1999048527A1 (en) 1998-03-27 1999-09-30 Genentech, Inc. Apo-2 ligand-anti-her-2 antibody synergism
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
DE69937291T2 (de) 1998-04-02 2008-07-10 Genentech, Inc., South San Francisco Antikörpervarianten und fragmente davon
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
ES2292682T3 (es) 1998-05-06 2008-03-16 Genentech, Inc. Purificacion de anticuerpos mediante cromatografia de intercambio ionico.
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
CA2341471C (en) 1998-08-27 2009-04-07 Spirogen Limited Pyrrolbenzodiazepines
KR101077001B1 (ko) 1999-01-15 2011-10-26 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1176195B1 (en) 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
DE60022369T2 (de) 1999-10-04 2006-05-18 Medicago Inc., Sainte Foy Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff
AU7950400A (en) 1999-10-19 2001-04-30 Kyowa Hakko Kogyo Co. Ltd. Process for producing polypeptide
WO2001044463A1 (en) 1999-12-15 2001-06-21 Genentech, Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
EP1242438B1 (en) 1999-12-29 2006-11-08 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
ES2637801T3 (es) 2000-04-11 2017-10-17 Genentech, Inc. Anticuerpos multivalentes y usos de los mismos
PT1282443E (pt) 2000-05-19 2009-12-04 Genentech Inc Análise de detecção génica para melhorar a probabilidade de uma resposta eficaz a uma terapia do cancro com um antagonista de erbb
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CN102311986B (zh) 2000-10-06 2015-08-19 协和发酵麒麟株式会社 产生抗体组合物的细胞
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP3523245B1 (ja) 2000-11-30 2004-04-26 メダレックス，インコーポレーテッド ヒト抗体作製用トランスジェニック染色体導入齧歯動物
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
RU2321630C2 (ru) 2001-08-03 2008-04-10 Гликарт Биотекнолоджи АГ Гликозилированные антитела (варианты), обладающие повышенной антителозависимой клеточной цитотоксичностью
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
WO2003026577A2 (en) 2001-09-24 2003-04-03 Seattle Genetics, Inc. P-amidobenzylethers in drug delivery agents
US20030157108A1 (en) 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
CA2467242A1 (en) 2001-11-20 2003-05-30 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US6660856B2 (en) 2002-03-08 2003-12-09 Kaohsiung Medical University Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
CN102911987B (zh) 2002-04-09 2015-09-30 协和发酵麒麟株式会社 基因组被修饰的细胞
JP4628679B2 (ja) 2002-04-09 2011-02-09 協和発酵キリン株式会社 Ｇｄｐ−フコースの輸送に関与する蛋白質の活性が低下または欠失した細胞
WO2003084569A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Drug containing antibody composition
US20040132140A1 (en) 2002-04-09 2004-07-08 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
AU2003236018A1 (en) 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa
US20050031613A1 (en) 2002-04-09 2005-02-10 Kazuyasu Nakamura Therapeutic agent for patients having human FcgammaRIIIa
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
JP4753578B2 (ja) 2002-06-03 2011-08-24 ジェネンテック， インコーポレイテッド 合成抗体ファージライブラリー
WO2004032828A2 (en) 2002-07-31 2004-04-22 Seattle Genetics, Inc. Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
AR040956A1 (es) 2002-07-31 2005-04-27 Schering Ag Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico
DE60336149D1 (de) 2002-08-16 2011-04-07 Immunogen Inc Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
ES2347241T3 (es) 2002-12-16 2010-10-27 Genentech, Inc. Variantes de inmunoglobulina y sus utilizaciones.
US20050079574A1 (en) 2003-01-16 2005-04-14 Genentech, Inc. Synthetic antibody phage libraries
MXPA05007668A (es) 2003-01-24 2005-09-30 Schering Ag Colorantes hidrofilicos de cianina, reactivos a tiol y conjugados de los mismos con biomoleculas para diagnostico por fluorescencia.
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
ATE421967T1 (de) 2003-03-31 2009-02-15 Council Scient Ind Res Nichtvernetzende pyrroloä2,1-cüä1, 4übenzodiazepine als potentielle antitumor- agentien und ihre herstellung
US7755007B2 (en) 2003-04-17 2010-07-13 K&H Manufacturing, Inc Heated pet mat
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
US20080241884A1 (en) 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
US20070134759A1 (en) 2003-10-09 2007-06-14 Harue Nishiya Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
WO2005040170A2 (en) 2003-10-22 2005-05-06 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
ES2672640T3 (es) 2003-11-05 2018-06-15 Roche Glycart Ag Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas
CN107213469A (zh) 2003-11-06 2017-09-29 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
WO2005053742A1 (ja) 2003-12-04 2005-06-16 Kyowa Hakko Kogyo Co., Ltd. 抗体組成物を含有する医薬
US7004206B2 (en) 2004-01-29 2006-02-28 Viken James P Automatic fluid exchanger
EP1718667B1 (en) 2004-02-23 2013-01-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
CA2558195C (en) 2004-03-01 2012-11-06 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
US7528126B2 (en) 2004-03-09 2009-05-05 Spirogen Limited Pyrrolobenzodiazepines
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
CN1942483B (zh) 2004-04-13 2012-09-26 弗·哈夫曼-拉罗切有限公司 抗p型选凝素抗体
FR2869231B1 (fr) 2004-04-27 2008-03-14 Sod Conseils Rech Applic Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
KR20110050567A (ko) 2004-07-22 2011-05-13 제넨테크, 인크. Ｈｅｒ２ 항체 조성물
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
UA94899C2 (ru) 2005-01-21 2011-06-25 Дженентек, Инк. Фиксированное дозирование антител к her
DK1850874T3 (da) 2005-02-23 2013-11-11 Genentech Inc Forlængelse af tid til sygdomsprogression eller overlevelse for ovariecancer ved anvendelse af pertuzumab
WO2007008603A1 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
DE602006021205D1 (de) 2005-10-07 2011-05-19 Exelixis Inc Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
EP1973951A2 (en) 2005-12-02 2008-10-01 Genentech, Inc. Binding polypeptides with restricted diversity sequences
SI1813614T1 (sl) 2006-01-25 2012-01-31 Sanofi 174 Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
WO2007134050A2 (en) 2006-05-09 2007-11-22 Genentech, Inc. Binding polypeptides with optimized scaffolds
NZ574215A (en) 2006-07-18 2012-07-27 Sanofi Aventis Antagonist antibody against epha2 for the treatment of cancer
EP2059533B1 (en) 2006-08-30 2012-11-14 Genentech, Inc. Multispecific antibodies
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
CN100592373C (zh) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 液晶显示面板驱动装置及其驱动方法
SI2019104T1 (sl) 2007-07-19 2013-12-31 Sanofi Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
SI2235064T1 (sl) 2008-01-07 2016-04-29 Amgen Inc. Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
ES2547552T3 (es) 2008-02-01 2015-10-07 Genentech, Inc. Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos
JP6067222B2 (ja) 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
GB0819097D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
SG173152A1 (en) 2009-02-05 2011-08-29 Immunogen Inc Novel benzodiazepine derivatives
CA3026727C (en) 2009-04-08 2022-03-22 Deutsches Krebsforschungszentrum Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
FR2949469A1 (fr) 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
WO2011069074A2 (en) 2009-12-04 2011-06-09 Genentech, Inc. Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1
CA2789337A1 (en) 2010-02-16 2011-08-25 Medimmune, Llc Hsa-related compositions and methods of use
CN102167742B (zh) * 2010-02-25 2014-05-14 上海百迈博制药有限公司 一种全人源抗her2单克隆抗体、其制备方法及用途
WO2011130598A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
KR101772354B1 (ko) 2010-04-15 2017-08-28 시애틀 지네틱스, 인크. 표적화된 피롤로벤조디아제핀 접합체
US9637557B2 (en) 2010-04-23 2017-05-02 Genentech, Inc. Production of heteromultimeric proteins
MX336540B (es) 2010-06-08 2016-01-22 Genentech Inc Conjugados y anticuerpos manipulados geneticamente con cisteina.
FR2963007B1 (fr) 2010-07-26 2013-04-05 Sanofi Aventis Derives anticancereux, leur preparation et leur application therapeutique
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
BR112013013127B1 (pt) 2010-12-02 2021-06-22 Nerviano Medical Sciences S.R.L. Processo para a preparação de derivados de morfolinil antraciclina, compostos derivados de morfolinil antraciclina e composição farmacêutica compreendendo estes compostos
CN103649117B (zh) 2011-02-04 2016-09-14 霍夫曼-拉罗奇有限公司 Fc变体及其生成方法
KR20190089048A (ko) 2011-02-15 2019-07-29 이뮤노젠 아이엔씨 컨쥬게이트의 제조방법
CN202049853U (zh) 2011-03-01 2011-11-23 旭丽电子(广州)有限公司 薄型变压器及灯管
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
BR112013024574B1 (pt) 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
WO2013041606A1 (en) 2011-09-20 2013-03-28 Spirogen Sàrl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
WO2013055987A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
BR112014008888A2 (pt) 2011-10-14 2017-04-18 Seattle Genetics Inc pirrolobenzodiazepinas
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
MX358757B (es) 2011-10-14 2018-09-03 Seattle Genetics Inc Pirrolobenzodiazepinas y conjugados dirigidos.
AR091033A1 (es) 2012-05-14 2014-12-30 Sanofi Sa Metodo para producir 11-des-o-metiltomaimicina recombinante
WO2013177481A1 (en) 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazepines and conjugates thereof
TW201406785A (zh) 2012-07-09 2014-02-16 Genentech Inc 抗ｃｄ２２抗體及免疫結合物
US20150218220A1 (en) 2012-09-12 2015-08-06 Brian Alan MENDELSOHN Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
MX364328B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina.
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
WO2014057118A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
HRP20190366T1 (hr) 2012-10-12 2019-04-19 Medimmune Limited Pirolobenzodiazepini i njihovi konjugati
WO2014057117A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
HRP20181646T2 (hr) 2012-10-12 2019-08-09 Adc Therapeutics Sa Konjugati pirolobenzodiazepin - anti-psma protutijela
PL2906251T3 (pl) 2012-10-12 2018-02-28 Adc Therapeutics Sa Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22
HRP20171264T1 (hr) 2012-10-12 2017-10-20 Adc Therapeutics Sa Konjugati protutijela anti-her2-pirolobenzodiazepina
AU2013366493B2 (en) 2012-12-21 2017-08-24 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
CN105246894A (zh) 2012-12-21 2016-01-13 斯皮罗根有限公司 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
RU2019109456A (ru) 2013-02-22 2019-04-10 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые конъюгаты антител и их применения
EP2774624A1 (en) 2013-03-04 2014-09-10 Heidelberg Pharma GmbH Amatoxin derivatives
US10442836B2 (en) 2013-08-12 2019-10-15 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
MX381017B (es) 2013-12-16 2025-03-12 Genentech Inc Compuestos peptidomiméticos y conjugados anticuerpo-fármaco de estos.
JP6895254B2 (ja) 2013-12-16 2021-06-30 ジェネンテック， インコーポレイテッド ペプチド模倣化合物及びその抗体−薬物コンジュゲート
AU2015314954B2 (en) 2014-09-12 2021-05-13 Genentech, Inc. Anti-HER2 antibodies and immunoconjugates
US10077318B2 (en) 2014-09-12 2018-09-18 Genentech, Inc. Cysteine engineered antibodies and conjugates
WO2016044396A1 (en) 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
JP2017533887A (ja) 2014-09-17 2017-11-16 ジェネンテック， インコーポレイテッド ピロロベンゾジアゼピン類及びその抗体ジスルフィドコンジュゲート
NZ741261A (en) 2015-10-02 2019-11-29 Genentech Inc Pyrrolobenzodiazepine antibody drug conjugates and methods of use
SE547027C2 (en) 2023-08-22 2025-04-08 S2H2 Bm Concept Ab Solar panel suspension system

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