BR112014008888A2 - pirrolobenzodiazepinas - Google Patents
pirrolobenzodiazepinasInfo
- Publication number
- BR112014008888A2 BR112014008888A2 BR112014008888A BR112014008888A BR112014008888A2 BR 112014008888 A2 BR112014008888 A2 BR 112014008888A2 BR 112014008888 A BR112014008888 A BR 112014008888A BR 112014008888 A BR112014008888 A BR 112014008888A BR 112014008888 A2 BR112014008888 A2 BR 112014008888A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolobenzodiazepines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547198P | 2011-10-14 | 2011-10-14 | |
| PCT/EP2012/070233 WO2013053873A1 (en) | 2011-10-14 | 2012-10-12 | Pyrrolobenzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014008888A2 true BR112014008888A2 (pt) | 2017-04-18 |
Family
ID=47019020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014008888A BR112014008888A2 (pt) | 2011-10-14 | 2012-10-12 | pirrolobenzodiazepinas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9399073B2 (pt) |
| EP (1) | EP2751111B1 (pt) |
| JP (1) | JP6170497B2 (pt) |
| KR (1) | KR101891859B1 (pt) |
| CN (1) | CN103998450B (pt) |
| AU (1) | AU2012322934B2 (pt) |
| BR (1) | BR112014008888A2 (pt) |
| CA (1) | CA2850103C (pt) |
| EA (1) | EA028457B1 (pt) |
| MX (1) | MX341523B (pt) |
| SG (1) | SG11201401021TA (pt) |
| WO (1) | WO2013053873A1 (pt) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| WO2013041606A1 (en) | 2011-09-20 | 2013-03-28 | Spirogen Sàrl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| EA027386B1 (ru) | 2011-10-14 | 2017-07-31 | Медимьюн Лимитед | Пирролобензодиазепины |
| EP2751111B1 (en) | 2011-10-14 | 2017-04-26 | MedImmune Limited | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases |
| JP6393617B2 (ja) | 2011-10-14 | 2018-09-19 | シアトル ジェネティクス，インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
| JP6399930B2 (ja) | 2011-10-14 | 2018-10-03 | シアトル ジェネティクス，インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
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2012
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| KR101891859B1 (ko) | 2018-08-24 |
| JP2014528467A (ja) | 2014-10-27 |
| MX2014004557A (es) | 2015-02-12 |
| EP2751111A1 (en) | 2014-07-09 |
| CA2850103C (en) | 2019-09-10 |
| CA2850103A1 (en) | 2013-04-18 |
| CN103998450A (zh) | 2014-08-20 |
| EP2751111B1 (en) | 2017-04-26 |
| JP6170497B2 (ja) | 2017-07-26 |
| KR20140099449A (ko) | 2014-08-12 |
| AU2012322934A1 (en) | 2014-05-29 |
| CN103998450B (zh) | 2017-03-08 |
| US20140274907A1 (en) | 2014-09-18 |
| EA201490535A1 (ru) | 2014-09-30 |
| AU2012322934B2 (en) | 2016-09-08 |
| SG11201401021TA (en) | 2014-08-28 |
| WO2013053873A1 (en) | 2013-04-18 |
| US9399073B2 (en) | 2016-07-26 |
| MX341523B (es) | 2016-08-24 |
| EA028457B1 (ru) | 2017-11-30 |
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