SI1879901T1 - Pirolobenzodiazepini - Google Patents
PirolobenzodiazepiniInfo
- Publication number
- SI1879901T1 SI1879901T1 SI200630604T SI200630604T SI1879901T1 SI 1879901 T1 SI1879901 T1 SI 1879901T1 SI 200630604 T SI200630604 T SI 200630604T SI 200630604 T SI200630604 T SI 200630604T SI 1879901 T1 SI1879901 T1 SI 1879901T1
- Authority
- SI
- Slovenia
- Prior art keywords
- me3sn
- nhr
- halo
- nitro
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0508084A GB0508084D0 (en) | 2005-04-21 | 2005-04-21 | Pyrrolobenzodiazepines |
| GB0522746A GB0522746D0 (en) | 2005-11-07 | 2005-11-07 | Pyrrolobenzodiazepines |
| EP06726846A EP1879901B1 (en) | 2005-04-21 | 2006-04-21 | Pyrrolobenzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1879901T1 true SI1879901T1 (sl) | 2010-04-30 |
Family
ID=36589321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200630604T SI1879901T1 (sl) | 2005-04-21 | 2006-04-21 | Pirolobenzodiazepini |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7612062B2 (sl) |
| EP (1) | EP1879901B1 (sl) |
| JP (1) | JP5061096B2 (sl) |
| KR (1) | KR101396095B1 (sl) |
| AT (1) | ATE452898T1 (sl) |
| AU (1) | AU2006238686B2 (sl) |
| BR (1) | BRPI0610284A8 (sl) |
| CA (1) | CA2604805C (sl) |
| CY (1) | CY1109911T1 (sl) |
| DE (1) | DE602006011300D1 (sl) |
| DK (1) | DK1879901T3 (sl) |
| ES (1) | ES2338696T3 (sl) |
| GB (1) | GB2439881C (sl) |
| MX (1) | MX2007013039A (sl) |
| NZ (1) | NZ563136A (sl) |
| PL (1) | PL1879901T3 (sl) |
| PT (1) | PT1879901E (sl) |
| SI (1) | SI1879901T1 (sl) |
| WO (1) | WO2006111759A1 (sl) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5079103U (sl) * | 1973-11-24 | 1975-07-09 | ||
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| EP2270010B1 (en) * | 2004-03-01 | 2012-01-25 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins |
| GB0404577D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0404574D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
| EP1723152B1 (en) * | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
| GB0410725D0 (en) * | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
| DE602006011300D1 (de) * | 2005-04-21 | 2010-02-04 | Spirogen Ltd | Pyrrolobenzodiazepine |
| ATE427949T1 (de) * | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
| KR100952137B1 (ko) * | 2008-04-18 | 2010-04-09 | 실리콘 디스플레이 (주) | 입체 영상 디스플레이 장치 및 그 제조방법 |
| WO2010008208A2 (ko) | 2008-07-17 | 2010-01-21 | 주식회사 파버나인코리아 | 유기 발광 다이오드 입체영상 표시장치 |
| GB0813432D0 (en) * | 2008-07-22 | 2008-08-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819097D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819095D0 (en) * | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| AU2011239522B2 (en) | 2010-04-15 | 2014-10-23 | Medimmune Limited | Targeted pyrrolobenzodiazapine conjugates |
| AU2011239525B2 (en) * | 2010-04-15 | 2015-04-09 | Medimmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
| KR101738203B1 (ko) | 2010-04-15 | 2017-05-19 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨주게이트 |
| GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
| EP2668210B1 (en) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
| RS59253B1 (sr) | 2011-05-08 | 2019-10-31 | Legochem Biosciences Inc | Konjugati aktivnog agensa proteina i postupak za njihovo dobijanje |
| AU2012311505B2 (en) | 2011-09-20 | 2016-09-29 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
| AU2012322933B2 (en) | 2011-10-14 | 2017-02-02 | Medimmune Limited | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
| US9526798B2 (en) * | 2011-10-14 | 2016-12-27 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| EP2750713B1 (en) | 2011-10-14 | 2015-09-16 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
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| JP6117801B2 (ja) | 2011-10-14 | 2017-04-19 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン |
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| GB9205051D0 (en) | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
| FR2696176B1 (fr) * | 1992-09-28 | 1994-11-10 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
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| GB9818732D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| DK1109812T3 (da) * | 1998-08-27 | 2005-09-05 | Spirogen Ltd | Pyrrolobenzodiazepiner |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| US6909006B1 (en) * | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
| US6660856B2 (en) * | 2002-03-08 | 2003-12-09 | Kaohsiung Medical University | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues |
| US20040138269A1 (en) * | 2002-10-11 | 2004-07-15 | Sugen, Inc. | Substituted pyrroles as kinase inhibitors |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| GB0321295D0 (en) * | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| GB0416511D0 (en) * | 2003-10-22 | 2004-08-25 | Spirogen Ltd | Pyrrolobenzodiazepines |
| AU2004284075A1 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
| EP2270010B1 (en) * | 2004-03-01 | 2012-01-25 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins |
| GB0404578D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0404577D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0404574D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
| EP1723152B1 (en) | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
| GB0410725D0 (en) * | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
| DE602006011300D1 (de) * | 2005-04-21 | 2010-02-04 | Spirogen Ltd | Pyrrolobenzodiazepine |
| ATE427949T1 (de) * | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
-
2006
- 2006-04-21 DE DE602006011300T patent/DE602006011300D1/de active Active
- 2006-04-21 CA CA2604805A patent/CA2604805C/en not_active Expired - Fee Related
- 2006-04-21 KR KR1020077027047A patent/KR101396095B1/ko active IP Right Grant
- 2006-04-21 PL PL06726846T patent/PL1879901T3/pl unknown
- 2006-04-21 MX MX2007013039A patent/MX2007013039A/es active IP Right Grant
- 2006-04-21 AU AU2006238686A patent/AU2006238686B2/en not_active Ceased
- 2006-04-21 PT PT06726846T patent/PT1879901E/pt unknown
- 2006-04-21 AT AT06726846T patent/ATE452898T1/de active
- 2006-04-21 NZ NZ563136A patent/NZ563136A/en not_active IP Right Cessation
- 2006-04-21 DK DK06726846.6T patent/DK1879901T3/da active
- 2006-04-21 BR BRPI0610284A patent/BRPI0610284A8/pt not_active Application Discontinuation
- 2006-04-21 US US11/911,890 patent/US7612062B2/en not_active Expired - Fee Related
- 2006-04-21 ES ES06726846T patent/ES2338696T3/es active Active
- 2006-04-21 JP JP2008507165A patent/JP5061096B2/ja not_active Expired - Fee Related
- 2006-04-21 GB GB0720721A patent/GB2439881C/en not_active Expired - Fee Related
- 2006-04-21 WO PCT/GB2006/001456 patent/WO2006111759A1/en not_active Application Discontinuation
- 2006-04-21 EP EP06726846A patent/EP1879901B1/en active Active
- 2006-04-21 SI SI200630604T patent/SI1879901T1/sl unknown
-
2009
- 2009-11-02 US US12/610,478 patent/US8633185B2/en not_active Expired - Fee Related
-
2010
- 2010-03-18 CY CY20101100248T patent/CY1109911T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2439881A (en) | 2008-01-09 |
| KR101396095B1 (ko) | 2014-05-15 |
| CY1109911T1 (el) | 2014-09-10 |
| GB2439881B (en) | 2009-04-08 |
| JP5061096B2 (ja) | 2012-10-31 |
| NZ563136A (en) | 2009-11-27 |
| EP1879901B1 (en) | 2009-12-23 |
| US20100113425A1 (en) | 2010-05-06 |
| JP2008536905A (ja) | 2008-09-11 |
| ES2338696T3 (es) | 2010-05-11 |
| DK1879901T3 (da) | 2010-05-03 |
| PT1879901E (pt) | 2010-03-29 |
| US20080167293A1 (en) | 2008-07-10 |
| MX2007013039A (es) | 2008-03-13 |
| CA2604805A1 (en) | 2006-10-26 |
| GB2439881C (en) | 2011-08-10 |
| US8633185B2 (en) | 2014-01-21 |
| GB0720721D0 (en) | 2007-12-05 |
| CA2604805C (en) | 2014-05-27 |
| AU2006238686A1 (en) | 2006-10-26 |
| BRPI0610284A8 (pt) | 2017-05-09 |
| US7612062B2 (en) | 2009-11-03 |
| WO2006111759A1 (en) | 2006-10-26 |
| PL1879901T3 (pl) | 2010-06-30 |
| ATE452898T1 (de) | 2010-01-15 |
| BRPI0610284A2 (pt) | 2010-06-08 |
| KR20080004618A (ko) | 2008-01-09 |
| AU2006238686B2 (en) | 2011-10-06 |
| EP1879901A1 (en) | 2008-01-23 |
| DE602006011300D1 (de) | 2010-02-04 |
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