DE602006011300D1 - Pyrrolobenzodiazepine - Google Patents
PyrrolobenzodiazepineInfo
- Publication number
- DE602006011300D1 DE602006011300D1 DE602006011300T DE602006011300T DE602006011300D1 DE 602006011300 D1 DE602006011300 D1 DE 602006011300D1 DE 602006011300 T DE602006011300 T DE 602006011300T DE 602006011300 T DE602006011300 T DE 602006011300T DE 602006011300 D1 DE602006011300 D1 DE 602006011300D1
- Authority
- DE
- Germany
- Prior art keywords
- me3sn
- nhr
- halo
- nitro
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0508084A GB0508084D0 (en) | 2005-04-21 | 2005-04-21 | Pyrrolobenzodiazepines |
GB0522746A GB0522746D0 (en) | 2005-11-07 | 2005-11-07 | Pyrrolobenzodiazepines |
PCT/GB2006/001456 WO2006111759A1 (en) | 2005-04-21 | 2006-04-21 | Pyrrolobenzodiazepines |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006011300D1 true DE602006011300D1 (de) | 2010-02-04 |
Family
ID=36589321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006011300T Active DE602006011300D1 (de) | 2005-04-21 | 2006-04-21 | Pyrrolobenzodiazepine |
Country Status (19)
Country | Link |
---|---|
US (2) | US7612062B2 (de) |
EP (1) | EP1879901B1 (de) |
JP (1) | JP5061096B2 (de) |
KR (1) | KR101396095B1 (de) |
AT (1) | ATE452898T1 (de) |
AU (1) | AU2006238686B2 (de) |
BR (1) | BRPI0610284A8 (de) |
CA (1) | CA2604805C (de) |
CY (1) | CY1109911T1 (de) |
DE (1) | DE602006011300D1 (de) |
DK (1) | DK1879901T3 (de) |
ES (1) | ES2338696T3 (de) |
GB (1) | GB2439881C (de) |
MX (1) | MX2007013039A (de) |
NZ (1) | NZ563136A (de) |
PL (1) | PL1879901T3 (de) |
PT (1) | PT1879901E (de) |
SI (1) | SI1879901T1 (de) |
WO (1) | WO2006111759A1 (de) |
Families Citing this family (106)
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AU2005219626B2 (en) * | 2004-03-01 | 2010-11-18 | Medimmune Limited | 11-hydroxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines |
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JP5166861B2 (ja) * | 2004-03-09 | 2013-03-21 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
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DK1879901T3 (da) * | 2005-04-21 | 2010-05-03 | Spirogen Ltd | Pyrrolobenzodiazepiner |
ATE427949T1 (de) * | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
KR100952137B1 (ko) * | 2008-04-18 | 2010-04-09 | 실리콘 디스플레이 (주) | 입체 영상 디스플레이 장치 및 그 제조방법 |
WO2010008208A2 (ko) | 2008-07-17 | 2010-01-21 | 주식회사 파버나인코리아 | 유기 발광 다이오드 입체영상 표시장치 |
GB0813432D0 (en) | 2008-07-22 | 2008-08-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
GB0819095D0 (en) * | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
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CA2795353C (en) * | 2010-04-15 | 2018-01-09 | Spirogen Developments Sarl | Pyrrolobenzodiazepines used to treat proliferative diseases |
SI2528625T1 (sl) | 2010-04-15 | 2013-11-29 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
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GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
AU2004284075A1 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
GB0416511D0 (en) * | 2003-10-22 | 2004-08-25 | Spirogen Ltd | Pyrrolobenzodiazepines |
GB0404574D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
AU2005219626B2 (en) * | 2004-03-01 | 2010-11-18 | Medimmune Limited | 11-hydroxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines |
GB0404578D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
JP5166861B2 (ja) | 2004-03-09 | 2013-03-21 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
GB0410725D0 (en) | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
DK1879901T3 (da) | 2005-04-21 | 2010-05-03 | Spirogen Ltd | Pyrrolobenzodiazepiner |
ATE427949T1 (de) | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
-
2006
- 2006-04-21 DK DK06726846.6T patent/DK1879901T3/da active
- 2006-04-21 SI SI200630604T patent/SI1879901T1/sl unknown
- 2006-04-21 WO PCT/GB2006/001456 patent/WO2006111759A1/en not_active Application Discontinuation
- 2006-04-21 JP JP2008507165A patent/JP5061096B2/ja not_active Expired - Fee Related
- 2006-04-21 BR BRPI0610284A patent/BRPI0610284A8/pt not_active Application Discontinuation
- 2006-04-21 PL PL06726846T patent/PL1879901T3/pl unknown
- 2006-04-21 MX MX2007013039A patent/MX2007013039A/es active IP Right Grant
- 2006-04-21 AU AU2006238686A patent/AU2006238686B2/en not_active Ceased
- 2006-04-21 NZ NZ563136A patent/NZ563136A/en not_active IP Right Cessation
- 2006-04-21 KR KR1020077027047A patent/KR101396095B1/ko active IP Right Grant
- 2006-04-21 GB GB0720721A patent/GB2439881C/en not_active Expired - Fee Related
- 2006-04-21 ES ES06726846T patent/ES2338696T3/es active Active
- 2006-04-21 AT AT06726846T patent/ATE452898T1/de active
- 2006-04-21 PT PT06726846T patent/PT1879901E/pt unknown
- 2006-04-21 EP EP06726846A patent/EP1879901B1/de active Active
- 2006-04-21 DE DE602006011300T patent/DE602006011300D1/de active Active
- 2006-04-21 US US11/911,890 patent/US7612062B2/en not_active Expired - Fee Related
- 2006-04-21 CA CA2604805A patent/CA2604805C/en not_active Expired - Fee Related
-
2009
- 2009-11-02 US US12/610,478 patent/US8633185B2/en not_active Expired - Fee Related
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2010
- 2010-03-18 CY CY20101100248T patent/CY1109911T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0610284A8 (pt) | 2017-05-09 |
EP1879901B1 (de) | 2009-12-23 |
AU2006238686A1 (en) | 2006-10-26 |
NZ563136A (en) | 2009-11-27 |
WO2006111759A1 (en) | 2006-10-26 |
GB2439881A (en) | 2008-01-09 |
BRPI0610284A2 (pt) | 2010-06-08 |
US20100113425A1 (en) | 2010-05-06 |
CY1109911T1 (el) | 2014-09-10 |
PT1879901E (pt) | 2010-03-29 |
ES2338696T3 (es) | 2010-05-11 |
JP2008536905A (ja) | 2008-09-11 |
GB2439881C (en) | 2011-08-10 |
US8633185B2 (en) | 2014-01-21 |
US7612062B2 (en) | 2009-11-03 |
GB0720721D0 (en) | 2007-12-05 |
SI1879901T1 (sl) | 2010-04-30 |
CA2604805A1 (en) | 2006-10-26 |
EP1879901A1 (de) | 2008-01-23 |
DK1879901T3 (da) | 2010-05-03 |
US20080167293A1 (en) | 2008-07-10 |
ATE452898T1 (de) | 2010-01-15 |
KR20080004618A (ko) | 2008-01-09 |
MX2007013039A (es) | 2008-03-13 |
GB2439881B (en) | 2009-04-08 |
AU2006238686B2 (en) | 2011-10-06 |
KR101396095B1 (ko) | 2014-05-15 |
CA2604805C (en) | 2014-05-27 |
JP5061096B2 (ja) | 2012-10-31 |
PL1879901T3 (pl) | 2010-06-30 |
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