BR112018015259A2 - métodos para preparação de anticorpos com um padrão de glicosilação definido - Google Patents

métodos para preparação de anticorpos com um padrão de glicosilação definido

Info

Publication number
BR112018015259A2
BR112018015259A2 BR112018015259A BR112018015259A BR112018015259A2 BR 112018015259 A2 BR112018015259 A2 BR 112018015259A2 BR 112018015259 A BR112018015259 A BR 112018015259A BR 112018015259 A BR112018015259 A BR 112018015259A BR 112018015259 A2 BR112018015259 A2 BR 112018015259A2
Authority
BR
Brazil
Prior art keywords
methods
molecules
preparing antibodies
antibodies
defined glycosylation
Prior art date
Application number
BR112018015259A
Other languages
English (en)
Inventor
Gao Changzhou
Toader Dorin
Dimasi Nazzareno
Thompson Pamela
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of BR112018015259A2 publication Critical patent/BR112018015259A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Abstract

a presente descrição se relaciona com um processo para preparação de anticorpos com um padrão de glicosilação definido, em particular anticorpos com uma glicana terminando em uma n-acetilglucosamina. os anticorpos da descrição são adequados para uso em um processo para conjugar uma carga útil com eles. a descrição se estende também a moléculas obtidas e obteníveis a partir do processo descrito aqui, novas moléculas e intermediários, composições compreendendo as referidas moléculas e usos das moléculas e composições, particularmente em tratamento, por exemplo, no tratamento de câncer.
BR112018015259A 2016-01-27 2017-01-26 métodos para preparação de anticorpos com um padrão de glicosilação definido BR112018015259A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662287472P 2016-01-27 2016-01-27
PCT/US2017/015005 WO2017132298A1 (en) 2016-01-27 2017-01-26 Methods for preparing antibodies with a defined glycosylation pattern

Publications (1)

Publication Number Publication Date
BR112018015259A2 true BR112018015259A2 (pt) 2018-12-18

Family

ID=59398609

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018015259A BR112018015259A2 (pt) 2016-01-27 2017-01-26 métodos para preparação de anticorpos com um padrão de glicosilação definido

Country Status (9)

Country Link
US (1) US11414477B2 (pt)
EP (1) EP3407914A4 (pt)
JP (1) JP6991978B2 (pt)
CN (1) CN108495653A (pt)
AU (1) AU2017212484C1 (pt)
BR (1) BR112018015259A2 (pt)
CA (1) CA3011734A1 (pt)
RU (1) RU2018128784A (pt)
WO (1) WO2017132298A1 (pt)

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GB202116442D0 (en) * 2021-11-15 2021-12-29 Actome Gmbh High-efficacy labeling of antibodies with oligonucleotide labels

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Also Published As

Publication number Publication date
RU2018128784A (ru) 2020-02-27
AU2017212484B2 (en) 2020-04-16
AU2017212484A1 (en) 2018-08-09
CN108495653A (zh) 2018-09-04
EP3407914A4 (en) 2019-08-07
WO2017132298A1 (en) 2017-08-03
JP6991978B2 (ja) 2022-02-03
CA3011734A1 (en) 2017-08-03
WO2017132298A8 (en) 2018-07-12
JP2019506161A (ja) 2019-03-07
AU2017212484C1 (en) 2020-11-05
EP3407914A1 (en) 2018-12-05
US20210214419A1 (en) 2021-07-15
US11414477B2 (en) 2022-08-16
RU2018128784A3 (pt) 2020-04-28

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2655 DE 23-11-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.