BR112017008696A2 - métodos e composições para células exterminadoras naturais - Google Patents

métodos e composições para células exterminadoras naturais

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Publication number
BR112017008696A2
BR112017008696A2 BR112017008696A BR112017008696A BR112017008696A2 BR 112017008696 A2 BR112017008696 A2 BR 112017008696A2 BR 112017008696 A BR112017008696 A BR 112017008696A BR 112017008696 A BR112017008696 A BR 112017008696A BR 112017008696 A2 BR112017008696 A2 BR 112017008696A2
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Brazil
Prior art keywords
methods
compositions
natural killer
exosomes
cells
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BR112017008696A
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English (en)
Inventor
J Copik Alicja
Altomare Deborah
L Oyer Jeremiah
Y Igarashi Robert
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Univ Central Florida Res Found Inc
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Publication of BR112017008696A2 publication Critical patent/BR112017008696A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/54—Interleukins [IL]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

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  • Health & Medical Sciences (AREA)
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Abstract

a presente invenção refere-se a novas composições e métodos para a estimulação e produção ou expansão de células exterminadoras naturais (nk). o número de células nk pode ser aumentado após o contato com os exosomas modificados com um ou mais peptídeos estimuladores. os métodos e composições para a produção de exosomas, em que os exosomas compreendem peptídeos estimuladores, também são descritos. também são descritos métodos de tratamento de câncer utilizando os exosomas estimuladores de nk divulgados ou células nk estimuladas pelos métodos divulgados.
BR112017008696A 2014-10-27 2015-10-27 métodos e composições para células exterminadoras naturais BR112017008696A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462069057P 2014-10-27 2014-10-27
PCT/US2015/057591 WO2016069607A1 (en) 2014-10-27 2015-10-27 Methods and compositions for natural killer cells

Publications (1)

Publication Number Publication Date
BR112017008696A2 true BR112017008696A2 (pt) 2017-12-26

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BR112017008696A BR112017008696A2 (pt) 2014-10-27 2015-10-27 métodos e composições para células exterminadoras naturais

Country Status (11)

Country Link
US (2) US11260076B2 (pt)
EP (1) EP3223856A4 (pt)
JP (3) JP7049830B2 (pt)
CN (2) CN107206100B (pt)
AU (2) AU2015339447B2 (pt)
BR (1) BR112017008696A2 (pt)
CA (1) CA2965952A1 (pt)
HK (1) HK1245080A1 (pt)
IL (2) IL294395A (pt)
SG (1) SG11201703397UA (pt)
WO (1) WO2016069607A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
KR102650803B1 (ko) * 2016-10-05 2024-03-25 유니버시티 오브 센트럴 플로리다 리서치 파운데이션, 인코포레이티드 Nk 세포 및 항-pdl1 암 요법과 관련된 방법 및 조성물
US10300089B2 (en) * 2016-11-08 2019-05-28 University Of Central Florida Research Foundation, Inc. Methods for high scale therapeutic production of memory NK cells
WO2018160673A1 (en) * 2017-02-28 2018-09-07 University Of Central Florida Research Foundation, Inc. Pm21 particles to improve bone marrow homing of nk cells
EP3600356A4 (en) 2017-03-27 2020-12-23 National University of Singapore ABBREVIATED NKG2D CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNOTHERAPY WITH NATURAL KILLER CELLS
AU2018245749A1 (en) 2017-03-27 2019-10-03 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
EP3600151A4 (en) * 2017-05-05 2021-01-13 Capricor, Inc. METHOD OF TREATMENT OF SYSTEMIC TRANSPLANT REJECTION WITH EXTRACELLULAR VESICLES
WO2018218151A1 (en) * 2017-05-25 2018-11-29 University Of Central Florida Research Foundation, Inc. Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells
WO2018217064A2 (ko) * 2017-05-26 2018-11-29 주식회사 녹십자랩셀 형질전환된 t세포를 이용한 자연살해세포의 배양방법
BR112020013131A2 (pt) * 2017-12-28 2020-12-08 Codiak Biosciences, Inc. Exossomos para imuno-oncologia e terapia anti-inflamatória
CN109467607B (zh) * 2017-12-28 2020-10-30 北京泽勤生物医药有限公司 一种靶向肿瘤的酸性敏感融合肽及其应用
KR20200118449A (ko) * 2018-01-30 2020-10-15 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 형질전환 성장 인자 베타-내성 자연 살해 세포
WO2019165097A1 (en) * 2018-02-21 2019-08-29 Board Of Regents,The University Of Taxas System Universal antigen presenting cells and uses thereof
CN109294985B (zh) 2018-10-25 2022-02-18 江苏普瑞康生物医药科技有限公司 一种用于nk细胞体外扩增的培养基体系及nk细胞体外扩增的方法
EP3656851A1 (en) * 2018-11-23 2020-05-27 Technische Universität Dresden Artificial hla-positive feeder cell lines for nk cells and uses thereof
CA3129843A1 (en) * 2019-02-14 2020-08-20 Research Institute At Nationwide Children's Hospital Use of plasma membrane particles, liposomes, and exosomes to assay immune cell potency
MX2021009786A (es) * 2019-02-14 2021-09-08 Res Institute At Nationwide Children´S Hospital Uso de un agente estimulante para evaluar la potencia de celulas inmunitarias.
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
KR20200110576A (ko) * 2019-03-15 2020-09-24 재단법인대구경북과학기술원 사이토카인 기반 면역세포 및 그의 면역 치료 용도
CN109846866A (zh) * 2019-03-27 2019-06-07 中国科学院昆明植物研究所 对映-贝壳杉烷型二萜类化合物Parvifoline AA在制药中的应用
CN112426438B (zh) * 2019-11-14 2023-12-05 上海鑫湾生物科技有限公司 用于调控酸性环境免疫应答的组合物、其制备方法和用途
CN110904052A (zh) * 2019-12-30 2020-03-24 北京鼎成肽源生物技术有限公司 一种snk细胞的培养方法
JP2023512562A (ja) 2020-02-05 2023-03-27 ダイアデム バイオセラピューティクス インコーポレイテッド 人工シナプス
WO2021201677A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting influenza
WO2021201679A1 (en) 2020-04-01 2021-10-07 Kiadis Pharma Intellectual Property B.V. Compositions and methods targeting coronaviruses
EP4142752A4 (en) * 2020-04-30 2024-08-07 Res Inst Nationwide Childrens Hospital ELIMINATION OF IMMUNOSUPPRESSION USING TGF-? RESISTANT NATURAL KILLER CELLS
CN112029722A (zh) * 2020-09-09 2020-12-04 广东昭泰体内生物医药科技有限公司 一种nk细胞培养基及其应用
CA3225138A1 (en) * 2021-06-23 2022-12-29 Editas Medicine, Inc. Engineered cells for therapy
WO2023147404A2 (en) * 2022-01-26 2023-08-03 Rutgers, The State University Of New Jersey Compositions and methods for expanding immune cells
CN114716566A (zh) * 2022-02-22 2022-07-08 广东粤港澳大湾区国家纳米科技创新研究院 一种融合蛋白及其在制备肿瘤药物中的应用
CN115058393B (zh) * 2022-07-13 2024-05-24 北京鼎成肽源生物技术有限公司 一种包被刺激物、培养试剂盒和自然杀伤细胞的培养方法
JP7220938B1 (ja) * 2022-09-28 2023-02-13 パナジー株式会社 微小粒子、ｎｋ細胞活性化剤、ｎｋ細胞の培養方法、活性化ｎｋ細胞の製造方法およびｎｋ細胞の活性化方法
CN115521914B (zh) * 2022-10-12 2024-04-19 西北工业大学 一种人原代自然杀伤细胞体外扩增体系及方法
WO2024182801A1 (en) * 2023-03-02 2024-09-06 Research Institute At Nationwide Children's Hospital Transforming growth factor-beta superfamily-imprinted natural killer cells for cancer immunotherapy
CN116676265B (zh) * 2023-04-18 2024-05-24 河南中医药大学第一附属医院 一种酸敏融合肽靶向外泌体及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624824A (en) 1989-03-24 1997-04-29 Yale University Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence
US5168053A (en) 1989-03-24 1992-12-01 Yale University Cleavage of targeted RNA by RNAase P
JP3015463B2 (ja) 1992-04-28 2000-03-06 エール ユニバーシティ 真核リボヌクレアーゼｐを用いるｒｎａの標的化切断および外部ガイド配列
US5869248A (en) 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US5683873A (en) 1995-01-13 1997-11-04 Innovir Laboratories, Inc. EGS-mediated inactivation of target RNA
US5877162A (en) 1996-03-14 1999-03-02 Innovir Laboratories, Inc. Short external guide sequences
US6849452B1 (en) * 1998-03-03 2005-02-01 Institut Gustave Roussy Methods for activating natural killer (NK) cells and means for carrying out said methods
FR2827872A1 (fr) 2001-07-30 2003-01-31 Roussy Inst Gustave Vesicules membranaires de fluide biologique preleve in vivo, leur preparation et utilisation dans la stimulation d'une reponse immunitaire
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
US20130266551A1 (en) * 2003-11-05 2013-10-10 St. Jude Children's Research Hospital, Inc. Chimeric receptors with 4-1bb stimulatory signaling domain
CA2504279A1 (en) * 2005-04-15 2006-10-15 University Of Saskatchewan Materials and method of modulating the immune response using t helper-antigen presenting cells
EP2493486A1 (en) * 2009-10-30 2012-09-05 University Of Arkansas For Medical Science Use of autologous effector cells and antibodies for treatment of multiple myeloma
CN102559600A (zh) * 2011-12-29 2012-07-11 上海交通大学医学院 一种人工抗原递呈细胞及其在nk细胞扩增中的应用
CN102586185A (zh) * 2012-03-12 2012-07-18 浙江中赢方舟生物工程股份有限公司 一种k562细胞扩增激活nk细胞的方法
HUE061931T2 (hu) * 2012-06-28 2023-09-28 Univ Of Central Florida Módszerek és készítmények természetes ölõsejtek számára
US9603873B2 (en) 2012-12-03 2017-03-28 Ohio State Innovation Foundation Activation of innate immunity by miRNA for cancer and infection treatment
CN103484429A (zh) * 2013-09-28 2014-01-01 青岛麦迪赛斯生物科技有限公司 一种nk细胞的制备方法

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JP2024028718A (ja) 2024-03-05
EP3223856A4 (en) 2018-05-02
IL294395A (en) 2022-08-01
US20220143092A1 (en) 2022-05-12
US12070474B2 (en) 2024-08-27
US11260076B2 (en) 2022-03-01
US20170333479A1 (en) 2017-11-23
SG11201703397UA (en) 2017-05-30
JP7049830B2 (ja) 2022-04-07
CN107206100A (zh) 2017-09-26
JP2022043068A (ja) 2022-03-15
AU2015339447A1 (en) 2017-05-25
IL251951B (en) 2022-07-01
JP2017532353A (ja) 2017-11-02
CN107206100B (zh) 2021-02-12
HK1245080A1 (zh) 2018-08-24
IL251951A0 (en) 2017-06-29
EP3223856A1 (en) 2017-10-04
CA2965952A1 (en) 2016-05-06
WO2016069607A1 (en) 2016-05-06
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AU2021266360A1 (en) 2021-12-09

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