AR115695A1 - Moléculas proteicas multifuncionales que comprenden decorina y uso de estas - Google Patents
Moléculas proteicas multifuncionales que comprenden decorina y uso de estasInfo
- Publication number
- AR115695A1 AR115695A1 ARP190101887A ARP190101887A AR115695A1 AR 115695 A1 AR115695 A1 AR 115695A1 AR P190101887 A ARP190101887 A AR P190101887A AR P190101887 A ARP190101887 A AR P190101887A AR 115695 A1 AR115695 A1 AR 115695A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein molecules
- multifunctional protein
- decorine
- molecules including
- decorin
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004237 Decorin Human genes 0.000 abstract 2
- 108090000738 Decorin Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a moléculas proteicas multifuncionales que comprenden decorina y usos de estas. En particular, la presente se refiere a moléculas proteicas multifuncionales que comprenden decorina y un polipéptido de direccionamiento tal como un anticuerpo y métodos para su producción y usos de estos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862693766P | 2018-07-03 | 2018-07-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115695A1 true AR115695A1 (es) | 2021-02-17 |
Family
ID=69060721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101887A AR115695A1 (es) | 2018-07-03 | 2019-07-03 | Moléculas proteicas multifuncionales que comprenden decorina y uso de estas |
Country Status (13)
Country | Link |
---|---|
US (3) | US11377488B2 (es) |
EP (1) | EP3817762A4 (es) |
JP (1) | JP2021529534A (es) |
KR (1) | KR20210040378A (es) |
CN (1) | CN112638403A (es) |
AR (1) | AR115695A1 (es) |
AU (1) | AU2019299110A1 (es) |
BR (1) | BR112020027026A2 (es) |
CA (1) | CA3105454A1 (es) |
MX (1) | MX2021000155A (es) |
SG (1) | SG11202013217PA (es) |
TW (1) | TW202012447A (es) |
WO (1) | WO2020009938A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11103590B2 (en) * | 2016-09-06 | 2021-08-31 | Cell-Medicine, Inc. | Immunostimulant |
CN114057877A (zh) * | 2020-08-07 | 2022-02-18 | 百奥泰生物制药股份有限公司 | 抗pd-l1抗体及其应用 |
CN115927472A (zh) * | 2021-07-05 | 2023-04-07 | 武汉纽福斯生物科技有限公司 | 一种抗vegf抗体体内表达系统的构建和应用 |
WO2023141856A1 (zh) * | 2022-01-27 | 2023-08-03 | 岩唐生物科技(杭州)有限责任公司 | 靶向cd3的多特异性抗体及其应用 |
CN117679505A (zh) * | 2022-09-09 | 2024-03-12 | 中山康方生物医药有限公司 | 药物组合及用途 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
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US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US20030224415A1 (en) | 2001-06-29 | 2003-12-04 | Gala Design, Inc. | Selection free growth of host cells containing multiple integrating vectors |
US20040235173A1 (en) | 2000-07-03 | 2004-11-25 | Gala Design, Inc. | Production of host cells containing multiple integrating vectors by serial transduction |
US6852510B2 (en) | 2000-07-03 | 2005-02-08 | Gala Design Inc | Host cells containing multiple integrating vectors |
WO2006038107A2 (en) | 2004-08-30 | 2006-04-13 | Mengsu Yang | Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein |
CN100376680C (zh) | 2005-11-01 | 2008-03-26 | 暨南大学 | 双重靶效应基因嵌合重组体及其构建方法和应用 |
WO2007056858A1 (en) * | 2005-11-18 | 2007-05-24 | Glenmark Pharmaceuticals S.A. | Anti-alpha2 integrin antibodies and their uses |
CN101333252A (zh) * | 2008-08-06 | 2008-12-31 | 温州医学院 | 能抑制肿瘤细胞生长和转移的饰胶蛋白及其制备方法和应用 |
US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
US8535681B2 (en) | 2008-10-16 | 2013-09-17 | Kathleen Cogan Farinas | Sustained drug delivery system |
EP2663647A4 (en) | 2011-01-14 | 2015-08-19 | Redwood Bioscience Inc | POLYPEPTIDE IMMUNOGLOBULINS WITH ALDEHYDIC MARKING AND THEIR USE METHOD |
JP5965927B2 (ja) * | 2011-03-14 | 2016-08-10 | キャタレント ファーマ ソリューションズ リミテッド ライアビリティ カンパニー | デコリン組成物およびその使用 |
CA2874541A1 (en) * | 2012-06-01 | 2013-12-05 | Ibc Pharmaceuticals, Inc. | Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy |
WO2016073906A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
ES2820768T3 (es) * | 2015-04-03 | 2021-04-22 | Xoma Technology Ltd | Tratamiento del cáncer usando inhibidores de TGF-beta y PD-1 |
WO2017214706A1 (en) | 2016-06-15 | 2017-12-21 | Tissue Regeneration Therapeutics Inc. | Anti-cancer use of genetically modified human umbilical cord perivascular cells (hucpvc) |
WO2017214707A1 (en) | 2016-06-15 | 2017-12-21 | Tissue Regeneration Therapeutics Inc. | Genetically modified human umbilical cord perivascular cells for wound healing |
WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
CA3207101A1 (en) | 2016-12-09 | 2018-06-14 | Genemedicine Co., Ltd. | Anticancer composition comprising recombinant adenovirus expressing degradation factor for extracellular matrix |
WO2018156649A1 (en) | 2017-02-22 | 2018-08-30 | Flagship Pioneering, Inc. | Compositions of t cell modulator (tcm) molecules and uses thereof |
CN111132693A (zh) * | 2017-04-20 | 2020-05-08 | 芝加哥大学 | 用与免疫治疗抗体连接的ecm亲和肽治疗癌症的方法和组合物 |
-
2019
- 2019-06-28 WO PCT/US2019/039862 patent/WO2020009938A1/en active Application Filing
- 2019-06-28 EP EP19830823.1A patent/EP3817762A4/en active Pending
- 2019-06-28 CA CA3105454A patent/CA3105454A1/en active Pending
- 2019-06-28 JP JP2020573436A patent/JP2021529534A/ja active Pending
- 2019-06-28 AU AU2019299110A patent/AU2019299110A1/en active Pending
- 2019-06-28 SG SG11202013217PA patent/SG11202013217PA/en unknown
- 2019-06-28 MX MX2021000155A patent/MX2021000155A/es unknown
- 2019-06-28 KR KR1020217003334A patent/KR20210040378A/ko active Search and Examination
- 2019-06-28 US US16/457,045 patent/US11377488B2/en active Active
- 2019-06-28 BR BR112020027026-1A patent/BR112020027026A2/pt unknown
- 2019-06-28 CN CN201980057445.4A patent/CN112638403A/zh active Pending
- 2019-07-03 TW TW108123497A patent/TW202012447A/zh unknown
- 2019-07-03 AR ARP190101887A patent/AR115695A1/es unknown
-
2022
- 2022-05-06 US US17/738,191 patent/US11879009B2/en active Active
-
2023
- 2023-12-07 US US18/532,395 patent/US20240150452A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3817762A1 (en) | 2021-05-12 |
TW202012447A (zh) | 2020-04-01 |
MX2021000155A (es) | 2021-05-12 |
US20200010539A1 (en) | 2020-01-09 |
CN112638403A (zh) | 2021-04-09 |
CA3105454A1 (en) | 2020-01-09 |
WO2020009938A1 (en) | 2020-01-09 |
AU2019299110A1 (en) | 2021-01-28 |
US20220275074A1 (en) | 2022-09-01 |
SG11202013217PA (en) | 2021-01-28 |
KR20210040378A (ko) | 2021-04-13 |
EP3817762A4 (en) | 2022-04-13 |
JP2021529534A (ja) | 2021-11-04 |
US20240150452A1 (en) | 2024-05-09 |
US11377488B2 (en) | 2022-07-05 |
BR112020027026A2 (pt) | 2021-04-06 |
US11879009B2 (en) | 2024-01-23 |
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