SG11202013217PA - Multifunctional protein molecules comprising decorin and use thereof - Google Patents

Multifunctional protein molecules comprising decorin and use thereof

Info

Publication number
SG11202013217PA
SG11202013217PA SG11202013217PA SG11202013217PA SG11202013217PA SG 11202013217P A SG11202013217P A SG 11202013217PA SG 11202013217P A SG11202013217P A SG 11202013217PA SG 11202013217P A SG11202013217P A SG 11202013217PA SG 11202013217P A SG11202013217P A SG 11202013217PA
Authority
SG
Singapore
Prior art keywords
decorin
protein molecules
multifunctional protein
multifunctional
molecules
Prior art date
Application number
SG11202013217PA
Inventor
Gregory T Bleck
Original Assignee
Catalent Pharma Solutions Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalent Pharma Solutions Llc filed Critical Catalent Pharma Solutions Llc
Publication of SG11202013217PA publication Critical patent/SG11202013217PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
SG11202013217PA 2018-07-03 2019-06-28 Multifunctional protein molecules comprising decorin and use thereof SG11202013217PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862693766P 2018-07-03 2018-07-03
PCT/US2019/039862 WO2020009938A1 (en) 2018-07-03 2019-06-28 Multifunctional protein molecules comprising decorin and use thereof

Publications (1)

Publication Number Publication Date
SG11202013217PA true SG11202013217PA (en) 2021-01-28

Family

ID=69060721

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202013217PA SG11202013217PA (en) 2018-07-03 2019-06-28 Multifunctional protein molecules comprising decorin and use thereof

Country Status (13)

Country Link
US (3) US11377488B2 (en)
EP (1) EP3817762A4 (en)
JP (1) JP2021529534A (en)
KR (1) KR20210040378A (en)
CN (1) CN112638403A (en)
AR (1) AR115695A1 (en)
AU (1) AU2019299110A1 (en)
BR (1) BR112020027026A2 (en)
CA (1) CA3105454A1 (en)
MX (1) MX2021000155A (en)
SG (1) SG11202013217PA (en)
TW (1) TW202012447A (en)
WO (1) WO2020009938A1 (en)

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US11103590B2 (en) * 2016-09-06 2021-08-31 Cell-Medicine, Inc. Immunostimulant
JP2023537022A (en) * 2020-08-07 2023-08-30 バイオ－テラ ソリュ－ションズ，エルティーディー． Anti-PD-L1 antibody and its application
EP4368203A1 (en) * 2021-07-05 2024-05-15 Wuhan Neurophth Biotechnology Limited Company Construction and use of anti-vegf antibody in-vivo expression system
WO2023141856A1 (en) * 2022-01-27 2023-08-03 岩唐生物科技(杭州)有限责任公司 Cd3-targeting multispecific antibody and use thereof
WO2024051223A1 (en) * 2022-09-09 2024-03-14 中山康方生物医药有限公司 Pharmaceutical composition and use thereof

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US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2108048T3 (en) 1990-08-29 1997-12-16 Genpharm Int PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US20030224415A1 (en) 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
US20040235173A1 (en) 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
US6852510B2 (en) 2000-07-03 2005-02-08 Gala Design Inc Host cells containing multiple integrating vectors
CN101115839B (en) 2004-08-30 2011-05-04 杨梦甦 Method for inhibiting fibrogenesis by an rhdecorin-fc fusion protein
CN100376680C (en) 2005-11-01 2008-03-26 暨南大学 Dual target effected chimera recombinant, its construction method and application
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
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AU2012205301B2 (en) 2011-01-14 2017-01-05 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
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WO2018195386A1 (en) 2017-04-20 2018-10-25 The University Of Chicago Methods and compositions for treating cancer with ecm-affinity peptides linked to immunotherapeutic antibodies

Also Published As

Publication number Publication date
US11879009B2 (en) 2024-01-23
TW202012447A (en) 2020-04-01
EP3817762A1 (en) 2021-05-12
CA3105454A1 (en) 2020-01-09
AU2019299110A1 (en) 2021-01-28
BR112020027026A2 (en) 2021-04-06
MX2021000155A (en) 2021-05-12
WO2020009938A1 (en) 2020-01-09
JP2021529534A (en) 2021-11-04
CN112638403A (en) 2021-04-09
US20220275074A1 (en) 2022-09-01
US11377488B2 (en) 2022-07-05
KR20210040378A (en) 2021-04-13
US20200010539A1 (en) 2020-01-09
EP3817762A4 (en) 2022-04-13
AR115695A1 (en) 2021-02-17
US20240150452A1 (en) 2024-05-09

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