BR112016027585A2 - construções de anticorpo multiespecíficas - Google Patents

construções de anticorpo multiespecíficas

Info

Publication number
BR112016027585A2
BR112016027585A2 BR112016027585-3A BR112016027585A BR112016027585A2 BR 112016027585 A2 BR112016027585 A2 BR 112016027585A2 BR 112016027585 A BR112016027585 A BR 112016027585A BR 112016027585 A2 BR112016027585 A2 BR 112016027585A2
Authority
BR
Brazil
Prior art keywords
multispecific antibody
antibody constructs
formula
present disclosure
vectors
Prior art date
Application number
BR112016027585-3A
Other languages
English (en)
Inventor
Bhatta Pallavi
Dave Emma
Philip Heywood Sam
Paul Humphreys David
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of BR112016027585A2 publication Critical patent/BR112016027585A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

a presente divulgação se refere a uma molécula de anticorpo multiespecífica compreendendo ou consistindo de: a) uma cadeia de polipeptídeo da fórmula (i): vh-ch1-x-v1; e b) uma cadeia de polipeptídeo da fórmula (ii): vl-cl-y-v2 e formulações farmacêuticas compreendendo, por exemplo para o uso em tratamento. a divulgação também fornece sequências de polinucleotídeo codificando as ditas moléculas de anticorpo multiespecífico, vetores compreendendo os polinucleotídeos e células hospedeiras compreendendo os ditos vetores e/ou sequências de polinucleotídeo. é fornecido um método de expressar uma molécula de anticorpo multiespecífico da presente divulgação a partir de uma célula hospedeira.
BR112016027585-3A 2014-06-25 2015-06-25 construções de anticorpo multiespecíficas BR112016027585A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1411320.3 2014-06-25
GBGB1411320.3A GB201411320D0 (en) 2014-06-25 2014-06-25 Antibody construct
PCT/EP2015/064409 WO2015197772A1 (en) 2014-06-25 2015-06-25 Multispecific antibody constructs

Publications (1)

Publication Number Publication Date
BR112016027585A2 true BR112016027585A2 (pt) 2018-01-30

Family

ID=51410123

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016027585-3A BR112016027585A2 (pt) 2014-06-25 2015-06-25 construções de anticorpo multiespecíficas

Country Status (27)

Country Link
US (2) US11345760B2 (pt)
EP (2) EP3161007B1 (pt)
JP (1) JP6765974B2 (pt)
KR (1) KR102271204B1 (pt)
CN (1) CN106459216B (pt)
AU (2) AU2015279128B2 (pt)
BR (1) BR112016027585A2 (pt)
CA (1) CA2951609C (pt)
CL (1) CL2016003324A1 (pt)
CY (2) CY1122175T1 (pt)
DK (2) DK3556777T3 (pt)
ES (2) ES2866398T3 (pt)
GB (1) GB201411320D0 (pt)
HR (2) HRP20191775T1 (pt)
HU (2) HUE046027T2 (pt)
IL (1) IL249003B (pt)
LT (2) LT3556777T (pt)
ME (1) ME03539B (pt)
MX (1) MX2016015952A (pt)
MY (2) MY176332A (pt)
PL (2) PL3556777T3 (pt)
PT (2) PT3556777T (pt)
RS (2) RS59416B1 (pt)
RU (1) RU2725812C2 (pt)
SG (2) SG10201911670QA (pt)
SI (2) SI3556777T1 (pt)
WO (1) WO2015197772A1 (pt)

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