ME03394B - Antidllз-antitelo-pbd konjugati i nihovа upotreba - Google Patents

Antidllз-antitelo-pbd konjugati i nihovа upotreba

Info

Publication number
ME03394B
ME03394B MEP-2019-182A MEP2019182A ME03394B ME 03394 B ME03394 B ME 03394B ME P2019182 A MEP2019182 A ME P2019182A ME 03394 B ME03394 B ME 03394B
Authority
ME
Montenegro
Prior art keywords
ser
gly
thr
leu
ala
Prior art date
Application number
MEP-2019-182A
Other languages
German (de)
English (en)
French (fr)
Inventor
Michael Torgov
Philip Wilson Howard
Original Assignee
Medimmune Ltd
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd, Abbvie Stemcentrx Llc filed Critical Medimmune Ltd
Publication of ME03394B publication Critical patent/ME03394B/me

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

SPISAK SEKVENCI
<110> Stem CentRx, Inc.
Spirogen Sarl
<120> NOVI KONJUGATI ANTITELA I NJIHOVE UPOTREBE
<130> P46010EP-PCT
<150> EP14753730.2
<151> 2013-02-22
<160> 437
<170> PatentIn verzija 3.5
<210> l
<211> 618
<212> PRT
<213> Homo sapiens
<400> l
Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu l 5 10 15
Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu
20 25 30
Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser
35 40 45
Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu
50 55 60
Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly
65 70 75 BO
1
Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala
85 90 95
Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe
100 105 110
Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg
115 120 125
Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala
130 135 140
Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg
145 150 155 160
Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala
165 170 175
Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg
180 185 190
Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala
195 200 205
Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys
210 215 220
Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu
225 230 235 240
Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser
245 250 255
Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val
260 265 270
Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser
275 280 285
Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe
290 295 300
Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro
305 310 115 320
2
Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala
32S 330 33S
Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys
340 34S 3SO
Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys
3SS 360 36S
Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala
370 37S 380
Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys
38S 390 39S 400
Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser
40S 410 41S
Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro
420 42S 430
Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe
43S 440 44S
Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys
4SO 4SS 460
Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro
46S 470 47S 480
Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala
48S 490 49S
Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu
soo sos S10
Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu
S1S S20 S2S
Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu
S30 S3S S40
Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser
S4S sso sss S60
3
Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val
S6S S70 S7S
Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe
S80 S8S S90
Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe
S9S 600 60S
Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys
610 61S
<210> 2
<211> S87
<212> PRT
<213> Homo sapiens
<400> 2
Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu l s 10 lS
Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu
20 2S 30
Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser
3S 40 4S
Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu
so ss 60
Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly
6S 70 7S 80
Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala
8S 90 9S
Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe
100 lOS 110
Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg llS 120 12S
Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala
130 13S 140
Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg
4
145 150 155 160
Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala
165 170 175
Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg
180 185 190
Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala
195 200 205
Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys
210 215 220
Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu
225 230 235 240
Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser
245 250 255
Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val
260 265 270
Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser
275 280 285
Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe
290 295 300
Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro
305 310 315 320
Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala
325 330 335
Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys
340 345 350
Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys
355 360 365
Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala
370 375 380
Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys
s
385 390 395 400
Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser
405 410 415
Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro
420 425 430
Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe
435 440 445
Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys
450 455 460
Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro
465 470 475 480
Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala
485 490 495
Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu
500 505 510
Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu
515 520 525
Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu
530 535 540
Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser
545 550 555 560
Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val
565 570 575
Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Ala
580 585
<210> 3
<211> 5
<212> PRT
<213> Homo sapiens
<400> 3
Gln Pro Gly Ala Pro
l 5
6
<210>
<211>
<212>
<213>
4
4
PRT
Homo sapiens
<220>
<221>
<222>
<223>
mise feature
( 2) •• ( 2)
Xaa može biti bilo koja prirodna aminokiselina
<400> 4
Gly Xaa Arg Pro
l
<210> 5
<211> 107
<212> PRT
<213> Homo sapiens
<400> 5
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
l 5 10 15
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
20 25 30
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
35 40 45
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
so 55 60
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65 70 75 80
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
85 90 95
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
100 105
<210> 6
<211> 329
<212> PRT
<213> Homo sapiens
<400> 6
7
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys l 5 10 15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
20 25 30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
50 55 60
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 15 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
85 90 95
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
100 105 110
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
115 120 125
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
130 135 140
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
165 170 175
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
180 185 190
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
210 215 220
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225 230 235 240
8
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
245 250 255
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
275 280 285
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305 310 315 320
Gln Lys Ser Leu Ser Leu Ser Pro Gly
325
<210> 7
<2ll> o
<212> PRT
<213> Homo sapiens
<400> 7
ooo
<210> 8
<2ll> o
<212> PRT
<213> Homo sapiens
<400> 8
ooo
<210> 9
<2ll> o
<212> PRT
<213> Homo sapiens
<400> 9
ooo
<210> 10
<2ll> o
<212> PRT
<213> Homo sapiens
<400> 10
ooo
<210> ll
<2ll> o
<212> PRT
<213> Homo sapiens
<400> ll
ooo
9
<210> 12
<211> o
<212> PRT
<213> Homo sapiens
<400> 12
ooo
<210> 13
<211> o
<212> PRT
<213> Homo sapiens
<400> 13
ooo
<210> 14
<211> o
<212> PRT
<213> Homo sapiens
<400> 14
ooo
<210> 15
<211> o
<212> PRT
<213> Homo sapiens
<400> 15
ooo
<210> 16
<211> o
<212> PRT
<213> Homo sapiens
<400> 16
ooo
<210> 17
<211> o
<212> PRT
<213> Homo sapiens
<400> 17
ooo
<210> 18
<211> o
<212> PRT
<213> Homo sapiens
<400> 18
ooo
<210> 19
<211> o
<212> PRT
<213> Homo sapiens
<400> 19
ooo
<210> 20
<211> 324
<212> DNA
<213> Mus musculus
10
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.3 VL
<220>
<221> cos
<222> (1)..(324)
<400> 20
eaa att gtt etc ace eag tet cca gea ate atg tet gta tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Val Ser Leu Gly
l 5 lO 15
gaa egg gtc ace atg ace tgc act gcc age tea agt gta agt tee agt 96
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eaa eaa aag cca gga tee tee ccc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cca get cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tat ttt ttc aea ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Phe Phe Thr Ile Ser Ser Met Glu
65 70 75 80
get gaa gat get gcc act tat tac tgc eac eag tat cat cgt tee cca 288
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
ttc acg ttc gge geg ggg aca aag ttg aaa ata aga 324
Phe Thr Phe Gly Ala Gly Thr Lys Leu Lys Ile Arg
100 105
<210> 21
<211> 108
<212> PRT
<213> Mus musculus
<400> 21
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Val Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
11
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
so ss 60
Gly Ser Gly Ser Gly Thr Ser Tyr Phe Phe Thr Ile Ser Ser Met Glu
6S 70 7S 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
8S 90 9S
Phe Thr Phe Gly Ala Gly Thr Lys Leu Lys Ile Arg
100 lOS
<210> 22
<211> 369
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(369)
<223> SC16.3 VH
<220>
<221> CDS
<222> (l)..(369)
<400> 22
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ecc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l s lO lS
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 2S 30
ggt atg ggt gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
3S 40 4S
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aac cca gcc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
so ss 60
ctg aag age ega eta act ate tee aag gat ace tee age age eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
6S 70 7S 80
ttc etc aag ate gcc agt gtg gac act gea gat act gcc aca tac tac 288
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
8S 90 9S
tgt get ega ata get gac tat gge gga gat tac tat get atg gac tac 336
Cys Ala Arg Ile Ala Asp Tyr Gly Gly Asp Tyr Tyr Ala Met Asp Tyr
100 lOS 110
12
tgg ggt caa gga ace tea gtc ace gtc tee tea
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 23
<211> 123
<212> PRT
<213> Mus musculus
<400> 23
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 10 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Ala Asp Tyr Gly Gly Asp Tyr Tyr Ala Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 24
<211> 321
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.4 VL
<220>
<221> cos
<222> (l)..(321)
<400> 24
13
369
gat ate eag atg aca eag act aca tet tee ctg tet gcc tet ctg gga 48
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aga gtc ace ate agt tgc agg gea agt eag gac att age aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
tac tac aca tea aga tta eac tea gge gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet gga aca gat tat tet etc ace att age aac ctg gag eta 240
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Leu
65 70 75 80
gaa gat att gcc act tac ttt tgc eaa eag ggt gat atg ctt ccg tgg 288
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Met Leu Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 25
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 25
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Leu
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Met Leu Pro Trp
85 90 95
14
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 26
<211> 351
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.4 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 26
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggt tat ace ttc aca gac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
tea atg eac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
gge tgg ata aac act gag act ggt gag cca gga tat gea gat gac ttc 192
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Gly Tyr Ala Asp Asp Phe
so ss 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
ttg eag ate aac aac etc aaa aat gag gac acg get aca tat ttc tgt 288
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
get egg tac gac ggg tat get atg gac tat tgg ggt eaa gga ace tea 336
Ala Arg Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 lOS 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 27
<211> 117
<212> PRT
<213> Mus rnusculus
<400> 27
15
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Gly Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 28
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(318)
<223> SC16.5 VL
<220>
<221> cos
<222> (l)..(318)
<400> 28
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tac atg
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
eac tgg tac eag eag aag tea gge ace tee ecc aaa aga tgg att tat
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
48
96
144
16
gac aca tee aaa ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age age atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc eag eag tgg act aga aac ccg etc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Arg Asn Pro Leu Thr
85 90 95
ttc ggg get gga ace aag ctg gag ctg aaa 318
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 29
<211> 106
<212> PRT
<213> Mus rnusculus
<400> 29
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Arg Asn Pro Leu Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 30
<211> 372
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
17
<222> (l)..(372)
<223> SC16.5 VH
<220>
<221> cos
<222> (l)..(372)
<400> 30
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att cgt eag cet tea gga gag ggt eta gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu Glu
35 40 45
tgg ctg gea gac att tgg tgg gat gac aat aag tac tat aac cca tee 192
Trp Leu Ala Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
so ss 60
ctg aag age egg etc aca ate tee aag gat ace tee age aac eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val
65 70 75 80
ttc etc aag ate ace agt gtg gac act gea gat act gcc act tac tac 288
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get ega aga gtt aac tat gtt tac gac ccg tac tat get atg gac 336
Cys Ala Arg Arg Val Asn Tyr Val Tyr Asp Pro Tyr Tyr Ala Met Asp
100 lOS 110
tac tgg ggt eaa gga ace tea gtc ace gtc tee tea 372
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
llS 120
<210> 31
<211> 124
<212> PRT
<213> Mus musculus
<400> 31
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu Glu
35 40 45
18
Trp Leu Ala Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
so ss 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val
6S 70 7S 80
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
8S 90 9S
Cys Ala Arg Arg Val Asn Tyr Val Tyr Asp Pro Tyr Tyr Ala Met Asp
100 lOS 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser llS 120
<210> 32
<211> 336
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.7 VL
<220>
<221> cos
<222> (l)..(336)
<400> 32
aac att atg atg aca eag tcg cca tea tet ctg get gtg tet gea gga 48
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly l s lO lS
gaa aag gtc act atg age tgt aag tee agt eaa agt gtt tta tac agt 96
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 2S 30
tea aat eag aag aac tac ttg gcc tgg tac eaa eag aaa cca ggg eag 144
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
3S 40 4S
tet cet aaa ctg ctg ate tac tgg gea tee act agg gaa tet ggt gtc 192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
so ss 60
cet gat cgc ttc aca gge agt gga tet ggg aca gat ttt act ctt ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
6S 70 7S 80
ate age act gta eaa gtt gaa gac ctg gea gtt tat tac tgt cat eaa 288
Ile Ser Thr Val Gln Val Glu Asp Leu Ala Val Tyr Tyr Cys His Gln
8S 90 9S
19
tac etc tee tcg tgg acg ttc ggt gga gge ace aag ctg gaa ate aaa
Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 33
<211> 112
<212> PRT
<213> Mus musculus
<400> 33
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
l 5 lO 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
20 25 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Thr Val Gln Val Glu Asp Leu Ala Val Tyr Tyr Cys His Gln
85 90 95
Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 34
<211> 357
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(357)
<223> SC16.7 VH
<220>
<221> cos
<222> (1)..(357)
<400> 34
gag gtc cag ctg caa cag tet gga cet gag ctg gtg aag cet ggg get Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
20
336
48
tea gtg aag att tee tgc aag get tet ggt tac tea ttc act gge tat 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 2S 30
aaa atg eac tgg gtg aag eaa age cat gta aag age ctt gag tgg att 144
Lys Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile
3S 40 4S
gga cgt att aat cet tac aat ggt get act age tac aac eag aat ttc 192
Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe
so ss 60
aag gac aag gcc ace ttg act gta gat aag tee tee age aca gcc tac 240
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
atg gac etc eac age ctg aca tet gag gac tet gea gtc tat ttc tgt 288
Met Asp Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
8S 90 9S
gea aga ggg gac tat agg tac gac tgg ttt get tac tgg gge eaa ggg 336
Ala Arg Gly Asp Tyr Arg Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly
100 lOS 110
act ctg gtc act gtc tet gea 3S7
Thr Leu Val Thr Val Ser Ala
11S
<210> 3S
<211> 119
<212> PRT
<213> Mus musculus
<400> 3S
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l s lO lS
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 2S 30
Lys Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile
3S 40 4S
Gly Arg Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Asn Phe
so ss 60
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
Met Asp Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
8S 90 9S
21
Ala Arg Gly Asp Tyr Arg Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 36
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.8 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 36
gaa ate cag atg ace eag tet cca tee tet atg tet gea tet ctg gga 48
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly l 5 lO 15
gac aga ata ace ate act tgc eag gea act eaa gac att gtt aag aat 96
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
tta aac tgg tat eag eag aaa cca ggg aaa ecc cet tea ttc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
35 40 45
tat tat gea att gaa ctg gea gaa ggg gtc cca tea agg ttc agt gge 192
Tyr Tyr Ala Ile Glu Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet ggg tea gac tat tet ctg aca ate age aac ctg gag tet 240
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser
65 70 75 80
gaa gat ttt gea gac tat tac tgt eta eag ttt tat gag ttt ccg ttc 288
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Phe
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 37
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 37
22
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly l s lO 15
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
3S 40 4S
Tyr Tyr Ala Ile Glu Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser
6S 70 75 80
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Phe
8S 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 38
<211> 363
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(363)
<223> SC16.8 VH
<220>
<221> cos
<222> (l)..(363)
<400> 38
eag gcc cag ctg eag eag tet gga get gag ctg gta agg cet ggg act 48
Gln Ala Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr l s lO lS
tea gtg aag gtg tee tgc aag get tet gga tac gcc ttc act aat tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
ttg ata gag tgg gta aag eag agg cet gga eag gge ctt gag tgg att 144
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga gtg att aat cet gga act ggt ggt act aac tac aat gag aac ttc 192
Gly Val Ile Asn Pro Gly Thr Gly Gly Thr Asn Tyr Asn Glu Asn Phe
so ss 60
23
aag gge aag gea act ctg act gea gac aaa tee tee agt act gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
atg eag etc age age ctg aca tet gat gac tet geg gtc tat ttc tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
8S 90 9S
gea aga tee ecc tat gat tac eac gag ggt get atg gac tac tgg ggt 336
Ala Arg Ser Pro Tyr Asp Tyr His Glu Gly Ala Met Asp Tyr Trp Gly
100 lOS 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
11S 120
<210> 39
<211> 121
<212> PRT
<213> Mus musculus
<400> 39
Gln Ala Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
l s lO lS
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 2S 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
Gly Val Ile Asn Pro Gly Thr Gly Gly Thr Asn Tyr Asn Glu Asn Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
8S 90 9S
Ala Arg Ser Pro Tyr Asp Tyr His Glu Gly Ala Met Asp Tyr Trp Gly
100 lOS 110
Gln Gly Thr Ser Val Thr Val Ser Ser
11S 120
<210> 40
<211> 324
<212> DNA
<213> Mus musculus
24
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.10 VL
<220>
<221> cos
<222> (l)..(324)
<400> 40
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gaa egg gtc ace atg ace tgc act gcc age tea agt gta agt tee agt 96
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag cca gga tea tee ccc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age act tee aac ctg get tet gga gtc cca act cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc aca ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
get gaa gat get gcc act tat tac tgc eac eag tat cat cgt tee cca 288
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
ttc acg ttc gge tcg ggg aca aag ttg gaa ata aaa 324
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 41
<211> 108
<212> PRT
<213> Mus musculus
<400> 41
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
25
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 BO
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 42
<211> 360
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.10 VH
<220>
<221> cos
<222> (l)..(360)
<400> 42
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag tee tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln
l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aac cca gtc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Val
50 55 60
ctg aag age ega ctg act ate tee aag gat ace tee age age eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
ttc etc aag ate gcc agt gtg gac act gea gat act gcc aca tac tat 288
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get ega tta gtt gat gat ctg tac tac ttt gac tac tgg gge eaa 336
Cys Ala Arg Leu Val Asp Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
26
ggc ace act etc aca gtc tee tea
Gly Thr Thr Leu Thr Val Ser Ser
115 120
360
<210> 43
<211> 120
<212> PRT
<213> Mus musculus
<400> 43
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln l 5 10 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Val
so 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 BO
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Leu Val Asp Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 44
<211> 336
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.11 VL
<220>
<221> CDS
<222> (l)..(336)
<400> 44
27
gat gtt gag atg ace eag act cca etc act ttg tcg gtt ace att gga 48
Asp Val Glu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
l 5 lO 15
eaa cca gcc tee ate tet tgc aag tea agt eag age etc tea gac agt 96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser
20 25 30
gat gga aag aca tat ttg aat tgg atg ttt eag agg cca gge egg tet 144
Asp Gly Lys Thr Tyr Leu Asn Trp Met Phe Gln Arg Pro Gly Arg Ser
35 40 45
cca aag cgc eta ate tat ctg gtg tet aaa ctg gac tet gga gtc cet 192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
gac agg ttc act gge agt gga tea ggg aca gat ttc aca ctg aaa ate 240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat ttg gga gtt tac tat tgc tgg eaa ggt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
aaa cat ttt ccg tgg acg ttc ggt gga gge ace aag ctg gaa ate aaa 336
Lys His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 45
<211> 112
<212> PRT
<213> Mus musculus
<400> 45
Asp Val Glu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly l 5 lO 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Met Phe Gln Arg Pro Gly Arg Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 7(J 75 BO
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
28
Lys His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS 110
<210> 46
<211> 3Sl
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(3Sl)
<223> SC16.ll VH
<220>
<221> CDS
<222> (l)..(3Sl)
<400> 46
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l s lO lS
aca gtc aag ate tee tgc aag get tet ggt tat ace ttc aca gac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 2S 30
tea atg eac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
3S 40 4S
gge tgg ata aac act gag act gtt gag cca aca tat gea gat gac ttc 192
Gly Trp Ile Asn Thr Glu Thr Val Glu Pro Thr Tyr Ala Asp Asp Phe
so ss 60
atg gga cgg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc ttt 240
Met Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
6S 70 7S 80
ttg eag ate aac aac etc gaa aat gag gac acg get aca tat ttc tgt 288
Leu Gln Ile Asn Asn Leu Glu Asn Glu Asp Thr Ala Thr Tyr Phe Cys
8S 90 9S
get aga ttt ggt tee tat get atg gac tac tgg ggt eaa gga ace tea 336
Ala Arg Phe Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 47
<211> 117
<212> PRT
<213> Mus rnusculus
<400> 47
29
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Val Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Met Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
65 70 75 80
Leu Gln Ile Asn Asn Leu Glu Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Phe Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 48
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) •. ( 318)
<223> SC16.13 VL
<220>
<221> cos
<222> (l) .. (318)
<400> 48
eaa att gtt etc ace eag tet cca gea etc gtg tet gea tet cca ggg Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Val Ser Ala Ser Pro Gly l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tac atg
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
tac tgg tac eag eag aaa cca aga tee tee ecc aaa ccc tgg att tat
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
48
96
144
30
etc aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
ggg tet ggg ace tet tac tet etc aca ate age age atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
6S 70 7S 80
gat get gcc act tat tac tgc eag eag tgg cgt agt aac cca ttc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Phe Thr
8S 90 9S
ttc gge tcg ggg aca aag ttg gaa ata aaa 318
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 49
<211> 106
<212> PRT
<213> Mus rnusculus
<400> 49
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Val Ser Ala Ser Pro Gly
l s lO lS
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
3S 40 4S
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
6S 70 7S 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Phe Thr
8S 90 9S
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> so
<211> 372
<212> DNA
<213> Mus rnusculus
<220>
<221> mise-feature
31
<222> (l)..(372)
<223> SC16.13 VH
<220>
<221> cos
<222> (l)..(372)
<400> 50
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att egg eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aac cca gcc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
ctg aag age ega ctg act ate tee aag gat ace tee age age eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
ttc etc aag ate gcc agt gtg gac act gea gat act gec aca tac tac 288
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get egc ata gtt tee ttt gat aac gac gtt gtc tet get atg gae 336
Cys Ala Arg Ile Val Ser Phe Asp Asn Asp Val Val Ser Ala Met Asp
100 105 110
tac tgg ggt eaa gga ace tea gtc ace gtc tee ten 372
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Xaa
115 120
<210> 51
<211> 124
<212> PRT
<213> Mus museulus
<220>
<221> mise feature
<222> (124).•(124)
<223> The 'Xaa' na mestu 124 predstavlja Ser.
<400> 51
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
32
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Val Ser Phe Asp Asn Asp Val Val Ser Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Xaa
115 120
<210> 52
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.15 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 52
gac ate cag atg act eag tet cca gcc tee ctg get gea tet gtg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly
l 5 lO 15
gaa act gtc gcc ate aea tgt ega gea agt gag aac att tac tac aat 96
Glu Thr Val Ala Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Asn
20 25 30
tta gea tgg tat eag eag aaa eaa ggg aaa tet cet eag etc ctg ate 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
tat act gea aac agt ttg gaa gat ggt gtc cca tcg agg ttc agt gge 192
Tyr Thr Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg aca eag tat tet ttg aag ate aac age atg eag cet 240
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met Gln Pro
65 70 75 80
33
gaa gat tee gea act tat ttc tgt aaa eag get tat gac gtt cet ccg
Glu Asp Ser Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Pro
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 53
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly l 5 lO 15
Glu Thr Val Ala Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
Tyr Thr Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Met Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 54
<211> 351
<212> DNA
<213> Mus rnusculus
288
321
<220>
<221>
<222>
<223>
mise feature (l)..(351) SC16.15 VH
<220>
<221>
<222>
cos
(l)..(351)
34
<400> 54
eag gtc cag ctt eag eag tet ggg get gaa ctg gea aaa cet ggg gcc 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala l 5 lO 15
tea gtg aag atg tee tgt aag get tet gge tac ace ttt act cgc tac 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
tgg ata eac tgg ata aaa eag agg cet gga eag ggt ctg gaa tgg att 144
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tac att aat cet aca act gtt tat act gag ttc aat eag aac ttc 192
Gly Tyr Ile Asn Pro Thr Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe
50 55 60
aag gac aag gcc act ttg act gea gac aaa tee tee ace aca gcc tee 240
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Ser
65 70 75 80
atg eaa ctg age age ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga gge ggt agt aac ttc ttt gac tac tgg gge eaa gge ace act 336
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
etc aca gtc tee tea 351
Leu Thr Val Ser Ser
115
<210> 55
<211> 117
<212> PRT
<213> Mus musculus
<400> 55
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Thr Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Ser
65 70 75 80
35
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 56
<211> 321
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.18 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 56
gat ate cag atg aca eag act aca tee tee ctg tet gcc tet ttg gga 48
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
gac aga gtc ace ate agt tgc agg gea agt eag aat att ate aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Ile Asn Tyr
20 25 30
tta aac tgg tat eag eag aag cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
tac tac aca tea aga tta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet ggg aca gat tat tet etc ace ate age aac ctg gaa cet 240
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65 70 75 80
gaa gat att gcc act tac tat tgt eaa eag tat agt gag cgt ccg tac 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Arg Pro Tyr
85 90 95
acg ttc ggg ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 57
<211> 107
36
<212> PRT
<213> Mus musculus
<400> 57
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Ile Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Arg Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210>
<211>
<212>
<213>
58
351
DNA
Mus musculus
<220>
<221>
<222>
<223>
mise feature (l) •. (351) SC16.18 VH
<220>
<221>
<222>
cos
(l) •• ( 351)
<400> 58
gaa gtg aag ctg gag Glu Val Lys Leu Glu l 5
gag tea gga gga ggc ttg gta caa cet gga gaa 48
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
10 15
tee atg aaa etc tet tgt get get tet gga ttc act ttt agt gat gcc
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
tgg atg gac tgg gtc cgc eag tet cca gag nng gga ctt gag tgg gtt
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
37
96
144
get gaa att aga aac aaa get aat aat cat gea aca tat tat get gag 192
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
tet gtg aaa ggg aaa ttc ace ate tea aga gat gat tee aaa agt aga 240
Ser Val Lys Gly Lys Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Arg
65 70 75 80
gtg tac ctg eaa atg aac aac tta aga get gea gac act gge att tat 288
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Ala Asp Thr Gly Ile Tyr
85 90 95
tac tgt acg gcc tat agt aac ttt get tac tgg gge eaa ggg act ctg 336
Tyr Cys Thr Ala Tyr Ser Asn Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 llO
gtc act gtc tet aca 351
Val Thr Val Ser Thr
ll5
<210> 59
<2ll> ll7
<212> PRT
<213> Mus musculus
<400> 59
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
l 5 lO 15
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu
50 55 60
Ser Val Lys Gly Lys Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Arg
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Ala Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Ala Tyr Ser Asn Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 llO
Val Thr Val Ser Thr
ll5
38
------
<210> 60
<211> 318
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.19 VL
<220>
<221> CDS
<222> (l)..(318)
<400> 60
gae ate eag atg aea eag tet cca tee tea ctg tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l s lO lS
gge aaa gtc ace ttc act tgc aag gea age eaa gac att eac aag tat 96
Gly Lys Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile His Lys Tyr
20 2S 30
gta get tgg tac eaa eac aag cet gga aaa ggt cet agg ctg etc ata 144
Val Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
3S 40 45
cat tac aca tet aca tta eag cca gge ate tea tea agg ttc agt gga 192
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Ser Ser Arg Phe Ser Gly
so ss 60
agt ggg tet ggg aga gat tat tee ttc age ate age aac ctg gag cet 240
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
6S 70 7S 80
gaa gat att gea act tat tat tgt eta eag tat aat aat ctg tac acg 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Asn Leu Tyr Thr
8S 90 9S
ttc gga ggg ggg ace aag ctg gaa ata aaa 318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 61
<211> 106
<212> PRT
<213> Mus musculus
<400> 61
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l s lO lS
Gly Lys Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile His Lys Tyr
20 2S 30
39
Val Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Ser Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Asn Leu Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 62
<211> 354
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)••(354)
<223> SC16.19 VH
<220>
<221> cos
<222> (l)..(354)
<400> 62
gag gtt cag ctg eag eag tet ggg get gag ctt gtg agg cca ggg gcc 48
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
l 5 lO 15
tea gtc aag ttg tee tgc aca get tet gge ttc aac att aaa gac age 96
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser
20 25 30
ctt ttg eac tgg gtg aag eag agg cet gaa aag gge ctg gag tgg att 144
Leu Leu His Trp Val Lys Gln Arg Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
ggg tgg att gat cet gag gat ggt gaa act aaa tat gcc ccg aac ttc 192
Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Asn Phe
50 55 60
eag gac aag gcc act ata act aca gac tea tee tee aac aca gcc tac 240
Gln Asp Lys Ala Thr Ile Thr Thr Asp Ser Ser Ser Asn Thr Ala Tyr
65 70 75 80
ctg eaa etc ate age ctg aca tet gtt gac act gcc ate tat tac tgt 288
Leu Gln Leu Ile Ser Leu Thr Ser Val Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
40
gcc tat ggt aac tac gtg egg eac ttt gac tac tgg gge eaa gge ace
Ala Tyr Gly Asn Tyr Val Arg His Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
act etc aca gtc tee tea
Thr Leu Thr Val Ser Ser
115
<210> 63
<211> 118
<212> PRT
<213> Mus musculus
<400> 63
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
l 5 lO 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser
20 25 30
Leu Leu His Trp Val Lys Gln Arg Pro Glu Lys Gly Leu Glu Trp Ile
35 40 45
336
354
Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Asn Phe
50 55 60
Gln Asp Lys Ala Thr Ile Thr Thr Asp Ser Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ile Ser Leu Thr Ser Val Asp Thr Ala Ile Tyr Tyr Cys
85 90 95
Ala Tyr Gly Asn Tyr Val Arg His Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 64
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.20 VL
41
<220>
<221> cos
<222> (l)..(321)
<400> 64
gaa ate cag atg ace eag tet cca tee tet atg tet gea tet ctg gga 48
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly
l 5 lO 15
gac aga ata ace ate act tgc eag gea act eaa gac att gtt aag aat 96
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
tta aac tgg tat eag eag aaa cca ggg aaa ecc cet tea ttc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
35 40 45
tat tat gea act gaa ctg gea gaa ggg gtc cca tea agg ttc agt gge 192
Tyr Tyr Ala Thr Glu Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet ggg tea gac tat tet ctg aca ate agg aac ctg gag tet 240
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Ser
65 70 75 80
gaa gac ttt gea gac cat tac tgt eta eag ttt tat gag ttt ccg ttc 288
Glu Asp Phe Ala Asp His Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Phe
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 65
<211> 107
<212> PRT
<213> Mus musculus
<400> 65
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly
l 5 lO 15
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
35 40 45
Tyr Tyr Ala Thr Glu Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Ser
65 70 75 80
42
Glu Asp Phe Ala Asp His Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 66
<211> 363
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(363)
<223> SC16.20 VH
<220>
<221> CDS
<222> (l)..(363)
<400> 66
eag gtc cag ttg eag eag tet gga act gag ctg gta agg cet ggg act 48
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Thr
l 5 lO 15
tea gtg agg gtg tee tgc aag get tet gga tac gcc ttc ggt aat eac 96
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Gly Asn His
20 25 30
ttg att gag tgg gtg aag eag agg cet gga eag gge ctt gag tgg att 144
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga gtg att aat cet gga act ggt ggt act eac tac aat gag aag ttc 192
Gly Val Ile Asn Pro Gly Thr Gly Gly Thr His Tyr Asn Glu Lys Phe
so ss 60
aag gac aag gea aga ctg ace gea gac aaa tee tee aac act gcc tac 240
Lys Asp Lys Ala Arg Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
atg eac etc aac age ctg aea tet gat gac tet geg gtc tat ttc tgt 288
Met His Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
85 90 95
gea aga tee ccc tat gat tac eac gag ggt get atg gac tac tgg ggt 336
Ala Arg Ser Pro Tyr Asp Tyr His Glu Gly Ala Met Asp Tyr Trp Gly
100 lOS 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 67
<211> 121
43
<212> PRT
<213> Mus musculus
<400> 67
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Thr l 5 10 15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Gly Asn His
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Thr Gly Gly Thr His Tyr Asn Glu Lys Phe
50 55 60
Lys Asp Lys Ala Arg Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 BO
Met His Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Pro Tyr Asp Tyr His Glu Gly Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 68
<211> 339
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) •.(339)
<223> SC16.21 VL
<220>
<221> cos
<222> (l) •.(339)
<400> 68
gac att gtg atg aca eag tet cca tee tee ctg get atg tea gta gga 48
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly
l 5 lO 15
eag aag gtc act atg age tgc aag tee agt eag age ctt tta aat agt 96
Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30 .
44
age aat eaa aag aat tat ttg gcc tgg tat eag eag gaa cca gga eag 144
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln
3S 40 4S
tet cet aaa ctt ctg gta tee ttt gea tee act agg gaa tet ggg gtc 192
Ser Pro Lys Leu Leu Val Ser Phe Ala Ser Thr Arg Glu Ser Gly Val
so ss 60
cet gat cgc ttc aca gge agt gga tet ggg aca gat ttc act ctt ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
6S 70 7S 80
ate age ggt gtg eag get gaa gac ctg gea gtt tat tac tgt eag eaa 288
Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
8S 90 9S
cat tat age att ccg etc acg ttc ggt get ggg ace aag ctg gag ctg 336
His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 lOS llO
aaa 339
Lys
<210> 69
<2ll> ll3
<212> PRT
<213> Mus musculus
<400> 69
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly l s 10 lS
Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 2S 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln
3S 40 4S
Ser Pro Lys Leu Leu Val Ser Phe Ala Ser Thr Arg Glu Ser Gly Val
so ss 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
6S 70 7S 80
Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
8S 90 9S
His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 lOS 110
45
Lys
<210> 70
<211> 372
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(372)
<223> SC16.21 VH
<220>
<221> cos
<222> (l)..(372)
<400> 70
eag gtt cag eta eaa eag tet gga cet gag ctg gtg aag cet ggg gcc 48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
tea gtg aag att tee tgc aag get tet gge tat gea ttc agt age tee 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
tgg atg aac tgg gtg aag eag agg cet gga aag ggt ctt gag tgg att 144
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
gga egg att tat cet gga gat gga gat act aac tac aat ggg aag ttc 192
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
so ss 60
aag gge aag gcc aca ctg act gea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eaa etc age age ctg aca tet gag gac tet geg gtc tac ttc tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
gea atg ggt att tat aac tac gat ggt age cgt tac tat tet atg gac 336
Ala Met Gly Ile Tyr Asn Tyr Asp Gly Ser Arg Tyr Tyr Ser Met Asp
100 lOS 110
tac tgg ggt eaa gga ace tea gtc ace gtc tee tea 372
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 71
<211> 124
<212> PRT
<213> Mus rnusculus
<400> 71
46
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
35 4o 45
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Met Gly Ile Tyr Asn Tyr Asp Gly Ser Arg Tyr Tyr Ser Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 72
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l) •• (321)
<223> SC16.22 VL
<220>
<221> cos
<222> (l) .. (321)
<400> 72
gat ate cag atg aca eag act aca tee tee ctg tet gcc tet ctg gga Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
gac aga gtc ace ate agt tgc agg gea agt eag gac att aag aat tat
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr
20 25 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa ecc ctg ate
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Pro Leu Ile
35 40 45
47
48
96
144
tac tac aca tea aga gta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Val His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet gga aca gat tat tet etc ace att age aac ctg gag eaa 240
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
gaa gat att gcc act tac ttt tgc eag eag ggt tat acg ctt cca ttc 288
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Thr Leu Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ath aar 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 73
<211> 107
<212> PRT
<213> Mus musculus
<400> 73
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Pro Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Val His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Thr Leu Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 74
<211> 360
<212> DNA
<213> Mus musculus
<220>
48
<221> mise feature
<222> (l)..(360)
<223> SC16.22 VH
<220>
<221> cos
<222> (l)..(360)
<400> 74
eag gtc cag ctg eag eag cet ggg get gaa ctg gtg aag cet ggg get 48
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ctg tee tgt aag get tet gga tac ace ttc act ace tac 96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
tgg atg eac tgg gtg aag eag agg cet gga eaa gge ctt gag tgg ate 144
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga gag att gat cet tet gat agt tat act tac tac aat eaa aag ttc 192
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca ttg act gta gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eaa etc age age ctg aca tet gag gac tet geg gtc tat tat tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg gac tat ggt aac ecc tat get atg gac tac tgg ggt eaa 336
Ala Arg Gly Asp Tyr Gly Asn Pro Tyr Ala Met Asp Tyr Trp Gly Gln
100 105 110
gga tee tea gtc ace gtc tee tea 360
Gly Ser Ser Val Thr Val Ser Ser
115 120
<210> 75
<211> 120
<212> PRT
<213> Mus musculus
<400> 75
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
49
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Asp Tyr Gly Asn Pro Tyr Ala Met Asp Tyr Trp Gly Gln
100 105 llO
Gly Ser Ser Val Thr Val Ser Ser ll5 120
<210> 76
<2ll> 324
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.23 VL
<220>
<221> CDS
<222> (l)..(324)
<400> 76
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cet ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc ace ttg ace tgc agt gcc age tea agt gta agt tee agg 96
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Arg
20 25 30
tac ttg tac tgg tac eag eag aag cca gga tee tee ccc aaa etc tgg 144
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cet get cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc ata ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Ile Ile Ser Ser Met Glu
65 70 75 80
get gaa gat get gcc tet tat ttc tgc cat eag tgg agt aat tac cca 288
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Asn Tyr Pro
85 90 95
so
etc acg ttc ggt get ggg ace aag ctg gag ctg aaa
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 77
<211> 108
<212> PRT
<213> Mus musculus
<400> 77
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
324
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Arg
20 25 30
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
so 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Ile Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Asn Tyr Pro
85 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 78
<211> 372
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(372)
<223> SC16.23 VH
<220>
<221> CDS
<222> (l)..(372)
<400> 78
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
Sl
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 2S 30
aat acg gge ata gge tgg att cgt eag cet tea ggg acg ggt ctg gag 144
Asn Thr Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Thr Gly Leu Glu
3S 40 4S
tgg ctg gea eac att tgg tgg aat gat gat aag tac tat aat cca tee 192
Trp Leu Ala His Ile Trp Trp Asn Asp Asp Lys Tyr Tyr Asn Pro Ser
so ss 60
ctg aag age egg etc aca ate tee aag gaa ace tee aac aac eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Glu Thr Ser Asn Asn Gln Val
6S 70 7S 80
ttc etc aag ate ace aat gtg gac act gea gat act gcc tea tac ttc 288
Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Ser Tyr Phe
8S 90 9S
tgt gtt eaa ate ggg cgc gac tac agt aac tac gcc tgg tat ttc gat 336
Cys Val Gln Ile Gly Arg Asp Tyr Ser Asn Tyr Ala Trp Tyr Phe Asp
100 lOS 110
gtc tgg gge gea ggg ace acg gtc ace gtc tee tea 372
Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
11S 120
<210> 79
<211> 124
<212> PRT
<213> Mus musculus
<400> 79
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
l s lO lS
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 2S 30
Asn Thr Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Thr Gly Leu Glu
3S 40 4S
Trp Leu Ala His Ile Trp Trp Asn Asp Asp Lys Tyr Tyr Asn Pro Ser
so ss 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Glu Thr Ser Asn Asn Gln Val
6S 70 7S 80
Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Ser Tyr Phe
8S 90 9S
52
Cys Val Gln Ile Gly Arg Asp Tyr Ser Asn Tyr Ala Trp Tyr Phe Asp
100 105 110
Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 80
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.25 VL
<220>
<221> CDS
<222> (l)..(318)
<400> 80
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
eac tgg tac eag eag aag tea gge ace tee ccc aaa aga tgg att tat 144
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
gac tea tee aaa ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age age atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc eag eag tgg agt agt aac ccg etc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
85 90 95
ttc ggt get ggg ace aag ctg gag ctg aaa 318
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 81
<211> 106
<212> PRT
<213> Mus museulus
<400> 81
53
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l s lO lS
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
3S 40 4S
Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
6S 70 7S 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
8S 90 9S
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 82
<211> 372
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(372)
<223> SC16.2S VH
<220>
<221> cos
<222> (l)..(372)
<400> 82
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l s lO lS
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 2S 30
ggt atg ggt gta gge tgg att cgt eag cet tea gga gag ggt eta gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu Glu
3S 40 4S
tgg ctg aca gac att tgg tgg gat gac aat aag tac tat aac cca tee 192
Trp Leu Thr Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
so ss 60
54
ctg aag age egg etc aca ate tee aag gat ace tee age aac eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val
65 70 75 80
ttc etc aat ate ace agt gtg gac act gea gat act gcc act tac tac 288
Phe Leu Asn Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get ega aga gtt aac tat tat tac gac ccg tac tat get atg gac 336
Cys Ala Arg Arg Val Asn Tyr Tyr Tyr Asp Pro Tyr Tyr Ala Met Asp
100 105 110
tac tgg ggt eaa gga ace tea gtc ace gtc tee tea 372
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 83
<211> 124
<212> PRT
<213> Mus musculus
<400> 83
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu Glu
35 40 45
Trp Leu Thr Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val
65 70 75 80
Phe Leu Asn Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Arg Val Asn Tyr Tyr Tyr Asp Pro Tyr Tyr Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 84
<211> 336
<212> DNA
ss
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.26 VL
<220>
<221> cos
<222> (l)..(336)
<400> 84
gat gtt gag atg ace eag act cca etc act ttg tcg gtt ace att gga 48
Asp Val Glu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly l 5 lO 15
eaa cca gcc tee ate tet tgc aag tea agt eag age etc tea gac agt 96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser
20 25 30
gat gga aag aca tat ttg aat tgg atg ttt eag agg cca gge egg tet 144
Asp Gly Lys Thr Tyr Leu Asn Trp Met Phe Gln Arg Pro Gly Arg Ser
35 40 45
cca aag cgc eta ate tat ctg gtg tet aaa ctg gac tet gga gtc cet 192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
gac agg ttc act gge agt gga tea ggg aca gat ttc aca ctg aaa ate 240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat ttg gga gtt tac tat tgc tgg eaa ggt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
aaa cat ttt ccg tgg acg ttc ggt gga gge ace aag ctg gaa ate aaa 336
Lys His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 85
<211> 112
<212> PRT
<213> Mus musculus
<400> 85
Asp Val Glu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly l 5 lO 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ser Asp Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Asn Trp Met Phe Gln Arg Pro Gly Arg Ser
35 40 45
56
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 BO
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
B5 90 95
Lys His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> B6
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.26 VH
<220>
<221> CDS
<222> (l)..(351)
<400> B6
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 4B Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggt tat tee ttc aca gac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
tea atg eac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
gge tgg ata aac act gag act gtt gag cca aca tat gea gat gac ttc 192
Gly Trp Ile Asn Thr Glu Thr Val Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
atg gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc ttt 240
Met Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
65 70 75 BO
ttg eag ate aac aac etc gaa aat gag gac acg get aca tat ttc tgt 2BB Leu Gln Ile Asn Asn Leu Glu Asn Glu Asp Thr Ala Thr Tyr Phe Cys
B5 90 95
get aga ttt ggt tee tat get atg gac tac tgg ggt eaa gga ace tea 336
Ala Arg Phe Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
57
gtn aev gtn ten ten
Val Xaa Val Xaa Xaa
115
351
<210> 87
<211> 117
<212> PRT
<213> Mus museulus
<220>
<221> mise feature
<222> (114)..(114)
<223> The 'Xaa' na mestu 114 predstavlja Thr.
<220>
<221>
<222>
<223>
mise feature
(116)..(116)
The 'Xaa' na mestu 116 predstavlja Ser.
<220>
<221>
<222>
<223>
mise feature
(117)..(117)
The 'Xaa' na mestu 117 predstavlja Ser.
<400> 87
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
20 25 30
Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Val Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Met Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe
65 70 75 80
Leu Gln Ile Asn Asn Leu Glu Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Phe Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Xaa Val Xaa Xaa
115
58
<210> 88
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.29 VL
<220>
<221> CDS
<222> (l)..(318)
<400> 88
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l s lO lS
gag aag gtc ace ata ace tgc agt gcc age tea agt gta agt tac atg 96
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
eac tgg ttc eag eag aag cca gge act tet ccc aaa etc tgg att tat 144
His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
3S 40 4S
ace aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
gga tet ggg ace tet tac tet etc aca gtc age ega atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Met Glu Ala Glu
6S 70 7S 80
gat get gcc act tat tac tgc eag eaa agg agt ctt tat ccg tac acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Leu Tyr Pro Tyr Thr
8S 90 9S
ttc gga ggg ggg ace aag gtg gaa ata aaa 318
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 lOS
<210> 89
<211> 106
<212> PRT
<213> Mus musculus
<400> 89
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l s lO lS
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
59
His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
3S 40 4S
Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Met Glu Ala Glu
6S 70 7S 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Leu Tyr Pro Tyr Thr
8S 90 9S
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 lOS
<210> 90
<211> 363
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(363)
<223> SC16.29 VH
<220>
<221> cos
<222> (l)..(363)
<400> 90
eag gtt cag eta eag eag tet gga get gag ctg geg agg ecc ggg get 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l s lO lS
tea gtg aag ctg tee tgc aag get tea gge tac ace ttc act gac eag 96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Gln
20 2S 30
tat ata aac tgg gtg aag eag agg act gga eag gge ctt gag tgg att 144
Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
gga gag att tat ccc gga agg ggt aat act tac tac aat gag aag ttc 192
Gly Glu Ile Tyr Pro Gly Arg Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
so ss 60
aag gge aag gcc aea ctg act gea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
atg eaa etc age age ctg aca tet gag gac tet gea gtc tat ttc tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
8S 90 9S
60
gea aga gag gat ggt ggt tac gac gat gcc tgg ttt get tac tgg gge
Ala Arg Glu Asp Gly Gly Tyr Asp Asp Ala Trp Phe Ala Tyr Trp Gly
100 105 110
eaa ggg act ctg gtc act gtc tet gea
Gln Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 91
<211> 121
<212> PRT
<213> Mus musculus
<400> 91
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Gln
20 25 30
Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Tyr Pro Gly Arg Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Asp Gly Gly Tyr Asp Asp Ala Trp Phe Ala Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ala
115 120
336
363
<210>
<211>
<212>
<213>
92
324
DNA
Mus musculus
<220>
<221>
<222>
<223>
mise feature (1)..(324) SC16.30 VL
<220>
61
<221> cos
<222> (l)..(324)
<400> 92
eaa att gtt ctg ace eag tet cca aca ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gaa cgg gtc ace atg ace tgc act gcc age tea agt gta act tee agt 96
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Thr Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag cca gga tee tee ccc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln (;ln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cca get cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc aca ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
get gaa gat get gcc act tat tac tgc eac eag ttt cat cgt tee cca 288
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
ttc acg ttc gge tcg ggg aca aag ttg gaa ata aaa 324
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 93
<211> 108
<212> PRT
<213> Mus museulus
<400> 93
Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Thr Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
62
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Phe His Arg Ser Pro
85 90 95
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 94
<211> 360
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.30 VH
<220>
<221> cos
<222> (l)..(360)
<400> 94
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ecc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aaa cca gcc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Lys Pro Ala
50 55 60
ctg aag age ega ctg act gtc tee aag gat ace tee age aac eag gtt 240
Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Ser Asn Gln Val
65 70 75 80
ttc etc aag ate gcc act gtg gac get gea gat act gge aca tac tac 288
Phe Leu Lys Ile Ala Thr Val Asp Ala Ala Asp Thr Gly Thr Tyr Tyr
85 90 95
tgt get ega ate gtt gat ggt eac ecc ccg ttt get tac tgg gge eaa 336
Cys Ala Arg Ile Val Asp Gly His Pro Pro Phe Ala Tyr Trp Gly Gln
100 105 110
ggg act ctg gtc act gtc tet gea 360
Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 95
<211> 120
<212> PRT
63
<213> Mus musculus
<400> 9S
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l s 10 lS
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 2S 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
3S 40 4S
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Lys Pro Ala
so ss 60
Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Ser Asn Gln Val
6S 70 7S 80
Phe Leu Lys Ile Ala Thr Val Asp Ala Ala Asp Thr Gly Thr Tyr Tyr
8S 90 9S
Cys Ala Arg Ile Val Asp Gly His Pro Pro Phe Ala Tyr Trp Gly Gln
100 lOS 110
Gly Thr Leu Val Thr Val Ser Ala llS 120
<210> 96
<211> 336
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.30 VL
<220>
<221> cos
<222> (l)..(336)
<400> 96
gac att gtg ctg ace eag tet cca etc tet ctg cet gtc aat att gga 48
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Ile Gly l s lO lS
gat eaa gcc tet ate tet tgc aag tet act aag agt ctt ctg aat agt 96
Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser
20 2S 30
64
gat gga ttc act tat ttg gac tgg tat ttg eag agg cca gge eag tet 144
Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
cca eaa ttc eta ata tat ttg gtt tet aat ega ttt tet gga gtt cca 192
Pro Gln Phe Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
gac agg ttc agt gge agt ggg tea gga aca gat ttc aea etc aag ate 240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat ttg gga gta tat tat tgc ttc eag agt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser
85 90 95
aac tat ctt ccg etc acg ttc ggt get ggg ace aag ctg gag ctg aga 336
Asn Tyr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105 110
<210> 97
<211> 112
<212> PRT
<213> Mus rnusculus
<400> 97
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Ile Gly l 5 lO 15
Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser
20 25 30
Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Gln Phe Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser
85 90 95
Asn Tyr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105 110
<210> 98
<211> 357
<212> DNA
<213> Mus rnusculus
65
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.31 VH
<220>
<221> cos
<222> (l)..(357)
<400> 98
gag gtc caa ctg eag eag tet gga cet gag ctg gtg aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc agt cgt ttc 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Arg Phe
20 25 30
tat atg eac tgg gtg aag eaa agt cet gaa aat agt ctt gag tgg att 144
Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu Glu Trp Ile
35 40 45
gga gag att aat cet age act ggg ggt aca age tac aac eag aag ttc 192
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca tta act gta gat aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eag etc aag age ctg aca tet gaa gag tet gea gtc tat tac tgt 288
Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
85 90 95
act agg ggt tac ggg age aac tgg tac ttc gat gtc tgg gge gea ggg 336
Thr Arg Gly Tyr Gly Ser Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly
100 105 110
ace acg gtc ace gtc tee aca 357
Thr Thr Val Thr Val Ser Thr
115
<210> 99
<211> 119
<212> PRT
<213> Mus musculus
<400> 99
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Arg Phe
20 25 30
66
Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu Glu Trp Ile
3S 40 4S
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
8S 90 9S
Thr Arg Gly Tyr Gly Ser Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly
100 lOS 110
Thr Thr Val Thr Val Ser Thr
11S
<210> 100
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l).•(321)
<223> SC16.34 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 100
agt att gtg atg ace eag act ecc aaa ttc ctg ctt gta tea gea gga 48
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l s lO lS
gac agg gtt ace ata ace tgc aag gcc agt eag agt gtg agt aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
gta get tgg tac eaa eag aag cca ggg eag tet cet aaa ctg ctg ata 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 4S
tac tat gea tee aat cgc tac agt gga gtc cet gat cgc ttc act gge 192
Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 5S 60
agt gga tat ggg acg gat ttc act ttc ace ate age act gtg eag get 240
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
67
gaa gac ctg gea gtt tat ttc tgt eag eag gat tat age tet ccg tgg
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 101
<211> 107
<212> PRT
<213> Mus musculus
<400> 101
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l 5 lO 15
288
321
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 102
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(354)
<223> SC16.34 VH
<220>
<221> CDS
<222> (l)..(354)
<400> 102
68
eag ate eag ttg gtg eag tet gga cet gag ctg aag agg cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Arg Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet gga tat ace ttc aca aac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gga atg aac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
gge tgg ata aac acg tac act gga gac cca aea tat get gat gac ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
ttg eag ate aac aac etc aaa aat gag gac acg get aca tat ttc tgt 288
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
gea aga att gge ggt aat agt ccc tet gat tac tgg gge eaa gge ace 336
Ala Arg Ile Gly Gly Asn Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
100 105 110
tet etc aca gtc tee tea 354
Ser Leu Thr Val Ser Ser
115
<210> 103
<211> 118
<212> PRT
<213> Mus musculus
<400> 103
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Arg Pro Gly Glu l 5 lO 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
69
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Ile Gly Gly Asn Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Leu Thr Val Ser Ser
115
<210> 104
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.35 VL
<220>
<221> cos
<222> (l)..(321)
<400> 104
gat ate cag atg aca eag act aca tee tee ctg tet gcc tet ctg gga 48
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aga gtc ace ate agt tgc agg gea agt eag gac att age aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
tac tac aca tea aga tta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet gga aca gat tat tet etc ace att age aac ctg gag eaa 240
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
gaa gat att gcc act tac ttt tgc eaa eag ggt aat acg ctt ccg tac 288
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 105
<211> 107
<212> PRT
70
<213> Mus musculus
<400> 105
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
so 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 106
<211> 360
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) •. (360)
<223> SC16.35 VH
<220>
<221> CDS
<222> (l) .• (360)
<400> 106 gat gtg cag Asp Val Gln l
ctt cag gag tcg gga cet ggc ctg gtg aaa cet tet cag 48
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
5 10 15
tet ctg tee etc ace tgc act gtc act gge tac tea ate ace agt gat
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
20 25 30
tat gcc tgg aac tgg ate egg eag ttt cca gga aac aaa ctg gag tgg
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
71
96
144
atg gge tac ata age tac agt ggt age act age tac aac cca tet etc 192
Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
50 55 60
aaa agt ega ate tet ate act ega gac aca tee aag aac eag ttc ttc 240
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
ctg eag ttg aat tet gtg act act gag gac aca gcc aca tat tac tgt 288
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
gea aga ttt tac tac ggt agt age tat get atg gac tac tgg ggt eaa 336
Ala Arg Phe Tyr Tyr Gly Ser Ser Tyr Ala Met Asp Tyr Trp Gly Gln
100 105 110
gga ace tea gtc ace gtc tee tea 360
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 107
<211> 120
<212> PRT
<213> Mus museulus
<400> 107
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln l 5 lO 15
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
20 25 30
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Phe Tyr Tyr Gly Ser Ser Tyr Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val ser Ser
115 120
72
<210> 108
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.36 VL
<220>
<221> cos
<222> (l)..(321)
<400> 108
gaa aca act gtg ace eag tet cca gea tee ctg tee gtg act aea gga 48
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Val Thr Thr Gly l 5 lO 15
gaa aaa gtc act ate aga tgc ata ace ace cet gat att gat gat gat 96
Glu Lys Val Thr Ile Arg Cys Ile Thr Thr Pro Asp Ile Asp Asp Asp
20 25 30
atg aac tgg tac eag eag aag cca ggg gaa cet cet aac etc ctt att 144
Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Asn Leu Leu Ile
35 40 45
tea gaa gge aat agt ctt cgt cet gga gtc cca tee ega ttc tee age 192
Ser Glu Gly Asn Ser Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
50 55 60
agt gge tat gge aca aat ttt gtt ttt aca att gaa aac acg etc tea 240
Ser Gly Tyr Gly Thr Asn Phe Val Phe Thr Ile Glu Asn Thr Leu Ser
65 70 75 80
gaa gat gtt gea gat tac tac tgt ttg eaa agt gat aac atg cca ttc 288
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Met Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aar 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 109
<211> 107
<212> PRT
<213> Mus museulus
<400> 109
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Val Thr Thr Gly l 5 lO 15
Glu Lys Val Thr Ile Arg Cys Ile Thr Thr Pro Asp Ile Asp Asp Asp
20 25 30
73
Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Asn Leu Leu Ile
3S 40 4S
Ser Glu Gly Asn Ser Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
so ss 60
Ser Gly Tyr Gly Thr Asn Phe Val Phe Thr Ile Glu Asn Thr Leu Ser
6S 70 7S 80
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Met Pro Phe
8S 90 9S
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 110
<211> 3S4
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3S4)
<223> SC16.3S VH
<220>
<221> cos
<222> (l)..(3S4)
<400> 110
eag gtc cag ctg eag eag tet ggg get gaa ctg gea aaa cet ggg gcc 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala l s lO lS
tea gtg aag atg tee tgc aag get tet gge tac ace ttt act ace tac 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 2S 30
tgg atg eac tgg gta aaa eag agg cet gga eag ggt ctg gaa tgg att 144
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
gga tac att aat cet age agt ggt tat act gag tac aat eag aag ttc 192
Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe
so ss 60
aag gac aag gcc aca ttg act gea gac aaa tee tee age aea gcc tac 240
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
atg eaa eta age age ctg aca tet gag gac tet tea gtc tat tac tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ser Val Tyr Tyr Cys
8S 90 9S
74
gea aga aag ggt agt aac agg ggg ttt get tac tgg gge eaa ggg act
Ala Arg Lys Gly Ser Asn Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 lOS 110
ctg gtc act gtc tet ten
Leu Val Thr Val Ser Xaa
11S
<210> 111
<211> 118
<212> PRT
<213> Mus musculus
<220>
<221> mise feature
<222> (118)..(118)
<223> The 'Xaa' na mestu 118 predstavlja Ser.
<400> 111
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala l s lO lS
336
354
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe
so ss 60
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ser Val Tyr Tyr Cys
85 90 95
Ala Arg Lys Gly Ser Asn Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Xaa
115
<210> 112
<211> 312
<212> DNA
<213> Mus musculus
<220>
75
<221> mise feature
<222> (l)..(312)
<223> SC16.38 VL
<220>
<221> cos
<222> (l)..(312)
<400> 112
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt ata aat tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Tyr Met
20 25 30
eac tgg tac eag eag aag cca gge ace tee ccc aaa aga tgg att tat 144
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
gac aca tee aaa ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tat tet etc aca ate age age atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc cat eag egg agt acg tgg acg ttc ggt 288
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Trp Thr Phe Gly
85 90 95
gga gge ace aag ctg gaa ate aaa 312
Gly Gly Thr Lys Leu Glu Ile Lys
100
<210> 113
<211> 104
<212> PRT
<213> Mus musculus
<400> 113
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
76
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
6S 70 7S 80
Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Trp Thr Phe Gly
8S 90 9S
Gly Gly Thr Lys Leu Glu Ile Lys
100
<210> 114
<211> 348
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.38 VH
<220>
<221> cos
<222> (l)..(348)
<400> 114
gag gtt cag ctg eag eag tet ggg gea gag ctt gtg aag cca ggg gcc 48
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala l s lO lS
tea gtc aag ttg tee tgc aca gtt tet gge ttc aac att aaa gac ace 96
Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Thr
20 2S 30
tat ata eac tgg gtg aag eag agg cet gaa eag gge ctg gag tgg att 144
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
3S 40 4S
gga agg att gat cet geg aat ggt aat act aaa tat gac ccg aag ttc 192
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
so ss 60
eag gge aag gcc act ata aca gea gac aca tee tee aac aca gcc tac 240
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
6S 70 7S 80
ctg eag etc age age ctg aca tet gag gac act gcc gtc tat tac tgt 288
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
8S 90 9S
get aga ccg acg ggg tac ttt gaa tac tgg gge eaa gge ace act etc 336
Ala Arg Pro Thr Gly Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Thr Leu
100 lOS 110
aca gtc tee tea 348
Thr Val Ser Ser
llS
77
<210> 115
<211> 116
<212> PRT
<213> Mus rnusculus
<400> 115
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Thr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
50 55 60
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Thr Gly Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 116
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l) .• (321)
<223> SC16.41 VL
<220>
<221> cos
<222> (l) ..(321)
<400> 116
gat ate cag atg aca eag act aca tee tee ctg tet gcc tet ttg gga 48
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
78
gac aga gtc ace ate agt tgc agg gea agt eag gat gtt ate aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Val Ile Asn Tyr
20 2S 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
3S 40 4S
tac tac aca tea agg tta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt ggg tet agg aca gat tat tet etc ace ate age aac ctg gaa cet 240
Ser Gly Ser Arg Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
6S 70 7S 80
gaa gat att gcc act tac tat tgt eag eag tat agt gag cgt ccg tac 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Arg Pro Tyr
8S 90 9S
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 117
<211> 107
<212> PRT
<213> Mus musculus
<400> 117
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l s lO lS
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Val Ile Asn Tyr
20 2S 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
3S 40 4S
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Arg Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
6S 70 7S 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Arg Pro Tyr
8S 90 9S
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
79
<210> 118
<211> 351
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.41 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 118
gaa gtg aag ctt gag gag tet gga gga gge ttg gtg eaa ttt gga gga 48
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Phe Gly Gly
l 5 lO 15
tee atg aaa etc tet tgt get get tet gga ttc act ttt agt gat gcc 96
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
tgg atg gac tgg gtc cgc eag tet cca gag aag ggg ctt gag tgg gtt 144
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
get gaa att aga aac aaa get aat aat cat gea aca tat tat cet gag 192
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Pro Glu
50 55 60
tet gtg aaa ggg agg ttc ace ate tea aga gat gat tee aaa agt aga 240
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Arg
65 70 75 80
gtg tac ctg eaa atg aac aac tta aga get gaa gac act gge att tat 288
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
tac tgt acg ggt tac tee tcg ttt get tac tgg gge eaa ggg act ctg 336
Tyr Cys Thr Gly Tyr Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 119
<211> 117
<212> PRT
<213> Mus musculus
<400> 119
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Phe Gly Gly l 5 10 15
80
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
20 25 30
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Pro Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Arg
65 70 75 80
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Gly Tyr Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 120
<211> 336
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.42 VL
<220>
<221> cos
<222> (l)..(336)
<400> 120
gat gtt ttg atg aca eag tet cca etc tee ctg tet gtc agt ctt gga 48
Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Leu Gly
l 5 lO 15
gat eaa gcc tee ate tet tgt aga tet agt eag aac att gta eac agt 96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser
20 25 30
gat aga tac ace tat tta gaa tgg tac ctg eag aaa cca gge eag tcg 144
Asp Arg Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
cca aaa etc ctg ata tat ggg gtt tee aac ega ttt tet ggg gtc cca 192
Pro Lys Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
81
gac agg ttc agt gge agt gga tea ggg aca gat ttc aca etc aag ate
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat atg gga gtt tat tac tgc ttt eaa ggt
Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
aca cat gtt ccg tac acg ttc gga ggg ggg ace aag ctg gaa ata aaa
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 121
<211> 112
<212> PRT
<213> Mus musculus
<400> 121
Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Leu Gly l 5 lO 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser
20 25 30
Asp Arg Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 122
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(354)
<223> SC16.42 VH
82
240
288
336
<220>
<221> cos
<222> (l)..(354)
<400> 122
eag ate cag ttg gtg eag tet gga cet gaa ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggg tat ace ttc aca act get 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala
20 25 30
gga atg eag tgg gtg eaa aag atg cca gga aag ggt ttt aag tgg att 144
Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile
35 40 45
gge tgg ata aac ace eac tet gga gag cca aaa tat gea gat gac ttc 192
Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
tta eag ata age aac etc aaa gac gag gac acg get acg ttt ttc tgt 288
Leu Gln Ile Ser Asn Leu Lys Asp Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
geg ccc eta tgg tee gat agt agt ttt get tac tgg gge eaa gga act 336
Ala Pro Leu Trp Ser Asp Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
ctg gtc act gtc tet gea 354
Leu Val Thr Val Ser Ala
115
<210> 123
<211> 118
<212> PRT
<213> Mus musculus
<400> 123
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala
20 25 30
Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile
35 40 45
Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Asp Asp Phe
50 55 60
83
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Ser Asn Leu Lys Asp Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
Ala Pro Leu Trp Ser Asp Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 124
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.45 VL
<220>
<221> cos
<222> (l)..(321)
<400> 124
gaa ate cag atg ace eag tet cca tee tet atg tet gea tet ctg gga 48
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly l 5 lO 15
gac aga ata ace ate act tgc eag gea act eaa gac att gtt aag aat 96
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
tta aac tgg tat cc;g eag aaa cca ggg aaa ccc cet tea ttc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
35 40 45
tat tat gea act gaa ctg gea gaa ggg gtc cca gea agg ttc agt gge 192
Tyr Tyr Ala Thr Glu Leu Ala Glu Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
agt ggg tet ggg tea gac tat tet ctg aca ate age aac ctg gag tet 240
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser
65 70 75 80
gaa gat ttt gea gac tat eac tgt eta eag ttt tat gag ttt ccg ttc 288
Glu Asp Phe Ala Asp Tyr His Cys Leu Gln Phe Tyr Glu Phe Pro Phe
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
84
<210> 125
<211> 107
<212> PRT
<213> Mus musculus
<400> 125
Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly l 5 10 15
Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Val Lys Asn
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile
35 40 45
Tyr Tyr Ala Thr Glu Leu Ala Glu Gly Val Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser
65 70 75 80
Glu Asp Phe Ala Asp Tyr His Cys Leu Gln Phe Tyr Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 126
<211> 363
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(363)
<223> SC16.45 VH
<220>
<221> cos
<222> (l) ..(363)
<400> 126
eag gtc cag ctg eag eag tet gga get gac ctg gta agg cet ggg act 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Thr
l 5 lO 15
tea gtg aag gtg tee tgc aag get tet gga tac tee ttc act aat tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr
20 25 30
85
ctg ata gag tgg gta aag eag agg cca gga eag gge ctt gag tgg att 144
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga gtg att aat cet gga agt ggt gga act eac tac aat gag aaa ttc 192
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr His Tyr Asn Glu Lys Phe
50 55 60
aag gac aag gea gtt ctg act gea gac aaa tee tee act act gcc eac 240
Lys Asp Lys Ala Val Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala His
65 70 75 80
atg eag etc age age ctg aea tet gat gac tet geg gtc tat ttc tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
85 90 95
gea aga tee ccc tat gat tat aac gat ggt get atg gac tac tgg ggt 336
Ala Arg Ser Pro Tyr Asp Tyr Asn Asp Gly Ala Met Asp Tyr Trp Gly
100 105 110
eaa gga ace tea gtc ace gtc tet tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 127
<211> 121
<212> PRT
<213> Mus musculus
<400> 127
Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Thr l 5 lO 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr His Tyr Asn Glu Lys Phe
50 55 60
Lys Asp Lys Ala Val Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala His
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Pro Tyr Asp Tyr Asn Asp Gly Ala Met Asp Tyr Trp Gly
100 105 110
86
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 128
<211> 336
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.47 VL
<220>
<221> cos
<222> (l).•(336)
<400> 128
gat gtt gtt etg ace eag tet cca etc tet etg cet gtc aat att gga 48
Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Ile Gly
l 5 lO 15
gat eaa gcc tet ate tet tge aag tet act aag agt ctt etg aat agt 96
Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser
20 25 30
gat gga ttc act tat ttg gac tgg tat ttg eag agg cca gge eag tet 144
Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
cca eaa ttc eta ata tat ttg gtt tet aat ega ttt tet gga gtt cca 192
Pro Gln Phe Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
gac agg ttc agt gge agt ggg tea gga aca gat ttc aca etc aag ate 240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat ttg gga gta tat tat tgc ttc eag agt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser
85 90 95
aac tat ctt ccg etc acg ttc ggt get ggg ace aag ctg gag ctg aga 336
Asn Tyr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105 110
<210> 129
<211> 112
<212> PRT
<213> Mus musculus
<400> 129
Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Asn Ile Gly l 5 lO 15
87
Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser
20 2S 30
Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser
3S 40 4S
Pro Gln Phe Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro
so ss 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
6S 70 7S 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser
8S 90 9S
Asn Tyr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 lOS 110
<210> 130
<211> 3S7
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3S7)
<223> SC16.47 VH
<220>
<221> cos
<222> (l)..(3S7)
<400> 130
gag gtc caa ctg eag eag tet gga cet gag ctg gtg aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l s lO lS
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc agt cgt ttc 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Arg Phe
20 2S 30
tat atg eac tgg gtg aag eaa agt cet gaa aat agt ctt gag tgg att 144
Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu Glu Trp Ile
3S 40 4S
gga gag att aat cet age act ggg ggt aca age tac aac eag aag ttc 192
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
aag gge aag gcc aca tta act gta gat aaa tee tee age aea gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
88
atg eag etc aag age ctg aca tet gaa gag tet gea gtc tat tac tgt
Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
85 90 95
act agg ggt tac ggg age aac tgt tac ttc gat gtc tgg gge gea ggg
Thr Arg Gly Tyr Gly Ser Asn Cys Tyr Phe Asp Val Trp Gly Ala Gly
100 lOS 110
ace acg gtc ace gtc tee aca
Thr Thr Val Thr Val Ser Thr
115
<210> 131
<211> 119
<212> PRT
<213> Mus musculus
<400> 131
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Arg Phe
20 25 30
Tyr Met His Trp Val Lys Gln Ser Pro Glu Asn Ser Leu Glu Trp Ile
35 40 45
Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Gly Tyr Gly Ser Asn Cys Tyr Phe Asp Val Trp Gly Ala Gly
100 105 110
Thr Thr Val Thr Val Ser Thr
115
<210> 132
<211> 321
<212> DNA
<213> Mus musculus
<220>
89
288
336
357
<221> mise feature
<222> (ll .•(32ll
<223> SC16.49 VL
<220>
<221> cos
<222> (ll ..(321l
<400> 132
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat agt tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
tta age tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat ega gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate ace age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Thr Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gaa ttt ccg etc 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 133
<211> 107
<212> PRT
<213> Mus musculus
<400> 133
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
90
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Thr Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 134
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(351)
<223> SC16.49 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 134
eag gtt caa ctg eag eag tet gga cet gag ctg gtg aag cet ggg act 48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
l 5 lO 15
tta gtg aag ata tee tgc aag get tet ggt tac ace ttc aca age tac 96
Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
gat ata aac tgg gtg aag eag agg cet gga eag gga ctt gaa tgg att 144
Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tgg att tat cet gga gat ggt aat act aag tac agt gag aaa ttc 192
Gly Trp Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Ser Glu Lys Phe
50 55 60
aag gge aag gcc aca ctg act gea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eag etc ace age ctg act tet gag aac tet gea gtc tat ttc tgt 288
Met Gln Leu Thr Ser Leu Thr Ser Glu Asn Ser Ala Val Tyr Phe Cys
85 90 95
gea aga gac tat gat tac cet ttt get tac tgg gge eaa ggg act ctg 336
Ala Arg Asp Tyr Asp Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
91
<210> 135
<211> 117
<212> PRT
<213> Mus musculus
<400> 135
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr l 5 10 15
Leu Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Ser Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Thr Ser Leu Thr Ser Glu Asn Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Asp Tyr Asp Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 136
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221>
<222>
<223>
mise feature (l) •• (318) SC16.50 VL
<220>
<221> cos
<222> (1)..(318)
<400> 136
gat ate cag atg aca cag act aca tee tee ctg tet gcc tet ctg gga 48
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
l 5 10 15
92
gac aga gtc ace ate agt tgc agg gea agt eag gac att age aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
tac tac aca tea aga tta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet ggt aca gat tat tet etc ace att age aac ctg gag eaa 240
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
gaa gat att gcc act tac ttt tgc eaa eag ggt aat acg ctt egg acg 288
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Arg Thr
85 90 95
ttc ggt gga gge ace aag ctg gaa ate aaa 318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 137
<211> 106
<212> PRT
<213> Mus musculus
<400> 137
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30
Leu Asn Trp Tyr·Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Arg Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
93
<210> 138
<211> 363
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l).•(363)
<223> SC16.50 VH
<220>
<221> cos
<222> (l).•(363)
<400> 138
gaa gtg cag ctg gtg gag tgt ggg gga tgc tta gtg aag cet gga ggg 48
Glu Val Gln Leu Val Glu Cys Gly Gly Cys Leu Val Lys Pro Gly Gly
l 5 lO 15
tac ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age tat 96
Tyr Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
gcc atg tet tgg gtt cgc eag tet cca gag aag agg ctg gag tgg gtc 144
Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
gea gaa ate agt att ggt ggt age tac ace tac tat cca gac act gtg 192
Ala Glu Ile Ser Ile Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val
50 55 60
acg gge ega ttc ace ate tee aga gac aat gcc aag aac ace ctg tac 240
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
ctg gaa atg age agt ctg agg tet gag gac acg gcc atg tat tac tgt 288
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
gea agg gag gge tat gat tac gac gtg aga get atg gac tac tgg ggt 336
Ala Arg Glu Gly Tyr Asp Tyr Asp Val Arg Ala Met Asp Tyr Trp Gly
100 105 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 139
<211> 121
<212> PRT
<213> Mus musculus
<400> 139
Glu Val Gln Leu Val Glu Cys Gly Gly Cys Leu Val Lys Pro Gly Gly l 5 lO 15
94
Tyr Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
Ala Glu Ile Ser Ile Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val
50 55 60
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Glu Gly Tyr Asp Tyr Asp Val Arg Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 140
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.52 VL
<220>
<221> cos
<222> (l)..(321)
<400> 140
gac ate cag atg att eag tet cca tcg tee atg ttt gcc tet ctg gga 48
Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Met Phe Ala Ser Leu Gly
l 5 lO 15
gac aga gtc agt etc tet tgt egg get agt eag gge att aga ggg act 96
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Gly Ile Arg Gly Thr
20 25 30
tta gac tgg tat eaa eag aaa cca aat gga act att aaa etc ctg ate 144
Leu Asp Trp Tyr Gln Gln Lys Pro Asn Gly Thr Ile Lys Leu Leu Ile
35 40 45
tac tee aca tee aat tta aat tet ggt gtc cca tea agg ttc agt gge 192
Tyr Ser Thr Ser Asn Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
95
agt ggg tet ggg tea gat tat tet etc ace ate age age eta gag tet
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 BO
gaa gat ttt gea gac tat tac tgt eta eag cgt aat geg tat cet etc
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Arg Asn Ala Tyr Pro Leu
B5 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
240
2BB
321
<210> 141
<211> 107
<212> PRT
<213> Mus musculus
<400> 141
Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Met Phe Ala Ser Leu Gly l 5 10 15
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Gly Ile Arg Gly Thr
20 25 30
Leu Asp Trp Tyr Gln Gln Lys Pro Asn Gly Thr Ile Lys Leu Leu Ile
35 40 45
Tyr Ser Thr Ser Asn Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 BO
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Arg Asn Ala Tyr Pro Leu
B5 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 142
<211> 357
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.52 VH
96
<220>
<221> CDS
<222> (l)..(3S7)
<400> 142
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ecc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l s lO lS
age ctg tee ate acg tgc get gtc tet gga ttt tea tta ace age ttt 96
Ser Leu Ser Ile Thr Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Phe
20 2S 30
gea ata eac tgg ttt cgc aag cet cca gga aag ggt ctg gag tgg ctg 144
Ala Ile His Trp Phe Arg Lys Pro Pro Gly Lys Gly Leu Glu Trp Leu
3S 40 4S
gga gta ata tgg act ggt gga ace aca aat tat aat tcg get etc atg 192
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
so ss 60
tee aga ctg age ate age aaa gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
6S 70 75 80
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
8S 90 9S
aga gac gat tac gac aat aat tat get atg gac tac tgg ggt eaa gga 336
Arg Asp Asp Tyr Asp Asn Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 lOS 110
ace tea gtc ace gtc tee tea 3S7
Thr Ser Val Thr Val Ser Ser
11S
<210> 143
<211> 119
<212> PRT
<213> Mus musculus
<400> 143
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l s lO lS
Ser Leu Ser Ile Thr Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Phe
20 25 30
Ala Ile His Trp Phe Arg Lys Pro Pro Gly Lys Gly Leu Glu Trp Leu
3S 40 45
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
so ss 60
97
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Asp Tyr Asp Asn Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Ser Val Thr Val Ser Ser
115
<210> 144
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.55 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 144
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat age tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
tta aac tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gag ttt ccg tac 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
98
<210> 145
<211> 107
<212> PRT
<213> Mus musculus
<400> 145
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 146
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) .. (351)
<223> SC16.55 VH
<220>
<221> cos
<222> (l) .. (351)
<400> 146
gag gtg cag ctt gtt gag tet ggt gga gga ttg gtg eag cet aaa ggg 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly
l 5 lO 15
tea ttg aaa etc tea tgt gea gtc tet gea ttc ace ttc act ace tac 96
Ser Leu Lys Leu Ser Cys Ala Val Ser Ala Phe Thr Phe Thr Thr Tyr
20 25 30
99
gcc atg aac tgg gtc cgc eag get cca gga aag ggt ttg gag tgg gtt 144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
get cgc ata aga aat aaa agt aat aat tat gea aca tat tat gcc gat 192
Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
tea gtg aaa gac agg ttc ace ate tee aga gat gat tea eaa age atg 240
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65 70 75 80
etc tat ctg eaa atg aac aac ttg aaa att gag gac aea gcc atg tat 288
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr
85 90 95
tac tgt gtg ttc tac tat gat tac gtc tac tgg gge eaa ggg act ctg 336
Tyr Cys Val Phe Tyr Tyr Asp Tyr Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 147
<211> 117
<212> PRT
<213> Mus musculus
<400> 147
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly l 5 lO 15
Ser Leu Lys Leu Ser Cys Ala Val Ser Ala Phe Thr Phe Thr Thr Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65 70 75 80
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr
85 90 95
Tyr Cys Val Phe Tyr Tyr Asp Tyr Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
100
Val Thr Val Ser Ala
115
<210> 148
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)•.(321)
<223> SC16.56 VL
<220>
<221> cos
<222> (l)..(321)
<400> 148
agt att gtg atg ace eag act ecc aaa ttc ctg ctt gta tea gea gga 48
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l 5 lO 15
gac agg gtt ace ata ace tgc aag gcc agt eag agt gtg agt aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
gta gta tgg tac eaa eag aag cca ggg eag tet cet aaa ctg ctg ata 144
Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tat gea tee aat cgc tac act gga gtc cet gat cgc ttc get gge 192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ala Gly
50 55 60
agt gga tat ggg acg gat ttc tet ttc ace ate age act gtg eag get 240
Ser Gly Tyr Gly Thr Asp Phe Ser Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
gaa gac ctg gea gtt tat ttc tgt eag eag gat tat ace tet ccg tgg 288
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Trp
85 90 95
acg ttc ggt gga ggc ace aag ctg gaa ate aga 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg
100 105
<210> 149
<211> 107
<212> PRT
<213> Mus musculus
<400> 149
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l 5 lO 15
101
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ala Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Ser Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg
100 105
<210> 150
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(354)
<223> SC16.56 VH
<220>
<221> CDS
<222> (1)..(354)
<400> 150
eag ate cag ttg gtg eag tet gga cet gaa ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggg tat ace ttc aca aac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gga atg aac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
gcc tgg ata aac ace tac act gga gag cca aca tat get gat gac ttc 192
Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tet 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Ser
65 70 75 80
102
ttg eag ate ate aac etc aaa aat gag gac acg get aca tat ttc tgt
Leu Gln Ile Ile Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
gea agg ate ggc gat agt agt ccc tet gac tac tgg ggg eag gge ace
Ala Arg Ile Gly Asp Ser Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
'100 lOS 110
act etc aca gtc tee tea
Thr Leu Thr Val Ser Ser
115
<210> 151
<211> 118
<212> PRT
<213> Mus musculus
<400> 151
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 10 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
so 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Ser
65 70 75 BO
Leu Gln Ile Ile Asn Leu Lys Asn Glu Asp hr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Ile Gly Asp Ser Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 152
<211> 321
<212> DNA
<213> Mus musculus
<220>
103
288
336
354
<221> mise feature
<222> {l)..(321)
<223> SC16.57 VL
<220>
<221> cos
<222> (l)..(321)
<400> 152
gac att gtg atg ace eag tet eac aaa ttc atg tee ata tea gta gga 48
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Ile Ser Val Gly
l 5 lO 15
gac agg gtc age ate ace tgc aag gcc agt eag gat gtg agt att ttt 96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Phe
20 25 30
gta gcc tgg tat eaa eag aaa cca gga eaa tet cet aaa eta ctg att 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tcg gea tee tac egg tac act gga gtc cet gat cgc ttc act gge 192
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tet ggg acg gat ttc att ttc ace ate age agt gtg eag get 240
Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
gaa gac ctg gea gtt tac tac tgt eag eaa cat tat ggt act cca ttc 288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Gly Thr Pro Phe
85 90 95
acg ttc gge tcg ggg aea aag ttg aaa ata aga 321
Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Arg
100 105
<210> 153
<211> 107
<212> PRT
<213> Mus musculus
<400> 153
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Ile Ser Val Gly l 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Phe
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
104
Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 BO
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Gly Thr Pro Phe
B5 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Arg
100 105
<210> 154
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (ll ..(354l
<223> SC16.57 VH
<220>
<221> cos
<222> (ll ..(354l
<400> 154
gaa gtg aaa ctg gtg gag tet ggg gga gac tta gtg aag cet gga ggg 4B
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly l 5 lO 15
tee eta aaa etc tee tgt gea gcc tet gga ttc get ttc agt agt tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr
20 25 30
gac atg tet tgg gtt cgc eag act ccg gag aag aga ctg gag tgg gtc 144
Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
gea ace att age agt ggt ggt agt tac ace tat tat cca gac agt gtg 192
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
50 55 60
aag gge ega ttc ace ate tee aga gac aat gtc agg gac ace ctg tac 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asp Thr Leu Tyr
65 70 75 BO
ctg eaa atg age agt ttg agg tet gag gac acg gcc ttg tat tac tgt 2BB Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
B5 90 95
gea aga eag gea att ggg acg tac ttt gac tac tgg gge eaa gge ace 336
Ala Arg Gln Ala Ile Gly Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
act etc aca gtc tee tea 354
Thr Leu Thr Val Ser Ser
115
lOS
<210> 155
<211> 118
<212> PRT
<213> Mus musculus
<400> 155
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly l 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr
20 25 30
Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asp Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
85 90 95
Ala Arg Gln Ala Ile Gly Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 156
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(321)
<223> SC16.58 VL
<220>
<221> cos
<222> (l) ..(321)
<400> 156
gac ate cag atg act eag tet cca gcc tee eta tet tea tet gtg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ser Ser Val Gly
l 5 lO 15
106
gaa act gtc ace ate aea tgt ega gea agt gag aat att tac agt tat 96
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 25 30
tta gea tgg tat eag eag aaa eag gga aaa tet cet eag etc ctg gtc 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
tat aat gea aaa act tta gea gaa ggt gtg cca tea agg ttc agt gge 192
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tea gge aea eag ttt tet ctg aag ate aac age ctg eag cet 240
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
gaa gat ttt ggg act tat tac tgt eaa cat cat tat gat tet ccg etc 288
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Asp Ser Pro Leu
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aga 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105
<210> 157
<211> 107
<212> PRT
<213> Mus musculus
<400> 157
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ser Ser Val Gly
l 5 lO 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Asp Ser Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg
100 105
107
<210> 158
<211> 360
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.58 VH
<220>
<221> cos
<222> (l)..(360)
<400> 158
gat gtg cag ctg gtg gag tet ggg gga gge tta gtg eag cet gga ggg 48
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
l 5 lO 15
tee egg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age ttt 96
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
20 25 30
gga atg eae tgg gtt cgt eag get cca gag aag ggg ctg gag tgg gtc 144
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
gea tac att agt agt gge agt agt aac ate tac tat gea gac aca gtg 192
Ala Tyr Ile Ser Ser Gly Ser Ser Asn Ile Tyr Tyr Ala Asp Thr Val
50 55 60
aag gge ega ttc ace ate tee aga gac aat ecc aag aac ace ctg ttc 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65 70 75 80
ctg eaa atg ace agt eta agg tet gag gac acg gcc atg tat tac tgt 288
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
gea aga gge tac tat ggt aac tac gat get atg gac tac tgg ggt eaa 336
Ala Arg Gly Tyr Tyr Gly Asn Tyr Asp Ala Met Asp Tyr Trp Gly Gln
100 105 110
gga ace tea gtc ace gtc tee tea 360
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 159
<211> 120
<212> PRT
<213> Mus musculus
<400> 159
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly l 5 lO 15
108
Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Tyr Ile Ser Ser Gly Ser Ser Asn Ile Tyr Tyr Ala Asp Thr Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Gly Tyr Tyr Gly Asn Tyr Asp Ala Met Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 160
<211> 339
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(339)
<223> SC16.61 VL
<220>
<221> cos
<222> (l)..(339)
<400> 160
gat att gtg atg aca eag tet aca tee tee ctg get atg tea gta gga 48
Asp Ile Val Met Thr Gln Ser Thr Ser Ser Leu Ala Met Ser Val Gly
l 5 lO 15
eag aag gtc act atg age tgc aag tee agt eag age ctt tta aat agt 96
Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
age aat eaa aag aat tat ttg gcc tgg tac eag eag gaa cca gga eag 144
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln
35 40 45
tet cet aaa ctt ctg gta tee ttt gea tee act agg gaa tet ggg gtc 192
Ser Pro Lys Leu Leu Val Ser Phe Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
109
cet gat cgc ttc aea gge agt gga tet ggg aca gat ttc act ctt ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
ate age ggt gtg eag get gaa gac ctg gea gtt tat tac tgt eag eaa 288
Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
cat tat age att ccg etc acg ttc ggt get gga ace aag ctg gag ctg 336
His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
aaa 339
Lys
<210> 161
<211> 113
<212> PRT
<213> Mus musculus
<400> 161
Asp Ile Val Met Thr Gln Ser Thr Ser Ser Leu Ala Met Ser Val Gly
l 5 10 15
Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Val Ser Phe Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 162
<211> 360
<212> DNA
110
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.61 VH
<220>
<221> cos
<222> (l)..(360)
<400> 162
gag gtc ctg etc eaa egg tet gga cet gac ctg gtg aag cet ggg get 48
Glu Val Leu Leu Gln Arg Ser Gly Pro Asp Leu Val Lys Pro Gly Ala l 5 lO 15
tea gtg acg ata ccc tgc aag get tet gga tac aca ttc act gac tac 96
Ser Val Thr Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
aac atg gac tgg gtg aag eag age cat gga aag age ctt gag tgg att 144
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga aat att aat act tac aat ggt ggt act ate tac aac eag aag ttc 192
Gly Asn Ile Asn Thr Tyr Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca ttg act gta gac aag ecc tee age aea gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc cgc age ctg aca tet gag gac act gea gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
gea aga cgt eta egg tat ggg gga eac tac ttt gac tac tgg gge eaa 336
Ala Arg Arg Leu Arg Tyr Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
gge ace get etc aca gtc tee tea 360
Gly Thr Ala Leu Thr Val Ser Ser
115 120
<210> 163
<211> 120
<212> PRT
<213> Mus musculus
<400> 163
Glu Val Leu Leu Gln Arg Ser Gly Pro Asp Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Thr Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
111
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asn Thr Tyr Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Leu Arg Tyr Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Ala Leu Thr Val Ser Ser
115 120
<210> 164
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.62 VL
<220>
<221> cos
<222> {l)..(321)
<400> 164
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat age ttt 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
tta age tgg ttc eag egg aaa cca ggg aaa tet ccg aag ace ctg ate 144
Leu Ser Trp Phe Gln Arg Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga tta gta gat gga gtc cca tea agg ttc act gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Thr Gly
50 55 60
agt gga tet ggg eaa gaa ttt tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Glu Phe Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
112
gaa gat ttg gga att tat tat tgt ctt eag tat gat gag ttt ccg tac
Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 165
<211> 107
<212> PRT
<213> Mus musculus
<400> 165
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe
20 25 30
Leu Ser Trp Phe Gln Arg Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Gln Glu Phe Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 166
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.62 VH
<220>
<221> cos
<222> (l)..(351)
113
288
321
<400> 166
gaa gtg atg ctg gta gag tet ggg gga gac tta gtg aag cet gga ggg 48
Glu Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
l s lO lS
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 2S 30
gcc atg tet tgg gtt cgc eag act ccg gag aag agg ctg gag tgg gtc 144
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
3S 40 4S
gea tac att age ggt ggt ggt gat eac ate tat tat cca gac agt gtg 192
Ala Tyr Ile Ser Gly Gly Gly Asp His Ile Tyr Tyr Pro Asp Ser Val
so ss 60
agg gge ega ttc ace ate tee aga gac aat gcc aag gac ace ctg tac 240
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr
6S 70 7S BO
ctg eaa atg age agt ctg agg tet gag gac acg gcc ttg tat gac tgt 288
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Asp Cys
8S 90 9S
gea aga gtg aga gac tgg tac ttc gat gtc tgg gge gea ggg ace acg 336
Ala Arg Val Arg Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr
100 lOS 110
gtc ace gtc tee tea 3Sl
Val Thr Val Ser Ser
11S
<210> 167
<211> 117
<212> PRT
<213> Mus rnusculus
<400> 167
Glu Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
l s lO lS
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 2S 30
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
3S 40 4S
Ala Tyr Ile Ser Gly Gly Gly Asp His Ile Tyr Tyr Pro Asp Ser Val
so ss 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Leu Tyr
6S 70 7S 80
114
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Asp Cys
85 90 95
Ala Arg Val Arg Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr
100 105 110
Val Thr Val Ser Ser
115
<210> 168
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.63 VL
<220>
<221> cos
<222> (l)..(318)
<400> 168
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gtc agt tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
tac tgg tac eag eag aag tea gge ace tee ecc aaa aga tgg att tat 144
Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
gac aca tee aaa ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age age atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc eag eag tgg agt agt aac ccg tac acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Tyr Thr
85 90 95
ttc gga ggg ggg ace aag ctg gaa ata aar 318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 169
<211> 106
115
<212> PRT
<213> Mus musculus
<400> 169
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
35 40 45
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu
65 70 75 BO
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 170
<211> 342
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(342)
<223> SC16.63 VH
<220>
<221> cos
<222> (l)..(342)
<400> 170
eag gtt cag ctg eag eag tet gga act gag ctg ctg agg cet ggg gcc 48
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Leu Arg Pro Gly Ala l 5 lO 15
tea gtg aag ata tee tgc aag get act gge tac aca ttc agt age tac 96
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
tgg atg gag tgg gta aag eag agg cet gga cat gge ctt gag tgg att 144
Trp Met Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
116
gga gag att tta cet gga agt ggt act act eag tac aat gag aag ttc 192
Gly Glu Ile Leu Pro Gly Ser Gly Thr Thr Gln Tyr Asn Glu Lys Phe
50 55 60
aag gge aag gcc ace ttc act gea gat aca tee tee aac aca gcc tac 240
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
atg cat etc age age ctg aca tet gag gac tet gcc gtc tat tac tgt 288
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg act aac tet etc tgg gge eaa ggg act ctg gtc act gtc 336
Ala Arg Gly Thr Asn Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 llO
tet gea 342
Ser Ala
<210> 171
<21l> ll4
<212> PRT
<213> Mus musculus
<400> 171
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Leu Arg Pro Gly Ala l 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
Trp Met Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Gly Thr Thr Gln Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Thr Asn Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ala
117
<210> 172
<211> 318
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.65 VL
<220>
<221> cos
<222> (l)..(318)
<400> 172
eaa att gtt etc ace eag tet cca gea etc atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc ace atg ace tgc agt gtc ace tea agt gta agt tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Val Thr Ser Ser Val Ser Tyr Met
20 25 30
tac tgg tac eag eag aag cet aga tee tee ecc aaa ccc tgg att tat 144
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
etc aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age age gtg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc eag eag tgg agg aat aac cca ttc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Asn Asn Pro Phe Thr
85 90 95
ttc gge tcg ggg aca aag gtg gaa ata aaa 318
Phe Gly Ser Gly Thr Lys Val Glu Ile Lys
100 105
<210> 173
<211> 106
<212> PRT
<213> Mus rnusculus
<400> 173
Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Met Thr Cys Ser Val Thr Ser Ser Val Ser Tyr Met
20 25 30
118
Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu
65 70 75 BO
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Asn Asn Pro Phe Thr
B5 90 95
Phe Gly Ser Gly Thr Lys Val Glu Ile Lys
100 105
<210> 174
<211> 372
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(372)
<223> SC16.65 VH
<220>
<221> cos
<222> (l)..(372)
<400> 174
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ecc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea etc att tgg tgg gat gat gtc aag cgc tat aat cca gcc 192
Trp Leu Ala Leu Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
ctg aag agt ega ctg act ate tee aag gat gcc tee age age eag gtc 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Ser Ser Gln Val
65 70 75 BO
ttc etc aag ate gcc agt gtg gac act gea gat act gcc aca tac tac 2B8
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
B5 90 95
119
tgt get ega ata get tee tat gat tac gac gta gtc tat get atg gac
Cys Ala Arg Ile Ala Ser Tyr Asp Tyr Asp Val Val Tyr Ala Met Asp
100 105 110
tac tgg ggt eaa gga ace tea gtc age gtc tee tea
Tyr Trp Gly Gln Gly Thr Ser Val Ser Val Ser Ser
115 120
<210> 175
<211> 124
<212> PRT
<213> Mus musculus
<400> 175
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala Leu Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Ser Ser Gln Val
65 70 75 80
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Ala Ser Tyr Asp Tyr Asp Val Val Tyr Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Ser Val Ser Val Ser Ser
115 120
<210> 176
<211> 327
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(327)
<223> SC16.67 VL
120
336
372
<220>
<221> cos
<222> (l)..(327)
<400> 176
eag get gtt gtg act eag gaa tet gea etc ace aca tea cet ggt gaa 48
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
l s lO lS
aca gtc aca etc act tgt cgc tea agt act ggg get gtt aca act agt 96
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 2S 30
aac tat gcc aac tgg ate eaa gaa aaa cca gat cat tta ttc act ggt 144
Asn Tyr Ala Asn Trp Ile Gln Glu Lys Pro Asp His Leu Phe Thr Gly
3S 40 4S
eta ata ggt ggt ace aac aac ega get cca ggt gtt cet gcc aga ttc 192
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
so ss 60
tea gge tee ctg att gga gac aag get gcc etc ace ate aca ggg gea 240
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
6S 70 7S 80
eag act gag gat gag gea ata tat ttc tgt ggt eta tgg tac age aac 288
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Gly Leu Trp Tyr Ser Asn
8S 90 9S
cat ttg gtg ttc ggt gga gga ace aaa ctg act gtc eta 327
His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 lOS
<210> 177
<211> 109
<212> PRT
<213> Mus rnusculus
<400> 177
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu
l s lO lS
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser
20 2S 30
Asn Tyr Ala Asn Trp Ile Gln Glu Lys Pro Asp His Leu Phe Thr Gly
3S 40 4S
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe
so ss 60
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala
6S 70 7S 80
121
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Gly Leu Trp Tyr Ser Asn
85 90 95
His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 178
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.67 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 178
gag gtg cag ctt gtt gag act ggt gga gga ttg gtg eag cet aaa ggg 48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly
l 5 lO 15
tea ttg aaa etc tea tgt gea gtc tet gea ttc ace ttc act ace tac 96
Ser Leu Lys Leu Ser Cys Ala Val Ser Ala Phe Thr Phe Thr Thr Tyr
20 25 30
gcc atg aac tgg gtc cgc eag get cca gga aag ggt ttg gag tgg gtt 144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
get cgc ata aga aat aaa agt aat aat tat gea aca tat tat gcc gat 192
Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
tea gtg aaa gac agg ttc ace ate tee aga gat gat tea eaa age atg 240
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65 70 75 80
etc tat ctg eaa atg aac aac ttg aaa att gag gac aca gcc atg tat 288
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr
85 90 95
tac tgt gtg ttc tac tat gat tac gtc tac tgg gge eaa ggg act ctg 336
Tyr Cys Val Phe Tyr Tyr Asp Tyr Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 179
<211> 117
122
<212> PRT
<213> Mus musculus
<400> 179
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly l 5 10 15
Ser Leu Lys Leu Ser Cys Ala Val Ser Ala Phe Thr Phe Thr Thr Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65 70 75 BO
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr
85 90 95
Tyr Cys Val Phe Tyr Tyr Asp Tyr Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 180
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) .• (321)
<223> SC16.68 VL
<220>
<221> CDS
<222> (l) •• (321)
<400> 180
gaa aca act gtg ace eag tet cca gea ttc ctg tee gtg get aca gga 48
Glu Thr Thr Val Thr Gln Ser Pro Ala Phe Leu Ser Val Ala Thr Gly
l 5 10 15
gaa aaa gtc act ate aga tgc ata ace age act gat att gat gat gat 96
Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp
20 25 30
123
atg aac tgg tac eag eag aag cca ggg gaa cet cet aat gtc ctt att 144
Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Asn Val Leu Ile
35 40 45
tea gaa gge aat act ctt cgt cet gga gtc cca tee ega ttc tee age 192
Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
50 55 60
agt gge tat gge aca gat ttt gtt ttt aca att gaa aac acg etc tea 240
Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser
65 70 75 80
gaa gat gtt gea gat tac tac tgt ttg eaa agt gat aac atg cet etc 288
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Met Pro Leu
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 181
<211> 107
<212> PRT
<213> Mus musculus
<400> 181
Glu Thr Thr Val Thr Gln Ser Pro Ala Phe Leu Ser Val Ala Thr Gly
l 5 lO 15
Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp
20 25 30
Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Asn Val Leu Ile
35 40 45
Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser
65 70 75 80
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Met Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 182
<211> 363
<212> DNA
124
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(363)
<223> SC16.68 VH
<220>
<221> cos
<222> (l)..(363)
<400> 182
eag gtg caa ctg eag eag cet ggg get gag ctg gtg aag cet ggg gcc 48
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag atg tee tgc aag get tet gge tac aca ttt ace aat tac 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
aat atg eac tgg gta aag eag aca cet gga eag gge ctg gaa tgg att 144
Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
ggg get att ttt cca gga aat ggt ggt act tee tac aat eag aag ttc 192
Gly Ala Ile Phe Pro Gly Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
aaa gge aag gcc aca ttg act gea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eag etc ace agt ttg aca tet ggg gac tet gea gtc tat tac tgt 288
Met Gln Leu Thr Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga tgg gge tac ggt agt gge ctt tat get atg gac tac tgg ggt 336
Ala Arg Trp Gly Tyr Gly Ser Gly Leu Tyr Ala Met Asp Tyr Trp Gly
100 105 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 183
<211> 121
<212> PRT
<213> Mus musculus
<400> 183
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
125
Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
Gly Ala Ile Phe Pro Gly Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
Met Gln Leu Thr Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys
8S 90 9S
Ala Arg Trp Gly Tyr Gly Ser Gly Leu Tyr Ala Met Asp Tyr Trp Gly
100 lOS 110
Gln Gly Thr Ser Val Thr Val Ser Ser
11S 120
<210> 184
<211> 318
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.72 VL
<220>
<221> CDS
<222> (l)..(318)
<400> 184
gaa aat gta etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly l s lO lS
gag aag gtc ace atg age tgc agg gcc age tea agt gta aat tac atg 96
Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met
20 2S 30
tee tgg tac eag eag aag tea gat gcc tee ecc aaa eta tgg att tat 144
Ser Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr
3S 40 4S
tac aca tee aac ctg get cet gga gtc cca get cgc ttc agt gge agt 192
Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser
so ss 60
ggg tet ggg aac tet tat tet etc aca ate age age atg gag ggt gaa 240
Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu
6S 70 7S 80
126
gat get gcc act tat tac tgc eag eag ttt act agt tee ccg tac acg
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Tyr Thr
85 90 95
ttc gga ggg ggg ace aag ctg gaa ata aaa
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 185
<211> 106
<212> PRT
<213> Mus musculus
<400> 185
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly l 5 lO 15
Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met
20 25 30
Ser Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr
35 40 45
Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Tyr Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 186
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.72 VH
<220>
<221> cos
<222> (l)..(351)
127
288
318
<400> 186
gag gtc cag ctg eag eag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act age tat 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att 144
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tat att aat cet tac aat gat ggt act aag tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
aaa gge aag gcc aca ctg act tea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ttg agg tcg agg get atg gac tac tgg ggt eaa gga ace tea 336
Ala Arg Leu Arg Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 187
<211> 117
<212> PRT
<213> Mus musculus
<400> 187
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
128
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Arg Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 188
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.73 VL
<220>
<221> cos
<222> (l)..(321)
<400> 188
gac ate cag atg ace eag tet cca tee tee tta tet gcc tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gag aga gtc agt etc act tgt egg gea agt eag gac att ggt tat age 96
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Tyr Ser
20 25 30
tta aac tgg ctt eag eag gaa cca gat gga act att aaa cgc ctg ate 144
Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
tac gcc aca tee agt tta gat tet ggt gtc ccc aaa agg ttc agt gge 192
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
50 55 60
agt agg tet ggg tea gat tat tet etc ace ate age age ctt gag tet 240
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
gaa gat ttt gta gac tat tac tgt eta eaa tat get agt tet ccg tgg 288
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 189
<211> 107
129
<212> PRT
<213> Mus musculus
<400> 189
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 10 15
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Tyr Ser
20 25 30
Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
35 40 45
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
so 55 60
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65 70 75 80
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 190
<211> 369
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(369)
<223> SC16.73 VH
<220>
<221> cos
<222> (l)..(369)
<400> 190
eag gtg cag ctg eag eag tet gga get gag ctg atg aag cet ggg gcc Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala l 5 lO lS
tea gtg aag ata tee tgc aag get aat gge tac aca ttc agt age tac
Ser Val Lys Ile Ser Cys Lys Ala Asn Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
tgg ata gag tgg tta agg eag agg cet gga cat gge ctt gag tgg att
Trp Ile Glu Trp Leu Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
130
48
96
144
gga gag att tta cet gga agt gat aat agt aat tat aat gag aag ttc 192
Gly Glu Ile Leu Pro Gly Ser Asp Asn Ser Asn Tyr Asn Glu Lys Phe
50 55 60
aag gge aag gcc aca ttc act gea gat aca tee tee aac aca gcc tac 240
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 BO
atg eaa etc age age ctg aca tet gag gaa tet gcc gtc tat tac tgt 2BB
Met Gln Leu Ser Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
B5 90 95
aca agg gga tta ega ega gac gge tea tat tac tat gtt atg gaa cat 336
Thr Arg Gly Leu Arg Arg Asp Gly Ser Tyr Tyr Tyr Val Met Glu His
100 105 110
tgg ggt eaa gga ace tea gtc ace gtc tee tea 369
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 191
<211> 123
<212> PRT
<213> Mus musculus
<400> 191
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala
l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Asn Gly Tyr Thr Phe Ser Ser Tyr
20 25 30
Trp Ile Glu Trp Leu Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Glu Ile Leu Pro Gly Ser Asp Asn Ser Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 BO
Met Gln Leu Ser Ser Leu Thr Ser Glu Glu Ser Ala Val Tyr Tyr Cys
B5 90 95
Thr Arg Gly Leu Arg Arg Asp Gly Ser Tyr Tyr Tyr Val Met Glu His
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
131
<210> 192
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.78 VL
<220>
<221> cos
<222> (l)..(321)
<400> 192
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l s lO lS
gag aga gtc act ate act tgc aag geg agt eag gac att aat age tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 2S 30
tta age tgg ttc eag eag aag cca ggg aga tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Arg Ser Pro Lys Thr Leu Ile
3S 40 4S
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gac tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr
6S 70 7S 80
gaa gat atg gga att tat tat tgt eta eag tat gat gaa ttt cca ttc 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
8S 90 9S
acg ttc gge tcg ggg aca aag ttg gar ath aar 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 193
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 193
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l s lO lS
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 2S 30
132
Leu Ser Trp Phe Gln Gln Lys Pro Gly Arg Ser Pro Lys Thr Leu Ile
3S 40 4S
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr
6S 70 7S 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
8S 90 9S
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 194
<211> 3S7
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3S7)
<223> SC16.78 VH
<220>
<221> CDS
<222> (l)..(3S7)
<400> 194
gaa gtg aag ctg gtg gag tet ggg gga gge tta gtg aag cet gga ggg 48
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly l s lO lS
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc ggt cgc tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg Tyr
20 2S 30
gtc atg tet tgg gtt cgc eag act cca gaa aag aaa ctg gag tgg gtc 144
Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Lys Leu Glu Trp Val
3S 40 4S
gea tee att act agt ggt ggt act ace tac tat cca gac agt gtg aag 192
Ala Ser Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys
so ss 60
gge ega ttc ace ate tee aga gat aat gcc agg aac ate ctg tac eta 240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu
6S 70 7S 80
eaa atg age agt ctg agg tet gag gac acg gcc atg tat tac tgt gea 288
Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala
8S 90 9S
133
aga gtc tac tat cat tac gac gac ate ttt get tac tgg gge eaa ggg
Arg Val Tyr Tyr His Tyr Asp Asp Ile Phe Ala Tyr Trp Gly Gln Gly
100 105 110
act ctg gtc act gtc tet gea
Thr Leu Val Thr Val Ser Ala
115
<210> 195
<211> 119
<212> PRT
<213> Mus musculus
<400> 195
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly l 5 lO 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg Tyr
20 25 30
336
357
Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Lys Leu Glu Trp Val
35 40 45
Ala Ser Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu
65 70 75 80
Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Val Tyr Tyr His Tyr Asp Asp Ile Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 196
<211> 336
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.79 VL
134
<220>
<221> cos
<222> (l)..(336)
<400> 196
gac att gtg atg tea eag tet cca tee tee ctg get gtg tea gea gga 48
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly l 5 lO 15
gag aag gtc act atg age tgc aaa tee agt eag agt ctg etc aac agt 96
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
aga ace ega aag aac tac ttg get tgg tac eag eag aaa cca ggg eag 144
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
tet cet aaa ctg ctg ate tac tgg gea tee act agg gaa tet ggg gtc 192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
cet gat cgc ttc aca gge agt gga tet ggg aca gat ttc act etc ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
ate age agt gtg eag get gaa gac ctg gea gtt tat tac tgc aag eaa 288
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln
85 90 95
tet tat aat ctt tac acg ttc gga ggg ggg ace aag ctg aaa ata aaa 336
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Lys Ile Lys
100 105 110
<210> 197
<211> 112
<212> PRT
<213> Mus musculus
<400> 197
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly l 5 lO 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
135
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln
85 90 95
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Lys Ile Lys
100 105 110
<210> 198
<211> 348
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.79 VH
<220>
<221> CDS
<222> (l)..(348)
<400> 198
gag gtc cag ctg eaa eag tet gga cet gag ctg gtg aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag act tet gga tac aca ttc act gaa tac 96
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
ace atg eac tgg gtg aag eag age cat gga aag age ctt gag tgg att 144
Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga ggt att aat cet aac aat ggt ggt act age tac aac eag aag ttc 192
Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aea ttg act gta gac aag tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 BO
atg gag etc cgc age ctg aca tet gag gat tet gea gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea agg ggt ecc gcc tgg ttt get tac tgg gge eaa ggg act ctg gtc 336
Ala Arg Gly Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea 348
Thr Val Ser Ala
115
<210> 199
<211> 116
136
<212> PRT
<213> Mus rnusculus
<400> 199
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30
Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 200
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l) .• ( 321)
<223> SC16.80 VL
<220>
<221> cos
<222> (l) •.(321)
<400> 200
gaa aca act gtg ace eag tet cca gea tee ctg tee atg get ata gga 48
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly
l 5 lO 15
gaa aaa gtc ace ate aga tgc ata ace age act gat att gat gat gat 96
Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp
20 25 30
137
atg ate tgg tac eag eag aag cca ggg gaa cet cet aag etc ctt att 144
Met Ile Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile
3S 40 4S
tea gaa gge aat act ctt cgt cet gga gtc cca tee ega ttc tee age 192
Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
so ss 60
agt gge tat ggt aca gat ttt gtt ttt aca att gaa aac atg etc tea 240
Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser
6S 70 7S 80
gaa gat gtt gcc gat tac tac tgt ttg aaa agg gat gac ttg cet tac 288
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Lys Arg Asp Asp Leu Pro Tyr
8S 90 9S
acg ttc gge ggg ggg aca eag gtg gaa att aaa 321
Thr Phe Gly Gly Gly Thr Gln Val Glu Ile Lys
100 lOS
<210> 201
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 201
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly
l s lO lS
Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp
20 2S 30
Met Ile Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile
3S 40 4S
Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
so ss 60
Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Met Leu Ser
6S 70 7S 80
Glu Asp Val Ala Asp Tyr Tyr Cys Leu Lys Arg Asp Asp Leu Pro Tyr
8S 90 9S
Thr Phe Gly Gly Gly Thr Gln Val Glu Ile Lys
100 lOS
<210> 202
<211> 3Sl
<212> DNA
138
<213> Mus musculus
<220>
<221> mise feature
<222> (l)•.(351)
<223> SC16.80 VH
<220>
<221> cos
<222> (l)..(351)
<400> 202
gag gtc cag ctg eaa eag tet gga cet gag ctg gtg aag cet gga ggt 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Gly
l 5 lO 15
tea aag aag ata tee tgc aag get tet ggt tac tea ttc act gge tac 96
Ser Lys Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
agt atg aac tgg gtg aag eag age cat gga aag aac ctt gag tgg att 144
Ser Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
gga ctt att aat cet tac agt ggt ggt act ate tac aac eag aaa ttc 192
Gly Leu Ile Asn Pro Tyr Ser Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca tta act gta gac aag tea tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc etc agt ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga agg agt gat tac ccg tta gtt tac tgg gge eaa ggg act ctg 336
Ala Arg Arg Ser Asp Tyr Pro Leu Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 203
<211> 117
<212> PRT
<213> Mus musculus
<400> 203
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Gly l 5 lO 15
Ser Lys Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
139
Ser Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
Gly Leu Ile Asn Pro Tyr Ser Gly Gly Thr Ile Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Ser Asp Tyr Pro Leu Val Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 204
<211> 324
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.81 VL
<220>
<221> cos
<222> (l)..(324)
<400> 204
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gaa egg gtc ace ctg ace tgc act gcc age tea agt gta agt tee agt 96
Glu Arg Val Thr Leu Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag cca gga tee tee ccc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cca act cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc aga ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Arg Ile Ser Ser Met Glu
65 70 75 80
140
get gaa gat get gcc act tat tac tgc eac eag tat aat cgt tee ccg
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Asn Arg Ser Pro
BS 90 95
etc acg ttc ggt get ggg ace aag ctg gag ctg aaa
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 205
<211> lOB
<212> PRT
<213> Mus rnusculus
<400> 205
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Leu Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser
so 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Arg Ile Ser Ser Met Glu
65 70 75 BO
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Asn Arg Ser Pro
BS 90 95
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 206
<211> 351
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.Bl VH
<220>
<221> cos
<222> (l)..(351)
141
2BB
324
<400> 206
eag gtg cag ctg aag gag tea gga cet gtc ctg gtg geg ecc tea eag 4B
Gln Val Gln Leu Lys Glu Ser Gly Pro Val Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate act tgc act gtc tet ggg ttt tea tta ace age tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
ggt gta eac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta att tgg get ggt gga agt aca aat tat aat tea get etc atg 192
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
tee aga ctg age ate age aaa gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 2BB
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
B5 90 95
aaa eag gge aac ttc tat get atg gac tac tgg ggt eaa gga ace tea 336
Lys Gln Gly Asn Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 207
<211> 117
<212> PRT
<213> Mus musculus
<400> 207
Gln Val Gln Leu Lys Glu Ser Gly Pro Val Leu Val Ala Pro Ser Gln
l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
142
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Lys Gln Gly Asn Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 208
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.84 VL
<220>
<221> cos
<222> (l)..(318)
<400> 208
gac ate cag atg aca eag tet cca tee tea ctg tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gge aaa gtc ace ate act tgc aag gea age eaa gac att aag aag tat 96
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Lys Tyr
20 25 30
ata get tgg tac eaa eac aag cet gga aaa ggt cet agg eta etc ata 144
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
cat tac aca tet aca tta gag cca gge ate cca tea agg ttc agt gga 192
His Tyr Thr Ser Thr Leu Glu Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
agt ggg tet ggg aga gat tat tee ttc age ate age aac ctg gag cet 240
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
65 70 75 80
gaa gat att gea act tat tat tgt eta eaa tat gat att ctg tgg acg 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ile Leu Trp Thr
85 90 95
ttc ggt gga gge ace aag ctg gaa ate aaa 318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 209
<211> 106
143
<212> PRT
<213> Mus musculus
<400> 209
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Lys Tyr
20 25 30
Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile
35 40 45
His Tyr Thr Ser Thr Leu Glu Pro Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Ile Leu Trp Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 210
<211> 363
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(363)
<223> SC16.84 VH
<220>
<221> cos
<222> (l)..(363)
<400> 210
gag gtc cag ctg eaa eag tet gga cet gag ctg gtg aag cet gga get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea atg aag ata tee tgc aag get tet ggt tac tea ttc act gge tac 96
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
ace atg aac tgg gtg aag eag age cat gga aag aae ctt gag tgg att 144
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
144
gga ctt att aat cet tac aat ggt ggt act ace tac aac eag aag ttc 192
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca tta act gta gac aag tea tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 BO
atg gag etc etc agt ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea tta ggt tac tat ggt aac tac agg agg tac ttc gat gtc tgg gge 336
Ala Leu Gly Tyr Tyr Gly Asn Tyr Arg Arg Tyr Phe Asp Val Trp Gly
100 105 110
gea ggg ace acg gtc ace gtc tee tea 363
Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 211
<211> 121
<212> PRT
<213> Mus rnusculus
<400> 211
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Leu Gly Tyr Tyr Gly Asn Tyr Arg Arg Tyr Phe Asp Val Trp Gly
100 105 110
Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
145
<210> 212
<211> 324
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.88 VL
<220>
<221> cos
<222> (1)..(324)
<400> 212
gaa aat gtg etc ace eag tet cca gea ata atg get gcc tet ctg ggg 48
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly
l 5 lO 15
eag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tee agt 96
Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag tea gge get tee ccc aaa ccc ttg 144
Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu
35 40 45
att cat agg aca tee aac ctg get tet gga gtc cca get cgc ttc agt 192
Ile His Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc aca ate age age gtg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65 70 75 80
get gaa gat gat gea act tat tac tgc egg eag tgg agt ggt tac ccg 288
Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Arg Gln Trp Ser Gly Tyr Pro
85 90 95
tgg acg ttc ggt gga gge ace aag ctg gaa ate aaa 324
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 213
<211> 108
<212> PRT
<213> Mus musculus
<400> 213
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly l 5 lO 15
Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
146
Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu
35 40 45
Ile His Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65 70 75 80
Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Arg Gln Trp Ser Gly Tyr Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 214
<211> 357
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.88 VH
<220>
<221> CDS
<222> (1)..(357)
<400> 214
eag gtt cag ctg eag eag tet ggg get gag ctg gea aga cet ggg get 48
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l 5 lO 15
tea gtg aag ttg tee tgc aag get tet gge tac ace tgt act age tac 96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Cys Thr Ser Tyr
20 25 30
tgg atg eag tgg gta aaa eag agg cet gga eag ggt ctg gaa tgg att 144
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
ggg get att tat cet gga gat ggt gat act agg tac act eag aag ttc 192
Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe
50 55 60
aag gge aag gcc aca ttg act gea gat aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eaa etc age age ttg gea tet gag gac tet geg gtc tat tac tgt 288
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
147
gea agg ggg agg egg acg gag gcc tgg ttt get tac tgg gge eaa ggg
Ala Arg Gly Arg Arg Thr Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
act ctg gtc act gtc tet gea
Thr Leu Val Thr Val Ser Ala
115
<210> 215
<211> 119
<212> PRT
<213> Mus musculus
<400> 215
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Cys Thr Ser Tyr
20 25 30
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Arg Arg Thr Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 216
<211> 324
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.101 VL
148
336
357
<220>
<221> cos
<222> (l)..(324)
<400> 216
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gaa egg gtc ace atg ace tgc act gcc age tea agt gta agt tee agt 96
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag cca gga tee tee ecc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cca get cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt gag tet ggg ace tet tac tet etc aca ate age aac atg gag 240
Gly Ser Glu Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu
65 70 75 80
get gag gat get gcc act tat tac tgc eac eag tat cat cgt tee cca 288
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
ttc acg ttc gge tcg ggg aca aag ttg gaa ata aaa 324
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 217
<211> 108
<212> PRT
<213> Mus musculus
<400> 217
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Glu Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu
65 70 75 80
149
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 218
<211> 360
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.101 VH
<220>
<221> cos
<222> (l)..(360)
<400> 218
eag gtt act ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
l 5 lO 15
ace etc agt ctg act tgt tet ttc tet gga ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg gge gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aac cca gcc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
ctt aag age ega ctg act ate tee aag gat gcc tee age age eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Ser Ser Gln Val
65 70 75 80
ttc etc aag ate gcc agt gtg gac act gea gaa act gcc aca tac tac 288
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Glu Thr Ala Thr Tyr Tyr
85 90 95
tgt gcc eac ate etc gac egg get tac tac ttt gac tac tgg gge eaa 336
Cys Ala His Ile Leu Asp Arg Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
gge ace act etc aca gtc ace tea 360
Gly Thr Thr Leu Thr Val Thr Ser
115 120
<210> 219
<211> 120
150
<212> PRT
<213> Mus musculus
<400> 219
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 10 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Ser Ser Gln Val
65 70 75 BO
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Glu Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala His Ile Leu Asp Arg Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Thr Ser
115 120
<210> 220
<211> 333
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(333)
<223> SC16.103 VL
<220>
<221> CDS
<222> (l) ..(333)
<400> 220
gac att gtg ctg aea eag tet cet get tee tta get gta tet ctg ggg 48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
l 5 lO 15
eag agg gcc ace ate tea tgc agg gcc age aaa agt gtc agt aea tet 96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
20 25 30
151
gge tat agt tat atg eac tgg tac eaa eag aaa cca gga eag cca ccc 144
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
aaa etc etc ate tat ctt gea tee aac eta gaa tet ggg gtc cet gcc 192
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
agg ttc agt gge agt ggg tet ggg aca gac ttc ace etc aac ate cat 240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
cet gtg gag gag gag gat get gea ace tat tac tgt eag eac agt agg 288
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
85 90 95
gag ctt cet etc acg ttc ggt get ggg ace aag ctg gag ctg aaa 333
Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 221
<211> 111
<212> PRT
<213> Mus rnusculus
<400> 221
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly l 5 lO 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
20 25 30
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
85 90 95
Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 222
<211> 357
<212> DNA
152
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.103 VH
<220>
<221> CDS
<222> (l)..(357)
<400> 222
eaa gtt act eta aaa gag tet gge cet ggg ata ttg aag ccc tea eag 48
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln
l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt ata gge tgg att cgt eag cet tea ggg aag ggt ctg gag 144
Gly Met Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gat aag tac tat aac cca tee 192
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser
50 55 60
ctg aag age eag etc aca ate tee aag gat tee tee aga aac eag gtt 240
Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Ser Ser Arg Asn Gln Val
65 70 75 80
ttc etc aag ate ace agt gtg gac act gea gat act gcc act tac tac 288
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get ega aga ggg act geg tac tac ttt gac tac tgg gge eaa gge 336
Cys Ala Arg Arg Gly Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
ace act etc aca gtc tee tea 357
Thr Thr Leu Thr Val Ser Ser
115
<210> 223
<211> 119
<212> PRT
<213> Mus musculus
<400> 223
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
153
Gly Met Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Ser Ser Arg Asn Gln Val
65 70 75 80
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Arg Gly Thr Ala Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Thr Leu Thr Val Ser Ser
115
<210> 224
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.104 VL
<220>
<221> cos
<222> (l)..(318)
<400> 224
eaa att gtt etc tee eag tet cca gea ate ctg tet gea tet cca ggg 48
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc aca atg act tgc agg gcc agt tea agt gta agt tac att 96
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
20 25 30
eac tgg tac egg eag aag cca gga tee tee ccc aaa ccc tgg att tat 144
His Trp Tyr Arg Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
gcc aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age aga gtg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 80
154
gat get gcc act tat tac tgc eag eag tgg age agt aat cca ccc acg
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
ttc ggt get ggg ace aag ctg gag ctg aaa
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 225
<211> 106
<212> PRT
<213> Mus rnusculus
<400> 225
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile
20 25 30
His Trp Tyr Arg Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 226
<211> 345
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(345)
<223> SC16.104 VH
<220>
<221> cos
<222> (l)..(345)
155
288
318
<400> 226
eag gtg cag ctg aag gag tea gga cet gac ctt gtg eag ccc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Gln Pro Ser Gln l 5 10 15
ace ctg tet etc ace tgc act gtc tet ggg ttc tea tta ace ttc tat 96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Phe Tyr
20 25 30
ggt gtt eac tgg gtt cgc eag cet cca gga aag gga ctg gag tgg gtg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
gga aca atg gge tgg gat gac aaa aaa tat tat aat tea get eta aaa 192
Gly Thr Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
tet ega ctg age ate age agg gat ace tee aag aac eag gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu
65 70 75 80
aaa ctg age agt ctg eaa act gaa gac aca gcc atg tac tac tgt act 288
Lys Leu Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr
85 90 95
aga ggt ggg acg ggg ttt gac tac tgg gge eaa gge ace act etc aca 336
Arg Gly Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
100 105 110
gtc tee tea 345
Val Ser Ser
115
<210> 227
<211> 115
<212> PRT
<213> Mus musculus
<400> 227
Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Gln Pro Ser Gln
l 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Phe Tyr
20 25 30
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Thr Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu
65 70 75 80
156
Lys Leu Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr
85 90 95
Arg Gly Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
100 105 110
Val Ser Ser
115
<210> 228
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (i) .. (321)
<223> SC16.105 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 228
gac att gtg atg ace eag tcg eac aaa ttc atg tee aca tea gta gga 48
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly l 5 lO 15
gac agg gtc age ate ace tgc aag gcc agt eag gat gtg ggt act get 96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
gta gcc tgg tat eaa eag aaa cca ggg eaa tet cet aaa eta ctg att 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tgg gea tee ate egg eac act gga gtc cet gat cgc ttc aca gge 192
Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tet ggg aca gat ttc act etc ace att age aat gtg eag tet 240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
gaa gac ttg gea gat tat ttc tgt eag eaa tat age age tat ccg etc 288
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 229
<211> 107
157
<212> PRT
<213> Mus rnusculus
<400> 229
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly l 5 10 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Ala Ser Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 230
<211> 363
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l) . . (363)
<223> SC16.105 VH
<220>
<221> cos
<222> (l) .. (363)
<400> 230
eag gtc caa ctg eag eag cet ggg get gag ctt gtg aag cet ggg get Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
tea gtg aag ctg tee tgc aag get tet gge tac ace ttc ace age tac
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
tgg atg eae tgg gtg aag eag agg cet gga eaa gge ctt gag tgg att
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
158
48
96
144
gga gtg att aat cet age aac ggt cgt act aac tac aat gag aag ttc 192
Gly Val Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
50 55 60
aag age aag gcc aca ctg act gta gac aaa tee tee age aca gcc tac 240
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eaa etc age age ctg aca tet gag gac tet geg gtc tat tac tgt 288
Met Gln Leu Ser Ser Leu ·Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga aga agg gaa ctg gga ace etc tat get atg gac tac tgg ggt 336
Ala Arg Arg Arg Glu Leu Gly Thr Leu Tyr Ala Met Asp Tyr Trp Gly
100 105 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 231
<211> 121
<212> PRT
<213> Mus rnusculus
<400> 231
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Arg Arg Glu Leu Gly Thr Leu Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
159
<210> 232
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.106 VL
<220>
<221> cos
<222> (l)..(321)
<400> 232
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat age tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
tta age tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gag ttt cca ttc 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 233
<211> 107
<212> PRT
<213> Mus musculus
<400> 233
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
160
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
3S 40 4S
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
6S 70 7S 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
8S 90 9S
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 234
<211> 34S
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(34S)
<223> SC16.106 VH
<220>
<221> cos
<222> (l)..(34S)
<400> 234
eag gtg caa ctg aag eag tea gga cet gge ctg gtg geg ecc tea eag 48
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l s lO lS
age ctg ttc ate aca tgc ace gtc tea ggg ttc tea tta ace age tat 96
Ser Leu Phe Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 2S 30
gaa ata aac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Glu Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
3S 40 4S
gga gtg ata tgg act ggt gga age aca aat tat aat tea get etc ata 192
Gly Val Ile Trp Thr Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Ile
so ss 60
tee aga ctg age ate age aaa gac aac tee aag age eta gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Leu Val Phe Leu
6S 70 7S 80
aaa atg aac agt ctg eaa act gat gac aca gcc ata tat tac tgt gta 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val
8S 90 9S
161
aga ggt gtt tat get atg gac tac tgg ggt eaa gga ace tea gtc ace
Arg Gly Val Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
gtc tee tea
Val Ser Ser
115
<210> 235
<211> 115
<212> PRT
<213> Mus rnusculus
<400> 235
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
Ser Leu Phe Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Glu Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Ile
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Leu Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val
85 90 95
Arg Gly Val Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
Val Ser Ser
115
<210> 236
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.107 VL
162
336
345
<220>
<221> cos
<222> (l)..(321)
<400> 236
gac att gtg atg ace eag tet eac aaa ttc atg tee aca tea gta gga 48
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
l s lO lS
gac agg gtc age ate ace tgc aag gcc agt eag gat gtg aat act get 96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
20 2S 30
gta gge tgg tat eaa eag aaa cca gga eaa tet cet aaa eta ctg att 144
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
3S 40 4S
tac tcg gea tee tac cgg tac act gga gtc cet gat cgc ttc act gge 192
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
so ss 60
agt gga tet ggg acg gat ttc act ttc ace ate age agt gtg eag get 240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
6S 70 7S BO
gaa gac ctg gea gtt tat tac tgt eag eaa cat tat agt agt ccg tac 288
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Tyr
ss 90 9S
acg ttc gga ggg ggg ace aag gtg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 lOS
<210> 237
<211> 107
<212> PRT
<213> Mus musculus
<400> 237
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
l s lO lS
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
20 2S 30
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
3S 40 4S
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
so ss 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
6S 70 7S 80
163
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 238
<211> 357
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.107 VH
<220>
<221> cos
<222> (l)..(357)
<400> 238
gag gtc cag ctg eag eag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act aac tat 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att 144
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tat att aat cet tac aat gat ggt act aaa tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
aaa gge aag gcc aca ctg act tea gac aaa tee tee ace aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80
atg geg etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Ala Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea gta gcc tac tat agt aac tgg ggg ttt get tac tgg gge eaa ggg 336
Ala Val Ala Tyr Tyr Ser Asn Trp Gly Phe Ala Tyr Trp Gly Gln Gly
100 105 110
act ctg gtc act gtc tet gea 357
Thr Leu Val Thr Val Ser Ala
115
<210> 239
<211> 119
164
<212> PRT
<213> Mus musculus
<400> 239
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l s 10 lS
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 2S 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala Tyr
6S 70 7S 80
Met Ala Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
8S 90 9S
Ala Val Ala Tyr Tyr Ser Asn Trp Gly Phe Ala Tyr Trp Gly Gln Gly
100 lOS 110
Thr Leu Val Thr Val Ser Ala
11S
<210> 240
<211> 321
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.108 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 240
gac ate cag atg act eag tet cca gcc tee eta tet gea tet gtg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l s lO lS
gaa act gtc ace ate aca tgt ega gea agt gag aat att tac agt tat 96
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 2S 30
165
tta gea tgg tat eag eag aaa eag gga aaa tet cet eag etc ctg gtc 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
3S 40 4S
tat aat gea aaa ace tta gea gaa ggt gtg cca tea agg ttc agt gge 192
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt aga tea gge tea eag ttt tet ctg aag ate aac age ctg eag cet 240
Ser Arg Ser Gly Ser Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
6S 70 7S BO
gaa gat ttt ggg agt tat tac tgt eaa cat cat tat ggt act ccg tac 2BB Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr
BS 90 9S
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 241
<211> 107
<212> PRT
<213> Mus musculus
<400> 241
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l s lO lS
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr
20 2S 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
3S 40 4S
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Arg Ser Gly Ser Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
6S 70 7S BO
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr
BS 90 9S
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 242
<211> 360
<212> DNA
166
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.108 VH
<220>
<221> cos
<222> (l)..(360)
<400> 242
eag gtt cag ctg gag gag tea ggg get gag ctg gea aga cet ggg get 48
Gln Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l 5 lO 15
tea gtg aag ttg tee tgc aag get tet gge tat age tac tgg atg eag 96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Tyr Trp Met Gln
20 25 30
tgg ata aaa eag agg cet gga eag ggt ctg gaa tgg att ggg get att 144
Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile
35 40 45
tat cet gga aat ggt gat act agg tac act eag aag ttc aag gge aag 192
Tyr Pro Gly Asn Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys Gly Lys
50 55 60
gcc aca ttg act gea gat aaa tee tee age aca gcc tac atg eaa etc 240
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu
65 70 75 80
age age ttg gea tet gag gac tet geg gtc tat tac tgt gea aga tet 288
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser
85 90 95
ccg gcc tac tat agg tac gge gag gge tac ttt gac tac tgg gge eaa 336
Pro Ala Tyr Tyr Arg Tyr Gly Glu Gly Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
gge ace act etc aca gtc tee tea 360
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 243
<211> 120
<212> PRT
<213> Mus musculus
<400> 243
Gln Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Tyr Trp Met Gln
20 25 30
167
Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile
35 40 45
Tyr Pro Gly Asn Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys Gly Lys
50 55 60
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu
65 70 75 80
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser
85 90 95
Pro Ala Tyr Tyr Arg Tyr Gly Glu Gly Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 244
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.109 VL
<220>
<221> cos
<222> (l)..(318)
<400> 244
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
tac tgg tac eag eag aag cca gga tee tee ccc aga etc ctg att tat 144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
gac aca tee aac ctg get tet gga gtc cet gtt cgc ttc agt gge agt 192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet ttc tet etc aca ate age ega atg gag get gaa 240
Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
168
- - - - - - - - -
gat act gcc act tat tac tgc eag gag tgg agt ggt aat ccg etc acg
Asp Thr Ala Thr Tyr Tyr Cys Gln Glu Trp Ser Gly Asn Pro Leu Thr
85 90 95
ttc ggt gat ggg ace aag ctg gag ctg aaa
Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 245
<211> 106
<212> PRT
<213> Mus musculus
<400> 245
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
l 5 10 15
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Thr Ala Thr Tyr Tyr Cys Gln Glu Trp Ser Gly Asn Pro Leu Thr
85 90 95
Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 246
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(354)
<223> SC16.109 VH
<220>
<221> cos
<222> (l)..(354)
169
288
318
<400> 246
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggg tat ace ttc aea aac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gga atg aac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
gge tgg ata aac ace tac act gga gag cca gea tat get gat gac ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Ala Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age get gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ala Ala Tyr
65 70 75 80
ttg eag ate aac aac etc aaa aat gag gac acg get act ttt ttc tgt 288
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
gea aat atg agg ccc acg agg ggg ttt get tac t gg ggg eaa ggg act 336
Ala Asn Met Arg Pro Thr Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
ctg gge act gtc tet gea 354
Leu Gly Thr Val Ser Ala
115
<210> 247
<211> 118
<212> PRT
<213> Mus musculus
<400> 247
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 lO 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Ala Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ala Ala Tyr
65 70 75 80
170
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Phe Phe Cys
85 90 95
Ala Asn Met Arg Pro Thr Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Gly Thr Val Ser Ala
115
<210> 248
<211> 321
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.110 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 248
aat att gtg atg ace eag act ecc aaa ttc ctg ctt gta tea gea gga 48
Asn Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
l 5 lO 15
gac agg gtt ace ata ace tgc aag gcc agt eag agt gtg agt aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
gta get tgg tac eaa eag aag cca ggg eag tet cet aaa ctg ctg ata 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tat gea tee aat cgc tac act gga gtc cet gat cgc ttc act gge 192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tat ggg acg gat ttc act ttc ace ate age act gtg eag get 240
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
gaa gac ctg gea gtt tat ttc tgt eag eag gat tat age tet cet ccg 288
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Pro
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 249
<211> 107
171
<212> PRT
<213> Mus musculus
<400> 249
Asn Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 BO
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 250
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(354)
<223> SC16.110 VH
<220>
<221> cos
<222> (l) ..(354)
<400> 250
gag gtc cag ctg eag eag tet gga cet ggg eta gtg agg act ggg get
Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Arg Thr Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc act ggt tac
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
tac atg eac tgg gtc aag eag age cat gga aag age ctt gag tgg att
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
172
48
96
144
gga tat att agt tgt tac aat ggt get act ace tac aac eag aac ttc 192
Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Thr Tyr Asn Gln Asn Phe
50 55 60
aag gge aag gcc aca ttt att gta gac aca tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Phe Ile Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 BO
atg eag ttc aac age ctg aca tet gag gac tet geg gtc tat tac tgt 2BB
Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
B5 90 95
gea aga tee gac ggg ggg cat get atg gac tac tgg ggt eaa gga ace 336
Ala Arg Ser Asp Gly Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
tea gtc ace gtc tee tea 354
Ser Val Thr Val Ser Ser
115
<210> 251
<211> 11B
<212> PRT
<213> Mus musculus
<400> 251
Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Arg Thr Gly Ala
l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Thr Tyr Asn Gln Asn Phe
50 55 60
Lys Gly Lys Ala Thr Phe Ile Val Asp Thr Ser Ser Ser Thr Ala Tyr
65 70 75 BO
Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
B5 90 95
Ala Arg Ser Asp Gly Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
173
<210> 252
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.111 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 252
gac ate cag atg act eag tet cca gcc tee ctg get gea tet gtg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly
l 5 lO 15
gaa act gtc ace ate aca tgt ega gea agt gag aac att tac tac agt 96
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser
20 25 30
tta gea tgg tat eag eag aag eaa ggg aaa tet cet eag etc ctg ate 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
tat aat gea aac age ttg gaa gat ggt gtc cca tcg agg ttc agt gge 192
Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg aea eag tat tet atg aag ate aac age atg eag cet 240
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro
65 70 75 80
gaa gat ace gea act tat ttc tgt aag eag act tat gac gtt ccg etc 288
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Thr Tyr Asp Val Pro Leu
85 90 95
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 253
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 253
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly l 5 lO 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser
20 25 30
174
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro
65 70 75 BO
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Thr Tyr Asp Val Pro Leu
B5 90 95
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 254
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.111 VH
<220>
<221> cos
<222> (l)..(351)
<400> 254
gag gtt cag ctg eag eag tet gga cet gag ctg gag aag cet gge get 4B Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc act gge tac 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
aac atg aac tgg gtg aag eag age aat gga aag age ctt gag tgg att 144
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga aat att gat cet tat tat ggt ggt tet age tac aaa eag aag ttc 192
Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Ser Ser Tyr Lys Gln Lys Phe
50 55 60
gag gge aag gcc aca ttg act gta gac aaa tee tee age aca gcc tac 240
Glu Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 BO
atg eag etc aag age ctg aca tet gag gac tet gea gtc tat tac tgt 2BB Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
B5 90 95
175
gea aga ggt ggt agt aac ttc ttt gac tac tgg gge eaa gge ace act
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
etc aca gtc tee tea
Leu Thr Val Ser Ser
115
<210> 255
<211> 117
<212> PRT
<213> Mus rnusculus
<400> 255
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Ser Ser Tyr Lys Gln Lys Phe
50 55 60
Glu Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 256
<211> 336
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.113 VL
176
336
351
<220>
<221> cos
<222> (l)..(336)
<400> 256
gat gtt gtg atg ace eag act cca etc act ttg tcg gtt ace att gga 48
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile G,lY
l 5 lO 15
eaa cca gcc tee ate tet tgc aag tea agt eag age etc tta gat agt 96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
gat gga acg aca tat ttg aat tgg ttg tta eag agg cca gge eag tet 144
Asp Gly Thr Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
cca aag cgc eta ate tat ctg gtg tet aaa ctg gac tet gga gtc cet 192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
gac agg ttc act gge agt gga tea ggg aca gat ttc aca ctg aaa ate 240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
age aga gtg gag get gag gat ttg gga gtt tat tat tgc tgg eaa ggt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
aca cat ttt ccg etc acg ttc ggt get ggg ace aag ctg gag ctg aaa 336
Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 257
<211> 112
<212> PRT
<213> Mus musculus
<400> 257
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
l 5 lO 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Thr Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
177
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
8S 90 9S
Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS 110
<210> 2S8
<211> 3Sl
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3Sl)
<223> SC16.113 VH
<220>
<221> cos
<222> (l)..(3Sl)
<400> 2S8
gac gtg aag ctg gtg gag tet ggg gga gge tta gtg aag cet gga ggg 48
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly l s lO lS
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 2S 30
ace atg tet tgg gtt cgc eag act ccg gag aag agg ctg gag tgg gtc 144
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
3S 40 4S
gea ace att agt agt ggt ggt agt tac ccc tac tat cca gac agt gtg 192
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Pro Tyr Tyr Pro Asp Ser Val
so ss 60
aag gge ega ttc ace ate tee aga gac aat gcc aag aac ace ctg tac 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
6S 70 7S 80
ctg eaa atg age agt ctg aag tet gag gac aca gcc atg tat tac tgt 288
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
8S 90 9S
aca aga gat gtc tat gat ggt tac tee tac tgg gge eaa gge ace act 336
Thr Arg Asp Val Tyr Asp Gly Tyr Ser Tyr Trp Gly Gln Gly Thr Thr
100 lOS 110
etc aca gtc tee tea 3Sl
Leu Thr Val Ser Ser
11S
<210> 2S9
<211> 117
178
<212> PRT
<213> Mus musculus
<400> 259
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly l 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Pro Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 BO
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Thr Arg Asp Val Tyr Asp Gly Tyr Ser Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 260
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) .• (318)
<223> SC16.114 VL
<220>
<221> CDS
<222> (l) ..(318)
<400> 260
eaa att gtt etc tee eag tet cca gea ate ctg tet gea tet cca ggg 48
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
l 5 lO 15
gag aag gtc aca atg act tgc agg gcc age tea agt gta agt tac atg 96
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
179
eac tgg tac eag eag aag cca gga tee tee ecc aaa ecc tgg att tat 144
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
gcc aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age aga gtg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 BO
gat get gcc act tat tac tgc eag eag tgg agt agt aac cca tac acg 2BB
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Tyr Thr
B5 90 95
ttc gga ggg ggg ace aag ctg gaa ata aaa 31B
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 261
<211> 106
<212> PRT
<213> Mus musculus
<400> 261
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly
l 5 lO 15
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr
35 40 45
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu
65 70 75 BO
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Tyr Thr
B5 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 262
<211> 369
<212> DNA
180
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(369)
<223> SC16.114 VH
<220>
<221> cos
<222> (l)..(369)
<400> 262
gag gtt cag ctg eag eag tet ggg gea gaa ctt gtg aag cca ggg gcc 48
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
tea gtc aaa ttg tee tgc aca get tet gge ttc aac att aaa gac ace 96
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
20 25 30
tat ata eac tgg gtg aaa eag agg cet gaa eag gge ctg gag tgg att 144
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
gga agg att gat cet geg aat ggt aat act aaa tat gac ccg aag ttc 192
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
50 55 60
eag gge aag gcc act ata aca cca gac aca tee tee aac aca gcc tac 240
Gln Gly Lys Ala Thr Ile Thr Pro Asp Thr Ser Ser Asn Thr Ala Tyr
65 70 75 80
ctg eag etc age age ctg aca tet gag gac act gcc gtc tat tac tgt 288
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
get aga age tgg ega aac tac ggt agt agt ttc tgg tac ttc gat gtc 336
Ala Arg Ser Trp Arg Asn Tyr Gly Ser Ser Phe Trp Tyr Phe Asp Val
100 105 110
tgg gge gea ggg ace acg gtc ace gtc tee tea 369
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 263
<211> 123
<212> PRT
<213> Mus musculus
<400> 263
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
20 25 30
181
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
3S 40 4S
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe
so ss 60
Gln Gly Lys Ala Thr Ile Thr Pro Asp Thr Ser Ser Asn Thr Ala Tyr
6S 70 7S 80
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
8S 90 9S
Ala Arg Ser Trp Arg Asn Tyr Gly Ser Ser Phe Trp Tyr Phe Asp Val
100 lOS 110
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
11S 120
<210> 264
<211> 336
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(336)
<223> SC16.11S VL
<220>
<221> cos
<222> (l)..(336)
<400> 264
gat gtt gtg atg ace eag act cca etc act ttg tcg gtt ace att gga 48
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly l s lO lS
eaa cca gcc tee ate tet tgc aag tea agt eag age etc tta gat agt 96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 2S 30
gat gga acg aca tat ttg aat tgg ttg tta eag agg cca gge eag tet 144
Asp Gly Thr Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
3S 40 4S
cca aag cgc eta ate tat ctg gtg tet aaa ctg gac tet gga gtc cet 192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
so ss 60
gac agg ttc act gge agt gga tea ggg aca gat ttc aca ctg aaa ate 240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
6S 70 7S 80
182
age aga gtg gag get gag gat ttg gga gtt tat tat tgc tgg eaa ggt
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
aca cat ttt ccg etc acg ttc ggt get ggg ace aag ctg gag ctg aaa
Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 265
<211> 112
<212> PRT
<213> Mus musculus
<400> 265
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly l 5 lO 15
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Gly Thr Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 BO
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
85 90 95
Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 266
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (ll .. ( 351l
<223> SC16.115 VH
<220>
<221> cos
<222> (ll ..(351l
183
288
336
<400> 266
gac gtg aag ctg gtg gag tet ggg gga gge tta gtg aag cet gga ggg 48
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
l 5 lO 15
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
ace atg tet tgg gtt cgc eag act ccg gag aag agg ctg gag tgg gtc 144
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
gea ace att agt agt ggt ggt agt tac ccc tac tat cca gac agt gtg 192
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Pro Tyr Tyr Pro Asp Ser Val
50 55 60
aag gge ega ttc ace ate tee aga gac aat gcc aag aac ace ctg tac 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
ctg eaa atg age agt ctg aag tet gag gac aca gcc atg tat tac tgt 288
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
aca aga gat gtc tat gat ggt tac tee tac tgg gge eaa gge ace act 336
Thr Arg Asp Val Tyr Asp Gly Tyr Ser Tyr Trp Gly Gln Gly Thr Thr
100 105 110
etc aca gtc tee tea 351
Leu Thr Val Ser Ser
115
<210> 267
<211> 117
<212> PRT
<213> Mus musculus
<400> 267
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly l 5 lO 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Pro Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
184
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Thr Arg Asp Val Tyr Asp Gly Tyr Ser Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 268
<211> 333
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(333)
<223> SC16.116 VL
<220>
<221> cos
<222> (l)..(333)
<400> 268
gac att gtg atg aca eag tet cca tee tee ctg act gtg aca gea gga 48
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly l 5 lO 15
gag aag gtc act atg age tgc acg tee agt eag agt ctg tta ace agt 96
Glu Lys Val Thr Met Ser Cys Thr Ser Ser Gln Ser Leu Leu Thr Ser
20 25 30
gga aat eaa aag aac tac ttg ace tgg tac eag eag aaa cca ggg eag 144
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
cet cet aaa ctg ttg ate tac tgg gea tee act agg gaa tet ggg gtc 192
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
cet gat cgc ttc aca gge agt gga tet gga aca gat ttc act etc ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
ate age agt ttg eag get gaa gac ctg gea gtt tat tac tgt eag aat 288
Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
gat tat agt etc acg ttc ggt get ggg ace aag ctg gag ctg aaa 333
Asp Tyr Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 269
<211> 111
185
<212> PRT
<213> Mus musculus
<400> 269
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly l 5 lO 15
Glu Lys Val Thr Met Ser Cys Thr Ser Ser Gln Ser Leu Leu Thr Ser
20 25 30
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 270
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(354)
<223> SC16.116 VH
<220>
<221> cos
<222> (l)..(354)
<400> 270
eag gtg cag ctg aag eag tea gga cet gge ega gtg eag ecc tea eag 48
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Arg Val Gln Pro Ser Gln
l 5 lO 15
age ctg tee ate ace tgc aca gtc tet ggt ttt tea tta act age aat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn
20 25 30
ggt gta eac tgg gtt cgc eag tet cca gga aag ggt ctg gag tgg ctg 144
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
186
gga gtg eta tgg agt ggt gga age aca gac tat aat gea get ttc ata 192
Gly Val Leu Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile
so ss 60
tee aga ctg age ate age aag gac aat tac aag age eaa gtt ttc ttt 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Tyr Lys Ser Gln Val Phe Phe
6S 70 7S 80
aaa atg aac agt ctg eaa get aat gac aca gcc ata tat tac tgt gcc 288
Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
8S 90 9S
aga aat aat aat agg tac gga get atg gac tac tgg ggt eaa gga ace 336
Arg Asn Asn Asn Arg Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 lOS 110
tea gtc ace gtc tee tea 3S4
Ser Val Thr Val Ser Ser
115
<210> 271
<211> 118
<212> PRT
<213> Mus rnusculus
<400> 271
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Arg Val Gln Pro Ser Gln l s lO lS
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn
20 2S 30
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
3S 40 4S
Gly Val Leu Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile
so ss 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Tyr Lys Ser Gln Val Phe Phe
6S 70 7S 80
Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
8S 90 9S
Arg Asn Asn Asn Arg Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
11S
187
<210> 272
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> {l)..{321)
<223> SC16.117 VL
<220>
<221> CDS
<222> {l)..{321)
<400> 272
gac ate cag atg aac eag tet cca tee agt ctg tet gea tee ctt gga 48
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aca att ace ate act tgc cat gtc agt eag aac att aat gtt tgg 96
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
tta age tgg tac eag eag aaa cca gga aat att cet aaa eta ttg ate 144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
eaa aag get tee aac ttg eac aca gge gtc ccc tea agg ttt agt gge 192
Gln Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gga aca ggt ttc aca tta ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
gaa gac att gcc act tac tac tgt eaa eag ggt eaa agt tat cca ttc 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 273
<211> 107
<212> PRT
<213> Mus musculus
<400> 273
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
188
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
3S 40 4S
Gln Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
6S 70 7S BO
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
ss 90 9S
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 274
<211> 3Sl
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3Sl)
<223> SC16.117 VH
<220>
<221> cos
<222> (l)..(3Sl)
<400> 274
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ecc tea eag 4B Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l s lO lS
age ctg tee ate act tgc act gtc tet ggg ttt tea tta ace aac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 2S 30
ggt gta eac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
3S 40 4S
gga gta ata tgg get ggt gga ate aca aat tat aat tcg get etc atg 192
Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Leu Met
so ss 60
tee aga ctg age ate age gaa gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Glu Asp Asn Ser Lys Ser Gln Val Phe Leu
6S 70 7S BO
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 2BB Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
BS 90 9S
189
aga aat tta ggt ccc tat get atg gac tac tgg ggt eaa gga ace tea
Arg Asn Leu Gly Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea
Val Thr Val Ser Ser
115
<210> 275
<211> 117
<212> PRT
<213> Mus museulus
<400> 275
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
Ser Arg Leu Ser Ile Ser Glu Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asn Leu Gly Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 276
<211> 333
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(333)
<223> SC16.118 VL
190
336
351
<220>
<221> cos
<222> (l)..(333)
<400> 276
gac att gtg ctg ace eaa tet cca get tet ttg get gtg tet eta ggg 48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
l s lO lS
eag agg gcc ace ate tee tgc aag gcc age eaa agt gtt gat tat gat 96
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 2S 30
ggt gat agt tat ttg ace tgg tac eaa eag aaa cca gga eag cca ccc 144
Gly Asp Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
3S 40 4S
aaa etc etc ate tat get gea tee aat eta gaa tet ggg ate cca gcc 192
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
so ss 60
agg ttt agt gge agt ggg tet ggg aca gac ttc ace etc aac ate cat 240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
6S 70 7S 80
cet gtg gag gag gag gac get gea ace tat tac tgt eag eaa agt aat 288
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
8S 90 9S
gag gat ccg tac acg ttc gga ggg ggg ace aag ctg gaa ata aaa 333
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS 110
<210> 277
<211> 111
<212> PRT
<213> Mus musculus
<400> 277
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
l s lO lS
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 2S 30
Gly Asp Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
3S 40 4S
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
so ss 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
6S 70 7S 80
191
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
85 90 95
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 278
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.118 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 278
gag gtc cag ctg eag eag tet gga cet gac ctg gtg aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc act gge tac 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
tac atg eac tgg gtg aag eag age cat gga aag age ctt gag tgg att 144
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga cgt gtt aat cet aac aat ggt ggt act age tac aac eag aag ttc 192
Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc ata tta act gea gac aag tea tee age aca gcc tac 240
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc cgc age ctg aea tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg agt tat gat tac gcc gag gge tgg gge eaa ggg act ctg 336
Ala Arg Gly Ser Tyr Asp Tyr Ala Glu Gly Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 279
<211> 117
192
<212> PRT
<213> Mus musculus
<400> 279
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Tyr Asp Tyr Ala Glu Gly Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 280
<211> 339
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) •• (339)
<223> SC16.120 VL
<220>
<221> CDS
<222> (l) •• (339)
<400> 280
gac att gtg atg tea eag tet cca tee tee eta get gtg tea gtt gga 48
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
l 5 10 15
gag aag gtt act atg age tgc aag tee agt eag age ctt tta tat agt 96
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
193
age act eaa aag aac tac ttg gcc tgg tac eag eag aaa cca ggg eag 144
Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
tet cet aaa ctg ctg att tac tgg gea tee act agg gaa tet ggg gtc 192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
cet gat cgc ttc aca gge agt gga tet ggg aca gat ttc act etc ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
ate age agt gtg aag get gaa gac ctg gea gtt tat tac tgt eag eaa 288
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
tat tat age tat ccg tac acg ttc gga ggg ggg ace aag ctg gaa ata 336
Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 llO
aaa 339
Lys
<210> 281
<2ll> ll3
<212> PRT
<213> Mus musculus
<400> 281
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly l 5 10 15
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
20 25 30
Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 105 110
194
Lys
<210> 282
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.120 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 282
gag ate cag ctg eag eag tet gga cet gag ctg gtg aag cet ggg get 48
Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag gta tee tgc aag get tet ggt tat gea ttc act age tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr
20 25 30
aac atg tac tgg gtg atg eag age cat gga aag age ctt gag tgg att 144
Asn Met Tyr Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga tat gtt gat cet tac aat ggt ggt act age tac aac eag aag ttc 192
Gly Tyr Val Asp Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc aca ttg act gtt gac aag tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg cat etc aac age ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga gaa aac tat agg tac ttt gac tac tgg gge eaa gge ace act 336
Ala Arg Glu Asn Tyr Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
etc aca gtc tee tea 351
Leu Thr Val Ser Ser
115
<210> 283
<211> 117
<212> PRT
<213> Mus musculus
<400> 283
195
Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l s 10 lS
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr
20 2S 30
Asn Met Tyr Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile
3S 4o 4s
Gly Tyr Val Asp Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S 80
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
8S 90 9S
Ala Arg Glu Asn Tyr Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 lOS 110
Leu Thr Val Ser Ser
11S
<210> 284
<211> 318
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.121 VL
<220>
<221> cos
<222> (l)..(318)
<400> 284
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l s lO lS
gag aag gtc ace ata ace tgc agt gcc age tea agt gta agt tac atg
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
eac tgg ttc eag eag aag cca gge act tet ccc aaa etc tgg att tat
His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
3S 40 4S
196
48
96
144
age aca tee aac ctg get tet gga gtc cet get cgc ttc agt gge agt 192
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
gga tet ggg ace tet tac tet etc aca ate age ega atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
gat get gcc act tat tac tgc eag eaa agg agt agt tac cca ccc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr
85 90 95
ttc gga ggg ggg ace aag ctg gaa ata aar 318
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 285
<211> 106
<212> PRT
<213> Mus musculus
<400> 285
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l 5 lO 15
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
35 40 45
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr
85 90 95
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 286
<211> 372
<212> DNA
<213> Mus museulus
<220>
197
<221> mise feature
<222> (l)..(372)
<223> SC16.121 VH
<220>
<221> CDS
<222> (l)..(372)
<400> 286
gag gtg cag ctt gtt gag tet ggt gga gga ttg gtg eag cet aaa ggg 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly
l 5 lO 15
tea ttg aaa etc tea tgt gea gcc tet gga ttc ace ttc aat ace tac 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
20 25 30
gcc atg aac tgg gtc cgc eag get cca gga aag ggt ttg gaa tgg gtt 144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
get cgc ata aga att aaa agt aat aat tat gea aca tat tat gcc gat 192
Ala Arg Ile Arg Ile Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
tea gta aaa gac agg ttc ace ate tee aga gat gat tea eaa aac atg 240
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met
65 70 75 80
etc tat ctg eaa atg aac aac ttg aaa act gag gac aca gcc gtg tat 288
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
tac tgt gtg aga eaa gge tat agt tac gac tgg gga ccc tgg ttt get 336
Tyr Cys Val Arg Gln Gly Tyr Ser Tyr Asp Trp Gly Pro Trp Phe Ala
100 105 110
tac tgg gge eaa ggg act ctg gtc act gtc tet gea 372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
115 120
<210> 287
<211> 124
<212> PRT
<213> Mus museulus
<400> 287
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly l 5 lO 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
198
Ala Arg Ile Arg Ile Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met
65 70 75 80
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Val Arg Gln Gly Tyr Ser Tyr Asp Trp Gly Pro Trp Phe Ala
100 105 llO
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala ll5 120
<210> 288
<2ll> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.122 VL
<220>
<221> cos
<222> (l)..(321)
<400> 288
gac att gtg atg ace eag tet eaa aaa ttc atg tee aca tea gta gga 48
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
l 5 lO 15
gac agg gtc age gtc ace tgc aag gcc agt eag aat gtg ggt act aat 96
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
gta gcc tgg tat eaa eag aaa cca ggg eaa tet cet aaa gta ctg att 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile
35 40 45
tac tcg gea tee tac egg tac agt gga gtc cet gat cgc ttc aca gge 192
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tet ggg aca gat ttc act etc ace ate age aat gtg eag tet 240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
gaa gac ttg gea gag ttt ttc tgt eag eaa tat aac age tat cet ctg 288
Glu Asp Leu Ala Glu Phe Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
85 90 95
199
acg ttc ggt gga gge ace aag ctg gaa ate aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 289
<211> 107
<212> PRT
<213> Mus musculus
<400> 289
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly
l 5 lO 15
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn
20 25 30
321
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
65 70 75 80
Glu Asp Leu Ala Glu Phe Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 290
<211> 354
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(354)
<223> SC16.122 VH
<220>
<221> cos
<222> (l)..(354)
<400> 290
gaa gtg cag ctg gtg gag tet ggg gga gge tta gtg aag cet gga ggg 48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
l 5 lO 15
200
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt gac tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
tac atg ttt tgg gtt cgc eag act ccg gaa aag agg ctg gag tgg gtc 144
Tyr Met Phe Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
gea ace att agt gat ggt ggt agt tac ace tac ttt cca gac agt gtg 192
Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Phe Pro Asp Ser Val
50 55 60
aag ggg ega ttc ace ate tee aga gac aat gcc eag aac aac ctg tac 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Asn Leu Tyr
65 70 75 BO
ctg eaa atg age agt ctg aag tet gag gac aca gcc atg tat tac tgt 2BB
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
B5 90 95
gea aga gcc ggg ace etc tat get atg gac tac tgg ggt eaa gga ace 336
Ala Arg Ala Gly Thr Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
tea gtc ace gtc tee tea 354
Ser Val Thr Val Ser Ser
115
<210> 291
<211> 11B
<212> PRT
<213> Mus musculus
<400> 291
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
l 5 lO 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Tyr Met Phe Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Phe Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Asn Leu Tyr
65 70 75 BO
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
B5 90 95
201
Ala Arg Ala Gly Thr Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Ser Val Thr Val Ser Ser
115
<210> 292
<211> 324
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(324)
<223> SC16.123 VL
<220>
<221> cos
<222> (l)..(324)
<400> 292
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gaa egg gtc ace atg ace tgc act gcc age tea agt gta agt tee agt 96
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
tac ttg eac tgg tac eag eag aag cca gga tee tee ccc aaa etc tgg 144
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
att tat age aca tee aac ctg get tet gga gtc cca get cgc ttc agt 192
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
gge agt ggg tet ggg ace tet tac tet etc aca ate age age atg gag 240
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
act gaa gat get gcc act tat tac tgc eac eag tat cat cgt tee ccc 288
Thr Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
ttc acg ttc gge tcg ggg aca aag ttg gaa ata aaa 324
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 293
<211> 108
<212> PRT
<213> Mus rnusculus
<400> 293
202
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Thr Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 294
<211> 366
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(366)
<223> SC16.123 VH
<220>
<221> CDS
<222> (l)..(366)
<400> 294
eag gtt get ctg aaa gag tet gge cet ggg ata ttg eag ccc tee eag 48
Gln Val Ala Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
l 5 lO 15
ace etc agt ctg act tgt tet ttc tet ggg ttt tea ctg age act tet 96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
ggt atg ggt gta gge tgg att cgt eag cca tea ggg aag ggt ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
tgg ctg gea eac att tgg tgg gat gat gtc aag cgc tat aac cca gcc 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
203
ctg aag age ega ctg act ate tee aag gat ace tee age age eag gta 240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
ttc etc aag ate gcc agt gtg gac act gea gat act gcc aca tac tac 288
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt get ega atg gag gac tac ggt agt age tee tac ttt gac ttc tgg 336
Cys Ala Arg Met Glu Asp Tyr Gly Ser Ser Ser Tyr Phe Asp Phe Trp
100 105 110
gge eac gge ace act etc aca gtc tee tea 366
Gly His Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 295
<211> 122
<212> PRT
<213> Mus musculus
<400> 295
Gln Val Ala Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln l 5 lO 15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val
65 70 75 80
Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Met Glu Asp Tyr Gly Ser Ser Ser Tyr Phe Asp Phe Trp
100 105 110
Gly His Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 296
<211> 321
<212> DNA
204
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.124 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 296
gac att cag atg ace eag tet cet gcc tee eag tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
gaa agt gtc ace ate aca tgc ctg gea agt eag ace att ggt aca tgg 96
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
tta gea tgg tat eag eag aaa cca ggg aaa tet cet eag etc ctg att 144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
tet get gea ace age ttg gea gat ggg gtc cca tea agg ttc agt ggt 192
Ser Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt gga tet gge aca aaa ttt tet ttc aag ate age age eta eag get 240
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65 70 75 80
gaa gat ttt gta agt tat tac tgt eaa eaa ctt tac agt act ccg tgg 288
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 297
<211> 107
<212> PRT
<213> Mus museulus
<400> 297
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly l 5 lO 15
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
205
Ser Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65 70 75 80
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 298
<211> 369
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(369)
<223> SC16.124 VH
<220>
<221> CDS
<222> (l)..(369)
<400> 298
gag gtc cag ctg eag eag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act age tat 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att 144
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tat att aat cet tac aat gat ggt act aag tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
aaa gge aag gcc aca ctg act tea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg get etc tac tat ggt aac tac ct.e ggg tac ttc gat gtc 336
Ala Arg Gly Ala Leu Tyr Tyr Gly Asn Tyr Leu Gly Tyr Phe Asp Val
100 105 110
206
tgg gge gea ggg ace acg gtc ace gtc tee tea
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
369
<210> 299
<211> 123
<212> PRT
<213> Mus musculus
<400> 299
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
so 55 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ala Leu Tyr Tyr Gly Asn Tyr Leu Gly Tyr Phe Asp Val
100 105 110
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 300
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.125 VL
<220>
<221> cos
<222> (l)..(321)
207
<400> 300
gac ate cag atg aac eag tet cca tee agt ctg tet gea tee ctt gga 48
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
gac aca att ace ate act tgc cat gcc agt eag aac att aat gtt tgg 96
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
tta age tgg tac eag eag aaa cca gga aat att cet aaa eta ttg ate 144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
tat aag get tee ate tta eac aca gge gtc cca tea agg ttt agt gge 192
Tyr Lys Ala Ser Ile Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gga aca ggt ttc aca tta ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
gaa gac att gcc act tac tee tgt eaa eag ggt eaa agt tat ccg tac 288
Glu Asp Ile Ala Thr Tyr Ser Cys Gln Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 301
<211> 107
<212> PRT
<213> Mus musculus
<400> 301
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ile Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Ser Cys Gln Gln Gly Gln Ser Tyr Pro Tyr
85 90 95
208
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 302
<211> 3S4
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3S4)
<223> SC16.12S VH
<220>
<221> CDS
<222> (l)..(3S4)
<400> 302
gat gtg cag ctt eag gag tea gga cet gac ctg gtg aaa cet tet eag 48
Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln l s lO lS
tea ctt tea etc ace tgc act gtc act gge tac tee ate ace agt ggt 96
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly
20 2S 30
tat age tgg eac tgg ate egg eag ttt cca gga aac aaa ctg gaa tgg 144
Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
3S 40 4S
atg gge tac ata eac tac agt ggt age act aac tac aac cca tet etc 192
Met Gly Tyr Ile His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu
so ss 60
aaa agt ega ate tet ate act ega gac aca tee aag aac eag ttc ttc 240
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
6S 70 7S 80
ctg eag ttc aaa tet gtg act act gaa gac tea gcc aca tat tac tgt 288
Leu Gln Phe Lys Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys
8S 90 9S
gcc eta gag ggg aat tac gac ggg ttt get tac tgg gge eaa ggg act 336
Ala Leu Glu Gly Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 lOS 110
ctg gtc act gtc tet ten 3S4
Leu Val Thr Val Ser Xaa
11S
<210> 303
<211> 118
<212> PRT
<213> Mus museulus
<220>
209
<221> mise feature
<222> (118)..(118)
<223> 'Xaa' na mestu 118 predstavlja Ser.
<400> 303
Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln l 5 10 15
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly
20 25 30
Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
Met Gly Tyr Ile His Tyr Ser Gly Ser Thr Asn ryr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
Leu Gln Phe Lys Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys
85 90 95
Ala Leu Glu Gly Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Xaa
115
<210> 304
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(321)
<223> SC16.126 VL
<220>
<221> cos
<222> (l) ..(321)
<400> 304
gac ate cag atg aac eag tet cca tee agt ctg tet gea tee ctt gga 48
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aca att ace ate act tgc cat gcc agt eag aac ata aat gtt tgg 96
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
210
20 25 30
tta age tgg tac eag eag aaa cca gga aat att cet aaa eta ttg ate 144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
tat aag get tee aac ttg eac aca gge gtc cca tea agg ttt agt gge 192
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gga aca ggt ttc aca tta ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 BO
gaa gac att gcc act tac tac tgt eaa eag ggt eaa agt tat cca ttc 2BB
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
B5 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 305
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 305
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 BO
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
B5 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 306
<211> 34B
211
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.126 VH
<220>
<221> cos
<222> (l)..(348)
<400> 306
eag gtg cag atg aag gag tea gga cet gge ctg gtg geg ccc tea eag 48
Gln Val Gln Met Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
age ctg tee ate act tgc act gtc tet ggg tet tea tta ace aac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Ser Ser Leu Thr Asn Tyr
20 25 30
ggt gta eac tgg gtt cgc eag cet cca gga aag ggt eta gag tgg ctg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta ata tgg get ggt gga age aca aat tat aat tcg get etc atg 192
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
tee aga ctg agt ate age aaa gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
aga gac tgg gag gge tgg ttt get tac tgg gge eaa ggg act ctg gtc 336
Arg Asp Trp Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea 348
Thr Val Ser Ala
115
<210> 307
<211> 116
<212> PRT
<213> Mus musculus
<400> 307
Gln Val Gln Met Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Ser Ser Leu Thr Asn Tyr
20 25 30
212
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Trp Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 308
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (1)..(321)
<223> SC16.129 VL
<220>
<221> cos
<222> (l)..(321)
<400> 308
gac att cag atg ace eag tet cet gcc tee eag tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
gaa agt gtc ace ate aea tgc ctg gea agt eag ace att ggt aca tgg 96
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
tta gea tgg tat eag eag aaa cca ggg aaa tet cet eag etc ctg att 144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
tat get gea ace age ttg gea gat ggg gtc cca tea agg ttc agt ggt 192
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gge aca aaa ttt tet ttc aag ate age age eta eag get 240
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
213
65 70 75 80
gaa gat ttt gta agt tat tac tgt eaa eaa ctt tac agt act ccg tac
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 309
<211> 107
<212> PRT
<213> Mus musculus
<400> 309
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
288
321
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65 70 75 80
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 310
<211> 348
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.129 VH
<220>
<221> cos
<222> (l)..(348)
214
<400> 310
eag gtg cag eta aag gag tea gga cet gge ctg gtg geg ccc tea eag 4B
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate aca tgc act gtc tea ggg ttc tea tta ace gac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
ggt gta age tgg att cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta ata tgg ggt ggt gga age aca tac tat aat tea get etc aaa 192
Gly Val Ile Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
tee aga ctg age ate age aag gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
gaa ctg aac agt ctg eaa act gat gac aea gcc att tac tac tgt gcc 2BB
Glu Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
B5 90 95
aaa cat tat ggt eac tac get get tac tgg gge eaa ggg act ctg gtc 336
Lys His Tyr Gly His Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea 34B
Thr Val Ser Ala
115
<210> 311
<211> 116
<212> PRT
<213> Mus musculus
<400> 311
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
215
Glu Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
85 90 95
Lys His Tyr Gly His Tyr Ala Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 10S 110
Thr Val Ser Ala
11S
<210> 312
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.130 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 312
gac ate cag ttg act eag tet cca gcc tee eta tet gea tet gtg gga 48
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l s lO lS
gaa act gtc ace ate aea tgt ega gea agt ggg agt att eac aat tat 96
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Ser Ile His Asn Tyr
20 2S 30
tta gea tgg tat eag eag aaa eag gga aag tet cet eag etc ctg gtc 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
3S 40 4S
tat aat gea aaa ace tta gta gat ggt gtg cca tea agg ttc agt gge 192
Tyr Asn Ala Lys Thr Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt gga tea gga aca eaa tat tet etc aag ate aac age ctg eag cet 240
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
6S 70 7S 80
gaa gat ttt ggg tat tat tac tgt eaa cat ttt tgg act act ccg tgg 288
Glu Asp Phe Gly Tyr Tyr Tyr Cys Gln His Phe Trp Thr Thr Pro Trp
8S 90 9S
aca ttc ggt gga ggc ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 313
216
<211> 107
<212> PRT
<213> Mus musculus
<400> 313
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Ser Ile His Asn Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Asn Ala Lys Thr Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Tyr Tyr Tyr Cys Gln His Phe Trp Thr Thr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 314
<211> 360
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(360)
<223> SC16.130 VH
<220>
<221> cos
<222> (l) .• (360)
<400> 314
gag gtc cag ctg cag cag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 10 15
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act age tat
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
217
96
144
35 40 45
gga tat att aat cet tac aat gat ggt act gag tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Glu Tyr Asn Glu Lys Phe
50 55 60
aaa gge aag gcc aca ctg act tea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg gtc tat gat ggt tac tet tac ttt gac tac tgg gge eaa 336
Ala Arg Gly Val Tyr Asp Gly Tyr Ser Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
gge ace act etc aca gtc tee tea 360
Gly Thr Thr Leu Thr Val Ser Ser
115 120
<210> 315
<211> 120
<212> PRT
<213> Mus musculus
<400> 315
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Glu Tyr Asn Glu Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Val Tyr Asp Gly Tyr Ser Tyr Phe Asp Tyr Trp Gly Gln
100 lOS 110
Gly Thr Thr Leu Thr Val Ser Ser
115 120
218
<210> 316
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.131 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 316
gac ate cag atg aac eag tet cca tee agt ctg tet gea tee ctt gga 48
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
gac aca att ace ate act tgc cat gtc agt eag aac att aat gtt tgg 96
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
tta age tgg tac eag eag aaa cca gga aat att cet aaa eta ttg ate 144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
eaa aag get tee aac ttg eac aca gge gtc ccc tea agg ttt agt gge 192
Gln Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gga aca ggt ttc aca tta ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
gaa gac att gcc act tac tac tgt eaa eag ggt eaa agt tat cca ttc 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 317
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 317
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asn Val Trp
20 25 30
219
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Gln Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 318
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.131 VH
<220>
<221> cos
<222> (l)..(351)
<400> 318
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ccc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
age ctg tee ate act tgc act gtc tet ggg ttt tea tta ace aac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
ggt gta eac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta ata tgg get ggt gga ate aca aat tat aat tcg get etc atg 192
Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
tee aga ctg age ate age gaa gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Glu Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 BO
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
220
85 90 95
aga aat tta ggt ccc tat get atg gac tac tgg ggt eaa gga ace tea
Arg Asn Leu Gly Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea
Val Thr Val Ser Ser
115
<210> 319
<211> 117
<212> PRT
<213> Mus musculus
<400> 319
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
336
351
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Leu Met
50 55 60
Ser Arg Leu Ser Ile Ser Glu Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asn Leu Gly Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 320
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.132 VL
221
<220>
<221> cos
<222> (l)..(321)
<400> 320
gac att eag atg ace eag tet cet gcc tee eag tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
gaa agt gtc ace ate aca tgc ctg gea agt eag ace att ggt aca tgg 96
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
tta gea tgg tat eag eag aaa cca ggg aaa tet cet eag etc ctg att 144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
tat get gea ace age ttg gea gat ggg gtc cca tea agg ttc agt ggt 192
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet gge aca aaa ttt tet ttc aag ate age age eta eag get 240
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65 70 75 80
gaa gat ttt gta agt tat tac tgt eaa eaa ctt tac agt act ccg tgg 288
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gag ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 321
<211> 107
<212> PRT
<213> Mus musculus
<400> 321
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 10 15
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
35 40 45
Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
65 70 75 80
222
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 322
<211> 348
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.132 VH
<220>
<221> cos
<222> (l)..(348)
<400> 322
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ccc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate aca tgc act gtc tea ggg ttc tea tta ace gac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
ggt gta age tgg att cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta gta tgg ggt ggt gga age aca tac tat aat tee get etc aaa 192
Gly Val Val Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
tee aga ctg age ate ace aag gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
aaa eag agg ggt eag tac ggg get tac tgg gge eaa ggg act ctg gtc 336
Lys Gln Arg Gly Gln Tyr Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea 348
Thr Val Ser Ala
115
<210> 323
223
<211> 116
<212> PRT
<213> Mus musculus
<400> 323
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 10 15
Ser eu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Val Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Lys Gln Arg Gly Gln Tyr Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 324
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(321)
<223> SC16.133 VL
<220>
<221> CDS
<222> (l) .. ( 321)
<400> 324
agt att gtg atg ace eag act ccc aaa ttc ctg ctt gtt tea gea gga 48
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
l 5 lO 15
gac agg gtt ace ata ace tgc aag gcc agt eag agt gtg agt aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
224
20 2S 30
gta get tgg tac eaa eag aag cca ggg eag tet cet aaa ctg ctg ata 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
3S 40 4S
tac tgt gea tee aat cgc tac act gga gtc cet gat cgc ttc act gge 192
Tyr Cys Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
so ss 60
agt gga tat ggg acg gat ttc act ttc ace ate age act gtg eag get 240
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
6S 70 7S 80
gaa gac ctg gea gtt tat ttc tgt eag eag gat tat age tet ccg etc 288
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu
8S 90 9S
acg ttc ggt get ggg ace aag ctg gag ctg aaa 321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 32S
<211> 107
<212> PRT
<213> Mus museulus
<400> 32S
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
l s lO lS
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 2S 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
3S 40 4S
Tyr Cys Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
so ss 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
6S 70 7S 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Leu
8S 90 9S
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 326
<211> 3S7
225
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.133 VH
<220>
<221> cos
<222> (l)..(357)
<400> 326
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ecc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate ace tgc aca gtc tet ggt ttc tea tta ace aac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
get gta eac tgg gtt cgc eag tet cca gga aag ggt ctg gag tgg ctg 144
Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gtg ata tgg agt gat gga age aca gac tat aat gea get ttc ata 192
Gly Val Ile Trp Ser Asp Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile
50 55 60
tet aga ctg age ate age aag gac aac tee aag age eaa gtt ttc ttt 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65 70 75 80
aag atg aac agt ctg eaa get gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
ega aag aaa gga gga tgg ttt ccc tgg ttt get tac tgg gge eaa ggg 336
Arg Lys Lys Gly Gly Trp Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
act ctg gtc act gtc tet gea 357
Thr Leu Val Thr Val Ser Ala
115
<210> 327
<211> 119
<212> PRT
<213> Mus rnusculus
<400> 327
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
20 25 30
226
Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ser Asp Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65 70 75 BO
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Lys Lys Gly Gly Trp Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 328
<211> 333
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(333)
<223> SC16.134 VL
<220>
<221> CDS
<222> (l)..(333)
<400> 328
gac att gtg ctg ace eaa tet cca get tet ttg get gtg tet eta ggg 48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
l 5 lO 15
eag agg gcc ace ate tee tgc aag gcc age eaa agt gtt gat cat get 96
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp His Ala
20 25 30
ggt gat agt tat atg aac tgg tac eaa eag aaa cca gga eag cca ccc 144
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
aaa etc etc ate tat get gea tee aat eta gaa tet ggg ate cca gcc 192
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
50 55 60
agg ttt agt gge agt ggg tet ggg aca gac ttc ace etc aac ate cat 240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
227
65 70 75 80
cet gtg gag gag gag gat get gea ace tat tac tgt eag eaa agt aat
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
85 90 95
gag gat ccg tac acg ttc gga ggg ggg ace aag ctg gaa ate aaa
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 329
<211> 111
<212> PRT
<213> Mus musculus
<400> 329
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly l 5 lO 15
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp His Ala
20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
85 90 95
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 330
<211> 351
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.134 VH
<220>
<221> cos
<222> (l)..(351)
228
288
333
<400> 330
gag gtc cag ctg eag eag tet gga cet gac ctg gtg aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet ggt tac tea ttc act gge tac 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
tac atg eac tgg gtg aag eag age cat gga aag agg ctt gag tgg att 144
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile
35 40 45
gga cgt gtt aat cet aac aat ggt ggt act aac tac aac eag aaa ttc 192
Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
aag gge aag gcc ata tta act gta gac aag tea tee age aca gcc tac 240
Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc cgc age ctg aca tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ggg agt tat gat aac gcc gag gge tgg gge eaa ggg act ctg 336
Ala Arg Gly Ser Tyr Asp Asn Ala Glu Gly Trp Gly Gln Gly Thr Leu
100 105 110
gtc act gtc tet gea 351
Val Thr Val Ser Ala
115
<210> 331
<211> 117
<212> PRT
<213> Mus musculus
<400> 331
Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Tyr Met His Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile
35 40 45
Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
229
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Tyr Asp Asn Ala Glu Gly Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ala
115
<210> 332
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.135 VL
<220>
<221> cos
<222> (l)..(321)
<400> 332
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat agg tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr
20 25 30
tta age tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gag ttt cca ttc 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 333
230
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 333
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 10 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 334
<211> 363
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l) •• (363)
<223> SC16.135 VH
<220>
<221> cos
<222> (l) •• (363)
<400> 334
eag gtc cag ttg eag eag tet gga get gag ctg gta agg cet ggg act
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
l 5 lO 15
tea gtg aag gtg tee tgc aag get tet gga tac gcc ttc act aat tac
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
ttg ata gag tgg gta aag eag agg cet gga eag gge ctt gag tgg att
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
231
48
96
144
35 40 45
ggg gtg att aat cet gga agt ggt ggt act aac tee aat gag aag ttc 192
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Ser Asn Glu Lys Phe
50 55 60
aag gcc aag gea aca ctg act gea gac aaa tee tee age act gcc tac 240
Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eag etc age age ctg aca tet get gac tet geg gtc tat ttc tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Phe Cys
85 90 95
gea aga tcg gac tat gat tac gcc ttc tat get atg gac tac tgg ggt 336
Ala Arg Ser Asp Tyr Asp Tyr Ala Phe Tyr Ala Met Asp Tyr Trp Gly
100 105 110
eaa gga ace tea gtc ace gtc tee tea 363
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 335
<211> 121
<212> PRT
<213> Mus musculus
<400> 335
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
l 5 lO 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr
20 25 30
Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Ser Asn Glu Lys Phe
50 55 60
Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Ser Asp Tyr Asp Tyr Ala Phe Tyr Ala Met Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
232
! _
<210> 336
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.136 VL
<220>
<221> cos
<222> (l)..(321)
<400> 336
gac ate cag atg act eag tet cca gcc tee eta tet gea tet gtg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l s 10 lS
gaa act gtc ace ate aca tgt ega gea agt ggg aat att eac aat tat 96
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
20 2S 30
tta gea tgg tat eag eag aaa eag gga aaa tet cet eac etc ctg gtc 144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val
3S 40 4S
tat aat gea aaa ace tta gea gat ggt gtg cca tea agg ttc agt gge 192
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt gga tea gga aea eaa tat tet etc aag ate aac age ctg eag cet 240
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
6S 70 7S 80
gaa gat ttt ggg agt tat tac tgt eaa cat ttt tgg agt act ccg tgg 288
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp
8S 90 9S
acg ttc ggt gga ggc ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 337
<211> 107
<212> PRT
<213> Mus musculus
<400> 337
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly l s lO lS
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr
20 2S 30
233
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val
35 40 45
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65 70 75 BO
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 338
<211> 366
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(366)
<223> SC16.136 VH
<220>
<221> CDS
<222> (l)..(366)
<400> 338
gag gtc cag ctg eag eag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act age tat 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att 144
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tat att aat cet tac aat gat ggt act aag tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
aaa gge aag gcc aea ctg act tea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg gag etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
234
85 90 95
gea aga gac agg tcg gge tac gaa gat tac tat ggt atg gac tac tgg
Ala Arg Asp Arg Ser Gly Tyr Glu Asp Tyr Tyr Gly Met Asp Tyr Trp
100 105 110
ggt eaa gga ace tea gtc ace gtc tee tea
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 339
<211> 122
<212> PRT
<213> Mus rnusculus
<400> 339
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
35· 40 45
336
366
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Ser Gly Tyr Glu Asp Tyr Tyr Gly Met Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 340
<211> 318
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(318)
<223> SC16.137 VL
235
<220>
<221> CDS
<222> (l)..(318)
<400> 340
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet eta ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l 5 lO 15
gag gag ate ace eta ace tgc agt gcc age tcg agt gta agt tac atg 96
Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
eac tgg tac eag eag aag tea gge act tet ecc aaa etc ttg att tat 144
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr
35 40 45
age aca tee aac ctg get tet gga gtc cet tet cgc ttc agt gge agt 192
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace ttt tat tet etc aca ate age agt gtg gag get gaa 240
Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu
65 70 75 80
gat get gcc gat tat tac tgc cat eag tgg agt agt tat eac acg ttc 288
Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr His Thr Phe
85 90 95
gga ggg ggg ace aag ctg gaa ata aaa egg 318
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 341
<211> 106
<212> PRT
<213> Mus rnusculus
<400> 341
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
l s lO 15
Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr
35 40 45
Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu
65 70 75 80
236
Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr His Thr Phe
85 90 95
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
100 105
<210> 342
<211> 351
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(351)
<223> SC16.137 VH
<220>
<221> CDS
<222> (l)..(351)
<400> 342
gag gtg cag ctg gtg gag tet ggg gga gac tta gtg aag cet gga ggg 48
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
l 5 lO 15
tee ctg aaa etc tee tgt gea gcc tet gga ttc act ttc agt age tat 96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
gge atg tet tgg gtt cgc eag act cca gac aag agg ctg gag tgg gtc 144
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
35 40 45
gea ace att agt agt ggt ggt agt tac ace tac tat cca gac agt gtg 192
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
50 55 60
aag ggg ega ttc ace ate tee aga gac aat gcc aag aac ace ctg tac 240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 BO
ctg eaa atg age agt ctg aag tet gag gac aea gcc atg tat tac tgt 288
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
gea aga ega aga gcc gat get atg gac tac tgg ggt eaa gga ace tea 336
Ala Arg Arg Arg Ala Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 343
237
<211> 117
<212> PRT
<213> Mus musculus
<400> 343
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly l 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ala Arg Arg Arg Ala Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 344
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) ..(321)
<223> SC16.138 VL
<220>
<221> CDS
<222> (l) .. (321)
<400> 344
gac att eag atg ace eag tet cet gcc tee eag tet gea tet ctg gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
gaa agt gtc ace ate aca tgc ctg gea agt eag ace att ggt aca tgg 96
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
238
20 2S 30
tta gea tgg tat eag eag aaa cca ggg aaa tet cet eag etc ctg att 144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
3S 40 4S
tat tet gea ace age ttg gea gat ggg gtc cca tea agg ttc agt ggt 192
Tyr Ser Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
agt gga tet gge aca aaa ttt tet ttc aag ate age age eta eag get 240
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
6S 70 7S 80
gaa gat ttt gta agt tat tac tgt eaa eaa ctt tac agt act ccg tgg 288
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
8S 90 9S
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 10S
<210> 34S
<211> 107
<212> PRT
<213> Mus musculus
<400> 34S
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly
l 5 lO 15
Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp
20 2S 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
3S 40 4S
Tyr Ser Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala
6S 70 7S 80
Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Trp
8S 90 9S
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 10S
<210> 346
<211> 348
239
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.138 VH
<220>
<221> cos
<222> (l)..(348)
<400> 346
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ecc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate aca tgc act gtc tea ggg ttc tea tta ace gac tat 96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
ggt gta age tgg att cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gta gta tgg ggt ggt gga age aca tac tat aat tee get etc aaa 192
Gly Val Val Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
tee aga ctg age ate age aag gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
aaa atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
aaa eag agg ggt eag tac ggg get tac tgg gge eaa ggg act ctg gtc 336
Lys Gln Arg Gly Gln Tyr Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea 348
Thr Val Ser Ala
115
<210> 347
<211> 116
<212> PRT
<213> Mus rnusculus
<400> 347
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr
20 25 30
240
Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Val Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Lys Gln Arg Gly Gln Tyr Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 348
<211> 321
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l).•(321)
<223> SC16.139 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 348
gac att gtg atg ace eag tet eac aaa ttc atg tee aca tea gta gga 48
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
l 5 lO 15
gac agg gtc age ate ace tgc aag gcc agt eag gat gtg aat act get 96
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
20 25 30
gta gge tgg tat eaa eag aaa cca gga eaa tet cet aaa eta ctg att 144
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tcg gea tee tac egg tac act gga gtc cet gat cgc ttc act gge 192
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tet ggg acg gat ttc act ttc ace ate age agt gtg eag get 240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
241
65 70
75 80
gaa gac ctg gea gtt tat tac tgt eag eaa cat tat agt agt ccg tac
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa att aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 349
<211> 107
<212> PRT
<213> Mus musculus
<400> 349
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly l 5 lO 15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala
20 25 30
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ser Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 350
<211> 357
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.139 VH
<220>
<221> cos
<222> (l)..(357)
242
288
321
<400> 3SO
gag gtc cag ctg eag eag tet gga cet gag ctg gta aag cet ggg get 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l s lO lS
tea gtg aag atg tee tgc aag get tet gga tac aca ttc act aac tat 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 2S 30
gtt atg eac tgg gtg aag eag aag cet ggg eag gge ctt gag tgg att 144
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
gga tat att aat cet tac aat gat ggt act aaa tac aat gag aag ttc 192
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
so ss 60
aaa gge aag gcc aca ctg act tea gac aaa tee tee ace aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala Tyr
6S 70 7S 80
atg geg etc age age ctg ace tet gag gac tet geg gtc tat tac tgt 288
Met Ala Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
8S 90 9S
gea gta gcc tac tat agt aac tgg ggg ttt get tac tgg gge eaa ggg 336
Ala Val Ala Tyr Tyr Ser Asn Trp Gly Phe Ala Tyr Trp Gly Gln Gly
100 lOS 110
act ctg gtc act gtc tet gea 3S7
Thr Leu Val Thr Val Ser Ala
llS
<210> 3Sl
<211> 119
<212> PRT
<213> Mus musculus
<400> 3Sl
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l s lO lS
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 2S 30
Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile
3S 40 4S
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe
so ss 60
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala Tyr
6S 70 7S 80
243
Met Ala Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Val Ala Tyr Tyr Ser Asn Trp Gly Phe Ala Tyr Trp Gly Gln Gly
100 lOS 110
Thr Leu Val Thr Val Ser Ala
115
<210> 352
<211> 333
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(333)
<223> SC16.140 VL
<220>
<221> CDS
<222> (l)..(333)
<400> 352
gac att gtg ctg aca eag tet ctt get tee tta get gta tet ctg ggg 48
Asp Ile Val Leu Thr Gln Ser Leu Ala Ser Leu Ala Val Ser Leu Gly
l 5 lO 15
eag agg gcc ace ate tea tgc agg gcc age aaa agt gtc agt aca tet 96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
20 25 30
gge tat agt tat atg eac tgg tac eaa eag aaa cca gga eag cca ccc 144
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
aaa etc etc att tat ctt gea tee aac eta gaa tet ggg gtc cet gcc 192
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
so ss 60
agg ttc agt gge agt ggg tet ggg aca gac ttc ace etc aac ate cat 240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 80
cet gtg gaa gac gaa gat get gea ace tat tac tgt eag eac agt agg 288
Pro Val Glu Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
85 90 95
gag ctt ccg ttc acg ttc gga ggg ggg ace aag ctg gaa ata aag 333
Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS 110
<210> 353
244
<211> 111
<212> PRT
<213> Mus musculus
<400> 353
Asp Ile Val Leu Thr Gln Ser Leu Ala Ser Leu Ala Val Ser Leu Gly l 5 lO 15
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser
20 25 30
Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
35 40 45
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
65 70 75 BO
Pro Val Glu Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg
85 90 95
Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 354
<211> 348
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(348l
<223> SC16.140 VH
<220>
<221> cos
<222> (ll ..(348l
<400> 354
eag gtc caa ctg eag eag tet ggg cet gag ctg gtg agg cet ggg get 48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
l 5 lO 15
tea gtg aag atg tee tgc aag get tea gge tat ace ttc ace age tac 96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
tgg atg eac tgg gtg aaa eag agg cet gga eaa gge ctt gag tgg att 144
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
245
35 40 45
gge atg att gat cet tee aat agt gaa act agg tta aat eag aag ttc 192
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Arg Leu Asn Gln Lys Phe
50 55 60
aag gac aag gcc aca ttg aat gta gac aaa tee tee aac aca gcc tac 240
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
atg eag etc age age ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea gta atg gac tac tac ttt gac tac tgg gge eaa gge ace act etc 336
Ala Val Met Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
aca gtc tee tea 348
Thr Val Ser Ser
115
<210> 355
<211> 116
<212> PRT
<213> Mus rnusculus
<400> 355
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
l 5 lO 15
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Arg Leu Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Val Met Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
246
<210> 356
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.141 VL
<220>
<221> cos
<222> (l)..(321)
<400> 356
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat age tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
tta age tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gag ttt cca ttc 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
acg ttc gge tcg ggg aca aag ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 357
<211> 107
<212> PRT
<213> Mus musculus
<400> 357
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly l 5 lO 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr
20 25 30
247
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 BO
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 358
<211> 345
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(345)
<223> SC16.141 VH
<220>
<221> cos
<222> (l)..(345)
<400> 358
eag gtg caa ctg aag eag tea gga cet gge ctg gtg geg ccc tea eag 48
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg ttc ate aca tgc ace gtc tea ggg ttc tea tta ace age tat 96
Ser Leu Phe Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
gaa ata aac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Glu Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gtg ata tgg act ggt gga age aca aat tat aat tea get etc ata 192
Gly Val Ile Trp Thr Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Ile
50 55 60
tee aga ctg age ate age aaa gac aac tee aag age eta gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Leu Val Phe Leu
65 70 75 80
aaa atg aac agt ctg eaa act gat gac aca gcc ata tat tac tgt gta 288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val
248
85 90 95
aga ggt gtt tat get atg gac tac tgg ggt eaa gga ace tea gtc ace
Arg Gly Val Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
gtc tee tea
Val Ser Ser
115
<210> 359
<211> 115
<212> PRT
<213> Mus musculus
<400> 359
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
Ser Leu Phe Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
20 25 30
Glu Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Thr Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Ile
50 55 60
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Leu Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val
85 90 95
Arg Gly Val Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
100 105 110
Val Ser Ser
115
<210> 360
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.142 VL
249
336
345
<220>
<221> cos
<222> (l)..(321)
<400> 360
gac ate aag atg ace eag tet cca tet tee atg tat gea tet eta gga 48
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
l 5 lO 15
gag aga gtc act ate act tgc aag geg agt eag gac att aat aat tat 96
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
tta age tgg ttc eag eag aaa cca ggg aaa tet cet aag ace ctg ate 144
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
tat cgt gea aac aga ttg gta gat ggg gtc cca tea agg ttc agt gge 192
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg eaa gat tat tet etc ace ate age age ctg gag tat 240
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
gaa gat atg gga att tat tat tgt eta eag tat gat gag ttt ccg tac 288
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
acg ttc gga ggg ggg ace aag ctg gaa ata aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 361
<211> 107
<212> PRT
<213> Mus rnusculus
<400> 361
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly
l 5 lO 15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile
35 40 45
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr
65 70 75 80
250
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 362
<211> 345
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(345)
<223> SC16.142 VH
<220>
<221> CDS
<222> (l)..(345)
<400> 362
gag gtc cag ctt eag eag tea gga cet gag ctg gtg aaa cet ggg gcc 48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg aag ata tee tgc aag get tet gga tac aca ttc act gac tac 96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
aac atg eac tgg gtg aag eag age cat gga aag age ctt gag tgg att 144
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
gga ttc ttt tat cet tac aac ggt aat act gtc tac age eag aag ttc 192
Gly Phe Phe Tyr Pro Tyr Asn Gly Asn Thr Val Tyr Ser Gln Lys Phe
50 55 60
aag age aag gcc aca ttg act gta gac aat tee tee age aca gcc tac 240
Lys Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr
65 70 75 BO
atg gag etc cgc age ctg aca tet gag gac tet gea gtc tat tac tgt 288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
gea aga ctt aac tgg gag gge tac tgg gge eaa gge ace ace etc acv 336
Ala Arg Leu Asn Trp Glu Gly Tyr Trp Gly Gln Gly Thr Thr Leu Xaa
100 105 110
gtn ten ten 345
Val Xaa Xaa
115
<210> 363
251
<211> 115
<212> PRT
<213> Mus museulus
<220>
<221> mise feature
<222> (112)..(112)
<223> The 'Xaa' na mestu 112 predstavlja Thr.
<220>
<221> mise feature
<222> (114)..(114)
<223> The 'Xaa' na mestu 114 predstavlja Ser.
<220>
<221> mise feature
<222> (115)..(115)
<223> The 'Xaa' na mestu 115 predstavlja Ser.
<400> 363
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Phe Phe Tyr Pro Tyr Asn Gly Asn Thr Val Tyr Ser Gln Lys Phe
50 55 60
Lys Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Asn Trp Glu Gly Tyr Trp Gly Gln Gly Thr Thr Leu Xaa
100 105 110
Val Xaa Xaa
115
<210> 364
<211> 336
<212> DNA
<213> Mus museulus
<220>
252
<221> mise feature
<222> (l)..(336)
<223> SC16.143 VL
<220>
<221> CDS
<222> (l)..(336)
<400> 364
gat gtt ttg atg ace eaa act cca etc tee ctg cet gtc agt ctt gga 48
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly l s lO lS
gat eaa gcc tee ate tet tgc aga tet agt eag age att gta cat agt 96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 2S 30
aat gga aac ace tat tta gaa tgg tac ctg eag aaa cca gge eag tet 144
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
3S 40 4S
cca aag etc ctg ate tac aaa gtt tee aac ega ttt tet ggg gtc cca 192
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
so ss 60
gac agg ttc agt gge agt gga tea ggg aca gat ttc aca etc aag ate 240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
6S 70 7S 80
age aga gtg gag get gag gat ctg gga gtt tat tac tgc ttt eaa ggt 288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
8S 90 9S
tea cat gtt ccg etc acg ttc ggt get ggg ace aag ctg gag ctg aaa 336
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 lOS 110
<210> 36S
<211> 112
<212> PRT
<213> Mus musculus
<400> 36S
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly l s lO lS
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
20 2S 30
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
3S 40 4S
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
so ss 60
253
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
85 90 95
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105 110
<210> 366
<211> 357
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(357)
<223> SC16.143 VH
<220>
<221> cos
<222> (l)..(357)
<400> 366
eag gtc cag ctg eag eag tet gga cet gag ctg gtg aag cet ggg get 48
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l 5 lO 15
tea gtg agg ata tee tgc aag get tet gge tac ace ttc aca age tac 96
Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
tat ata eac tgg gtg aag eag agg cet gga eag gga ctt gag tgg att 144
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
gga tgg att tat cet gga aat ggt aat act aag tac aat gag aag ttc 192
Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
aag gge aag gcc aca ctg act gea gac aaa tee tee age aca gcc tac 240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
atg eag ate age age ctg ace tet gag gac tet geg gtc tat ttc tgt 288
Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
gea aga gag aga tgg tta eta eta tgg ttt get tac tgg gge eaa ggg 336
Ala Arg Glu Arg Trp Leu Leu Leu Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
act ctg gtc act gtc tet gea 357
Thr Leu Val Thr Val Ser Ala
115
254
<210> 367
<211> 119
<212> PRT
<213> Mus musculus
<400> 367
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 10 15
Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
20 25 30
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Ala Arg Glu Arg Trp Leu Leu Leu Trp Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ala
115
<210> 368
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l) •• (321)
<223> SC16.144 VL
<220>
<221> cos
<222> (l) •• (321)
<400> 368
agt att gtg atg ace cag act ccc aaa ttc ctg ctt gta tea gea gga 48
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
l 5 10 15
255
gac agg gtt ace ata ace tgc aag gcc agt eag agt gtg agt aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
gta ggt tgg tac eaa eag aag cca ggg eag tet cet aaa ctg ctg ata 144
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
tac tat gea tee aat cgc tac aat gga gtc cet gat cgc ttc act gge 192
Tyr Tyr Ala Ser Asn Arg Tyr Asn Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
agt gga tat ggg acg gat ttc act ttc ace ate age act gtg eag get 240
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
gaa gac ctg gea gtt tat ttc tgt eag eag gat tat age tet ccg tgg 288
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 369
<211> 107
<212> PRT
<213> Mus musculus
<400> 369
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly l 5 lO 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Asn Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala
65 70 75 80
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
256
<210> 370
<211> 354
<212> DNA
<213> Mus rnusculus
<220>
<221> mise feature
<222> (l)..(354)
<223> SC16.144 VH
<220>
<221> cos
<222> (l).•(354)
<400> 370
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag get tet ggg tat ace ttc aca aac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gga atg aac tgg gtg aag eag get cca gga aag ggt tta aag tgg gtg 144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Val
35 40 45
gge tgg ata aac ace tac act gga gag cca aca tat get gat gac ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 BO
ttg eag ate gac aac etc aaa aat gag gac acg get aca tat ttc tgt 288
Leu Gln Ile Asp Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
gea aga gtg ggg gat tac gtc gge ttt gac tac tgg gge eaa gge ace 336
Ala Arg Val Gly Asp Tyr Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
act etc aca gtc tee tea 354
Thr Leu Thr Val Ser Ser
ll5
<210> 371
<2ll> ll8
<212> PRT
<213> Mus rnusculus
<400> 371
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l 5 lO 15
257
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Val
35 40 45
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asp Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
85 90 95
Ala Arg Val Gly Asp Tyr Val Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Leu Thr Val Ser Ser
115
<210> 372
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.147 VL
<220>
<221> cos
<222> (l)..(321)
<400> 372
gat ate cag atg aea eag act gea tee tee ctg tet gcc tet ctg gga 48
Asp Ile Gln Met Thr Gln Thr Ala Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aga gtc ace ate agt tgc agg gea agt eag gac att aac aat tat 96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr
20 25 30
tta aac tgg tat eag eag aaa cca gat gga act gtt aaa etc ctg ate 144
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
tac tac aca tea aga tta eac tea gga gtc cca tea agg ttc agt gge 192
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
258
agt ggg tet gga aca gat tat tet etc ace att age ate ctg gaa eaa
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ile Leu Glu Gln
6S 70 7S 80
gaa gat att gcc act tac ttt tgc eaa eag ggt gat acg ctt ccg tgg
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp
8S 90 9S
acg ttc ggt gga gge ace aag ctg gaa ate aaa
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 373
<211> 107
<212> PRT
<213> Mus musculus
<400> 373
Asp Ile Gln Met Thr Gln Thr Ala Ser Ser Leu Ser Ala Ser Leu Gly l s lO lS
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr
20 2S 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
3S 40 4S
Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
so ss 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ile Leu Glu Gln
6S 70 7S 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp
8S 90 9S
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 374
<211> 3Sl
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(3Sl)
<223> SC16.147 VH
259
240
288
321
<220>
<221> cos
<222> (l)..(351)
<400> 374
eag ate cag ttg gtg eag tet gga cet gag ctg acg aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Thr Lys Pro Gly Glu
l 5 lO 15
aca gtc aag ate tee tgc aag gcc tet gga tat ace ttc aca gac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
tea ttg eac tgg gtg aag eag get eta gga aag ggt tta aag tgg atg 144
Ser Leu His Trp Val Lys Gln Ala Leu Gly Lys Gly Leu Lys Trp Met
35 40 45
gge tgg ata aac act gag act ggt gag cca gea tat gea gat gac ttc 192
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Ala Tyr Ala Asp Asp Phe
50 55 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc age act gcc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
ttg eag ate aac gac etc aaa aat gag gac acg act aca tat ttc tgt 288
Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Thr Thr Thr Tyr Phe Cys
85 90 95
ggt att tac gac ggg tat get atg gac tac tgg ggt eaa gga ace tea 336
Gly Ile Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
gtc ace gtc tee tea 351
Val Thr Val Ser Ser
115
<210> 375
<211> 117
<212> PRT
<213> Mus musculus
<400> 375
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Thr Lys Pro Gly Glu
l 5 lO 15
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Ser Leu His Trp Val Lys Gln Ala Leu Gly Lys Gly Leu Lys Trp Met
35 40 45
Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Ala Tyr Ala Asp Asp Phe
50 55 60
260
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Thr Thr Thr Tyr Phe Cys
85 90 95
Gly Ile Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
100 105 110
Val Thr Val Ser Ser
115
<210> 376
<211> 318
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> {l)..{318)
<223> SC16.148 VL
<220>
<221> cos
<222> {l)..{318)
<400> 376
eaa att gtt etc ace eag tet cca gea ate atg tet gea tet cca ggg 48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
l 5 10 15
gag aag gtc ace atg ace tgc agt gcc age tea agt gta agt tac atg 96
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
tac tgg tac eag eag aag cca gga tee tee ccc aga etc ctg att tat 144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
35 40 45
gac aea tee aae ctg get tet gga gtc cet gtt cgc ttc agt gge agt 192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
50 55 60
ggg tet ggg ace tet tac tet etc aca ate age ega atg gag get gaa 240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65 70 75 80
gat act gcc act tat tat tgc eag gag tgg agt aat aat ccg etc acg 288
Asp Thr Ala Thr Tyr Tyr Cys Gln Glu Trp Ser Asn Asn Pro Leu Thr
85 90 95
ttc ggt gat ggg ace aag ctg gag ctg aaa 318
Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys
100 105
261
<210> 377
<211> 106
<212> PRT
<213> Mus musculus
<400> 377
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly l s 10 lS
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 2S 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
3S 40 4S
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
so ss 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
6S 70 7S 80
Asp Thr Ala Thr Tyr Tyr Cys Gln Glu Trp Ser Asn Asn Pro Leu Thr
8S 90 9S
Phe Gly Asp Gly Thr Lys Leu Glu Leu Lys
100 lOS
<210> 378
<211> 3S4
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3S4)
<223> SC16.148 VH
<220>
<221> cos
<222> (l)..(3S4)
<400> 378
eag ate cag ttg gtg eag tet gga cet gag ctg aag aag cet gga gag 48
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu l s lO lS
aca gtc aag ate tee tgc aag get tet ggg tat ace etc aca aac tat 96
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asn Tyr
20 2S 30
262
gga atg aac tgg gtg aag eag get cca gga aag ggt tta aag tgg atg 144
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
3S 40 4S
gge tgg ata aac ace tac act gga gag cca aca tat get gat gac ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
so ss 60
aag gga egg ttt gcc ttc tet ttg gaa ace tet gcc agg att gtc tat 240
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Ile Val Tyr
6S 70 7S 80
ttg eag ate aac aac etc aaa aat gag gac acg get aca tat ttc tgt 288
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
8S 90 9S
gea aaa tat gag gcc eac gag ggg ttt gtt tat tgg gge eaa ggg act 336
Ala Lys Tyr Glu Ala His Glu Gly Phe Val Tyr Trp Gly Gln Gly Thr
100 lOS 110
ctg gtc act gtc tet gea 3S4
Leu Val Thr Val Ser Ala
11S
<210> 379
<211> 118
<212> PRT
<213> Mus museulus
<400> 379
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
l s lO lS
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asn Tyr
20 2S 30
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
3S 40 4S
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
so ss 60
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Ile Val Tyr
6S 70 7S 80
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
8S 90 9S
Ala Lys Tyr Glu Ala His Glu Gly Phe Val Tyr Trp Gly Gln Gly Thr
100 lOS 110
263
Leu Val Thr Val Ser Ala
115
<210> 380
<211> 321
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(321)
<223> SC16.149 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 380
gac ate cag atg aac eag tet cca tee agt ctg tet gea tee ctt gga 48
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
l 5 lO 15
gac aca att ace ate act tgc cat gcc agt eag aac att aat gtt tgg 96
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
tta age tgg tac eag eag aaa cca gga aat att cca aaa eta ttg ate 144
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
tat aag get tee eae ttg eac aca gge gtc cca tea agg ttg agt gge 192
Tyr Lys Ala Ser His Leu His Thr Gly Val Pro Ser Arg Leu Ser Gly
50 55 60
agt gga tet gga aca ggt ttc aca tta ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 BO
gaa gac att gcc act tac tac tgt eaa eag ggt eaa agt tat cca ttc 288
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
85 90 95
acg ttc gge tcg ggg aca acg ttg gaa ata aaa 321
Thr Phe Gly Ser Gly Thr Thr Leu Glu Ile Lys
100 105
<210> 381
<211> 107
<212> PRT
<213> Mus musculus
<400> 381
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly l 5 lO 15
264
Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser His Leu His Thr Gly Val Pro Ser Arg Leu Ser Gly
50 55 60
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Thr Leu Glu Ile Lys
100 105
<210> 382
<211> 348
<212> DNA
<213> Mus museulus
<220>
<221> mise feature
<222> (l)..(348)
<223> SC16.149 VH
<220>
<221> CDS
<222> (l)..(348)
<400> 382
eag gtg cag ctg aag gag tea gga cet gge ctg gtg geg ecc tea eag 48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
l 5 lO 15
age ctg tee ate act tgc get gtc tet ggg ttt tea tta ace age ttt 96
Ser Leu Ser Ile Thr Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Phe
20 25 30
ggt gta eac tgg gtt cgc eag cet cca gga aag ggt ctg gag tgg ctg 144
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
gga gtt ata tgg get ggt gga age aca aat tat tat tcg get etc atg 192
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Tyr Ser Ala Leu Met
50 55 60
tee aga ctg age ate age ata gac aac tee aag age eaa gtt ttc tta 240
Ser Arg Leu Ser Ile Ser Ile Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
265
aag atg aac agt ctg eaa act gat gac aca gcc atg tac tac tgt gcc
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
aga gac tgg gag gge tgg ttt get tac tgg gge eaa ggg act ctg gtc
Arg Asp Trp Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
act gtc tet gea
Thr Val Ser Ala
115
<210> 383
<211> 116
<212> PRT
<213> Mus musculus
<400> 383
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln l 5 lO 15
Ser Leu Ser Ile Thr Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Phe
20 25 30
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Tyr Ser Ala Leu Met
50 55 60
Ser Arg Leu Ser Ile Ser Ile Asp Asn Ser Lys Ser Gln Val Phe Leu
65 70 75 80
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
85 90 95
Arg Asp Trp Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 384
<211> 339
<212> DNA
<213> Mus musculus
<220>
266
288
336
348
<221> mise feature
<222> (l)..(339)
<223> SC16.1SO VL
<220>
<221> cos
<222> (l)..(339)
<400> 384
gac att gtg atg tea eag tet cca tee tee eta act gtg tea gtt gga 48
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly l s lO lS
gag aag gtt act atg age tgc atg tee agt eag age ctt tta tat agt 96
Glu Lys Val Thr Met Ser Cys Met Ser Ser Gln Ser Leu Leu Tyr Ser
20 2S 30
age act eaa aag aac tac ttg gcc tgg tac eag eag aaa cca ggg eag 144
Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
3S 40 4S
tet cet aaa ctg ctg att tac tgg gea tee act agg gaa tet ggg gtc 192
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
so ss 60
cet gat cgc ttc aca gge agt gga tet ggg aca gat ttc act etc ace 240
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
6S 70 7S BO
ate age agt gtg aag get gaa gac ctg gea gtt tat tac tgt eag eaa 288
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
BS 90 9S
tat tat age tat ccg tac acg ttc gga ggg ggg ace aag ctg gaa ata 336
Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 lOS 110
aaa 339
Lys
<210> 38S
<211> 113
<212> PRT
<213> Mus musculus
<400> 38S
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly l s 10 lS
Glu Lys Val Thr Met Ser Cys Met Ser Ser Gln Ser Leu Leu Tyr Ser
20 2S 30
Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
3S 40 4S
267
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
so ss 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
6S 70 7S BO
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
BS 90 9S
Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
100 lOS 110
Lys
<210> 3B6
<211> 3Sl
<212> DNA
<213> Mus musculus
<220>
<221> mise feature
<222> (l)..(3Sl)
<223> SC16.1SO VH
<220>
<221> cos
<222> (l)..(3Sl)
<400> 3B6
gag ate cag ctg eag eag tet gga cet gag ctg gtg aag cet ggg get 4B Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
l s lO lS
tea gtg aag gta tee tgc aag get tet ggt tat gea ttc act age tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr
20 2S 30
aac atg tac tgg gtg agt eag age cat gga aag age ctt gag tgg att 144
Asn Met Tyr Trp Val Ser Gln Ser His Gly Lys Ser Leu Glu Trp Ile
3S 40 4S
gga tat att gat cet tac aat ggt gge act age tac aac eag aag ttc 192
Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
so ss 60
agg gge aag gcc aca ttg act gtt gac aag tee tea age aca gcc tac 240
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
6S 70 7S BO
atg cat etc aac age ctg aca tet gag gac tcg gea gtc tat tat tgt 2BB Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
BS 90 9S
268
gea aga gag aac tat agg tac ttt gac ttc tgg gge eaa gge ace act
Ala Arg Glu Asn Tyr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr
100 105 110
etc aca gtc tee tea
Leu Thr Val Ser Ser
115
<210> 387
<211> 117
<212> PRT
<213> Mus musculus
<400> 387
Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala l 5 lO 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr
20 25 30
Asn Met Tyr Trp Val Ser Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asn Tyr Arg Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 388
<211> 318
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
269
336
351
<222> (l)..(318)
<223> HSC16.13 VL
<220>
<221> cos
<222> (l)..(318)
<400> 388
gac ate cag atg ace eag tet cca tee tee ctg tet gea tet gta gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
l 5 lO 15
gac aga gtc ace ate act tgc agt gea agt age age gtt age tat atg 96
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
tat tgg tat eag eag aaa cca ggg aaa gcc cet aag etc ctg ate tac 144
Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45
etc act agt aac ttg gea agt ggg gtc cca tea agg ttc agt gge agt 192
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
gga tet ggg aca gat ttc act etc ace ate age agt ctg eaa cet gaa 240
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
gat ttt gea act tac tac tgt eaa eag tgg cgt agt aac cca ttc acg 288
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Phe Thr
85 90 95
ttc gge eag ggg aca aag ttg gaa ata aaa 318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 389
<211> 106
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 389
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly l 5 lO 15
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45
Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
270
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
65 70 75 80
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Phe Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 390
<211> 372
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
<222> (l)..(372)
<223> HSC16.13 VH
<220>
<221> CDS
<222> (l)..(372)
<400> 390
eag ate ace ttg aag gag tet ggt cet acg ctg gtg aaa ccc aca eag 48
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
l 5 lO 15
ace etc acg ctg ace tgc ace ttc tet ggg ttc tea etc age act agt 96
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
gga atg ggt gtg gge tgg ate cgt eag ccc cca gga aag gcc ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
tgg ctt gea eac att tgg tgg gat gat gtt aag cgc tac age cca tet 192
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Ser Pro Ser
50 55 60
ctg aag age agg etc ace ate ace aag gac ace tee aaa aac eag gtg 240
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
gtc ctt aca atg ace aac atg gac cet gtg gac aca gcc aca tat tac 288
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt gea cgc ata gtt tee ttt gat aac gac gtt gtc tet get atg gac 336
Cys Ala Arg Ile Val Ser Phe Asp Asn Asp Val Val Ser Ala Met Asp
271
100 105 110
tac tgg ggt eaa gga ace eta gtc ace gtc tee tee
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 391
<211> 124
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 391
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
l 5 lO 15
372
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Ser Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Ile Val Ser Phe Asp Asn Asp Val Val Ser Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 392
<211> 321
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
272
<222> (l)..(321)
<223> HSC16.15 VL
<220>
<221> cos
<222> (l)..(321)
<400> 392
gcc ate cag ttg ace eag tet cca tee tee ctg tet gea tet gta gga 48
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
l 5 lO 15
gac aga gtc ace ate act tgc egg gea agt gag aac att tat tat aat 96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Asn
20 25 30
tta gcc tgg tat eag eag aaa cca ggg aaa get cet aag etc ctg ate 144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
tat act gcc aat agt ttg gaa gat ggg gtc cca tea agg ttc age gge 192
Tyr Thr Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg aca gat ttc act etc ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
gaa gat ttt gea act tat ttt tgt aaa eag get tat gac gtt cet ccg 288
Glu Asp Phe Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Pro
85 90 95
acg ttc ggt gga gge ace aag ctg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 393
<211> 107
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 393
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly l 5 lO 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Thr Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly
273
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Pro
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 394
<211> 351
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
<222> (l)..(351)
<223> HSC16.15 VH
<220>
<221> cos
<222> (l)..(351)
<400> 394
eag gtg cag ctg gtg eag tet ggg get gag gtg aag aag cet ggg gcc 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
l 5 lO 15
tea gtg aag gtt tee tgc aag gea tet gga tac ace ttc ace agg tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
tgg ata eac tgg ata ega eag gcc cet gga eaa ggg ctt gag tgg atg 144
Trp Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
gga tac ate aac cet aca act gtt tat act gag ttc aat eag aac ttc 192
Gly Tyr Ile Asn Pro Thr Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe
50 55 60
aag gac aga gtc ace atg ace agg gac acg tee acg age aca gtc tac 240
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
atg gag ctg age age ctg aga tet gag gac acg gcc gtg tat tac tgt 288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
geg aga gge ggt agt aac ttc ttt gac tac tgg gge eaa gge ace act 336
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
274
100 105 110
gtc aca gtc tee tea Val Thr Val Ser Ser ll5
351
<210> 395
<2ll> ll7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 395
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala l 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
20 25 30
Trp Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Tyr Ile Asn Pro Thr Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe
50 55 60
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Gly Ser Asn Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Val Thr Val Ser Ser ll5
<210> 396
<2ll> 318
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
275
<222> (l)..(318)
<223> HSC16.25 VL
<220>
<221> CDS
<222> (l)..(318)
<400> 396
gaa att gtg ctg act eag tet cca gac ttt eag tet gtg act cca aag 48
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys l 5 lO 15
gag aaa gtc ace ate ace tgc agt gcc agt age agt gtg age tac atg 96
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
eac tgg tac eag eag aaa cca gat eag tet cca aag etc etc ate aag 144
His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
35 40 45
gat agt tee aaa etc gcc tea ggg gtc ecc tcg agg ttc agt gge agt 192
Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
50 55 60
gga tet ggg aea gat ttc ace etc ace ate aat age ctg gaa get gaa 240
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
gat get gea acg tat tac tgt eag eag tgg agt agt aac ccg etc acg 288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
85 90 95
ttc ggt eag ggg ace aag ctg gag ate aaa 318
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 397
<211> 106
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 397
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys l 5 lO 15
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
20 25 30
His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys
35 40 45
Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
276
50 55 60
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr
85 90 95
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 398
<211> 372
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
<222> (l)..(372)
<223> HSC16.25 VH
<220>
<221> CDS
<222> (l)..(372)
<400> 398
eag ate ace ttg aag gag tet ggt cet acg ctg gtg aaa ccc aca eag 48
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
l 5 lO 15
ace etc acg ctg ace tgc ace ttc tet ggg ttc tea etc age act agt 96
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
gga atg ggt gtg gge tgg ate cgt eag cce cca gga aag gcc ctg gag 144
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
tgg ctt aca gac att tgg tgg gat gat aat aag tac tac aac cca tet 192
Trp Leu Thr Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
50 55 60
ctg aag age agg etc ace ate ace aag gac ace tee aaa aac eag gtg 240
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
gtc ctt aca atg ace aac atg gac cet gtg gac aca gcc aca tat tac 288
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
tgt gea ega aga gtt aac tat tat tac gac ccg tac tat get atg gac 336
Cys Ala Arg Arg Val Asn Tyr Tyr Tyr Asp Pro Tyr Tyr Ala Met Asp
277
100 105 110
tac tgg ggt eaa gga ace eta gtc ace gtc tee tea
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 399
<211> 124
<212> PRT
<213> Ve tačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 399
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln
l 5 lO 15
372
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Thr Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val
65 70 75 80
Val Leu Thr Met hr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr
85 90 95
Cys Ala Arg Arg Val Asn Tyr Tyr Tyr Asp Pro Tyr Tyr Ala Met Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 400
<211> 321
<212> DNA
<213> Ve tačka sekvenca
<220>
<223> Sekvenca hurnanizovanog antitela
<220>
<221> mise feature
278
<222> (l)..(321)
<223> HSC16.34 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 400
gac ate cag atg ace eag tet cca tee tee ctg tet gea tet gta gga 48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
l 5 lO 15
gac aga gtc ace ate act tgc aag geg agt eag age gtt age aat gat 96
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
gta gcc tgg tat eag eag aaa cca ggg aaa gtt cet aag etc ctg ate 144
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
35 40 45
tat tat gea tee aat agg tac tea ggg gtc cca tet egg ttc agt gge 192
Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
agt gga tet ggg aea gat ttc act etc ace ate age age ctg eag cet 240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
gaa gat gtt gea act tat ttc tgt eag eag gat tat age tet ccg tgg 288
Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
acg ttc ggt gga gge ace aag gtg gaa ate aaa 321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 401
<211> 107
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 401
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly l 5 lO 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
35 40 45
Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
279
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 402
<211> 354
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca hurnanizovanog antitela
<220>
<221> mise feature
<222> (l)..(354)
<223> HSC16.34 VH
<220>
<221> CDS
<222> (l)..(354)
<400> 402
eag gtc cag ctt gtg eag tet ggg get gag gtg aag aag cet ggg gcc 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
l 5 lO 15
tea gtg aag gtt tee tgc aag get tet gga tac ace ttc act aac tat 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
ggt atg aat tgg gtg cgc eag gcc ecc gga eaa agg ctt gag tgg atg 144
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
gga tgg ate aac act tac act ggt gac cca aca tat gea gat gat ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe
50 55 60
aag gge aga gtc ace att ace agg gac aca tee geg age aca gcc tac 240
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
atg gag ctg age age ctg aga tet gaa gac acg get gtg tat tac tgt 288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
geg aga att ggc ggt aat agt ccc tet gat tac tgg gge eaa gge ace 336
Ala Arg Ile Gly Gly Asn Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
280
100 105 110
act gtc aca gtc tee tea
Thr Val Thr Val Ser Ser
115
354
<210> 403
<211> 118
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 403
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala l 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly Gly Asn Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Thr Val Thr Val Ser Ser
115
<210> 404
<211> 321
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
281
<222> (l)..(321)
<223> HSC16.S6 VL
<220>
<221> CDS
<222> (l)..(321)
<400> 404
gag ate gtg atg ace eag tee cet gcc aca ctg tee gtg tee cet gga 48
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly l s lO lS
gag agg gcc ace ctg tee tgc aag gcc tee eag tee gtg tee aac gac 96
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 2S 30
gtg gtg tgg tac eag eag aag ccc gga eag get ccc agg ctg ctg ate 144
Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
3S 40 4S
tac tac gcc tee aac agg tac ace gge ate cet gcc agg ttc tee gga 192
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
so ss 60
tee gga tee gge ace gag ttc ace ctg ace ate tee tee ctg eag tee 240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
6S 70 7S BO
gag gac ttc gcc gtg tac tac tgc eag eag gac tac ace tee ccc tgg 288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Thr Ser Pro Trp
8S 90 9S
ace ttt gge eag gge ace aag ctg gag ate aag 321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 lOS
<210> 40S
<211> 107
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 40S
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly l s lO lS
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
20 2S 30
Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
3S 40 4S
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly
282
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Thr Ser Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 406
<211> 354
<212> DNA
<213> Veštačka sekvenca
<220>
<223> Sekvenca humanizovanog antitela
<220>
<221> mise feature
<222> (l)..(354)
<223> HSC16.56 VH
<220>
<221> CDS
<222> (l)..(354)
<400> 406
eag gtg cag ctg gtg eag tee gge gcc gaa gtg aag aaa ccc gge gcc 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
l 5 lO 15
tee gtg aag gtg tee tgc aag gcc tee gge tac ace ttc ace aac tac 96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
gge atg aac tgg gtg agg eag get cet gga eag gga ctg gag tgg atg 144
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
gge tgg ate aac ace tac ace gge gaa ccc ace tac gcc gac gac ttc 192
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
aag gge agg gtg ace atg ace ace gac ace tee ace tee ace gcc tac 240
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
atg gag ctg agg tee ctg agg tee gac gac ace gcc gtg tac tac tgc 288
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
get agg att gge gac tee tee ccc tee gat tac tgg gga eag gge ace 336
Ala Arg Ile Gly Asp Ser Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
283
100 105 110
etc gtg ace gtc tee tee
Leu Val Thr Val Ser Ser
115
<210> 407
<211> 118
<212> PRT
<213> Veštačka sekvenca
<220>
<223> Sintetički konstrukt
<400> 407
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala l 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe
50 55 60
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ile Gly Asp Ser Ser Pro Ser Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 408
<211> lO
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRLl
<400> 408
Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr
284
354
l 5 lO
<210> 409
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRL2
<400> 409
Leu Thr Ser Asn Leu Ala Ser l 5
<210> 410
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRL3
<400> 410
Gln Gln Trp Arg Ser Asn Pro Phe Thr l 5
<210> 411
<211> ll
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.15 CDRLl
<400> 411
Arg Ala Ser Glu Asn Ile Tyr Tyr Asn Leu Ala l 5 lO
<210> 412
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.15 CDRL2
<400> 412
Thr Ala Asn Ser Leu Glu Asp l 5
<210> 413
285
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.15 CDRL3
<400> 413
Lys Gln Ala Tyr Asp Val Pro Pro Thr
l 5
<210> 414
<211> 10
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.25 CDRLl
<400> 414
Ser Ala Ser Ser Ser Val Ser Tyr Met His l 5 10
<210> 415
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.25 CDRL2
<400> 415
Asp Ser Ser Lys Leu Ala Ser l 5
<210> 416
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.25 CDRL3
<400> 416
Gln Gln Trp Ser Ser Asn Pro Leu Thr l 5
<210> 417
<211> ll
<212> PRT
<213> Veštačka sekvenca
286
<220>
<223> HSC16.34 CDRLl
<400> 417
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala l 5 lO
<210> 418
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.34 CDRL2
<400> 418
Tyr Ala Ser Asn Arg Tyr Ser l 5
<210> 419
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.34 CDRL3
<400> 419
Gln Gln Asp Tyr Ser Ser Pro Trp Thr l 5
<210> 420
<211> ll
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRLl
<400> 420
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Val l 5 lO
<210> 421
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRL2
<400> 421
287
Tyr Ala Ser Asn Arg Tyr Thr
l 5
<210> 422
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRL3
<400> 422
Gln Gln Asp Tyr Thr Ser Pro Trp Thr l 5
<210> 423
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRHl
<400> 423
Thr Ser Gly Met Gly Val Gly l 5
<210> 424
<211> 16
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRH2
<400> 424
His Ile Trp Trp Asp Asp Val Lys Arg Tyr Ser Pro Ser Leu Lys Ser l 5 10 15
<210> 425
<211> 14
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.13 CDRH3
<400> 425
Ile Val Ser Phe Asp Asn Asp Val Val Ser Ala Met Asp Tyr l 5 10
288
<210> 426
<211> s
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.1S CDRHl
<400> 426
Arg Tyr Trp Ile His l s
<210> 427
<211> 17
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.1S CDRH2
<400> 427
Tyr Ile Asn Pro Thr Thr Val Tyr Thr Glu Phe Asn Gln Asn Phe Lys l s 10 lS
Asp
<210> 428
<211> 8
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.lS CDRH3
<400> 428
Gly Gly Ser Asn Phe Phe Asp Tyr
l s
<210> 429
<211> 7
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.2S CDRHl
<400> 429
Thr Ser Gly Met Gly Val Gly l s
289
<210> 430
<211> 16
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.25 CDRH2
<400> 430
Asp Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Asn Pro Ser Leu Lys Ser l 5 lO 15
<210> 431
<211> 14
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.25 CDRH3
<400> 431
Arg Val Asn Tyr Tyr Tyr Asp Pro Tyr Tyr Ala Met Asp Tyr l 5 lO
<210> 432
<211> 5
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.34 CDRHl
<400> 432
Asn Tyr Gly Met Asn l 5
<210> 433
<211> 17
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.34 CDRH2
<400> 433
Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe Lys l 5 lO 15
Gly
290
<210> 434
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.34 CDRH3
<400> 434
Ile Gly Gly Asn Ser Pro Ser Asp Tyr
l 5
<210> 435
<211> 5
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRHl
<400> 435
Asn Tyr Gly Met Asn l 5
<210> 436
<211> 17
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRH2
<400> 436
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys l 5 10 15
Gly
<210> 437
<211> 9
<212> PRT
<213> Veštačka sekvenca
<220>
<223> HSC16.56 CDRH3
<400> 437
Ile Gly Asp Ser Ser Pro Ser Asp Tyr
l 5
291

Claims (30)

1. Konjugat antitela i leka (ADC) koji sadrži DLL3 agens za vezivanje ćelija kovalentno vezan preko veznika za pirolobenzodiazepin (PBD), gde je DLL3 agens za vezivanje ćelija anti-DLL3 antitelo, i gde je PBD:
2. Konjugat antitela i leka prema patentnom zahtevu l, gde veznik sadrži veznik koji se može razdvojiti.
3. Konjugat antitela i leka prema patentnom zahtevu 2, gde veznik koji se može razdvojiti sadrži peptidilni veznik koji sadrži najmanje dve aminokiseline.
4. Konjugat antitela i leka prema patentnom zahtevu 3, gde peptidilni veznik sadrži valinalanin dipeptid.
5. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 4, koji obuhvata strukturu:gde zvezdica označava tačku vezivanja za PBD, i gde talasasta linija označava tačku vezivanja za preostali deo veznika.
6. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 5, gde je veza između anti-DLL3 antitela i veznika formirana reakcijom sa maleimidnom grupom veznika.
7. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 6, gde ADC ima opterećenje leka koje iznosi 2.
8. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 6, gde su PBD l do 8kovalentno vezani za anti-DLL3 antitelo.
9. Konjugat antitela i leka prema patentnom zahtevu l, gde je konjugat antitela i leka ADCS:ADCSgde Ab sadrži anti-DLL3 antitelo.
10.Konjugat antitela i leka prema patentnom zahtevu l, gde ADC je ADCS, i gde ADC ima opterećenje leka koje iznosi 2.
11.Konjugat antitela i leka prema patentnom zahtevu l, gde ADC je ADCS, i gde su PBD l do 8 kovalentno vezani za Ab.
12. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do ll, gde je anti-DLL3 antitelo izabrano iz grupe koja se sastoji od monoklonskog antitela, himemog antitela, CDR graftovanog antitela, humanizovanog antitela, ljudskog antitela, multispecifičnog antitela, bispecifičnog antitela, monovalentnog antitela, multivalentnog antitela, Fah fragmenta, F(ab')2 fragmenta, Fv fragmenta i ScFv fragmenta; ili njihovog imunoreaktivnog fragmenta.
13. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 12, gde se anti-DLL3 antitelo specifično vezuje za epitop unutar DSL domena od DLL3 proteina koji je naveden u SEQ ID NO: l ili 2.
14. Konjugat antitela i leka prema patentnom zahtevu 13, gde se anti-DLL3 antitelo specifično vezuje za epitop koji sadrži aminokiseline 0203, R205 i P206 (SEQ ID NO: 4).
15.Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 14, gde ADC je ADC5 i anti-DLL3 antitelo sadrži ili se nadmeće za vezivanje za ljudski DLL3 protein sa antitelom koji sadrži varijabilni region lakog lanca dat kao SEQ ID NO: 149 i varijabilni region teškoglanca dat kao SEQ ID NO: 151.
16.Konjugat antitela i leka prema patentnom zahtevu 15, gde anti-DLL3 antitelo sadrži triCDR varijabilnog regiona lakog lanca datog kao SEQ ID NO: 149 i tri CDR varijabilnog regiona teškog lanca datog kao SEQ ID NO: 151.
17. Konjugat antitela i leka prema patentnom zahtevu 16, gde anti-DLL3 antitelo sadrži ostatke 24-34 od SEQ ID NO: 149 za CDR-Ll, ostatke 50-56 od SEQ ID NO: 149 za CDR L2, ostatke 89-97 od SEQ ID NO: 149 za CDR-L3, ostatke 31-35 od SEQ ID NO: 151 za CDR-Hl, ostatke 50-65 od SEQ ID NO: 151 za CDR-H2, i ostatke 95-102 od SEQ ID NO:151 za CDR-H3, gde su ostaci numerisani prema Kabatu.
18. Konjugat antitela i leka prema patentnom zahtevu 15, gde anti-DLL3 antitelo sadrži varijabilni region lakog lanca koji sadrži aminokiselinsku sekvencu datu kao SEQ ID NO:405 i varijabilni region teškog lanca koja sadrži aminokiselinsku sekvencu datu kao SEQ ID NO: 407.
19. Farmaceutski sastav koja sadrži (a) konjugat antitela i leka prema bilo kom patentnom zahtevu od l do 18, i (b) farmaceutski prihvatljiv nosač.
20. Farmaceutski sastav prema patentnom zahtevu 19, koji obuhvata odnos leka prema antitelu (DAR) od l, 2, 3, 4, 5, 6, 7 ili 8, svi +/- 0,4.
21. Farmaceutski sastav prema patentnom zahtevu 20, koji obuhvata DAR od 2 +/- 0,4.
22. Farmaceutski sastav prema bilo kom od patentnih zahteva 19 do 21, koji obuhvata manje od 30% nepreovladujućih ADC vrsta.
23. Komplet koji sadrži (a) jedan ili više kontejnera koje sadrže konjugat antitela i leka prema bilo kom patentnih zahteva od l do 18; i (b) oznaku ili uputstvo za upotrebu kojisu na, ilikoji su u vezi sa jednim ili više kontejnera, gde oznaka ili uputstvo za upotrebu ukazuje daje konjugat antitela i leka namenjen za tretman raka.
24. Komplet koji sadrži (a) jedan ili više kontejnera koji sadrži farmaceutski sastav prema bilo kom od patentnih zahteva 19 do 22; i (b) oznaku ili uputstvo za upotrebu koji su na, ili koji su u vezi sa jednim ili više kontejnera, gde oznaka ili uputstvo za upotrebu ukazuje daje konjugat antitela i leka namenjen za tretman raka.
25. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 18, ili farmaceutski sastav prema bilo kom od patentnih zahteva 19 do 22, za upotrebu u tretmanu raka u pacijentu.
26. Konjugat antitela i leka ili farmaceutski sastav za upotrebu prema patentnom zahtevu 25, gde rak obuhvata rak malih ćelija pluća, rak prostate, rak štitne žlezde ili neuroendokrini karcinom velikih ćelija.
27. Konjugat antitela i leka ili farmaceutski sastav za upotrebu prema patentnom zahtevu 2 , gde rak obuhvata rak malih ćelija pluća.
28. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 18, ili farmaceutski sastav prema bilo kom od patentnih zahteva 19 do 22, za upotrebu u smanjenju učestalosti ćelija koje iniciraju tumor kod pacijenta.
29. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 18, ili farmaceutski sastav prema bilo kom od patentnih zahteva 19 do 22, za primenu u isporuci PBD u ćeliju raka.
30. Konjugat antitela i leka prema bilo kom od patentnih zahteva l do 18, ili farmaceutski sastav prema bilo kom patentnom zahtevu od 19 do 22, za upotrebu u terapiji.296
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