|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
USRE38008E1
(en)
|
1986-10-09 |
2003-02-25 |
Neorx Corporation |
Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5191066A
(en)
|
1990-12-07 |
1993-03-02 |
Abbott Laboratories |
Site-specific conjugation of immunoglobulins and detectable labels
|
|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
EP0604580A1
(en)
|
1991-09-19 |
1994-07-06 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
|
|
US6146850A
(en)
|
1991-11-04 |
2000-11-14 |
Xoma Corporation |
Proteins encoding gelonin sequences
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US5981194A
(en)
|
1992-07-10 |
1999-11-09 |
University Of British Columbia |
Use of p97 and iron binding proteins as diagnostic and therapeutic agents
|
|
DE69308573T2
(de)
|
1992-08-17 |
1997-08-07 |
Genentech Inc |
Bispezifische immunoadhesine
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
PT938320E
(pt)
|
1996-03-26 |
2010-09-22 |
Michael S Kopreski |
Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro
|
|
US6753165B1
(en)
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
AU760562B2
(en)
|
1997-12-05 |
2003-05-15 |
Scripps Research Institute, The |
Humanization of murine antibody
|
|
AU2559799A
(en)
|
1998-01-22 |
1999-08-09 |
Genentech Inc. |
Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same
|
|
CA2341471C
(en)
|
1998-08-27 |
2009-04-07 |
Spirogen Limited |
Pyrrolbenzodiazepines
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
JP4414023B2
(ja)
|
1999-08-05 |
2010-02-10 |
オリエンタル酵母工業株式会社 |
関節炎関連メラノトランスフェリンの測定方法および試薬
|
|
EP1285272A2
(en)
|
2000-02-08 |
2003-02-26 |
University of British Columbia |
Compositions and methods for screening therapeutic agents
|
|
KR20020007432A
(ko)
|
2000-07-13 |
2002-01-29 |
박현석 |
멜라노트랜스페린에 대한 단클론 항체를 유효성분으로포함하는 알츠하이머병의 진단시약
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
US6362331B1
(en)
|
2001-03-30 |
2002-03-26 |
Council Of Scientific And Industrial Research |
Process for the preparation of antitumor agents
|
|
EP1256354A1
(en)
|
2001-05-11 |
2002-11-13 |
Schering Corporation |
Methods for treating cancer
|
|
TW200303759A
(en)
|
2001-11-27 |
2003-09-16 |
Schering Corp |
Methods for treating cancer
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
AU2003287345A1
(en)
|
2002-10-31 |
2004-06-07 |
Genentech, Inc. |
Methods and compositions for increasing antibody production
|
|
EP1419786A1
(en)
|
2002-11-13 |
2004-05-19 |
Bracco Imaging S.p.A. |
Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
CA2525243C
(en)
|
2003-05-09 |
2014-05-27 |
Transfert Plus |
Use of melanotransferrin (p97) for regulating plasminogen activation and cell migration
|
|
EP1633784B1
(en)
|
2003-05-09 |
2011-07-13 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
|
GB0315457D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
JP2007504245A
(ja)
|
2003-09-05 |
2007-03-01 |
ジェネンテック・インコーポレーテッド |
変更したエフェクター機能を有する抗体
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
US7807392B1
(en)
|
2003-09-15 |
2010-10-05 |
Celera Corporation |
Lung disease targets and uses thereof
|
|
GB0404577D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
CA2558195C
(en)
|
2004-03-01 |
2012-11-06 |
Spirogen Limited |
11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
|
|
JP4942643B2
(ja)
|
2004-03-02 |
2012-05-30 |
シアトル ジェネティックス, インコーポレイテッド |
部分的に付加された抗体およびそれらの結合体化方法
|
|
US7189710B2
(en)
|
2004-03-30 |
2007-03-13 |
Council Of Scientific And Industrial Research |
C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
|
|
FR2869231B1
(fr)
|
2004-04-27 |
2008-03-14 |
Sod Conseils Rech Applic |
Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
|
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
WO2006065533A2
(en)
|
2004-11-29 |
2006-06-22 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
JP5129122B2
(ja)
|
2005-04-26 |
2013-01-23 |
トリオン ファーマ ゲーエムベーハー |
癌治療のための抗体およびグルココルチコイドの組み合わせ
|
|
WO2006116260A2
(en)
|
2005-04-26 |
2006-11-02 |
Medimmune, Inc. |
Modulation of antibody effector function by hinge domain engineering
|
|
GB0514779D0
(en)
|
2005-07-19 |
2005-08-24 |
Celltech R&D Ltd |
Biological products
|
|
US7521195B1
(en)
|
2005-07-21 |
2009-04-21 |
Celera Corporation |
Lung disease targets and uses thereof
|
|
US20070123448A1
(en)
|
2005-11-23 |
2007-05-31 |
The Hospital For Sick Children |
Novel chemical entities affecting neuroblastoma tumor-initiating cells
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
CL2007001536A1
(es)
|
2006-05-30 |
2008-01-25 |
Genentech Inc |
Anticuerpos anti-cd22; polinucleotidos que los codifica; vector y celula huesped que los comprende; metodo de fabricacion; metodo de deteccion del anticuerpo en una muestra biologica; inmunoconjugado que comprende al anticuerpo; composicion que lo comprende y su uso para tratar trastornos proliferativos de celulas b.
|
|
CA2658003A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
US20080220448A1
(en)
|
2006-09-01 |
2008-09-11 |
Blincko Stuart J |
Antigenic protein conjugates and process for preparing same
|
|
PL3207941T6
(pl)
|
2006-09-07 |
2020-11-16 |
Scott & White Memorial Hospital |
Sposoby i kompozycje oparte na koniugacie ludzkiej interleukiny (IL)-3 z toksyną błoniczą
|
|
GB0619291D0
(en)
|
2006-09-29 |
2006-11-08 |
Ucb Sa |
Altered antibodies
|
|
US8309354B2
(en)
|
2007-01-22 |
2012-11-13 |
Macrogenics West, Inc. |
Human cancer stem cells
|
|
AR066476A1
(es)
|
2007-05-08 |
2009-08-19 |
Genentech Inc |
Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos
|
|
EP2022848A1
(en)
|
2007-08-10 |
2009-02-11 |
Hubrecht Institut |
A method for identifying, expanding, and removing adult stem cells and cancer stem cells
|
|
EP2185188B1
(en)
|
2007-08-22 |
2014-08-06 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
|
|
US20090130105A1
(en)
|
2007-08-28 |
2009-05-21 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
MX2010002683A
(es)
|
2007-09-14 |
2010-03-26 |
Amgen Inc |
Poblaciones de anticuerpos homogeneos.
|
|
US20090155255A1
(en)
|
2007-09-27 |
2009-06-18 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
|
BRPI0907046A2
(pt)
|
2008-01-18 |
2015-07-28 |
Medimmune Llc |
Anticorpo de cisteína engenheirada, ácido nucleico isolado, vetor, célula hospedeira, conjugado de anticorpo, composição farmacêutica, métodos de detecção de câncer, doenças ou distúrbios autoimunes, inflamatórios ou infecciosos em um indivíduo e de inibição de proliferação de uma célula alvo
|
|
WO2010037134A2
(en)
|
2008-09-29 |
2010-04-01 |
Stemlifeline, Inc. |
Multi-stage stem cell carcinogenesis
|
|
JP5787446B2
(ja)
|
2009-03-19 |
2015-09-30 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
EA201290804A1
(ru)
|
2010-02-21 |
2013-03-29 |
БАЙЕР ХелсКер ЛЛСи |
Способ активации и сопряжения биомолекул
|
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
KR101772354B1
(ko)
*
|
2010-04-15 |
2017-08-28 |
시애틀 지네틱스, 인크. |
표적화된 피롤로벤조디아제핀 접합체
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
ES2623057T3
(es)
|
2010-04-15 |
2017-07-10 |
Medimmune Limited |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
|
|
WO2011130598A1
(en)
|
2010-04-15 |
2011-10-20 |
Spirogen Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
MX336540B
(es)
|
2010-06-08 |
2016-01-22 |
Genentech Inc |
Conjugados y anticuerpos manipulados geneticamente con cisteina.
|
|
WO2013119964A2
(en)
|
2012-02-08 |
2013-08-15 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US20130061342A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
CN106434561A
(zh)
|
2010-09-03 |
2017-02-22 |
艾伯维施特姆森特克斯有限责任公司 |
细胞亚群的鉴定和富集
|
|
US9778264B2
(en)
|
2010-09-03 |
2017-10-03 |
Abbvie Stemcentrx Llc |
Identification and enrichment of cell subpopulations
|
|
US20130061340A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
CN103221419B
(zh)
|
2010-09-17 |
2015-12-09 |
独立行政法人产业技术综合研究所 |
肺癌鉴定标志物
|
|
WO2012064733A2
(en)
|
2010-11-09 |
2012-05-18 |
Medimmune, Llc |
Antibody scaffold for homogenous conjugation
|
|
US20130259806A1
(en)
|
2010-12-09 |
2013-10-03 |
David Light |
Dimeric molecular complexes with free cysteine residues and conjugates thereof
|
|
BR112013021460B1
(pt)
|
2011-03-02 |
2022-12-20 |
Roche Glycart Ag |
Anticorpos, composição e uso do anticorpo
|
|
AU2012278944B2
(en)
|
2011-07-05 |
2015-09-17 |
Bioasis Technologies Inc. |
p97-antibody conjugates and methods of use
|
|
EP2739649B1
(en)
|
2011-08-05 |
2017-09-27 |
Bioasis Technologies Inc. |
P97 fragments with transfer activity
|
|
CA2852594A1
(en)
|
2011-10-19 |
2013-04-25 |
Theratechnologies Inc. |
Peptide compounds derived from melanotransferrin and uses thereof
|
|
KR20110136776A
(ko)
*
|
2011-12-12 |
2011-12-21 |
경북대학교 산학협력단 |
당뇨병성 신증 진단용 바이오마커 및 이의 동정방법
|
|
HRP20201004T1
(hr)
|
2011-12-20 |
2020-10-16 |
Medimmune, Llc |
Modificirani polipeptidi za skelete bispecifičnog protutijela
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
KR102099073B1
(ko)
*
|
2012-02-24 |
2020-04-10 |
애브비 스템센트알엑스 엘엘씨 |
항 sez6 항체들 및 사용 방법
|
|
CN104379602B
(zh)
*
|
2012-03-08 |
2017-05-03 |
哈洛齐梅公司 |
具有条件活性的抗表皮生长因子受体抗体及其使用方法
|
|
EP2834259A4
(en)
|
2012-04-02 |
2016-08-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
|
CN107459508A
(zh)
*
|
2012-07-20 |
2017-12-12 |
克里弗生物科学公司 |
作为p97复合物的抑制剂的稠合嘧啶
|
|
EP2905290B1
(en)
|
2012-10-05 |
2019-12-04 |
Kyowa Kirin Co., Ltd. |
Heterodimeric protein composition
|
|
HRP20190366T1
(hr)
|
2012-10-12 |
2019-04-19 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
KR101645905B1
(ko)
|
2012-10-12 |
2016-08-04 |
스피로즌 살 |
피롤로벤조디아제핀 및 그의 컨주게이트
|
|
BR112015018899B1
(pt)
|
2013-02-08 |
2023-09-26 |
Novartis Ag |
Imunoconjugados, composição farmacêutica, anticorpos igg modificados ou fragmentos de anticorpo modificados dos mesmos e seu método de produção, e célula hospedeira
|
|
RU2019109456A
(ru)
|
2013-02-22 |
2019-04-10 |
ЭББВИ СТЕМСЕНТРКС ЭлЭлСи |
Новые конъюгаты антител и их применения
|
|
JP6586412B2
(ja)
|
2013-03-13 |
2019-10-02 |
バイオアシス テクノロジーズ インコーポレイテッド |
p97のフラグメントおよびその使用
|
|
BR112015030514A2
(pt)
|
2013-06-04 |
2017-08-29 |
Cytomx Therapeutics Inc |
Composições e métodos para conjugação de anticorpos ativáveis
|
|
CN105431524B
(zh)
|
2013-06-10 |
2020-04-21 |
达娜-法勃肿瘤研究所公司 |
用于降低肿瘤细胞的免疫抑制的方法和组合物
|
|
CA2938626A1
(en)
|
2013-07-26 |
2015-01-29 |
John Rothman |
Compositions to improve the therapeutic benefit of bisantrene
|
|
US20150093399A1
(en)
|
2013-08-28 |
2015-04-02 |
Bioasis Technologies, Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
WO2015031698A1
(en)
|
2013-08-28 |
2015-03-05 |
Stem Centrx, Inc. |
Site-specific antibody conjugation methods and compositions
|
|
JP6623353B2
(ja)
|
2013-09-13 |
2019-12-25 |
ベイジーン スウィッツァーランド ゲーエムベーハー |
抗pd−1抗体並びにその治療及び診断のための使用
|
|
JP6713931B2
(ja)
|
2014-02-11 |
2020-06-24 |
シアトル ジェネティクス,インコーポレイティド |
タンパク質の選択的還元
|
|
KR20170008202A
(ko)
|
2014-02-21 |
2017-01-23 |
애브비 스템센트알엑스 엘엘씨 |
흑색종에 사용하기 위한 항-dll3 항체 및 약물 접합체
|
|
EP3209334A2
(en)
|
2014-10-20 |
2017-08-30 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions, and methods of use
|