JP2016531915A5 - - Google Patents

Info

Publication number

JP2016531915A5

JP2016531915A5 JP2016537871A JP2016537871A JP2016531915A5 JP 2016531915 A5 JP2016531915 A5 JP 2016531915A5 JP 2016537871 A JP2016537871 A JP 2016537871A JP 2016537871 A JP2016537871 A JP 2016537871A JP 2016531915 A5 JP2016531915 A5 JP 2016531915A5

Authority

JP

Japan

Prior art keywords

seq

residues

amino acid

cdr

acid sequence

Prior art date

2014-08-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001413 amino acids Chemical group 0.000 claims 59
• 239000000611 antibody drug conjugate Substances 0.000 claims 29
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 29
• 229940127089 cytotoxic agent Drugs 0.000 claims 28
• 239000002254 cytotoxic agent Substances 0.000 claims 28
• 231100000599 cytotoxic agent Toxicity 0.000 claims 28
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 27
• 238000000034 method Methods 0.000 claims 17
• 239000008194 pharmaceutical composition Substances 0.000 claims 17
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 13
• 101000864751 Homo sapiens Seizure protein 6 homolog Proteins 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 12
• 102100030057 Seizure protein 6 homolog Human genes 0.000 claims 12
• 201000011510 cancer Diseases 0.000 claims 12
• 239000003814 drug Substances 0.000 claims 8
• 229940079593 drug Drugs 0.000 claims 5
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 4
• 229930195731 calicheamicin Natural products 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 3
• 239000003381 stabilizer Substances 0.000 claims 3
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
• 108010027164 Amanitins Proteins 0.000 claims 1
• 235000019766 L-Lysine Nutrition 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
• 229930064664 L-arginine Natural products 0.000 claims 1
• 235000014852 L-arginine Nutrition 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• 208000009018 Medullary thyroid cancer Diseases 0.000 claims 1
• 206010041067 Small cell lung cancer Diseases 0.000 claims 1
• CIORWBWIBBPXCG-JZTFPUPKSA-N amanitin Chemical compound O=C1N[C@@H](CC(N)=O)C(=O)N2CC(O)C[C@H]2C(=O)N[C@@H](C(C)[C@@H](O)CO)C(=O)N[C@@H](C2)C(=O)NCC(=O)N[C@@H](C(C)CC)C(=O)NCC(=O)N[C@H]1CS(=O)C1=C2C2=CC=C(O)C=C2N1 CIORWBWIBBPXCG-JZTFPUPKSA-N 0.000 claims 1
• 150000001412 amines Chemical group 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 230000001268 conjugating effect Effects 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 1
• 229960005501 duocarmycin Drugs 0.000 claims 1
• 229930184221 duocarmycin Natural products 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• -1 maytansinoid Chemical compound 0.000 claims 1
• 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 1
• 229910052697 platinum Inorganic materials 0.000 claims 1
• 238000004237 preparative chromatography Methods 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1