JP2017500028A5 - - Google Patents
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- Publication number
- JP2017500028A5 JP2017500028A5 JP2016538019A JP2016538019A JP2017500028A5 JP 2017500028 A5 JP2017500028 A5 JP 2017500028A5 JP 2016538019 A JP2016538019 A JP 2016538019A JP 2016538019 A JP2016538019 A JP 2016538019A JP 2017500028 A5 JP2017500028 A5 JP 2017500028A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- region shown
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical group C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 34
- 239000000611 antibody drug conjugate Substances 0.000 claims 33
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 33
- 229940127089 cytotoxic agent Drugs 0.000 claims 26
- 239000002254 cytotoxic agent Substances 0.000 claims 26
- 231100000599 cytotoxic agent Toxicity 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 230000003796 beauty Effects 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 101000864130 Homo sapiens Dipeptidase 3 Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 102100029857 Dipeptidase 3 Human genes 0.000 claims 5
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 239000000562 conjugate Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
- 229930195731 calicheamicin Natural products 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 230000002611 ovarian Effects 0.000 claims 2
- 208000012988 ovarian serous adenocarcinoma Diseases 0.000 claims 2
- 201000003709 ovarian serous carcinoma Diseases 0.000 claims 2
- 201000010198 papillary carcinoma Diseases 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 102000053267 human DPEP3 Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915321P | 2013-12-12 | 2013-12-12 | |
| US61/915,321 | 2013-12-12 | ||
| PCT/US2014/070110 WO2015089449A2 (en) | 2013-12-12 | 2014-12-12 | Novel anti-dpep3 antibodies and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017500028A JP2017500028A (ja) | 2017-01-05 |
| JP2017500028A5 true JP2017500028A5 (enExample) | 2018-04-19 |
Family
ID=53371972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538019A Pending JP2017500028A (ja) | 2013-12-12 | 2014-12-12 | 新規の抗ｄｐｅｐ３抗体および使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10189910B2 (enExample) |
| EP (1) | EP3080607A4 (enExample) |
| JP (1) | JP2017500028A (enExample) |
| KR (1) | KR20160097336A (enExample) |
| CN (2) | CN106104273A (enExample) |
| AU (1) | AU2014361856A1 (enExample) |
| BR (1) | BR112016013048A2 (enExample) |
| CA (1) | CA2932476A1 (enExample) |
| CL (1) | CL2016001432A1 (enExample) |
| IL (1) | IL245946A0 (enExample) |
| MX (1) | MX2016007369A (enExample) |
| PE (1) | PE20160993A1 (enExample) |
| PH (1) | PH12016501109A1 (enExample) |
| SG (1) | SG11201604664PA (enExample) |
| WO (1) | WO2015089449A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102553870B1 (ko) | 2014-03-27 | 2023-07-10 | 버드 락 바이오, 인크. | 인간 카나비노이드 1(cb1) 수용체 결합 항체 |
| CN108025084B (zh) | 2015-06-22 | 2024-08-09 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
| CA2990398A1 (en) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates of kinesin spindel protein (ksp) inhibitors with anti-cd123-antibodies |
| HK1252696A1 (zh) * | 2015-08-28 | 2019-05-31 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| IL300015A (en) * | 2015-09-30 | 2023-03-01 | Bird Rock Bio Inc | Antibodies that bind human cannabinoid receptor 1 |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| WO2018005904A2 (en) * | 2016-07-01 | 2018-01-04 | Ludwig Institute For Cancer Research Ltd | Methods and compositions for pdgf-cc inhibition |
| US10415080B2 (en) | 2016-11-21 | 2019-09-17 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
| WO2018107109A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Novel anti-kremen2 antibodies and methods of use |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| WO2018114578A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
| WO2018148595A1 (en) * | 2017-02-10 | 2018-08-16 | Washington University | Antibodies to tip1 and methods of use thereof |
| JP7140103B2 (ja) * | 2017-03-10 | 2022-09-21 | コニカミノルタ株式会社 | 治療有効性の予測方法 |
| WO2018213680A1 (en) * | 2017-05-19 | 2018-11-22 | Abbvie Stemcentrx Llc | Diagnostic antibodies and methods of use |
| AU2018282094B2 (en) | 2017-06-05 | 2024-06-27 | Janssen Biotech, Inc. | Antibodies that specifically bind PD-1 and methods of use |
| EP3760641A4 (en) * | 2018-02-27 | 2021-11-24 | Eisai R&D Management Co., Ltd. | MONOCLONAL ANTIBODIES AGAINST APOA4, IMMUNOASSAY AND KIT FOR MEASUREMENT |
| AU2019271028B2 (en) | 2018-05-14 | 2025-09-18 | Bruker Spatial Biology, Inc. | Chemical compositions and methods of using same |
| CN112512638B (zh) | 2018-06-08 | 2025-01-28 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| CN113517029A (zh) * | 2020-08-07 | 2021-10-19 | 广东省计划生育科学技术研究所（广东省计划生育专科医院） | 一种调控dpep3提高精液质量的方法 |
| JP7621481B2 (ja) * | 2020-11-13 | 2025-01-24 | アイバイオ， インク． | Ｃｄ２５抗体 |
| WO2023028451A2 (en) * | 2021-08-25 | 2023-03-02 | Ibio, Inc. | Anti-cd-25 antibody |
| EP4526351A2 (en) * | 2022-05-16 | 2025-03-26 | City of Hope | Anti-cd84 antibodies and uses thereof |
| CN116693672B (zh) * | 2023-06-15 | 2025-08-08 | 郑州伊美诺生物技术有限公司 | 抗3型人副流感病毒单克隆抗体及其制备方法和应用 |
| CN119306830B (zh) * | 2023-07-11 | 2025-06-20 | 东莞市朋志生物科技有限公司 | 抗皮质醇抗体、检测皮质醇的试剂和试剂盒 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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| US6362331B1 (en) | 2001-03-30 | 2002-03-26 | Council Of Scientific And Industrial Research | Process for the preparation of antitumor agents |
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| CN111187348A (zh) | 2014-02-11 | 2020-05-22 | 西雅图基因公司 | 蛋白质的选择性还原 |
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-
2014
- 2014-12-12 AU AU2014361856A patent/AU2014361856A1/en not_active Abandoned
- 2014-12-12 CA CA2932476A patent/CA2932476A1/en not_active Abandoned
- 2014-12-12 JP JP2016538019A patent/JP2017500028A/ja active Pending
- 2014-12-12 SG SG11201604664PA patent/SG11201604664PA/en unknown
- 2014-12-12 EP EP14870395.2A patent/EP3080607A4/en not_active Withdrawn
- 2014-12-12 MX MX2016007369A patent/MX2016007369A/es unknown
- 2014-12-12 WO PCT/US2014/070110 patent/WO2015089449A2/en not_active Ceased
- 2014-12-12 CN CN201480073038.XA patent/CN106104273A/zh active Pending
- 2014-12-12 BR BR112016013048A patent/BR112016013048A2/pt not_active Application Discontinuation
- 2014-12-12 PE PE2016000784A patent/PE20160993A1/es unknown
- 2014-12-12 KR KR1020167018641A patent/KR20160097336A/ko not_active Withdrawn
- 2014-12-12 CN CN201811271990.7A patent/CN109575136A/zh active Pending
-
2016
- 2016-05-31 IL IL245946A patent/IL245946A0/en unknown
- 2016-06-10 CL CL2016001432A patent/CL2016001432A1/es unknown
- 2016-06-10 PH PH12016501109A patent/PH12016501109A1/en unknown
- 2016-06-13 US US15/181,353 patent/US10189910B2/en not_active Expired - Fee Related
- 2016-10-21 US US15/331,282 patent/US9777071B2/en not_active Expired - Fee Related
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