JP2018127469A5 - - Google Patents
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- JP2018127469A5 JP2018127469A5 JP2018052506A JP2018052506A JP2018127469A5 JP 2018127469 A5 JP2018127469 A5 JP 2018127469A5 JP 2018052506 A JP2018052506 A JP 2018052506A JP 2018052506 A JP2018052506 A JP 2018052506A JP 2018127469 A5 JP2018127469 A5 JP 2018127469A5
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- heavy chain
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- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000000611 antibody drug conjugate Substances 0.000 claims 11
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 239000002254 cytotoxic agent Substances 0.000 claims 6
- 231100000599 cytotoxic agent Toxicity 0.000 claims 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
- 201000005202 lung cancer Diseases 0.000 claims 5
- 208000020816 lung neoplasm Diseases 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108010027164 Amanitins Proteins 0.000 claims 2
- 101100477420 Homo sapiens SEZ6 gene Proteins 0.000 claims 2
- CIORWBWIBBPXCG-JZTFPUPKSA-N amanitin Chemical compound O=C1N[C@@H](CC(N)=O)C(=O)N2CC(O)C[C@H]2C(=O)N[C@@H](C(C)[C@@H](O)CO)C(=O)N[C@@H](C2)C(=O)NCC(=O)N[C@@H](C(C)CC)C(=O)NCC(=O)N[C@H]1CS(=O)C1=C2C2=CC=C(O)C=C2N1 CIORWBWIBBPXCG-JZTFPUPKSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
- 229930195731 calicheamicin Natural products 0.000 claims 2
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 2
- 229960005501 duocarmycin Drugs 0.000 claims 2
- 229930184221 duocarmycin Natural products 0.000 claims 2
- 229940127121 immunoconjugate Drugs 0.000 claims 2
- -1 maytansinoid Chemical compound 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 210000005102 tumor initiating cell Anatomy 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 101000864751 Homo sapiens Seizure protein 6 homolog Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 102100030057 Seizure protein 6 homolog Human genes 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603203P | 2012-02-24 | 2012-02-24 | |
| US61/603,203 | 2012-02-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558901A Division JP6401060B2 (ja) | 2012-02-24 | 2013-02-22 | 抗ｓｅｚ６抗体及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018127469A JP2018127469A (ja) | 2018-08-16 |
| JP2018127469A5 true JP2018127469A5 (enExample) | 2018-09-27 |
Family
ID=47790548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558901A Expired - Fee Related JP6401060B2 (ja) | 2012-02-24 | 2013-02-22 | 抗ｓｅｚ６抗体及び使用方法 |
| JP2018052506A Pending JP2018127469A (ja) | 2012-02-24 | 2018-03-20 | 抗ｓｅｚ６抗体及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558901A Expired - Fee Related JP6401060B2 (ja) | 2012-02-24 | 2013-02-22 | 抗ｓｅｚ６抗体及び使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9676850B2 (enExample) |
| EP (2) | EP2817339B1 (enExample) |
| JP (2) | JP6401060B2 (enExample) |
| KR (1) | KR102099073B1 (enExample) |
| CN (2) | CN108383909B (enExample) |
| AU (3) | AU2013203506B2 (enExample) |
| CA (1) | CA2865415C (enExample) |
| CL (2) | CL2014002237A1 (enExample) |
| CO (1) | CO7151485A2 (enExample) |
| ES (1) | ES2741936T3 (enExample) |
| IL (1) | IL234208B (enExample) |
| MX (2) | MX373141B (enExample) |
| MY (1) | MY178120A (enExample) |
| NZ (1) | NZ631197A (enExample) |
| PE (1) | PE20150091A1 (enExample) |
| PH (2) | PH12020500604A1 (enExample) |
| RU (1) | RU2691698C2 (enExample) |
| SG (2) | SG10201801444WA (enExample) |
| WO (1) | WO2013126810A1 (enExample) |
| ZA (1) | ZA201406967B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108383909B (zh) * | 2012-02-24 | 2021-08-24 | 艾伯维施特姆森特克斯有限责任公司 | 抗sez6抗体及使用方法 |
| US11531028B2 (en) * | 2013-05-10 | 2022-12-20 | Nordic Bioscience A/S | Collagen type X alpha-1 assay |
| RU2016111139A (ru) | 2013-08-28 | 2017-10-03 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые модуляторы sez6 и способы их применения |
| KR20160044042A (ko) * | 2013-08-28 | 2016-04-22 | 스템센트알엑스 인코포레이티드 | 부위-특이적 항체 접합 방법 및 조성물 |
| PE20161413A1 (es) * | 2013-11-04 | 2017-01-10 | Stemcentrx Inc | Conjugados de anticuerpo anti-efna4-farmaco |
| WO2015084262A2 (en) * | 2013-12-03 | 2015-06-11 | Agency For Science, Technology And Research | Cytotoxic antibody |
| EP3101131B1 (en) * | 2014-01-29 | 2020-08-19 | KM Biologics Co., Ltd. | Anti-transthyretin humanized antibody |
| KR102240417B1 (ko) | 2014-01-29 | 2021-04-13 | 케이엠 바이올로직스 가부시키가이샤 | 항-트랜스티레틴 인간 항체 |
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| AU2017344411A1 (en) * | 2016-10-19 | 2019-05-09 | Novelogics Biotechnology, Inc. | Antibodies to MICA and MICB proteins |
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| EP3559043A4 (en) * | 2016-12-23 | 2020-08-05 | Bluefin Biomedicine, Inc. | ANTI-SEZ6L2 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES |
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| US11795230B2 (en) | 2018-04-13 | 2023-10-24 | Dingfu Biotarget Co., Ltd. | Anti-CD27 antibodies and use thereof |
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