SG10201801444WA - Anti sez6 antibodies and methods of use - Google Patents

Anti sez6 antibodies and methods of use

Info

Publication number
SG10201801444WA
SG10201801444WA SG10201801444WA SG10201801444WA SG10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA
Authority
SG
Singapore
Prior art keywords
methods
sez6 antibodies
anti sez6
antibodies
sez6
Prior art date
Application number
SG10201801444WA
Inventor
Laura Saunders
Scott Dylla
Orit Foord
Robert Stull
Michael Torgov
Hui Shao
David Liu
Original Assignee
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Stemcentrx Llc filed Critical Abbvie Stemcentrx Llc
Publication of SG10201801444WA publication Critical patent/SG10201801444WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SG10201801444WA 2012-02-24 2013-02-22 Anti sez6 antibodies and methods of use SG10201801444WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261603203P 2012-02-24 2012-02-24

Publications (1)

Publication Number Publication Date
SG10201801444WA true SG10201801444WA (en) 2018-04-27

Family

ID=47790548

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201405130UA SG11201405130UA (en) 2012-02-24 2013-02-22 Anti sez6 antibodies and methods of use
SG10201801444WA SG10201801444WA (en) 2012-02-24 2013-02-22 Anti sez6 antibodies and methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201405130UA SG11201405130UA (en) 2012-02-24 2013-02-22 Anti sez6 antibodies and methods of use

Country Status (21)

Country Link
US (3) US9676850B2 (en)
EP (2) EP3539985A1 (en)
JP (2) JP6401060B2 (en)
KR (1) KR102099073B1 (en)
CN (2) CN108383909B (en)
AU (3) AU2013203506B2 (en)
CA (1) CA2865415C (en)
CL (2) CL2014002237A1 (en)
CO (1) CO7151485A2 (en)
ES (1) ES2741936T3 (en)
HK (1) HK1205517A1 (en)
IL (1) IL234208B (en)
MX (2) MX2014010094A (en)
MY (1) MY178120A (en)
NZ (1) NZ631197A (en)
PE (1) PE20150091A1 (en)
PH (1) PH12014501914B1 (en)
RU (1) RU2691698C2 (en)
SG (2) SG11201405130UA (en)
WO (1) WO2013126810A1 (en)
ZA (1) ZA201406967B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3539985A1 (en) * 2012-02-24 2019-09-18 AbbVie Stemcentrx LLC Anti sez6 antibodies and methods of use
US11531028B2 (en) * 2013-05-10 2022-12-20 Nordic Bioscience A/S Collagen type X alpha-1 assay
SG11201601416VA (en) * 2013-08-28 2016-03-30 Stemcentrx Inc Novel sez6 modulators and methods of use
AU2014312215B2 (en) * 2013-08-28 2020-02-27 Abbvie Stemcentrx Llc Site-specific antibody conjugation methods and compositions
EP3065780A1 (en) 2013-11-04 2016-09-14 Pfizer Inc. Anti-efna4 antibody-drug conjugates
WO2015084262A2 (en) * 2013-12-03 2015-06-11 Agency For Science, Technology And Research Cytotoxic antibody
JP6818268B2 (en) * 2014-01-29 2021-01-20 Kmバイオロジクス株式会社 Anti-transthyretin humanized antibody
WO2015115332A1 (en) 2014-01-29 2015-08-06 一般財団法人化学及血清療法研究所 Anti-transthyretin human antibody
EP3107576A4 (en) 2014-02-21 2017-09-06 Abbvie Stemcentrx LLC Anti-dll3 antibodies and drug conjugates for use in melanoma
AU2015280436A1 (en) 2014-06-23 2017-02-02 Bionomics, Inc. Antibodies that bind LGR4
TW201617368A (en) 2014-09-05 2016-05-16 史坦森特瑞斯公司 Novel anti-MFI2 antibodies and methods of use
WO2016057683A2 (en) 2014-10-07 2016-04-14 Ann And Robert H. Lurie Children's Hospital Of Chicago Novel anti-nodal antibodies and methods of using same
JP2018529656A (en) * 2015-08-20 2018-10-11 アッヴィ・ステムセントルクス・エル・エル・シー Anti-DLL3 antibody drug conjugates and methods of use
EP3955021B1 (en) 2015-10-06 2024-08-14 Pioneer Corporation Light control device, light control method and program
WO2017087547A1 (en) * 2015-11-17 2017-05-26 Oncomed Pharmaceuticals, Inc. Pd-l1-binding agents and uses thereof
TWI752012B (en) 2016-03-04 2022-01-11 美商Jn生物科學有限責任公司 Antibodies to tigit
EP3525814A4 (en) 2016-10-14 2020-09-23 Nima Labs, Inc. Anti-gliadin antibodies
AU2017344411A1 (en) * 2016-10-19 2019-05-09 Novelogics Biotechnology, Inc. Antibodies to MICA and MICB proteins
WO2018107116A1 (en) * 2016-12-09 2018-06-14 Abbvie Stemcentrx Llc Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby
CA3048224A1 (en) * 2016-12-23 2018-06-28 Bluefin Biomedicine, Inc. Anti-sez6l2 antibodies and antibody drug conjugates
EP3424528A1 (en) 2017-07-07 2019-01-09 AVA Lifescience GmbH Biologic binding molecules
EP3774898A4 (en) 2018-04-13 2022-01-26 Dingfu Biotarget Co., Ltd. Anti-cd27 antibodies and use thereof
HUE053616T2 (en) 2018-05-30 2021-07-28 Abbvie Stemcentrx Llc Anti-sez6 antibody drug conjugates and methods of use
WO2020013644A1 (en) * 2018-07-11 2020-01-16 고려대학교 산학협력단 Epitope specific to smo protein, antibody recognizing same, and composition comprising same
KR20210049792A (en) * 2018-08-24 2021-05-06 지앙수 헨그루이 메디슨 컴퍼니 리미티드 Human IL-4R binding antibody, antigen binding fragment thereof, and medical use thereof
AU2021284273A1 (en) 2020-06-02 2022-12-15 Arcus Biosciences, Inc. Antibodies to TIGIT
CN114106176B (en) * 2020-09-01 2024-04-09 深圳市菲鹏生物治疗股份有限公司 CD22 antibody and application thereof
US20230287090A1 (en) * 2020-09-02 2023-09-14 The Feinstein Institutes For Medical Research USE OF SARS-CoV-2 RECEPTOR BINDING MOTIF (RBM)-REACTIVE MONOCLONAL ANTIBODIES TO TREAT COVID-19
CA3198996A1 (en) 2020-11-24 2022-06-02 Matthew T. Burger Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
CN114790241A (en) * 2021-01-26 2022-07-26 北京免疫方舟医药科技有限公司 anti-TIGIT antibody and application thereof
CN113307875B (en) * 2021-06-10 2022-09-02 福州迈新生物技术开发有限公司 Monoclonal antibody for resisting TCR beta F1 protein, cell strain, preparation method and application thereof
WO2023019174A2 (en) * 2021-08-11 2023-02-16 Apollos Diagnostics, Llc Antibodies to sars-cov-2
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
WO2023223097A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody drug conjugates
CN115975036B (en) * 2022-08-18 2023-06-09 北京诺赛国际医学研究院 Pharmaceutical composition comprising stem cells and use thereof for treating cancer
CN117736331B (en) * 2024-02-04 2024-05-07 南昌大学第一附属医院 Monoclonal antibody specifically binding to extracellular segment of PSMA and application thereof

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3101690B2 (en) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド Modifications of or for denatured antibodies
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
KR900005995A (en) 1988-10-31 1990-05-07 우메모또 요시마사 Modified Interleukin-2 and Method of Making the Same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5112946A (en) 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
WO1991006570A1 (en) 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
ES2096749T3 (en) 1990-12-14 1997-03-16 Cell Genesys Inc CHEMICAL CHAINS FOR SIGNAL TRANSDUCTION ROADS ASSOCIATED WITH A RECEIVER.
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
ATE196606T1 (en) 1992-11-13 2000-10-15 Idec Pharma Corp THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES DIRECTED AGAINST A DIFFERENTIATION ANTIGEN WHICH EXPRESSION IS RESTRICTED TO HUMAN B LYMPHOCYTES, FOR THE TREATMENT OF B-CELL LYMPHOMA
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
CN1117155C (en) 1994-07-29 2003-08-06 史密丝克莱恩比彻姆有限公司 Novel compounds
DE69833755T2 (en) 1997-05-21 2006-12-28 Biovation Ltd. METHOD FOR PRODUCING NON-IMMUNOGENOUS PROTEINS
DK1034298T3 (en) 1997-12-05 2012-01-30 Scripps Research Inst Humanization of murine antibody
ES2244210T3 (en) 1998-08-27 2005-12-01 Spirogen Limited PIRROLOBENZODIAZEPINAS.
JP2002534959A (en) 1998-12-08 2002-10-22 バイオベーション リミテッド Methods for modifying immunogenic proteins
US20040067490A1 (en) * 2001-09-07 2004-04-08 Mei Zhong Therapeutic polypeptides, nucleic acids encoding same, and methods of use
AU2001256977A1 (en) * 2000-04-28 2001-11-12 Eli Lilly And Company Human sez6 nucleic acids and polypeptides
US7608704B2 (en) 2000-11-08 2009-10-27 Incyte Corporation Secreted proteins
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
US20030211991A1 (en) 2001-04-17 2003-11-13 Su Eric Wen Human sez6 nucleic acids and polypeptides
CN1343774A (en) 2001-05-28 2002-04-10 复旦大学 Coding sequence of epilepsia associated protein, polypeptide coded by it, and its preparing process and application
US20040001835A1 (en) 2002-03-04 2004-01-01 Medimmune, Inc. Prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
WO2004072266A2 (en) 2003-02-13 2004-08-26 Kalobios Inc. Antibody affinity engineering by serial epitope-guided complementarity replacement
EP1633784B1 (en) 2003-05-09 2011-07-13 Diadexus, Inc. Ovr110 antibody compositions and methods of use
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
BR122018071808B8 (en) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugate
SI2270010T1 (en) 2004-03-01 2012-05-31 Spirogen Ltd 11-hydroxy-5h-pyrrolo?á2,1-c?å?á1,4?åbenzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
US7189710B2 (en) 2004-03-30 2007-03-13 Council Of Scientific And Industrial Research C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
FR2869231B1 (en) 2004-04-27 2008-03-14 Sod Conseils Rech Applic THERAPEUTIC COMPOSITION CONTAINING AT LEAST ONE PYRROLOBENZODIAZEPINE DERIVATIVE AND FLUDARABINE
NZ553500A (en) 2004-09-23 2009-11-27 Genentech Inc Genentech Inc Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain
US20070123448A1 (en) 2005-11-23 2007-05-31 The Hospital For Sick Children Novel chemical entities affecting neuroblastoma tumor-initiating cells
RS52060B (en) 2006-01-25 2012-04-30 Sanofi Cytotoxic agents comprising new tomaymycin derivatives
EP2032694A4 (en) 2006-06-06 2010-09-15 Univ Tennessee Res Foundation Compositions enriched in neoplastic stem cells and methods comprising same
CA2652703C (en) 2006-06-07 2018-08-28 Bioalliance C.V. Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
CA3007075C (en) 2006-09-07 2019-10-15 Arthur E. Frankel Methods and compositions based on diphtheria toxin-interleukin-3 conjugates
JP2010516259A (en) 2007-01-22 2010-05-20 レイベン バイオテクノロジーズ Human cancer stem cells
NZ600758A (en) * 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
US9289492B2 (en) 2007-07-17 2016-03-22 The General Hospital Corporation Collecting ovarian cancer stem cells from ovarian cancer cells
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
WO2009043051A2 (en) 2007-09-27 2009-04-02 Biogen Idec Ma Inc. Cd23 binding molecules and methods of use thereof
EP2244729B1 (en) 2008-01-18 2016-11-02 MedImmune, LLC Cysteine engineered antibodies for site-specific conjugation
EP2282769A4 (en) 2008-04-29 2012-04-25 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US20100162416A1 (en) 2008-09-29 2010-06-24 Stemlifeline, Inc. Multi-stage stem cell carcinogenesis
US8788213B2 (en) 2009-01-12 2014-07-22 Intrexon Corporation Laser mediated sectioning and transfer of cell colonies
US20110020221A1 (en) 2009-04-09 2011-01-27 The Johns Hopkins University Cancer stem cell expression patterns and compounds to target cancer stem cells
SG178602A1 (en) 2009-09-01 2012-04-27 Abbott Lab Dual variable domain immunoglobulins and uses thereof
EP3620467A1 (en) * 2010-03-12 2020-03-11 Debiopharm International SA Cd37-binding molecules and immunoconjugates thereof
KR101671360B1 (en) 2010-04-15 2016-11-01 시애틀 지네틱스, 인크. Targeted pyrrolobenzodiazepine conjugates
WO2011130616A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines used to treat proliferative diseases
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
JP5972864B2 (en) 2010-04-15 2016-08-17 メディミューン リミテッド Pyrrolobenzodiazepines and their conjugates
US20120100560A1 (en) 2010-07-23 2012-04-26 The Johns Hopkins University Device for capture, enumeration, and profiling of circulating tumor cells
WO2012019060A1 (en) * 2010-08-05 2012-02-09 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications
EP2689787A1 (en) 2010-09-03 2014-01-29 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
US20130061340A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc. Identification and Enrichment of Cell Subpopulations
WO2013119964A2 (en) 2012-02-08 2013-08-15 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
US20130061342A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc. Identification and Enrichment of Cell Subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
ES2874306T3 (en) 2010-09-29 2021-11-04 Agensys Inc Conjugates of antibodies and drugs (CAF) that bind to 191P4D12 proteins
EP3539985A1 (en) * 2012-02-24 2019-09-18 AbbVie Stemcentrx LLC Anti sez6 antibodies and methods of use
AU2014312215B2 (en) * 2013-08-28 2020-02-27 Abbvie Stemcentrx Llc Site-specific antibody conjugation methods and compositions
SG11201601416VA (en) * 2013-08-28 2016-03-30 Stemcentrx Inc Novel sez6 modulators and methods of use
US20190209704A1 (en) 2014-10-20 2019-07-11 Igenica Biotherapeutics, Inc. Novel antibody-drug conjugates and related compounds, compositions and methods of use
MA41645A (en) * 2015-03-04 2018-01-09 Abbvie Stemcentrx Llc SITE-SPECIFIC GENETICALLY ENGINEERED ANTIBODIES AND METHODS OF USE
CA3048224A1 (en) 2016-12-23 2018-06-28 Bluefin Biomedicine, Inc. Anti-sez6l2 antibodies and antibody drug conjugates

Also Published As

Publication number Publication date
MY178120A (en) 2020-10-05
PE20150091A1 (en) 2015-02-16
PH12014501914A1 (en) 2014-11-24
KR102099073B1 (en) 2020-04-10
EP3539985A1 (en) 2019-09-18
US20150018531A1 (en) 2015-01-15
NZ631197A (en) 2017-05-26
US10533051B2 (en) 2020-01-14
AU2016225828B2 (en) 2018-05-31
WO2013126810A1 (en) 2013-08-29
RU2014138420A (en) 2016-04-10
AU2018223053A1 (en) 2018-09-20
US20200181256A1 (en) 2020-06-11
SG11201405130UA (en) 2014-11-27
PH12014501914B1 (en) 2014-11-24
CL2017002823A1 (en) 2018-03-23
JP2015509948A (en) 2015-04-02
IL234208B (en) 2020-11-30
CN108383909B (en) 2021-08-24
EP2817339B1 (en) 2019-05-15
MX2014010094A (en) 2014-09-16
KR20150002621A (en) 2015-01-07
AU2013203506B2 (en) 2016-06-09
AU2018223053B2 (en) 2020-05-14
CN104334580A (en) 2015-02-04
CN108383909A (en) 2018-08-10
AU2013203506A1 (en) 2013-09-12
HK1205517A1 (en) 2015-12-18
CL2014002237A1 (en) 2015-05-15
CA2865415C (en) 2022-06-21
RU2691698C2 (en) 2019-06-17
CN104334580B (en) 2018-03-30
CO7151485A2 (en) 2014-12-29
JP2018127469A (en) 2018-08-16
ZA201406967B (en) 2021-06-30
MX2020003713A (en) 2020-07-22
US20170369571A1 (en) 2017-12-28
BR112014020816A2 (en) 2017-10-10
JP6401060B2 (en) 2018-10-03
EP2817339A1 (en) 2014-12-31
CA2865415A1 (en) 2013-08-29
AU2016225828A1 (en) 2016-09-22
ES2741936T3 (en) 2020-02-12
US9676850B2 (en) 2017-06-13

Similar Documents

Publication Publication Date Title
HK1205517A1 (en) Anti sez6 antibodies and methods of use sez6
HK1255608A1 (en) Anti-htra1 antibodies and methods of use
HK1212256A1 (en) Anti-mcam antibodies and associated methods of use -mcam
HK1231488A1 (en) Anti dll3 antibodies and methods of use thereof dll3
HK1213581A1 (en) Anti-cd40 antibodies and methods of use -cd40
IL238227A0 (en) Anti-c16orf54 antibodies and methods of use thereof
HK1208167A1 (en) Anti-ly6e antibodies and immunoconjugates and methods of use ly6e
ZA201404675B (en) Anti-lrp5 antibodies and methods of use
ZA201403760B (en) Anti-cd98 antibodies and methods of use thereof
HK1201843A1 (en) Anti-polyubiquitin antibodies and methods of use
HK1208235A1 (en) Anti-biotin antibodies and methods of use
EP2938632A4 (en) Anti-granulysin antibodies and methods of use thereof
EP2874650A4 (en) Antibody specific for cd22 and methods of use thereof
HK1209432A1 (en) Anti-jagged antibodies and methods of use
HK1203354A1 (en) Anti-theophylline antibodies and methods of use