SG10201801444WA - Anti sez6 antibodies and methods of use - Google Patents
Anti sez6 antibodies and methods of useInfo
- Publication number
- SG10201801444WA SG10201801444WA SG10201801444WA SG10201801444WA SG10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA SG 10201801444W A SG10201801444W A SG 10201801444WA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- sez6 antibodies
- anti sez6
- antibodies
- sez6
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261603203P | 2012-02-24 | 2012-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201801444WA true SG10201801444WA (en) | 2018-04-27 |
Family
ID=47790548
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201405130UA SG11201405130UA (en) | 2012-02-24 | 2013-02-22 | Anti sez6 antibodies and methods of use |
SG10201801444WA SG10201801444WA (en) | 2012-02-24 | 2013-02-22 | Anti sez6 antibodies and methods of use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201405130UA SG11201405130UA (en) | 2012-02-24 | 2013-02-22 | Anti sez6 antibodies and methods of use |
Country Status (21)
Country | Link |
---|---|
US (3) | US9676850B2 (en) |
EP (2) | EP3539985A1 (en) |
JP (2) | JP6401060B2 (en) |
KR (1) | KR102099073B1 (en) |
CN (2) | CN108383909B (en) |
AU (3) | AU2013203506B2 (en) |
CA (1) | CA2865415C (en) |
CL (2) | CL2014002237A1 (en) |
CO (1) | CO7151485A2 (en) |
ES (1) | ES2741936T3 (en) |
HK (1) | HK1205517A1 (en) |
IL (1) | IL234208B (en) |
MX (2) | MX2014010094A (en) |
MY (1) | MY178120A (en) |
NZ (1) | NZ631197A (en) |
PE (1) | PE20150091A1 (en) |
PH (1) | PH12014501914B1 (en) |
RU (1) | RU2691698C2 (en) |
SG (2) | SG11201405130UA (en) |
WO (1) | WO2013126810A1 (en) |
ZA (1) | ZA201406967B (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3539985A1 (en) * | 2012-02-24 | 2019-09-18 | AbbVie Stemcentrx LLC | Anti sez6 antibodies and methods of use |
US11531028B2 (en) * | 2013-05-10 | 2022-12-20 | Nordic Bioscience A/S | Collagen type X alpha-1 assay |
SG11201601416VA (en) * | 2013-08-28 | 2016-03-30 | Stemcentrx Inc | Novel sez6 modulators and methods of use |
AU2014312215B2 (en) * | 2013-08-28 | 2020-02-27 | Abbvie Stemcentrx Llc | Site-specific antibody conjugation methods and compositions |
EP3065780A1 (en) | 2013-11-04 | 2016-09-14 | Pfizer Inc. | Anti-efna4 antibody-drug conjugates |
WO2015084262A2 (en) * | 2013-12-03 | 2015-06-11 | Agency For Science, Technology And Research | Cytotoxic antibody |
JP6818268B2 (en) * | 2014-01-29 | 2021-01-20 | Kmバイオロジクス株式会社 | Anti-transthyretin humanized antibody |
WO2015115332A1 (en) | 2014-01-29 | 2015-08-06 | 一般財団法人化学及血清療法研究所 | Anti-transthyretin human antibody |
EP3107576A4 (en) | 2014-02-21 | 2017-09-06 | Abbvie Stemcentrx LLC | Anti-dll3 antibodies and drug conjugates for use in melanoma |
AU2015280436A1 (en) | 2014-06-23 | 2017-02-02 | Bionomics, Inc. | Antibodies that bind LGR4 |
TW201617368A (en) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | Novel anti-MFI2 antibodies and methods of use |
WO2016057683A2 (en) | 2014-10-07 | 2016-04-14 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Novel anti-nodal antibodies and methods of using same |
JP2018529656A (en) * | 2015-08-20 | 2018-10-11 | アッヴィ・ステムセントルクス・エル・エル・シー | Anti-DLL3 antibody drug conjugates and methods of use |
EP3955021B1 (en) | 2015-10-06 | 2024-08-14 | Pioneer Corporation | Light control device, light control method and program |
WO2017087547A1 (en) * | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
TWI752012B (en) | 2016-03-04 | 2022-01-11 | 美商Jn生物科學有限責任公司 | Antibodies to tigit |
EP3525814A4 (en) | 2016-10-14 | 2020-09-23 | Nima Labs, Inc. | Anti-gliadin antibodies |
AU2017344411A1 (en) * | 2016-10-19 | 2019-05-09 | Novelogics Biotechnology, Inc. | Antibodies to MICA and MICB proteins |
WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
CA3048224A1 (en) * | 2016-12-23 | 2018-06-28 | Bluefin Biomedicine, Inc. | Anti-sez6l2 antibodies and antibody drug conjugates |
EP3424528A1 (en) | 2017-07-07 | 2019-01-09 | AVA Lifescience GmbH | Biologic binding molecules |
EP3774898A4 (en) | 2018-04-13 | 2022-01-26 | Dingfu Biotarget Co., Ltd. | Anti-cd27 antibodies and use thereof |
HUE053616T2 (en) | 2018-05-30 | 2021-07-28 | Abbvie Stemcentrx Llc | Anti-sez6 antibody drug conjugates and methods of use |
WO2020013644A1 (en) * | 2018-07-11 | 2020-01-16 | 고려대학교 산학협력단 | Epitope specific to smo protein, antibody recognizing same, and composition comprising same |
KR20210049792A (en) * | 2018-08-24 | 2021-05-06 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Human IL-4R binding antibody, antigen binding fragment thereof, and medical use thereof |
AU2021284273A1 (en) | 2020-06-02 | 2022-12-15 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
CN114106176B (en) * | 2020-09-01 | 2024-04-09 | 深圳市菲鹏生物治疗股份有限公司 | CD22 antibody and application thereof |
US20230287090A1 (en) * | 2020-09-02 | 2023-09-14 | The Feinstein Institutes For Medical Research | USE OF SARS-CoV-2 RECEPTOR BINDING MOTIF (RBM)-REACTIVE MONOCLONAL ANTIBODIES TO TREAT COVID-19 |
CA3198996A1 (en) | 2020-11-24 | 2022-06-02 | Matthew T. Burger | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
CN114790241A (en) * | 2021-01-26 | 2022-07-26 | 北京免疫方舟医药科技有限公司 | anti-TIGIT antibody and application thereof |
CN113307875B (en) * | 2021-06-10 | 2022-09-02 | 福州迈新生物技术开发有限公司 | Monoclonal antibody for resisting TCR beta F1 protein, cell strain, preparation method and application thereof |
WO2023019174A2 (en) * | 2021-08-11 | 2023-02-16 | Apollos Diagnostics, Llc | Antibodies to sars-cov-2 |
WO2023225359A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
WO2023223097A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody drug conjugates |
CN115975036B (en) * | 2022-08-18 | 2023-06-09 | 北京诺赛国际医学研究院 | Pharmaceutical composition comprising stem cells and use thereof for treating cancer |
CN117736331B (en) * | 2024-02-04 | 2024-05-07 | 南昌大学第一附属医院 | Monoclonal antibody specifically binding to extracellular segment of PSMA and application thereof |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3101690B2 (en) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | Modifications of or for denatured antibodies |
US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
KR900005995A (en) | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | Modified Interleukin-2 and Method of Making the Same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
WO1991006570A1 (en) | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
ES2096749T3 (en) | 1990-12-14 | 1997-03-16 | Cell Genesys Inc | CHEMICAL CHAINS FOR SIGNAL TRANSDUCTION ROADS ASSOCIATED WITH A RECEIVER. |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
ATE196606T1 (en) | 1992-11-13 | 2000-10-15 | Idec Pharma Corp | THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES DIRECTED AGAINST A DIFFERENTIATION ANTIGEN WHICH EXPRESSION IS RESTRICTED TO HUMAN B LYMPHOCYTES, FOR THE TREATMENT OF B-CELL LYMPHOMA |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
CN1117155C (en) | 1994-07-29 | 2003-08-06 | 史密丝克莱恩比彻姆有限公司 | Novel compounds |
DE69833755T2 (en) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | METHOD FOR PRODUCING NON-IMMUNOGENOUS PROTEINS |
DK1034298T3 (en) | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanization of murine antibody |
ES2244210T3 (en) | 1998-08-27 | 2005-12-01 | Spirogen Limited | PIRROLOBENZODIAZEPINAS. |
JP2002534959A (en) | 1998-12-08 | 2002-10-22 | バイオベーション リミテッド | Methods for modifying immunogenic proteins |
US20040067490A1 (en) * | 2001-09-07 | 2004-04-08 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
AU2001256977A1 (en) * | 2000-04-28 | 2001-11-12 | Eli Lilly And Company | Human sez6 nucleic acids and polypeptides |
US7608704B2 (en) | 2000-11-08 | 2009-10-27 | Incyte Corporation | Secreted proteins |
US6362331B1 (en) | 2001-03-30 | 2002-03-26 | Council Of Scientific And Industrial Research | Process for the preparation of antitumor agents |
US20030211991A1 (en) | 2001-04-17 | 2003-11-13 | Su Eric Wen | Human sez6 nucleic acids and polypeptides |
CN1343774A (en) | 2001-05-28 | 2002-04-10 | 复旦大学 | Coding sequence of epilepsia associated protein, polypeptide coded by it, and its preparing process and application |
US20040001835A1 (en) | 2002-03-04 | 2004-01-01 | Medimmune, Inc. | Prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
WO2004072266A2 (en) | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
EP1633784B1 (en) | 2003-05-09 | 2011-07-13 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
BR122018071808B8 (en) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugate |
SI2270010T1 (en) | 2004-03-01 | 2012-05-31 | Spirogen Ltd | 11-hydroxy-5h-pyrrolo?á2,1-c?å?á1,4?åbenzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins |
GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
US7189710B2 (en) | 2004-03-30 | 2007-03-13 | Council Of Scientific And Industrial Research | C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers |
FR2869231B1 (en) | 2004-04-27 | 2008-03-14 | Sod Conseils Rech Applic | THERAPEUTIC COMPOSITION CONTAINING AT LEAST ONE PYRROLOBENZODIAZEPINE DERIVATIVE AND FLUDARABINE |
NZ553500A (en) | 2004-09-23 | 2009-11-27 | Genentech Inc Genentech Inc | Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain |
US20070123448A1 (en) | 2005-11-23 | 2007-05-31 | The Hospital For Sick Children | Novel chemical entities affecting neuroblastoma tumor-initiating cells |
RS52060B (en) | 2006-01-25 | 2012-04-30 | Sanofi | Cytotoxic agents comprising new tomaymycin derivatives |
EP2032694A4 (en) | 2006-06-06 | 2010-09-15 | Univ Tennessee Res Foundation | Compositions enriched in neoplastic stem cells and methods comprising same |
CA2652703C (en) | 2006-06-07 | 2018-08-28 | Bioalliance C.V. | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
CA3007075C (en) | 2006-09-07 | 2019-10-15 | Arthur E. Frankel | Methods and compositions based on diphtheria toxin-interleukin-3 conjugates |
JP2010516259A (en) | 2007-01-22 | 2010-05-20 | レイベン バイオテクノロジーズ | Human cancer stem cells |
NZ600758A (en) * | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
US9289492B2 (en) | 2007-07-17 | 2016-03-22 | The General Hospital Corporation | Collecting ovarian cancer stem cells from ovarian cancer cells |
EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
WO2009043051A2 (en) | 2007-09-27 | 2009-04-02 | Biogen Idec Ma Inc. | Cd23 binding molecules and methods of use thereof |
EP2244729B1 (en) | 2008-01-18 | 2016-11-02 | MedImmune, LLC | Cysteine engineered antibodies for site-specific conjugation |
EP2282769A4 (en) | 2008-04-29 | 2012-04-25 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
US20100162416A1 (en) | 2008-09-29 | 2010-06-24 | Stemlifeline, Inc. | Multi-stage stem cell carcinogenesis |
US8788213B2 (en) | 2009-01-12 | 2014-07-22 | Intrexon Corporation | Laser mediated sectioning and transfer of cell colonies |
US20110020221A1 (en) | 2009-04-09 | 2011-01-27 | The Johns Hopkins University | Cancer stem cell expression patterns and compounds to target cancer stem cells |
SG178602A1 (en) | 2009-09-01 | 2012-04-27 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
EP3620467A1 (en) * | 2010-03-12 | 2020-03-11 | Debiopharm International SA | Cd37-binding molecules and immunoconjugates thereof |
KR101671360B1 (en) | 2010-04-15 | 2016-11-01 | 시애틀 지네틱스, 인크. | Targeted pyrrolobenzodiazepine conjugates |
WO2011130616A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
JP5972864B2 (en) | 2010-04-15 | 2016-08-17 | メディミューン リミテッド | Pyrrolobenzodiazepines and their conjugates |
US20120100560A1 (en) | 2010-07-23 | 2012-04-26 | The Johns Hopkins University | Device for capture, enumeration, and profiling of circulating tumor cells |
WO2012019060A1 (en) * | 2010-08-05 | 2012-02-09 | Joslin Diabetes Center, Inc. | Predicting and treating diabetic complications |
EP2689787A1 (en) | 2010-09-03 | 2014-01-29 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
US20130061340A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc. | Identification and Enrichment of Cell Subpopulations |
WO2013119964A2 (en) | 2012-02-08 | 2013-08-15 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
US20130061342A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc. | Identification and Enrichment of Cell Subpopulations |
US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
ES2874306T3 (en) | 2010-09-29 | 2021-11-04 | Agensys Inc | Conjugates of antibodies and drugs (CAF) that bind to 191P4D12 proteins |
EP3539985A1 (en) * | 2012-02-24 | 2019-09-18 | AbbVie Stemcentrx LLC | Anti sez6 antibodies and methods of use |
AU2014312215B2 (en) * | 2013-08-28 | 2020-02-27 | Abbvie Stemcentrx Llc | Site-specific antibody conjugation methods and compositions |
SG11201601416VA (en) * | 2013-08-28 | 2016-03-30 | Stemcentrx Inc | Novel sez6 modulators and methods of use |
US20190209704A1 (en) | 2014-10-20 | 2019-07-11 | Igenica Biotherapeutics, Inc. | Novel antibody-drug conjugates and related compounds, compositions and methods of use |
MA41645A (en) * | 2015-03-04 | 2018-01-09 | Abbvie Stemcentrx Llc | SITE-SPECIFIC GENETICALLY ENGINEERED ANTIBODIES AND METHODS OF USE |
CA3048224A1 (en) | 2016-12-23 | 2018-06-28 | Bluefin Biomedicine, Inc. | Anti-sez6l2 antibodies and antibody drug conjugates |
-
2013
- 2013-02-22 EP EP19154773.6A patent/EP3539985A1/en not_active Withdrawn
- 2013-02-22 KR KR1020147026846A patent/KR102099073B1/en active IP Right Grant
- 2013-02-22 CN CN201810153825.5A patent/CN108383909B/en active Active
- 2013-02-22 PE PE2014001301A patent/PE20150091A1/en active IP Right Grant
- 2013-02-22 WO PCT/US2013/027476 patent/WO2013126810A1/en active Application Filing
- 2013-02-22 NZ NZ631197A patent/NZ631197A/en not_active IP Right Cessation
- 2013-02-22 MX MX2014010094A patent/MX2014010094A/en active IP Right Grant
- 2013-02-22 US US14/380,665 patent/US9676850B2/en active Active
- 2013-02-22 SG SG11201405130UA patent/SG11201405130UA/en unknown
- 2013-02-22 EP EP13707529.7A patent/EP2817339B1/en active Active
- 2013-02-22 CA CA2865415A patent/CA2865415C/en active Active
- 2013-02-22 CN CN201380010534.6A patent/CN104334580B/en active Active
- 2013-02-22 RU RU2014138420A patent/RU2691698C2/en active
- 2013-02-22 SG SG10201801444WA patent/SG10201801444WA/en unknown
- 2013-02-22 MY MYPI2014002467A patent/MY178120A/en unknown
- 2013-02-22 AU AU2013203506A patent/AU2013203506B2/en not_active Ceased
- 2013-02-22 ES ES13707529T patent/ES2741936T3/en active Active
- 2013-02-22 JP JP2014558901A patent/JP6401060B2/en not_active Expired - Fee Related
-
2014
- 2014-08-19 IL IL234208A patent/IL234208B/en active IP Right Grant
- 2014-08-21 MX MX2020003713A patent/MX2020003713A/en unknown
- 2014-08-22 CL CL2014002237A patent/CL2014002237A1/en unknown
- 2014-08-26 PH PH12014501914A patent/PH12014501914B1/en unknown
- 2014-09-23 ZA ZA2014/06967A patent/ZA201406967B/en unknown
- 2014-09-23 CO CO14210871A patent/CO7151485A2/en unknown
-
2015
- 2015-06-19 HK HK15105897.6A patent/HK1205517A1/en not_active IP Right Cessation
-
2016
- 2016-09-07 AU AU2016225828A patent/AU2016225828B2/en not_active Ceased
-
2017
- 2017-06-05 US US15/614,548 patent/US10533051B2/en not_active Expired - Fee Related
- 2017-11-08 CL CL2017002823A patent/CL2017002823A1/en unknown
-
2018
- 2018-03-20 JP JP2018052506A patent/JP2018127469A/en active Pending
- 2018-08-31 AU AU2018223053A patent/AU2018223053B2/en not_active Expired - Fee Related
-
2019
- 2019-12-12 US US16/712,324 patent/US20200181256A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1205517A1 (en) | Anti sez6 antibodies and methods of use sez6 | |
HK1255608A1 (en) | Anti-htra1 antibodies and methods of use | |
HK1212256A1 (en) | Anti-mcam antibodies and associated methods of use -mcam | |
HK1231488A1 (en) | Anti dll3 antibodies and methods of use thereof dll3 | |
HK1213581A1 (en) | Anti-cd40 antibodies and methods of use -cd40 | |
IL238227A0 (en) | Anti-c16orf54 antibodies and methods of use thereof | |
HK1208167A1 (en) | Anti-ly6e antibodies and immunoconjugates and methods of use ly6e | |
ZA201404675B (en) | Anti-lrp5 antibodies and methods of use | |
ZA201403760B (en) | Anti-cd98 antibodies and methods of use thereof | |
HK1201843A1 (en) | Anti-polyubiquitin antibodies and methods of use | |
HK1208235A1 (en) | Anti-biotin antibodies and methods of use | |
EP2938632A4 (en) | Anti-granulysin antibodies and methods of use thereof | |
EP2874650A4 (en) | Antibody specific for cd22 and methods of use thereof | |
HK1209432A1 (en) | Anti-jagged antibodies and methods of use | |
HK1203354A1 (en) | Anti-theophylline antibodies and methods of use |