JP2019516394A5 - - Google Patents
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- JP2019516394A5 JP2019516394A5 JP2019500712A JP2019500712A JP2019516394A5 JP 2019516394 A5 JP2019516394 A5 JP 2019516394A5 JP 2019500712 A JP2019500712 A JP 2019500712A JP 2019500712 A JP2019500712 A JP 2019500712A JP 2019516394 A5 JP2019516394 A5 JP 2019516394A5
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- JP
- Japan
- Prior art keywords
- antibody
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- pharmaceutical composition
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010074708 B7-H1 Antigen Proteins 0.000 claims 17
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000007935 neutral effect Effects 0.000 claims 8
- 230000002378 acidificating effect Effects 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 238000001727 in vivo Methods 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 101100450694 Arabidopsis thaliana HFR1 gene Proteins 0.000 claims 2
- 238000013096 assay test Methods 0.000 claims 2
- 231100000628 reference dose Toxicity 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000002638 palliative care Methods 0.000 claims 1
- 238000011499 palliative surgery Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022008113A JP7345578B2 (ja) | 2016-03-23 | 2022-01-21 | 新規抗ｐｄ－ｌ１抗体 |
| JP2023143484A JP7624484B2 (ja) | 2016-03-23 | 2023-09-05 | 新規抗ｐｄ－ｌ１抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/077082 | 2016-03-23 | ||
| CN2016077082 | 2016-03-23 | ||
| PCT/CN2017/073242 WO2017161976A1 (en) | 2016-03-23 | 2017-02-10 | Novel anti-pd-l1 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008113A Division JP7345578B2 (ja) | 2016-03-23 | 2022-01-21 | 新規抗ｐｄ－ｌ１抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516394A JP2019516394A (ja) | 2019-06-20 |
| JP2019516394A5 true JP2019516394A5 (enExample) | 2020-03-19 |
| JP7080213B2 JP7080213B2 (ja) | 2022-06-03 |
Family
ID=59900827
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500712A Active JP7080213B2 (ja) | 2016-03-23 | 2017-02-10 | 新規抗ｐｄ－ｌ１抗体 |
| JP2022008113A Active JP7345578B2 (ja) | 2016-03-23 | 2022-01-21 | 新規抗ｐｄ－ｌ１抗体 |
| JP2023143484A Active JP7624484B2 (ja) | 2016-03-23 | 2023-09-05 | 新規抗ｐｄ－ｌ１抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022008113A Active JP7345578B2 (ja) | 2016-03-23 | 2022-01-21 | 新規抗ｐｄ－ｌ１抗体 |
| JP2023143484A Active JP7624484B2 (ja) | 2016-03-23 | 2023-09-05 | 新規抗ｐｄ－ｌ１抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10822416B2 (enExample) |
| EP (1) | EP3433277A4 (enExample) |
| JP (3) | JP7080213B2 (enExample) |
| KR (1) | KR102937285B1 (enExample) |
| CN (2) | CN108779180B (enExample) |
| CA (1) | CA3007135A1 (enExample) |
| RU (1) | RU2744959C2 (enExample) |
| WO (1) | WO2017161976A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106243225B (zh) * | 2015-06-11 | 2021-01-19 | 智翔（上海）医药科技有限公司 | 新型抗-pd-l1抗体 |
| JP7080213B2 (ja) * | 2016-03-23 | 2022-06-03 | スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド | 新規抗ｐｄ－ｌ１抗体 |
| CN109069638B (zh) | 2016-03-24 | 2022-03-29 | 璟尚生物制药公司 | 用于癌症治疗的三特异性抑制剂 |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | CHECKPOINT REGULATOR ANTAGONISTS |
| JP7021454B2 (ja) * | 2017-02-03 | 2022-02-17 | 株式会社三洋物産 | 遊技機 |
| CN110914302A (zh) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | 可活化抗pdl1抗体及其使用方法 |
| JP7402158B2 (ja) * | 2017-11-30 | 2023-12-20 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体及びｐｄ－ｌ１を検出するためにそれを使用する方法 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| KR102845020B1 (ko) * | 2017-12-28 | 2025-08-12 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-l1에 대한 항체 및 변이체 |
| JP2021525806A (ja) | 2018-06-01 | 2021-09-27 | タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド | 疾患または状態を処置するための組成物およびそれらの使用 |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| JP2021529557A (ja) | 2018-06-29 | 2021-11-04 | ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． | 抗腫瘍免疫チェックポイント調節因子アンタゴニスト |
| WO2020014419A2 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1 |
| CN113795511B (zh) * | 2019-01-23 | 2024-07-23 | 大有华夏生物医药集团有限公司 | 抗pd-l1双抗体及其用途 |
| CN118267468A (zh) * | 2019-01-25 | 2024-07-02 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物组合物 |
| CN109929037B (zh) * | 2019-04-01 | 2023-03-17 | 华博生物医药技术（上海）有限公司 | 针对程序性死亡配体的结合物及其应用 |
| US20220241412A1 (en) | 2019-05-24 | 2022-08-04 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| JP2022534982A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| CN110194798A (zh) * | 2019-05-31 | 2019-09-03 | 杭州科兴生物科技有限公司 | 抗pd-l1单克隆抗体、片段及其医药用途 |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| GB201910138D0 (en) | 2019-07-15 | 2019-08-28 | Capella Bioscience Ltd | Anti-pd-l1 antibodies |
| CN115038718B (zh) * | 2019-11-08 | 2024-07-02 | 山东先声生物制药有限公司 | 抗人程序性死亡配体-1（pd-l1）的抗体及其用途 |
| JP7512413B2 (ja) * | 2020-03-31 | 2024-07-08 | ビオテウス・インコーポレイテッド | 抗ｐｄ－ｌ１およびｐｄ－ｌ２抗体ならびにその誘導体および用途 |
| CN121319180A (zh) * | 2020-07-28 | 2026-01-13 | 乐普生物科技股份有限公司 | 靶向PD-L1和TGF-β的双功能分子 |
| CA3187850A1 (en) | 2020-08-04 | 2022-02-10 | Bryan Glaser | Pd-l1 binding agents and uses thereof |
| CN111929447B (zh) * | 2020-09-24 | 2021-02-26 | 菁良基因科技(深圳)有限公司 | 一种pd-l1免疫组织化学参考品及其制备方法和应用 |
| JP2023550419A (ja) * | 2020-11-18 | 2023-12-01 | スーチョウ・トランスセンタ・セラピューティクス・カンパニー・リミテッド | 二機能性分子 |
| CN112285366B (zh) * | 2020-12-25 | 2021-06-08 | 南京广祺医药科技有限公司 | 一种测定血清中双特异性抗体BsAb的ELISA方法及应用 |
| EP4373848A2 (en) | 2021-07-22 | 2024-05-29 | University of Dundee | Therapeutic muteins |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| CN118215681A (zh) * | 2021-09-18 | 2024-06-18 | 江苏康宁杰瑞生物制药有限公司 | 包含pd-l1抗原结合片段的组合物及其用途 |
| TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| TW202333785A (zh) * | 2021-11-16 | 2023-09-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | Ｃｌａｕｄｉｎ１８．２拮抗劑和ｐｄ－１／ｐｄ－ｌ１軸抑制劑的組合療法 |
| US20250282874A1 (en) * | 2022-05-17 | 2025-09-11 | Suzhou Transcenta Therapeutics Co., Ltd. | Bifunctional protein, and preparation thereof and use thereof |
| CN114939161B (zh) * | 2022-06-24 | 2023-02-28 | 南方医科大学南方医院 | Pd-1抗体在制备治疗肌腱损伤的药物中的应用 |
| JP2026517051A (ja) * | 2023-01-18 | 2026-05-28 | エルピサイエンス・（スージョウ）・バイオファーマ，リミテッド | 抗ｐｄｌ１単一ドメイン抗体、融合タンパク質及びその使用 |
| AU2024269754A1 (en) * | 2023-05-08 | 2025-10-23 | F. Hoffmann-La Roche Ag | Targeted interferon alpha fusion proteins and methods of use |
| WO2025240670A2 (en) * | 2024-05-15 | 2025-11-20 | Abalytics Oncology, Inc. | Anti-pd-1 antibodies and related binding molecules and methods and uses thereof |
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| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
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| WO2014165082A2 (en) * | 2013-03-13 | 2014-10-09 | Medimmune, Llc | Antibodies and methods of detection |
| KR20150131269A (ko) * | 2013-03-15 | 2015-11-24 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| JP7080213B2 (ja) | 2016-03-23 | 2022-06-03 | スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド | 新規抗ｐｄ－ｌ１抗体 |
-
2017
- 2017-02-10 JP JP2019500712A patent/JP7080213B2/ja active Active
- 2017-02-10 CN CN201780018886.4A patent/CN108779180B/zh active Active
- 2017-02-10 CN CN202010174431.5A patent/CN111363041B/zh active Active
- 2017-02-10 WO PCT/CN2017/073242 patent/WO2017161976A1/en not_active Ceased
- 2017-02-10 EP EP17769253.0A patent/EP3433277A4/en active Pending
- 2017-02-10 KR KR1020187024767A patent/KR102937285B1/ko active Active
- 2017-02-10 CA CA3007135A patent/CA3007135A1/en active Pending
- 2017-02-10 US US16/086,013 patent/US10822416B2/en active Active
- 2017-02-10 RU RU2018124602A patent/RU2744959C2/ru active
-
2020
- 2020-09-28 US US17/033,970 patent/US11753473B2/en active Active
-
2022
- 2022-01-21 JP JP2022008113A patent/JP7345578B2/ja active Active
-
2023
- 2023-09-05 JP JP2023143484A patent/JP7624484B2/ja active Active
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