CA3007135A1 - Novel anti-pd-l1 antibodies - Google Patents
Novel anti-pd-l1 antibodies Download PDFInfo
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- CA3007135A1 CA3007135A1 CA3007135A CA3007135A CA3007135A1 CA 3007135 A1 CA3007135 A1 CA 3007135A1 CA 3007135 A CA3007135 A CA 3007135A CA 3007135 A CA3007135 A CA 3007135A CA 3007135 A1 CA3007135 A1 CA 3007135A1
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| PCT/CN2017/073242 WO2017161976A1 (en) | 2016-03-23 | 2017-02-10 | Novel anti-pd-l1 antibodies |
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| CN106243225B (zh) * | 2015-06-11 | 2021-01-19 | 智翔（上海）医药科技有限公司 | 新型抗-pd-l1抗体 |
| RU2744959C2 (ru) * | 2016-03-23 | 2021-03-17 | Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд | Новые анти-pd-l1 антитела |
| US10894823B2 (en) | 2016-03-24 | 2021-01-19 | Gensun Biopharma Inc. | Trispecific inhibitors for cancer treatment |
| CN109071656B (zh) | 2017-01-05 | 2021-05-18 | 璟尚生物制药公司 | 检查点调节物拮抗剂 |
| JP7021454B2 (ja) * | 2017-02-03 | 2022-02-17 | 株式会社三洋物産 | 遊技機 |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| JP7402158B2 (ja) * | 2017-11-30 | 2023-12-20 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体及びｐｄ－ｌ１を検出するためにそれを使用する方法 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| CN111542543B (zh) | 2017-12-28 | 2023-12-22 | 南京传奇生物科技有限公司 | 针对pd-l1的抗体及其变体 |
| WO2019228514A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| WO2020006516A1 (en) | 2018-06-29 | 2020-01-02 | Gensun Biopharma, Inc. | Antitumor immune checkpoint regulator antagonists |
| CN112996910A (zh) * | 2018-07-11 | 2021-06-18 | 动量制药公司 | 与靶向PD-L1的工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| WO2020151572A1 (en) * | 2019-01-23 | 2020-07-30 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-l1 diabodies and the use thereof |
| US12421313B2 (en) | 2019-01-25 | 2025-09-23 | Chia Tia Tianqing Pharmaceutical Group Co., Ltd. | Combined pharmaceutical composition for treating tumor |
| CN109929037B (zh) * | 2019-04-01 | 2023-03-17 | 华博生物医药技术（上海）有限公司 | 针对程序性死亡配体的结合物及其应用 |
| CA3141531A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| JP2022534982A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| CN110194798A (zh) * | 2019-05-31 | 2019-09-03 | 杭州科兴生物科技有限公司 | 抗pd-l1单克隆抗体、片段及其医药用途 |
| WO2020263312A1 (en) | 2019-06-28 | 2020-12-30 | Gensun Biopharma, Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFβ1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| US20220356255A1 (en) * | 2019-07-15 | 2022-11-10 | Capella Bioscience Ltd | Anti-pd-l1 antibodies |
| US20230002492A1 (en) * | 2019-11-08 | 2023-01-05 | Simcere (Shanghai) Pharmaceutical Co., Ltd. | Anti-human programmed cell death ligand-1 (pd-l1) antibody and use thereof |
| WO2021197358A1 (zh) * | 2020-03-31 | 2021-10-07 | 普米斯生物技术(珠海)有限公司 | 一种抗pd-l1和pd-l2抗体及其衍生物和用途 |
| CN119462927B (zh) * | 2020-07-28 | 2025-07-29 | 乐普生物科技股份有限公司 | 靶向PD-L1和TGF-β的双功能分子 |
| CA3187850A1 (en) * | 2020-08-04 | 2022-02-10 | Bryan Glaser | Pd-l1 binding agents and uses thereof |
| CN111929447B (zh) * | 2020-09-24 | 2021-02-26 | 菁良基因科技(深圳)有限公司 | 一种pd-l1免疫组织化学参考品及其制备方法和应用 |
| CA3201518A1 (en) * | 2020-11-18 | 2022-05-27 | Suzhou Transcenta Therapeutics Co., Ltd. | Bi-functional molecules |
| CN112285366B (zh) * | 2020-12-25 | 2021-06-08 | 南京广祺医药科技有限公司 | 一种测定血清中双特异性抗体BsAb的ELISA方法及应用 |
| US20240352084A1 (en) | 2021-07-22 | 2024-10-24 | University Of Dundee | Therapeutic muteins |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| CN118215681A (zh) * | 2021-09-18 | 2024-06-18 | 江苏康宁杰瑞生物制药有限公司 | 包含pd-l1抗原结合片段的组合物及其用途 |
| WO2023057882A1 (en) | 2021-10-05 | 2023-04-13 | Pfizer Inc. | Combinations of azalactam compounds with a pd-1 axis binding antagonist for the treatment of cancer |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| TW202333785A (zh) * | 2021-11-16 | 2023-09-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | Ｃｌａｕｄｉｎ１８．２拮抗劑和ｐｄ－１／ｐｄ－ｌ１軸抑制劑的組合療法 |
| CN119213034A (zh) * | 2022-05-17 | 2024-12-27 | 苏州创胜医药集团有限公司 | 双功能蛋白质及其制剂和用途 |
| CN114939161B (zh) * | 2022-06-24 | 2023-02-28 | 南方医科大学南方医院 | Pd-1抗体在制备治疗肌腱损伤的药物中的应用 |
| CN120603849A (zh) * | 2023-01-18 | 2025-09-05 | 科望(苏州)生物医药科技有限公司 | 抗pdl1单域抗体、融合蛋白及其用途 |
| AR132623A1 (es) * | 2023-05-08 | 2025-07-16 | Hoffmann La Roche | PROTEÍNAS DE FUSIÓN DE INTERFERÓN a DIRIGIDAS Y MÉTODOS DE USO |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| EP0656946B2 (en) | 1992-08-21 | 2010-03-31 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| DE69427974T2 (de) | 1993-04-29 | 2001-12-06 | Unilever N.V., Rotterdam | Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae |
| EP0770628B9 (en) | 1994-07-13 | 2007-02-28 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| KR101411165B1 (ko) * | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| US8217849B2 (en) | 2008-04-07 | 2012-07-10 | Intelleflex Corporation | Small profile antenna and RFID device having same |
| WO2010077634A1 (en) * | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| US8741295B2 (en) * | 2009-02-09 | 2014-06-03 | Universite De La Mediterranee | PD-1 antibodies and PD-L1 antibodies and uses thereof |
| RU2416645C2 (ru) * | 2009-05-04 | 2011-04-20 | Общество с ограниченной ответственностью "Промоген-МАТ" | Одноцепочечное антитело, связывающее фактор некроза опухоли альфа, днк, плазмидная днк и способ получения одноцепочечного антитела |
| NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| WO2013055404A1 (en) * | 2011-10-10 | 2013-04-18 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| EP2785375B1 (en) * | 2011-11-28 | 2020-07-22 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
| US9856320B2 (en) * | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| CN104736168B (zh) * | 2012-05-31 | 2018-09-21 | 索伦托治疗有限公司 | 与pd-l1结合的抗原结合蛋白 |
| JP6461800B2 (ja) * | 2012-10-04 | 2019-01-30 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ヒトモノクローナル抗ｐｄ−ｌ１抗体および使用方法 |
| AR093984A1 (es) * | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| WO2014165082A2 (en) * | 2013-03-13 | 2014-10-09 | Medimmune, Llc | Antibodies and methods of detection |
| JP6483082B2 (ja) * | 2013-03-15 | 2019-03-13 | ジェネンテック， インコーポレイテッド | Ｐｄ−１及びｐｄ−ｌ１に関連する状態を治療するためのバイオマーカー及び方法 |
| RU2744959C2 (ru) * | 2016-03-23 | 2021-03-17 | Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд | Новые анти-pd-l1 антитела |
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2017
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- 2017-02-10 US US16/086,013 patent/US10822416B2/en active Active
- 2017-02-10 CA CA3007135A patent/CA3007135A1/en active Pending
- 2017-02-10 CN CN202010174431.5A patent/CN111363041B/zh active Active
- 2017-02-10 WO PCT/CN2017/073242 patent/WO2017161976A1/en not_active Ceased
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| RU2744959C2 (ru) | 2021-03-17 |
| KR20180127971A (ko) | 2018-11-30 |
| WO2017161976A1 (en) | 2017-09-28 |
| JP2022068161A (ja) | 2022-05-09 |
| CN108779180B (zh) | 2020-10-16 |
| JP7080213B2 (ja) | 2022-06-03 |
| JP2023171733A (ja) | 2023-12-05 |
| EP3433277A4 (en) | 2020-06-17 |
| JP7345578B2 (ja) | 2023-09-15 |
| US10822416B2 (en) | 2020-11-03 |
| US20190330348A1 (en) | 2019-10-31 |
| RU2018124602A (ru) | 2020-01-14 |
| CN111363041B (zh) | 2022-02-22 |
| RU2021106377A (ru) | 2021-03-31 |
| CN108779180A (zh) | 2018-11-09 |
| RU2018124602A3 (enExample) | 2020-03-06 |
| US20210009693A1 (en) | 2021-01-14 |
| RU2021106377A3 (enExample) | 2021-12-28 |
| JP7624484B2 (ja) | 2025-01-30 |
| EP3433277A1 (en) | 2019-01-30 |
| CN111363041A (zh) | 2020-07-03 |
| JP2019516394A (ja) | 2019-06-20 |
| US11753473B2 (en) | 2023-09-12 |
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