RU2018124602A3 - - Google Patents
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- RU2018124602A3 RU2018124602A3 RU2018124602A RU2018124602A RU2018124602A3 RU 2018124602 A3 RU2018124602 A3 RU 2018124602A3 RU 2018124602 A RU2018124602 A RU 2018124602A RU 2018124602 A RU2018124602 A RU 2018124602A RU 2018124602 A3 RU2018124602 A3 RU 2018124602A3
- Authority
- RU
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Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/077082 | 2016-03-23 | ||
| CN2016077082 | 2016-03-23 | ||
| PCT/CN2017/073242 WO2017161976A1 (en) | 2016-03-23 | 2017-02-10 | Novel anti-pd-l1 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021106377A Division RU2776121C2 (ru) | 2016-03-23 | 2017-02-10 | Новые анти-pd-l1 антитела |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018124602A RU2018124602A (ru) | 2020-01-14 |
| RU2018124602A3 true RU2018124602A3 (enExample) | 2020-03-06 |
| RU2744959C2 RU2744959C2 (ru) | 2021-03-17 |
Family
ID=59900827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018124602A RU2744959C2 (ru) | 2016-03-23 | 2017-02-10 | Новые анти-pd-l1 антитела |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10822416B2 (enExample) |
| EP (1) | EP3433277A4 (enExample) |
| JP (3) | JP7080213B2 (enExample) |
| KR (1) | KR102937285B1 (enExample) |
| CN (2) | CN108779180B (enExample) |
| CA (1) | CA3007135A1 (enExample) |
| RU (1) | RU2744959C2 (enExample) |
| WO (1) | WO2017161976A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106243225B (zh) * | 2015-06-11 | 2021-01-19 | 智翔（上海）医药科技有限公司 | 新型抗-pd-l1抗体 |
| JP7080213B2 (ja) * | 2016-03-23 | 2022-06-03 | スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド | 新規抗ｐｄ－ｌ１抗体 |
| CN109069638B (zh) | 2016-03-24 | 2022-03-29 | 璟尚生物制药公司 | 用于癌症治疗的三特异性抑制剂 |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | CHECKPOINT REGULATOR ANTAGONISTS |
| JP7021454B2 (ja) * | 2017-02-03 | 2022-02-17 | 株式会社三洋物産 | 遊技機 |
| CN110914302A (zh) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | 可活化抗pdl1抗体及其使用方法 |
| JP7402158B2 (ja) * | 2017-11-30 | 2023-12-20 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体及びｐｄ－ｌ１を検出するためにそれを使用する方法 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| KR102845020B1 (ko) * | 2017-12-28 | 2025-08-12 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-l1에 대한 항체 및 변이체 |
| JP2021525806A (ja) | 2018-06-01 | 2021-09-27 | タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド | 疾患または状態を処置するための組成物およびそれらの使用 |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| JP2021529557A (ja) | 2018-06-29 | 2021-11-04 | ジェンサン バイオファーマ、 インコーポレイテッドＧｅｎｓｕｎ Ｂｉｏｐｈａｒｍａ， Ｉｎｃ． | 抗腫瘍免疫チェックポイント調節因子アンタゴニスト |
| WO2020014419A2 (en) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc-antigen binding domain constructs targeted to pd-l1 |
| CN113795511B (zh) * | 2019-01-23 | 2024-07-23 | 大有华夏生物医药集团有限公司 | 抗pd-l1双抗体及其用途 |
| CN118267468A (zh) * | 2019-01-25 | 2024-07-02 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物组合物 |
| CN109929037B (zh) * | 2019-04-01 | 2023-03-17 | 华博生物医药技术（上海）有限公司 | 针对程序性死亡配体的结合物及其应用 |
| US20220241412A1 (en) | 2019-05-24 | 2022-08-04 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| JP2022534982A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| CN110194798A (zh) * | 2019-05-31 | 2019-09-03 | 杭州科兴生物科技有限公司 | 抗pd-l1单克隆抗体、片段及其医药用途 |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| GB201910138D0 (en) | 2019-07-15 | 2019-08-28 | Capella Bioscience Ltd | Anti-pd-l1 antibodies |
| CN115038718B (zh) * | 2019-11-08 | 2024-07-02 | 山东先声生物制药有限公司 | 抗人程序性死亡配体-1（pd-l1）的抗体及其用途 |
| JP7512413B2 (ja) * | 2020-03-31 | 2024-07-08 | ビオテウス・インコーポレイテッド | 抗ｐｄ－ｌ１およびｐｄ－ｌ２抗体ならびにその誘導体および用途 |
| CN121319180A (zh) * | 2020-07-28 | 2026-01-13 | 乐普生物科技股份有限公司 | 靶向PD-L1和TGF-β的双功能分子 |
| CA3187850A1 (en) | 2020-08-04 | 2022-02-10 | Bryan Glaser | Pd-l1 binding agents and uses thereof |
| CN111929447B (zh) * | 2020-09-24 | 2021-02-26 | 菁良基因科技(深圳)有限公司 | 一种pd-l1免疫组织化学参考品及其制备方法和应用 |
| JP2023550419A (ja) * | 2020-11-18 | 2023-12-01 | スーチョウ・トランスセンタ・セラピューティクス・カンパニー・リミテッド | 二機能性分子 |
| CN112285366B (zh) * | 2020-12-25 | 2021-06-08 | 南京广祺医药科技有限公司 | 一种测定血清中双特异性抗体BsAb的ELISA方法及应用 |
| EP4373848A2 (en) | 2021-07-22 | 2024-05-29 | University of Dundee | Therapeutic muteins |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| CN118215681A (zh) * | 2021-09-18 | 2024-06-18 | 江苏康宁杰瑞生物制药有限公司 | 包含pd-l1抗原结合片段的组合物及其用途 |
| TW202327595A (zh) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | 用於治療癌症之氮雜內醯胺化合物的組合 |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| TW202333785A (zh) * | 2021-11-16 | 2023-09-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | Ｃｌａｕｄｉｎ１８．２拮抗劑和ｐｄ－１／ｐｄ－ｌ１軸抑制劑的組合療法 |
| US20250282874A1 (en) * | 2022-05-17 | 2025-09-11 | Suzhou Transcenta Therapeutics Co., Ltd. | Bifunctional protein, and preparation thereof and use thereof |
| CN114939161B (zh) * | 2022-06-24 | 2023-02-28 | 南方医科大学南方医院 | Pd-1抗体在制备治疗肌腱损伤的药物中的应用 |
| JP2026517051A (ja) * | 2023-01-18 | 2026-05-28 | エルピサイエンス・（スージョウ）・バイオファーマ，リミテッド | 抗ｐｄｌ１単一ドメイン抗体、融合タンパク質及びその使用 |
| AU2024269754A1 (en) * | 2023-05-08 | 2025-10-23 | F. Hoffmann-La Roche Ag | Targeted interferon alpha fusion proteins and methods of use |
| WO2025240670A2 (en) * | 2024-05-15 | 2025-11-20 | Abalytics Oncology, Inc. | Anti-pd-1 antibodies and related binding molecules and methods and uses thereof |
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| US9175082B2 (en) * | 2012-05-31 | 2015-11-03 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| BR112015007672A2 (pt) * | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| AR093984A1 (es) * | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| WO2014165082A2 (en) * | 2013-03-13 | 2014-10-09 | Medimmune, Llc | Antibodies and methods of detection |
| KR20150131269A (ko) * | 2013-03-15 | 2015-11-24 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| JP7080213B2 (ja) | 2016-03-23 | 2022-06-03 | スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド | 新規抗ｐｄ－ｌ１抗体 |
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2017
- 2017-02-10 JP JP2019500712A patent/JP7080213B2/ja active Active
- 2017-02-10 CN CN201780018886.4A patent/CN108779180B/zh active Active
- 2017-02-10 CN CN202010174431.5A patent/CN111363041B/zh active Active
- 2017-02-10 WO PCT/CN2017/073242 patent/WO2017161976A1/en not_active Ceased
- 2017-02-10 EP EP17769253.0A patent/EP3433277A4/en active Pending
- 2017-02-10 KR KR1020187024767A patent/KR102937285B1/ko active Active
- 2017-02-10 CA CA3007135A patent/CA3007135A1/en active Pending
- 2017-02-10 US US16/086,013 patent/US10822416B2/en active Active
- 2017-02-10 RU RU2018124602A patent/RU2744959C2/ru active
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2020
- 2020-09-28 US US17/033,970 patent/US11753473B2/en active Active
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2022
- 2022-01-21 JP JP2022008113A patent/JP7345578B2/ja active Active
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2023
- 2023-09-05 JP JP2023143484A patent/JP7624484B2/ja active Active
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| Publication number | Publication date |
|---|---|
| KR102937285B1 (ko) | 2026-03-11 |
| RU2021106377A (ru) | 2021-03-31 |
| JP7345578B2 (ja) | 2023-09-15 |
| RU2021106377A3 (enExample) | 2021-12-28 |
| EP3433277A4 (en) | 2020-06-17 |
| CN111363041B (zh) | 2022-02-22 |
| JP2022068161A (ja) | 2022-05-09 |
| EP3433277A1 (en) | 2019-01-30 |
| JP7080213B2 (ja) | 2022-06-03 |
| JP2019516394A (ja) | 2019-06-20 |
| US10822416B2 (en) | 2020-11-03 |
| KR20180127971A (ko) | 2018-11-30 |
| JP7624484B2 (ja) | 2025-01-30 |
| CN108779180A (zh) | 2018-11-09 |
| US20190330348A1 (en) | 2019-10-31 |
| CN108779180B (zh) | 2020-10-16 |
| US20210009693A1 (en) | 2021-01-14 |
| WO2017161976A1 (en) | 2017-09-28 |
| US11753473B2 (en) | 2023-09-12 |
| CN111363041A (zh) | 2020-07-03 |
| RU2018124602A (ru) | 2020-01-14 |
| JP2023171733A (ja) | 2023-12-05 |
| RU2744959C2 (ru) | 2021-03-17 |
| CA3007135A1 (en) | 2017-09-28 |
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