JP2017512759A5 - - Google Patents
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- JP2017512759A5 JP2017512759A5 JP2016554855A JP2016554855A JP2017512759A5 JP 2017512759 A5 JP2017512759 A5 JP 2017512759A5 JP 2016554855 A JP2016554855 A JP 2016554855A JP 2016554855 A JP2016554855 A JP 2016554855A JP 2017512759 A5 JP2017512759 A5 JP 2017512759A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cancer
- amino acid
- homologous
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- -1 Globo H Proteins 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977824P | 2014-04-10 | 2014-04-10 | |
| US61/977,824 | 2014-04-10 | ||
| US201462057381P | 2014-09-30 | 2014-09-30 | |
| US62/057,381 | 2014-09-30 | ||
| PCT/US2015/025305 WO2015157629A2 (en) | 2014-04-10 | 2015-04-10 | Antibodies, pharmaceutical compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017512759A JP2017512759A (ja) | 2017-05-25 |
| JP2017512759A5 true JP2017512759A5 (enExample) | 2019-06-27 |
Family
ID=54288553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554855A Pending JP2017512759A (ja) | 2014-04-10 | 2015-04-10 | 抗体、前記抗体を産生するハイブリドーマ、前記抗体を含む薬学的組成物及びその用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9902779B2 (enExample) |
| EP (2) | EP3129048B1 (enExample) |
| JP (1) | JP2017512759A (enExample) |
| KR (1) | KR101966408B1 (enExample) |
| CN (2) | CN112390887B (enExample) |
| AU (2) | AU2015243246B2 (enExample) |
| BR (1) | BR112016020009A2 (enExample) |
| CA (2) | CA3104268A1 (enExample) |
| CL (1) | CL2016002569A1 (enExample) |
| ES (1) | ES2772817T3 (enExample) |
| IL (2) | IL246837B (enExample) |
| PH (1) | PH12016501976A1 (enExample) |
| RU (1) | RU2016138744A (enExample) |
| SG (1) | SG11201607258SA (enExample) |
| TW (3) | TWI697503B (enExample) |
| WO (1) | WO2015157629A2 (enExample) |
| ZA (1) | ZA201605175B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ714555A (en) | 2013-09-17 | 2020-03-27 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| TW201622743A (zh) | 2014-03-19 | 2016-07-01 | 財團法人臺灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 | 免疫原醣肽、包含該醣肽之組合物及其用途 |
| EP3129048B1 (en) | 2014-04-10 | 2020-01-15 | OBI Pharma Inc. | Antibodies binding to tumour associated carbohydrate antigens, pharmaceutical compositions and uses thereof |
| EP3344806A4 (en) | 2015-09-04 | 2019-03-20 | OBI Pharma, Inc. | GLYCANARRAYS AND METHOD OF USE |
| BR112018006140A2 (pt) * | 2015-10-07 | 2018-10-23 | Obi Pharma Inc | anticorpo ou uma porção de ligação a antígeno do mesmo, composição farmacêutica, e, método para inibição de proliferação de células cancerígenas. |
| BR112018070097A2 (pt) | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| CA3021548A1 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| GB201612317D0 (en) * | 2016-07-15 | 2016-08-31 | Philogen Spa | Antibody compositions |
| AU2017302038B2 (en) | 2016-07-27 | 2024-03-21 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| KR102528998B1 (ko) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | 인간 항체, 제약 조성물 및 방법 |
| US11000601B2 (en) * | 2016-11-21 | 2021-05-11 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| WO2018218068A1 (en) * | 2017-05-24 | 2018-11-29 | Development Center For Biotechnology | Humanized antibodies against globo h and uses thereof in cancer treatments |
| KR20200131846A (ko) | 2018-03-14 | 2020-11-24 | 메모리얼 슬로안 케터링 캔서 센터 | 항-폴리시알산 항체 및 그 용도 |
| WO2019232519A1 (en) * | 2018-06-01 | 2019-12-05 | Obi Pharma, Inc. | Combination therapy by using anti-globo h or anti-ssea-4 antibody with anti-negative immune check points antibody |
| US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| WO2020198699A2 (en) * | 2019-03-28 | 2020-10-01 | Obi Pharma, Inc. | Companion diagnostic assay for globo-h related cancer therapy |
| CA3204922A1 (en) * | 2021-02-09 | 2022-08-18 | Ming-Tain Lai | Globo series antigens-binding chimeric antigen receptors and uses thereof |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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| CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
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| TW201622743A (zh) | 2014-03-19 | 2016-07-01 | 財團法人臺灣基督長老教會馬偕紀念社會事業基金會馬偕紀念醫院 | 免疫原醣肽、包含該醣肽之組合物及其用途 |
| EP3129048B1 (en) | 2014-04-10 | 2020-01-15 | OBI Pharma Inc. | Antibodies binding to tumour associated carbohydrate antigens, pharmaceutical compositions and uses thereof |
-
2015
- 2015-04-10 EP EP15777370.6A patent/EP3129048B1/en active Active
- 2015-04-10 CN CN202011258954.4A patent/CN112390887B/zh active Active
- 2015-04-10 TW TW106128654A patent/TWI697503B/zh active
- 2015-04-10 US US15/303,132 patent/US9902779B2/en active Active
- 2015-04-10 TW TW104111557A patent/TWI609886B/zh active
- 2015-04-10 AU AU2015243246A patent/AU2015243246B2/en not_active Ceased
- 2015-04-10 RU RU2016138744A patent/RU2016138744A/ru not_active Application Discontinuation
- 2015-04-10 WO PCT/US2015/025305 patent/WO2015157629A2/en not_active Ceased
- 2015-04-10 CA CA3104268A patent/CA3104268A1/en not_active Abandoned
- 2015-04-10 BR BR112016020009A patent/BR112016020009A2/pt not_active IP Right Cessation
- 2015-04-10 ES ES15777370T patent/ES2772817T3/es active Active
- 2015-04-10 EP EP20151337.1A patent/EP3662928A1/en not_active Withdrawn
- 2015-04-10 JP JP2016554855A patent/JP2017512759A/ja active Pending
- 2015-04-10 TW TW106128651A patent/TWI695013B/zh active
- 2015-04-10 CN CN201580011286.6A patent/CN106456727B/zh active Active
- 2015-04-10 SG SG11201607258SA patent/SG11201607258SA/en unknown
- 2015-04-10 KR KR1020167024072A patent/KR101966408B1/ko not_active Expired - Fee Related
- 2015-04-10 CA CA2941029A patent/CA2941029C/en active Active
-
2016
- 2016-07-19 IL IL246837A patent/IL246837B/en active IP Right Grant
- 2016-07-25 ZA ZA2016/05175A patent/ZA201605175B/en unknown
- 2016-10-04 PH PH12016501976A patent/PH12016501976A1/en unknown
- 2016-10-07 CL CL2016002569A patent/CL2016002569A1/es unknown
-
2017
- 2017-11-28 US US15/824,733 patent/US10815307B2/en active Active
-
2018
- 2018-10-26 AU AU2018253589A patent/AU2018253589B2/en not_active Ceased
-
2020
- 2020-08-13 IL IL276695A patent/IL276695B/en unknown
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