JP2017512759A5 - - Google Patents
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- JP2017512759A5 JP2017512759A5 JP2016554855A JP2016554855A JP2017512759A5 JP 2017512759 A5 JP2017512759 A5 JP 2017512759A5 JP 2016554855 A JP2016554855 A JP 2016554855A JP 2016554855 A JP2016554855 A JP 2016554855A JP 2017512759 A5 JP2017512759 A5 JP 2017512759A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cancer
- amino acid
- homologous
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 239000000427 antigen Substances 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- -1 Globo H Proteins 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977824P | 2014-04-10 | 2014-04-10 | |
| US61/977,824 | 2014-04-10 | ||
| US201462057381P | 2014-09-30 | 2014-09-30 | |
| US62/057,381 | 2014-09-30 | ||
| PCT/US2015/025305 WO2015157629A2 (en) | 2014-04-10 | 2015-04-10 | Antibodies, pharmaceutical compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017512759A JP2017512759A (ja) | 2017-05-25 |
| JP2017512759A5 true JP2017512759A5 (enExample) | 2019-06-27 |
Family
ID=54288553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554855A Pending JP2017512759A (ja) | 2014-04-10 | 2015-04-10 | 抗体、前記抗体を産生するハイブリドーマ、前記抗体を含む薬学的組成物及びその用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9902779B2 (enExample) |
| EP (2) | EP3662928A1 (enExample) |
| JP (1) | JP2017512759A (enExample) |
| KR (1) | KR101966408B1 (enExample) |
| CN (2) | CN112390887B (enExample) |
| AU (2) | AU2015243246B2 (enExample) |
| BR (1) | BR112016020009A2 (enExample) |
| CA (2) | CA3104268A1 (enExample) |
| CL (1) | CL2016002569A1 (enExample) |
| ES (1) | ES2772817T3 (enExample) |
| IL (2) | IL246837B (enExample) |
| PH (1) | PH12016501976A1 (enExample) |
| RU (1) | RU2016138744A (enExample) |
| SG (1) | SG11201607258SA (enExample) |
| TW (3) | TWI695013B (enExample) |
| WO (1) | WO2015157629A2 (enExample) |
| ZA (1) | ZA201605175B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2666141C2 (ru) | 2013-09-17 | 2018-09-06 | Оби Фарма, Инк. | Композиции углеводной вакцины для индукции иммунного ответа и их применение при лечении рака |
| MX2016012124A (es) | 2014-03-19 | 2017-04-06 | Mackay Medical Found The Presbyterian Church In Taiwan Mackay Memorial Hospital | Anticuerpos contra glicopeptidos inmunogenicos, composicion que los comprende y usos de estos. |
| JP2017512759A (ja) | 2014-04-10 | 2017-05-25 | オービーアイ ファーマ インコーポレイテッド | 抗体、前記抗体を産生するハイブリドーマ、前記抗体を含む薬学的組成物及びその用途 |
| US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
| CN108472362B (zh) * | 2015-10-07 | 2022-03-29 | 台湾浩鼎生技股份有限公司 | 新颖糖类抗体、医药组成物及其用途 |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| WO2017185089A2 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| GB201612317D0 (en) | 2016-07-15 | 2016-08-31 | Philogen Spa | Antibody compositions |
| WO2018022933A1 (en) | 2016-07-27 | 2018-02-01 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| JP7121724B2 (ja) | 2016-07-29 | 2022-08-18 | オービーアイ ファーマ，インコーポレイテッド | ヒト抗体、医薬組成物及び方法 |
| WO2018094414A1 (en) * | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| CA3064443A1 (en) * | 2017-05-24 | 2018-11-29 | Development Center For Biotechnology | Humanized antibodies against globo h and uses thereof in cancer treatments |
| CN112566642B (zh) * | 2018-03-14 | 2025-01-17 | 纪念斯隆凯特琳癌症中心 | 抗聚唾液酸抗体及其用途 |
| KR20210031651A (ko) * | 2018-06-01 | 2021-03-22 | 오비아이 파머 인코퍼레이티드 | 항-음성 면역 관문 항체와 항-globo h 또는 항-ssea-4 항체를 사용한 병용 요법 |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| US20250327822A1 (en) * | 2019-03-28 | 2025-10-23 | Ming-Tain Lai | Companion diagnostic assay for globo-h related cancer therapy |
| CA3204922A1 (en) * | 2021-02-09 | 2022-08-18 | Ming-Tain Lai | Globo series antigens-binding chimeric antigen receptors and uses thereof |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
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| CN1423700A (zh) | 2000-03-24 | 2003-06-11 | 麦克美特股份公司 | 含有针对nkg2d受体复合物的表位的结合位点的多功能多肽 |
| CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| ES2276735T3 (es) * | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| BR0107262B1 (pt) | 2001-12-17 | 2014-04-22 | Da Fonseca Clovis Orlando Pereira | Composição farmacêutica inalatória |
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| ATE444972T1 (de) * | 2002-04-30 | 2009-10-15 | Kyowa Hakko Kirin Co Ltd | ANTIKÖRPER GEGEN DEN HUMANEN ßINSULIN-LIKEß WACHSTUMSFAKTOR |
| JP4524181B2 (ja) * | 2002-05-30 | 2010-08-11 | マクロジェニクス，インコーポレーテッド | Ｃｄ１６ａ結合タンパク質および免疫障害治療のための使用 |
| AT413486B (de) | 2002-07-03 | 2006-03-15 | Igeneon Krebs Immuntherapie | Verwendung eines antikörpers gerichtet gegen lewis-antigene |
| PT1766093E (pt) | 2004-02-06 | 2011-08-24 | Univ Massachusetts | Anticorpos contra toxinas de clostridium difficile e utilizações dos mesmos |
| AU2005259221B2 (en) * | 2004-07-01 | 2011-02-10 | Innate Pharma | Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use |
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| CL2007002668A1 (es) * | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
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| US20100145032A1 (en) * | 2007-01-18 | 2010-06-10 | Suomen Punainen Risti, Veripalelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
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| CA2728574C (en) | 2008-06-16 | 2020-10-20 | Academia Sinica | Cancer diagnosis based on levels of antibodies against globo h and its fragments |
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| BR112014020826A8 (pt) | 2012-02-24 | 2017-09-19 | Stem Centrx Inc | Anticorpo que se liga especificamente a um epítopo, ácido nucleico, vetor ou célula hospedeira, conjugado de fármaco anticorpo, composição farmacêutica compreendendo o referido anticorpo, uso do mesmo, kit e método de preparação do conjugado |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| MX2016012124A (es) * | 2014-03-19 | 2017-04-06 | Mackay Medical Found The Presbyterian Church In Taiwan Mackay Memorial Hospital | Anticuerpos contra glicopeptidos inmunogenicos, composicion que los comprende y usos de estos. |
| JP2017512759A (ja) | 2014-04-10 | 2017-05-25 | オービーアイ ファーマ インコーポレイテッド | 抗体、前記抗体を産生するハイブリドーマ、前記抗体を含む薬学的組成物及びその用途 |
-
2015
- 2015-04-10 JP JP2016554855A patent/JP2017512759A/ja active Pending
- 2015-04-10 CA CA3104268A patent/CA3104268A1/en not_active Abandoned
- 2015-04-10 EP EP20151337.1A patent/EP3662928A1/en not_active Withdrawn
- 2015-04-10 TW TW106128651A patent/TWI695013B/zh active
- 2015-04-10 US US15/303,132 patent/US9902779B2/en active Active
- 2015-04-10 ES ES15777370T patent/ES2772817T3/es active Active
- 2015-04-10 BR BR112016020009A patent/BR112016020009A2/pt not_active IP Right Cessation
- 2015-04-10 CA CA2941029A patent/CA2941029C/en active Active
- 2015-04-10 KR KR1020167024072A patent/KR101966408B1/ko active Active
- 2015-04-10 EP EP15777370.6A patent/EP3129048B1/en active Active
- 2015-04-10 RU RU2016138744A patent/RU2016138744A/ru not_active Application Discontinuation
- 2015-04-10 CN CN202011258954.4A patent/CN112390887B/zh active Active
- 2015-04-10 TW TW104111557A patent/TWI609886B/zh active
- 2015-04-10 CN CN201580011286.6A patent/CN106456727B/zh active Active
- 2015-04-10 WO PCT/US2015/025305 patent/WO2015157629A2/en not_active Ceased
- 2015-04-10 SG SG11201607258SA patent/SG11201607258SA/en unknown
- 2015-04-10 AU AU2015243246A patent/AU2015243246B2/en not_active Ceased
- 2015-04-10 TW TW106128654A patent/TWI697503B/zh active
-
2016
- 2016-07-19 IL IL246837A patent/IL246837B/en active IP Right Grant
- 2016-07-25 ZA ZA2016/05175A patent/ZA201605175B/en unknown
- 2016-10-04 PH PH12016501976A patent/PH12016501976A1/en unknown
- 2016-10-07 CL CL2016002569A patent/CL2016002569A1/es unknown
-
2017
- 2017-11-28 US US15/824,733 patent/US10815307B2/en active Active
-
2018
- 2018-10-26 AU AU2018253589A patent/AU2018253589B2/en not_active Ceased
-
2020
- 2020-08-13 IL IL276695A patent/IL276695B/en unknown
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