JP2021500916A5 - - Google Patents
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- JP2021500916A5 JP2021500916A5 JP2020527848A JP2020527848A JP2021500916A5 JP 2021500916 A5 JP2021500916 A5 JP 2021500916A5 JP 2020527848 A JP2020527848 A JP 2020527848A JP 2020527848 A JP2020527848 A JP 2020527848A JP 2021500916 A5 JP2021500916 A5 JP 2021500916A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- polypeptide sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229920001184 polypeptide Polymers 0.000 claims 53
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims 53
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 14
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 5
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 5
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 102000049109 human HAVCR2 Human genes 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762538277P | 2017-07-28 | 2017-07-28 | |
| US62/538,277 | 2017-07-28 | ||
| PCT/US2018/043800 WO2019023410A1 (en) | 2017-07-28 | 2018-07-26 | ANTI-TIM-1 ANTIBODIES AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500916A JP2021500916A (ja) | 2021-01-14 |
| JP2021500916A5 true JP2021500916A5 (enExample) | 2021-07-26 |
Family
ID=65040974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527848A Ceased JP2021500916A (ja) | 2017-07-28 | 2018-07-26 | 抗ｔｉｍ−３抗体及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11214615B2 (enExample) |
| EP (2) | EP4039274A1 (enExample) |
| JP (1) | JP2021500916A (enExample) |
| KR (1) | KR20200032156A (enExample) |
| CN (1) | CN111050797B (enExample) |
| AU (1) | AU2018306321A1 (enExample) |
| CA (1) | CA3070295A1 (enExample) |
| EA (1) | EA202090401A1 (enExample) |
| WO (1) | WO2019023410A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12454574B2 (en) | 2018-10-30 | 2025-10-28 | Board Of Regents, The University Of Texas System | Anti-CD79B antibodies and chimeric antigen receptors and methods of use thereof |
| WO2021051352A1 (zh) * | 2019-09-19 | 2021-03-25 | 上药生物治疗（香港）有限公司 | 一种分离的抗原结合蛋白及其用途 |
| JP7900284B2 (ja) * | 2019-12-17 | 2026-08-04 | フェインズ セラピューティクス，インコーポレーテッド | 鎖間システインが選択的にマッチングされた二重特異性抗体及びその使用 |
| EP4084826A2 (en) * | 2019-12-30 | 2022-11-09 | University Of Louisville Research Foundation, Inc. | Virus-like particle binding agents, related compositions, and related methods |
| WO2021169948A1 (zh) * | 2020-02-24 | 2021-09-02 | 苏州恒康生命科学有限公司 | Tim3结合分子及其应用 |
| US20230183371A1 (en) * | 2020-04-30 | 2023-06-15 | Board Of Regents, The University Of Texas System | Anti-cd79b antibodies and chimeric antigen receptors and methods of use thereof |
| GB202015115D0 (en) * | 2020-09-24 | 2020-11-11 | Imperial College Innovations Ltd | ZIP12 Antibody |
| CN113151186B (zh) * | 2021-02-04 | 2022-02-18 | 上海交通大学 | 抗人cd271的单克隆抗体及用途 |
| CN117377692A (zh) | 2021-04-23 | 2024-01-09 | 苏州逻晟生物医药有限公司 | Tim-3-靶向抗体及其用途 |
| WO2023105528A1 (en) * | 2021-12-12 | 2023-06-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to ceacam1 |
| CN116925216B (zh) * | 2022-04-11 | 2024-09-24 | 东莞市朋志生物科技有限公司 | 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒 |
| WO2025035133A1 (en) * | 2023-08-10 | 2025-02-13 | Board Of Regents, The University Of Texas System | Bmp-7 antibody compositions & methods for treating cancer |
| CN119264251B (zh) * | 2024-12-09 | 2025-03-14 | 上海交通大学医学院附属仁济医院 | 一种cbln1单克隆抗体和应用 |
| CN120590523B (zh) * | 2025-06-20 | 2026-01-27 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种犬瘟热病毒n蛋白单克隆抗体，快速检测胶体金试纸条及其制备方法 |
| CN120623323B (zh) * | 2025-06-23 | 2026-04-21 | 江苏东抗生物医药科技有限公司 | 一种靶向猴痘病毒的抗体及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4694128B2 (ja) | 2002-01-30 | 2011-06-08 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | ＴＩＭ−３、Ｔｈ１特異的細胞表面分子に関連した組成物および方法 |
| AU2005256113B2 (en) | 2004-07-09 | 2011-02-10 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody |
| KR20070094890A (ko) * | 2004-10-25 | 2007-09-27 | 머크 앤드 캄파니 인코포레이티드 | 안티 ａｄｄｌ 항체 및 그 용도 |
| US9416165B2 (en) | 2007-10-26 | 2016-08-16 | The Regents Of The University Of California | Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors |
| US8647623B2 (en) | 2009-04-10 | 2014-02-11 | Kyowa Hakko Kirin Co., Ltd | Method for treatment of blood tumor using anti-TIM-3 antibody |
| CN103079644B (zh) * | 2010-06-11 | 2017-02-15 | 协和发酵麒麟株式会社 | 抗tim‑3抗体 |
| US9163087B2 (en) | 2010-06-18 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| CN103173412B (zh) * | 2012-12-07 | 2015-04-22 | 天津三箭生物技术有限公司 | 小鼠抗人cd20单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株 |
| KR102060540B1 (ko) | 2013-04-03 | 2019-12-31 | 삼성전자주식회사 | 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물 |
| CA2913052A1 (en) * | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| PL3099717T3 (pl) * | 2014-01-31 | 2019-10-31 | Novartis Ag | Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie |
| AU2015340056A1 (en) | 2014-10-27 | 2017-05-25 | Agency For Science, Technology And Research | Anti-TIM-3 antibodies |
| GB201419094D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-TIM-3-antibodies |
| MY193661A (en) | 2014-11-06 | 2022-10-24 | Hoffmann La Roche | Anti-tim3 antibodies and methods of use |
| US20160200815A1 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| AU2016229189A1 (en) | 2015-03-06 | 2017-09-21 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind TIM3 |
| PL3277321T3 (pl) | 2015-04-01 | 2024-11-18 | Anaptysbio, Inc. | Przeciwciała skierowane przeciwko białku 3 immunoglobuliny limfocytów t i mucyny (tim-3) |
| US20180271861A1 (en) | 2015-07-14 | 2018-09-27 | Kyowa Hakko Kirin Co., Ltd. | Therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody |
| US20180207273A1 (en) | 2015-07-29 | 2018-07-26 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
| EP3337826A1 (en) | 2015-08-20 | 2018-06-27 | Sutro Biopharma, Inc. | Anti-tim-3 antibodies, compositions comprising anti-tim-3 antibodies and methods of making and using anti-tim-3 antibodies |
| WO2017055393A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules |
| MA43028B1 (fr) | 2015-10-02 | 2021-09-30 | Hoffmann La Roche | Anticorps bispécifiques pour pd1 et tim3 |
| PT3370768T (pt) | 2015-11-03 | 2022-04-21 | Janssen Biotech Inc | Anticorpos que se ligam especificamente ao pd-1 e seus usos |
| EP3448874A4 (en) * | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
-
2018
- 2018-07-26 JP JP2020527848A patent/JP2021500916A/ja not_active Ceased
- 2018-07-26 US US16/633,262 patent/US11214615B2/en active Active
- 2018-07-26 CN CN201880050603.9A patent/CN111050797B/zh active Active
- 2018-07-26 KR KR1020207004818A patent/KR20200032156A/ko not_active Withdrawn
- 2018-07-26 CA CA3070295A patent/CA3070295A1/en active Pending
- 2018-07-26 EA EA202090401A patent/EA202090401A1/ru unknown
- 2018-07-26 WO PCT/US2018/043800 patent/WO2019023410A1/en not_active Ceased
- 2018-07-26 EP EP22151361.7A patent/EP4039274A1/en not_active Withdrawn
- 2018-07-26 EP EP18837224.7A patent/EP3658185A4/en not_active Withdrawn
- 2018-07-26 AU AU2018306321A patent/AU2018306321A1/en not_active Abandoned