JP2021500916A5 - - Google Patents
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- JP2021500916A5 JP2021500916A5 JP2020527848A JP2020527848A JP2021500916A5 JP 2021500916 A5 JP2021500916 A5 JP 2021500916A5 JP 2020527848 A JP2020527848 A JP 2020527848A JP 2020527848 A JP2020527848 A JP 2020527848A JP 2021500916 A5 JP2021500916 A5 JP 2021500916A5
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- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- polypeptide sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229920001184 polypeptide Polymers 0.000 claims 53
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims 53
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 14
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 5
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 5
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 102000049109 human HAVCR2 Human genes 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762538277P | 2017-07-28 | 2017-07-28 | |
| US62/538,277 | 2017-07-28 | ||
| PCT/US2018/043800 WO2019023410A1 (en) | 2017-07-28 | 2018-07-26 | ANTI-TIM-1 ANTIBODIES AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500916A JP2021500916A (ja) | 2021-01-14 |
| JP2021500916A5 true JP2021500916A5 (enExample) | 2021-07-26 |
Family
ID=65040974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527848A Ceased JP2021500916A (ja) | 2017-07-28 | 2018-07-26 | 抗ｔｉｍ−３抗体及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11214615B2 (enExample) |
| EP (2) | EP3658185A4 (enExample) |
| JP (1) | JP2021500916A (enExample) |
| KR (1) | KR20200032156A (enExample) |
| CN (1) | CN111050797B (enExample) |
| AU (1) | AU2018306321A1 (enExample) |
| CA (1) | CA3070295A1 (enExample) |
| EA (1) | EA202090401A1 (enExample) |
| WO (1) | WO2019023410A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019370276A1 (en) | 2018-10-30 | 2021-06-10 | Board Of Regents, The University Of Texas System | Anti-CD79b antibodies and chimeric antigen receptors and methods of use thereof |
| WO2021051352A1 (zh) * | 2019-09-19 | 2021-03-25 | 上药生物治疗（香港）有限公司 | 一种分离的抗原结合蛋白及其用途 |
| CN114929739A (zh) * | 2019-12-17 | 2022-08-19 | 凡恩世制药公司 | 具有可替换匹配的链间半胱氨酸的双特异性抗体及其用途 |
| CN113150150B (zh) * | 2020-02-24 | 2023-08-11 | 苏州恒康生命科学有限公司 | Tim3结合分子及其应用 |
| KR20230003580A (ko) * | 2020-04-30 | 2023-01-06 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 항-cd79b 항체 및 키메라 항원 수용체 및 이의 사용 방법 |
| CN113151186B (zh) * | 2021-02-04 | 2022-02-18 | 上海交通大学 | 抗人cd271的单克隆抗体及用途 |
| CN117377692A (zh) | 2021-04-23 | 2024-01-09 | 苏州逻晟生物医药有限公司 | Tim-3-靶向抗体及其用途 |
| WO2023105528A1 (en) * | 2021-12-12 | 2023-06-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to ceacam1 |
| CN116925216B (zh) * | 2022-04-11 | 2024-09-24 | 东莞市朋志生物科技有限公司 | 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒 |
| WO2025035133A1 (en) * | 2023-08-10 | 2025-02-13 | Board Of Regents, The University Of Texas System | Bmp-7 antibody compositions & methods for treating cancer |
| CN119264251B (zh) * | 2024-12-09 | 2025-03-14 | 上海交通大学医学院附属仁济医院 | 一种cbln1单克隆抗体和应用 |
| CN120590523B (zh) * | 2025-06-20 | 2026-01-27 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种犬瘟热病毒n蛋白单克隆抗体，快速检测胶体金试纸条及其制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3020413A1 (en) | 2002-01-30 | 2016-05-18 | The Brigham and Women's Hospital, Inc. | Compositions and methods related to TIM-3, a TH1-specific cell surface molecule |
| PL1674111T3 (pl) | 2004-07-09 | 2011-04-29 | Chugai Pharmaceutical Co Ltd | Przeciwciała anty-glipikan 3 |
| NZ554725A (en) * | 2004-10-25 | 2009-10-30 | Merck & Co Inc | Anti-ADDL antibodies and uses thereof |
| CA2703947C (en) | 2007-10-26 | 2018-12-04 | Governing Council Of The University Of Toronto | Therapeutic and diagnostic methods using tim-3 |
| WO2010117057A1 (ja) | 2009-04-10 | 2010-10-14 | 協和発酵キリン株式会社 | 抗tim-3抗体を用いた血液腫瘍治療法 |
| ES2682078T3 (es) | 2010-06-11 | 2018-09-18 | Kyowa Hakko Kirin Co., Ltd. | Anticuerpo anti-TIM-3 |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| CN103173412B (zh) | 2012-12-07 | 2015-04-22 | 天津三箭生物技术有限公司 | 小鼠抗人cd20单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株 |
| KR102060540B1 (ko) * | 2013-04-03 | 2019-12-31 | 삼성전자주식회사 | 항 c-Met 항체 및 항 Ang2 항체를 포함하는 병용 투여용 약학 조성물 |
| WO2014190273A1 (en) * | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| DK3099717T3 (da) * | 2014-01-31 | 2019-07-01 | Novartis Ag | Antistofmolekyler med tim-3 og anvendelser deraf |
| CA2965960A1 (en) | 2014-10-27 | 2016-05-06 | Agency For Science, Technology And Research | Anti-tim-3 antibodies |
| GB201419094D0 (en) | 2014-10-27 | 2014-12-10 | Agency Science Tech & Res | Anti-TIM-3-antibodies |
| PL3215532T3 (pl) | 2014-11-06 | 2020-03-31 | F. Hoffmann-La Roche Ag | Przeciwciała anty-TIM3 i sposoby ich zastosowania |
| US20160200815A1 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| JP2018510151A (ja) | 2015-03-06 | 2018-04-12 | ソレント・セラピューティクス・インコーポレイテッド | Ｔｉｍ３に結合する抗体医薬 |
| CN107847589B (zh) | 2015-04-01 | 2022-03-29 | 安奈普泰斯生物有限公司 | 针对t细胞免疫球蛋白和粘蛋白蛋白3(tim-3)的抗体 |
| CA2992238A1 (en) | 2015-07-14 | 2017-01-19 | Kyowa Hakko Kirin Co., Ltd. | A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody |
| EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| WO2017031242A1 (en) | 2015-08-20 | 2017-02-23 | Sutro Biopharma, Inc. | Anti-tim-3 antibodies, compositions comprising anti-tim-3 antibodies and methods of making and using anti-tim-3 antibodies |
| WO2017055393A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules |
| SMT202100506T1 (it) | 2015-10-02 | 2021-11-12 | Hoffmann La Roche | Anticorpi bispecifici specifici per pd1 e tim3 |
| SMT202200118T1 (it) | 2015-11-03 | 2022-05-12 | Janssen Biotech Inc | Anticorpi che legano specificamente pd-1 e loro usi |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
-
2018
- 2018-07-26 EP EP18837224.7A patent/EP3658185A4/en not_active Withdrawn
- 2018-07-26 EP EP22151361.7A patent/EP4039274A1/en not_active Withdrawn
- 2018-07-26 JP JP2020527848A patent/JP2021500916A/ja not_active Ceased
- 2018-07-26 CN CN201880050603.9A patent/CN111050797B/zh active Active
- 2018-07-26 WO PCT/US2018/043800 patent/WO2019023410A1/en not_active Ceased
- 2018-07-26 CA CA3070295A patent/CA3070295A1/en active Pending
- 2018-07-26 KR KR1020207004818A patent/KR20200032156A/ko not_active Withdrawn
- 2018-07-26 US US16/633,262 patent/US11214615B2/en active Active
- 2018-07-26 AU AU2018306321A patent/AU2018306321A1/en not_active Abandoned
- 2018-07-26 EA EA202090401A patent/EA202090401A1/ru unknown