JP2020536488A5 - - Google Patents
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- JP2020536488A5 JP2020536488A5 JP2020505360A JP2020505360A JP2020536488A5 JP 2020536488 A5 JP2020536488 A5 JP 2020536488A5 JP 2020505360 A JP2020505360 A JP 2020505360A JP 2020505360 A JP2020505360 A JP 2020505360A JP 2020536488 A5 JP2020536488 A5 JP 2020536488A5
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- Prior art keywords
- seq
- variable region
- chain variable
- polypeptide sequence
- heavy chain
- Prior art date
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- 229920001184 polypeptide Polymers 0.000 claims 77
- 108090000765 processed proteins & peptides Proteins 0.000 claims 77
- 102000004196 processed proteins & peptides Human genes 0.000 claims 77
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 15
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 6
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 2
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010057249 Phagocytosis Diseases 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 102000044459 human CD47 Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000008782 phagocytosis Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 102000034285 signal transducing proteins Human genes 0.000 claims 1
- 108091006024 signal transducing proteins Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762540118P | 2017-08-02 | 2017-08-02 | |
| US62/540,118 | 2017-08-02 | ||
| US201862657094P | 2018-04-13 | 2018-04-13 | |
| US62/657,094 | 2018-04-13 | ||
| PCT/US2018/044384 WO2019027903A1 (en) | 2017-08-02 | 2018-07-30 | ANTI-CD47 ANTIBODIES AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536488A JP2020536488A (ja) | 2020-12-17 |
| JP2020536488A5 true JP2020536488A5 (enExample) | 2021-07-26 |
| JP7262440B2 JP7262440B2 (ja) | 2023-04-21 |
Family
ID=65233054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505360A Active JP7262440B2 (ja) | 2017-08-02 | 2018-07-30 | 抗ｃｄ４７抗体及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11401329B2 (enExample) |
| EP (1) | EP3661965A4 (enExample) |
| JP (1) | JP7262440B2 (enExample) |
| KR (1) | KR102646468B1 (enExample) |
| CN (1) | CN111183155B (enExample) |
| AU (1) | AU2018312222B2 (enExample) |
| BR (1) | BR112020001679A2 (enExample) |
| CA (1) | CA3071860A1 (enExample) |
| IL (1) | IL272330B1 (enExample) |
| MX (1) | MX2020001309A (enExample) |
| NZ (1) | NZ761568A (enExample) |
| SG (1) | SG11202000053TA (enExample) |
| WO (1) | WO2019027903A1 (enExample) |
| ZA (1) | ZA202000373B (enExample) |
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2018
- 2018-07-30 EP EP18840724.1A patent/EP3661965A4/en active Pending
- 2018-07-30 WO PCT/US2018/044384 patent/WO2019027903A1/en not_active Ceased
- 2018-07-30 BR BR112020001679-9A patent/BR112020001679A2/pt unknown
- 2018-07-30 CA CA3071860A patent/CA3071860A1/en active Pending
- 2018-07-30 US US16/633,730 patent/US11401329B2/en active Active
- 2018-07-30 NZ NZ761568A patent/NZ761568A/en unknown
- 2018-07-30 IL IL272330A patent/IL272330B1/en unknown
- 2018-07-30 JP JP2020505360A patent/JP7262440B2/ja active Active
- 2018-07-30 CN CN201880050597.7A patent/CN111183155B/zh active Active
- 2018-07-30 AU AU2018312222A patent/AU2018312222B2/en active Active
- 2018-07-30 SG SG11202000053TA patent/SG11202000053TA/en unknown
- 2018-07-30 MX MX2020001309A patent/MX2020001309A/es unknown
- 2018-07-30 KR KR1020207006052A patent/KR102646468B1/ko active Active
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2020
- 2020-01-20 ZA ZA2020/00373A patent/ZA202000373B/en unknown
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