JP2018536393A5 - - Google Patents
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- Publication number
- JP2018536393A5 JP2018536393A5 JP2018518451A JP2018518451A JP2018536393A5 JP 2018536393 A5 JP2018536393 A5 JP 2018536393A5 JP 2018518451 A JP2018518451 A JP 2018518451A JP 2018518451 A JP2018518451 A JP 2018518451A JP 2018536393 A5 JP2018536393 A5 JP 2018536393A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- region
- antibody
- fragment
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 15
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239438P | 2015-10-09 | 2015-10-09 | |
| US62/239,438 | 2015-10-09 | ||
| GB1517913.8 | 2015-10-09 | ||
| GBGB1517913.8A GB201517913D0 (en) | 2015-10-09 | 2015-10-09 | Anti-WT1/HLA-specific antibodies |
| EP15189753 | 2015-10-14 | ||
| EP15189753.5 | 2015-10-14 | ||
| PCT/EP2016/073587 WO2017060201A1 (en) | 2015-10-09 | 2016-10-04 | Anti-wt1/hla-specific antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536393A JP2018536393A (ja) | 2018-12-13 |
| JP2018536393A5 true JP2018536393A5 (enExample) | 2019-11-14 |
| JP6862435B2 JP6862435B2 (ja) | 2021-04-21 |
Family
ID=58487775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518451A Expired - Fee Related JP6862435B2 (ja) | 2015-10-09 | 2016-10-04 | 抗ｗｔ１／ｈｌａ特異的抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10836829B2 (enExample) |
| EP (1) | EP3359565A1 (enExample) |
| JP (1) | JP6862435B2 (enExample) |
| HK (1) | HK1258444A1 (enExample) |
| MA (1) | MA45004A (enExample) |
| WO (1) | WO2017060201A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4317432A3 (en) | 2016-12-08 | 2024-04-17 | Immatics Biotechnologies GmbH | T cell receptors with improved pairing |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| EP3366704A1 (en) * | 2017-02-28 | 2018-08-29 | Affimed GmbH | Antibodies specific for mmp1/hla-a2 complex |
| KR102412805B1 (ko) * | 2017-05-31 | 2022-06-27 | 크라제 메디컬 씨오 리미티드 | 세포 면역 요법을 위한 조성물 및 방법 |
| US20190016802A1 (en) | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Dual specificity polypeptide molecule |
| DE102017127984B4 (de) | 2017-11-27 | 2019-12-05 | Immatics US, Inc. | Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen |
| PE20201149A1 (es) | 2017-12-21 | 2020-10-26 | Hoffmann La Roche | Anticuerpos de union a hla-a2/wt1 |
| KR20200119840A (ko) | 2018-02-09 | 2020-10-20 | 이매틱스 유에스 인코포레이티드 | T 세포의 제조 방법 |
| DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| US20200297768A1 (en) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| KR20220029584A (ko) | 2019-05-27 | 2022-03-08 | 이매틱스 유에스 인코포레이티드 | 바이러스 벡터 및 입양 세포 요법에서 그 사용 |
| AU2020286756A1 (en) | 2019-06-06 | 2022-01-27 | Immatics Biotechnologies Gmbh | Sorting with counter selection using sequence similar peptides |
| US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
| JP2023515131A (ja) | 2020-02-24 | 2023-04-12 | イマティクス ユーエス，アイエヌシー． | がんおよび関連する悪性腫瘍の治療のためにｔ細胞を増殖させる方法 |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| DE102020106710A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| WO2022040631A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
| CR20230295A (es) | 2020-12-31 | 2023-07-27 | Immatics Us Inc | Polipéptidos cd8, composiciones y métodos de uso de estos |
| KR20240004937A (ko) | 2021-05-05 | 2024-01-11 | 이매틱스 바이오테크놀로지스 게엠베하 | Bma031 항원 결합 폴리펩타이드 |
| EP4392441A1 (en) | 2021-08-24 | 2024-07-03 | Immatics US, Inc. | Selection of immune cells using peptide mhc complexes generated by conditional ligand exchange |
| US20230089392A1 (en) | 2021-09-20 | 2023-03-23 | Immatics US, Inc. | Monocyte depletion of t cells populations for t-cell therapy |
| CN118541392A (zh) | 2021-09-28 | 2024-08-23 | 准星生物医药有限公司 | 多种形式的分子复合物 |
| WO2023081925A1 (en) | 2021-11-08 | 2023-05-11 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
| WO2023212655A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| KR20250018168A (ko) | 2022-04-28 | 2025-02-04 | 이매틱스 유에스 인코포레이티드 | 막-결합된 il-15, cd8 폴리펩티드, 세포, 조성물, 및 이의 사용 방법 |
| US20230348561A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| EP4519418A1 (en) | 2022-05-05 | 2025-03-12 | Immatics US, Inc. | Methods for improving t cell efficacy |
| US20260226173A1 (en) * | 2023-02-06 | 2026-08-06 | Memorial Sloan-Kettering Cancer Center | Compositions including anti-wt-1 antibodies & antigen binding fragments and uses thereof |
| US20250134931A1 (en) | 2023-11-01 | 2025-05-01 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| WO2026006495A1 (en) * | 2024-06-25 | 2026-01-02 | Alloy Therapeutics, Inc. | Anti-wt1/hla-a2 antibody and uses thereof |
| WO2026096743A1 (en) | 2024-10-30 | 2026-05-07 | Immatics US, Inc. | Methods for gamma delta t cells manufacturing |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015070061A1 (en) * | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Anti-wt1/hla bi-specific antibody |
| ES2785081T3 (es) * | 2011-04-01 | 2020-10-05 | Memorial Sloan Kettering Cancer Center | Anticuerpos biespecíficos similares a receptores de células T específicos para un péptido de WT1 presentado por HLA-A2 |
| US20140271644A1 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Combination/adjuvant therapy for wt-1-positive disease |
| CA2934033A1 (en) * | 2013-11-07 | 2015-05-14 | Memorial Sloan-Kettering Cancer Center | Fc-enhanced anti-wt1/hla antibody |
| WO2015130766A1 (en) * | 2014-02-25 | 2015-09-03 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
| US20190031759A1 (en) * | 2015-04-30 | 2019-01-31 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
| NL2014935B1 (en) * | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
-
2016
- 2016-10-04 WO PCT/EP2016/073587 patent/WO2017060201A1/en not_active Ceased
- 2016-10-04 HK HK19100718.0A patent/HK1258444A1/zh unknown
- 2016-10-04 MA MA045004A patent/MA45004A/fr unknown
- 2016-10-04 EP EP16782018.2A patent/EP3359565A1/en not_active Ceased
- 2016-10-04 JP JP2018518451A patent/JP6862435B2/ja not_active Expired - Fee Related
- 2016-10-07 US US15/288,145 patent/US10836829B2/en not_active Expired - Fee Related
-
2020
- 2020-10-13 US US17/069,136 patent/US20210024635A1/en not_active Abandoned
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