JP2013543384A5 - - Google Patents

Info

Publication number

JP2013543384A5

JP2013543384A5 JP2013532152A JP2013532152A JP2013543384A5 JP 2013543384 A5 JP2013543384 A5 JP 2013543384A5 JP 2013532152 A JP2013532152 A JP 2013532152A JP 2013532152 A JP2013532152 A JP 2013532152A JP 2013543384 A5 JP2013543384 A5 JP 2013543384A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

chain amino

heavy chain

Prior art date

2011-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 41
• 102000004169 proteins and genes Human genes 0.000 claims 18
• 108090000623 proteins and genes Proteins 0.000 claims 18
• 230000027455 binding Effects 0.000 claims 7
• 229920001184 polypeptide Polymers 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 102100020790 Interleukin-12 receptor subunit beta-1 Human genes 0.000 claims 5
• 101710103841 Interleukin-12 receptor subunit beta-1 Proteins 0.000 claims 5
• 102000013462 Interleukin-12 Human genes 0.000 claims 3
• 108010065805 Interleukin-12 Proteins 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 2
• 102000013264 Interleukin-23 Human genes 0.000 claims 2
• 108010065637 Interleukin-23 Proteins 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 238000010367 cloning Methods 0.000 claims 2
• 238000012875 competitive assay Methods 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 102100037850 Interferon gamma Human genes 0.000 claims 1
• 108010074328 Interferon-gamma Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 210000000601 blood cell Anatomy 0.000 claims 1
• 239000013599 cloning vector Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1