JP2013543384A - 抗−ｉｌ１２ｒベータ１抗体ならびに自己免疫性および炎症性疾患の処置おけるその使用 - Google Patents
抗−ｉｌ１２ｒベータ１抗体ならびに自己免疫性および炎症性疾患の処置おけるその使用 Download PDFInfo
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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|---|---|---|---|
| US38991610P | 2010-10-05 | 2010-10-05 | |
| US61/389,916 | 2010-10-05 | ||
| PCT/EP2011/067237 WO2012045703A1 (en) | 2010-10-05 | 2011-10-03 | Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders |
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| JP2013543384A5 JP2013543384A5 (enExample) | 2014-11-20 |
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| EP (1) | EP2625203A1 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2021512613A (ja) * | 2018-02-08 | 2021-05-20 | ジェネンテック， インコーポレイテッド | 二重特異性抗原結合分子及びその使用方法 |
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| ES2864326T3 (es) | 2012-12-05 | 2021-10-13 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a EPO |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| EP3334842B1 (en) | 2015-08-12 | 2022-03-02 | Novartis AG | Methods of treating ophthalmic disorders |
| MA50435A (fr) * | 2017-05-24 | 2020-09-02 | Als Therapy Development Inst | Anticorps anti-ligand anti-cd40 thérapeutiques |
| CA3076872A1 (en) * | 2017-11-03 | 2019-05-09 | Novartis Ag | Anti-cd40 antibodies for use in treatment of sjogren's syndrome |
| US20200376135A1 (en) * | 2018-10-23 | 2020-12-03 | Magenta Therapeutics, Inc. | Fc silenced antibody drug conjugates (adcs) and uses thereof |
| SG11202103568PA (en) * | 2018-10-23 | 2021-05-28 | Magenta Therapeutics Inc | Fc silenced antibody drug conjugates (adcs) and uses thereof |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| WO2022032042A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il12 receptor synthetic cytokines and methods of use |
| WO2022031929A1 (en) * | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il12rb1-binding molecules and methods of use |
| JP7743500B2 (ja) | 2020-08-05 | 2025-09-24 | シンセカイン インコーポレイテッド | Ｉｌ１０受容体結合性分子および使用方法 |
| WO2022031890A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Ifngr2 binding molecules and methods of use |
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| CA3200885A1 (en) * | 2020-11-23 | 2022-05-27 | Genentech, Inc. | Methods for modulating host cell surface interactions with sars-cov-2 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US20250019450A1 (en) * | 2023-05-19 | 2025-01-16 | Diagonal Therapeutics Inc. | Bispecific agonistic antibodies to il12 receptor |
| CN117903313B (zh) * | 2023-12-27 | 2024-09-03 | 浙江大学 | 一种抗iars抗体及其应用 |
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- 2011-10-03 CN CN2011800485488A patent/CN103154037A/zh active Pending
- 2011-10-03 WO PCT/EP2011/067237 patent/WO2012045703A1/en not_active Ceased
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- 2011-10-04 US US13/252,721 patent/US8574573B2/en not_active Expired - Fee Related
- 2011-10-05 UY UY0001033651A patent/UY33651A/es unknown
- 2011-10-05 AR ARP110103692A patent/AR083310A1/es unknown
-
2012
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2013
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021512613A (ja) * | 2018-02-08 | 2021-05-20 | ジェネンテック， インコーポレイテッド | 二重特異性抗原結合分子及びその使用方法 |
| US11866498B2 (en) | 2018-02-08 | 2024-01-09 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| JP7475275B2 (ja) | 2018-02-08 | 2024-04-26 | ジェネンテック， インコーポレイテッド | 二重特異性抗原結合分子及びその使用方法 |
| US12297270B2 (en) | 2018-02-08 | 2025-05-13 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201217524A (en) | 2012-05-01 |
| US8574573B2 (en) | 2013-11-05 |
| US20140120101A1 (en) | 2014-05-01 |
| US8999708B2 (en) | 2015-04-07 |
| US8945548B2 (en) | 2015-02-03 |
| WO2012045703A1 (en) | 2012-04-12 |
| US20140087402A1 (en) | 2014-03-27 |
| EP2625203A1 (en) | 2013-08-14 |
| CN103154037A (zh) | 2013-06-12 |
| US20140099708A1 (en) | 2014-04-10 |
| US20120082681A1 (en) | 2012-04-05 |
| AR083310A1 (es) | 2013-02-13 |
| UY33651A (es) | 2012-04-30 |
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