MX2019000172A - Anticuerpos con inmunogenicidad baja y usos de estos. - Google Patents

Anticuerpos con inmunogenicidad baja y usos de estos.

Info

Publication number
MX2019000172A
MX2019000172A MX2019000172A MX2019000172A MX2019000172A MX 2019000172 A MX2019000172 A MX 2019000172A MX 2019000172 A MX2019000172 A MX 2019000172A MX 2019000172 A MX2019000172 A MX 2019000172A MX 2019000172 A MX2019000172 A MX 2019000172A
Authority
MX
Mexico
Prior art keywords
antibodies
low immunogenicity
antigen
methods
binding fragments
Prior art date
Application number
MX2019000172A
Other languages
English (en)
Inventor
Sun Jeonghoon
Hariharan Kandasamy
C Johnson Jeffrey
Dearth Lawrence
Hadjivassiliou Haralambos
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2019000172A publication Critical patent/MX2019000172A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

En la presente se proporcionan anticuerpos y fragmentos de unión al antígeno de estos con inmunogenicidad baja o nula en seres humanos y opcionalmente con características de fabricación deseables. También se proporcionan composiciones que comprenden tales anticuerpos o fragmentos de unión al antígeno, métodos para utilizar tales anticuerpos y métodos para elaborar tales anticuerpos.
MX2019000172A 2016-07-06 2017-07-05 Anticuerpos con inmunogenicidad baja y usos de estos. MX2019000172A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662359150P 2016-07-06 2016-07-06
PCT/US2017/040653 WO2018009499A1 (en) 2016-07-06 2017-07-05 Antibodies with low immunogenicity and uses thereof

Publications (1)

Publication Number Publication Date
MX2019000172A true MX2019000172A (es) 2019-09-26

Family

ID=60913146

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000172A MX2019000172A (es) 2016-07-06 2017-07-05 Anticuerpos con inmunogenicidad baja y usos de estos.

Country Status (19)

Country Link
US (1) US11427632B2 (es)
EP (1) EP3481862A4 (es)
JP (1) JP7120989B2 (es)
KR (1) KR20190035737A (es)
CN (1) CN109689684B (es)
AR (1) AR108975A1 (es)
AU (1) AU2017292752B2 (es)
BR (1) BR112019000166A2 (es)
CA (1) CA3029977A1 (es)
CL (1) CL2019000019A1 (es)
CO (1) CO2019001112A2 (es)
EA (1) EA201990218A1 (es)
EC (1) ECSP19008417A (es)
IL (1) IL264009A (es)
MX (1) MX2019000172A (es)
SG (1) SG11201811788SA (es)
TW (1) TW201811824A (es)
WO (1) WO2018009499A1 (es)
ZA (1) ZA201900070B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11401329B2 (en) 2017-08-02 2022-08-02 Phanes Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
KR102115300B1 (ko) 2018-06-01 2020-05-26 재단법인 목암생명과학연구소 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법
TW202104260A (zh) 2019-04-05 2021-02-01 美商西建公司 腫瘤選擇性結合ｃｄ４７之抗體之工程
JP7561775B2 (ja) 2019-06-07 2024-10-04 エーエルエックス オンコロジー インコーポレイテッド 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための方法及び試薬
EP4225793A1 (en) 2020-10-07 2023-08-16 Celgene Corporation Bispecific antibody treatment of lymphoid malignant neoplasm conditions
EP4256336A1 (en) 2020-12-06 2023-10-11 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0768377A1 (en) 1988-09-02 1997-04-16 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
GB9026912D0 (en) 1990-12-11 1991-01-30 Wessex Instrumentation Limited Reaction detection equipment
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
CA2110799A1 (en) 1991-06-14 1992-12-23 Arnold H. Horwitz Microbially-produced antibody fragments and their conjugates
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
ES2313867T3 (es) 1991-12-02 2009-03-16 Medical Research Council Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos.
DK0859841T3 (da) * 1995-08-18 2002-09-09 Morphosys Ag Protein/(poly)peptidbiblioteker
US7321026B2 (en) * 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
CA2491864C (en) 2001-07-12 2012-09-11 Jefferson Foote Super humanized antibodies
WO2004091510A2 (en) * 2003-04-11 2004-10-28 Medimmune, Inc. Recombinant il-9 antibodies and uses thereof
US20060228350A1 (en) 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
AU2004283850C1 (en) 2003-10-16 2011-11-03 Amgen Research (Munich) Gmbh Multispecific deimmunized CD3-binders
US7354854B2 (en) 2005-05-24 2008-04-08 Texas Instruments Incorporated Nickel silicide method and structure
EP1888644A1 (en) * 2005-06-01 2008-02-20 Micromet AG Anti-il2 antibodies
EP2004693B1 (en) 2006-03-30 2012-06-06 Novartis AG Compositions and methods of use for antibodies of c-met
MX2009006659A (es) 2006-12-20 2009-10-12 Mmr Information Systems Inc Anticuerpos y metodos de elaboracion y uso.
EP2014681A1 (en) * 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
EP3498731A1 (en) 2009-12-23 2019-06-19 ESBATech, an Alcon Biomedical Research Unit LLC Method for decreasing immunogenicity
US8785604B2 (en) 2010-02-18 2014-07-22 Effimune Anti-CD28 humanized antibodies
KR102338833B1 (ko) * 2012-02-06 2021-12-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
AU2013270684B2 (en) 2012-06-08 2018-04-19 Sutro Biopharma, Inc. Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
JP6826367B2 (ja) 2012-08-31 2021-02-03 ストロ バイオファーマ インコーポレーテッド アジド基を含む修飾アミノ酸
BR112015018851A2 (pt) 2013-02-06 2017-07-18 Inhibrx Llc anticorpos cd47 de não depleção de plaquetas e de não depleção de células vermelhas do sangue, e métodos de uso dos mesmos
WO2016073906A2 (en) 2014-11-06 2016-05-12 Scholar Rock, Inc. Transforming growth factor-related immunoassays
SG11201704058TA (en) 2014-11-18 2017-06-29 Janssen Pharmaceutica Nv Cd47 antibodies, methods, and uses
EA037654B1 (ru) * 2014-12-30 2021-04-27 Селджин Корпорейшн Анти-cd47-антитела и их применения
EP3353209B1 (en) * 2015-09-21 2022-03-16 Erasmus University Medical Center Rotterdam Anti-cd47 antibodies and methods of use

Also Published As

Publication number Publication date
JP2019524087A (ja) 2019-09-05
WO2018009499A1 (en) 2018-01-11
AU2017292752B2 (en) 2023-07-27
CN109689684A (zh) 2019-04-26
EP3481862A4 (en) 2020-08-12
US20190241654A1 (en) 2019-08-08
TW201811824A (zh) 2018-04-01
ZA201900070B (en) 2023-08-30
AU2017292752A1 (en) 2019-01-24
ECSP19008417A (es) 2019-02-28
AR108975A1 (es) 2018-10-17
SG11201811788SA (en) 2019-01-30
JP7120989B2 (ja) 2022-08-17
EA201990218A1 (ru) 2019-07-31
KR20190035737A (ko) 2019-04-03
EP3481862A1 (en) 2019-05-15
BR112019000166A2 (pt) 2019-10-01
IL264009A (en) 2019-01-31
CA3029977A1 (en) 2018-01-11
CO2019001112A2 (es) 2019-02-19
CL2019000019A1 (es) 2019-06-28
US11427632B2 (en) 2022-08-30
CN109689684B (zh) 2022-09-23

Similar Documents

Publication Publication Date Title
PH12018502225A1 (en) Anti-il-33 antibodies, compositions, methods and uses thereof
PH12019500193A1 (en) Chimeric antigen receptors targeting bcma and methods of use thereof
PH12019501357A1 (en) Anti-ox40 antibodies and their uses
PH12019501973A1 (en) Anti-phf-tau antibodies and uses thereof
MX2022012749A (es) Moleculas de union a linfopoyetina estromal timica (tslp) y metodos de uso de las moleculas.
MX2019007021A (es) Anticuerpos il-11ra.
ZA201900070B (en) Antibodies with low immunogenicity and uses thereof
MX2019007020A (es) Anticuerpos il-11.
TN2018000076A1 (en) Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
SG10201803042PA (en) Anti-tim-3 antibodies
PH12017500022A1 (en) Carrier-antibody compositions and methods of making and using the same
NZ766131A (en) Antibodies binding axl
MY191581A (en) Anti-pd-1 antibodies
WO2014152157A3 (en) Methods and compositions for the generation and use of conformation-specific antibodies
WO2017136659A3 (en) Humanized anti-cd3 antibodies, conjugates and uses thereof
MX2017016169A (es) Anticuerpos anti-her2 y metodos de uso.
NZ720769A (en) Anti-siglec-8 antibodies and methods of use thereof
MX2019004690A (es) Constructos de anticuerpos.
PH12018502137A1 (en) Anti-complement factor bb antibodies and uses thereof
WO2017075173A3 (en) Anti-factor d antibodies and conjugates
EP3455261A4 (en) ANTI-ROR2 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOF
MX2018005785A (es) Conjugados de anticuerpo anti-cd22-maytansina y metodos de uso de los mismos.
IL237852A0 (en) Antibodies against amphigoline, medical preparations containing them and their use
EA201591808A1 (ru) Композиции и способы лечения грибковых и бактериальных патогенов
MX2017016258A (es) Antigenos de leucemia mieloide aguda (aml) y usos de los mismos.