|
EP3211001B1
(en)
|
2010-12-22 |
2020-10-07 |
The Board of Trustees of the Leland Stanford Junior University |
Superagonists and antagonists of interleukin-2
|
|
BR112013032630B1
(pt)
|
2011-06-30 |
2022-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Polipeptídeo heterodimerizado compreendendo região fc de igg
|
|
WO2014149067A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Momenta Pharmaceuticals, Inc. |
Methods related to ctla4-fc fusion proteins
|
|
EP2996772B1
(en)
|
2013-05-13 |
2018-12-19 |
Momenta Pharmaceuticals, Inc. |
Methods for the treatment of neurodegeneration
|
|
HUE057598T2
(hu)
|
2013-08-08 |
2022-05-28 |
Cytune Pharma |
IL-15 és IL-15R-alfa sushi domén alapú modulokinek
|
|
ES2760249T3
(es)
|
2013-08-08 |
2020-05-13 |
Cytune Pharma |
Composición farmacéutica combinada
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
US20160257754A1
(en)
|
2013-10-16 |
2016-09-08 |
Momenta Pharmaceuticals Inc. |
Sialylated glycoproteins
|
|
JP2017504324A
(ja)
*
|
2014-01-02 |
2017-02-09 |
メモリアル スローン−ケタリング キャンサー センター |
免疫療法に対する癌応答の決定因子
|
|
CA2946398A1
(en)
|
2014-04-24 |
2015-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Superagonists, partial agonists and antagonists of interleukin-2
|
|
CN105296433B
(zh)
|
2014-08-01 |
2018-02-09 |
中山康方生物医药有限公司 |
一种ctla4抗体、其药物组合物及其用途
|
|
JP6800141B2
(ja)
|
2014-08-12 |
2020-12-16 |
マサチューセッツ インスティテュート オブ テクノロジー |
Il−2およびインテグリン結合性fc融合タンパク質による相乗的な腫瘍処置
|
|
US20170216403A1
(en)
|
2014-08-12 |
2017-08-03 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
|
MX391478B
(es)
|
2014-10-10 |
2025-03-21 |
Idera Pharmaceuticals Inc |
Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
|
|
US10983128B2
(en)
|
2015-02-05 |
2021-04-20 |
Bristol-Myers Squibb Company |
CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
|
|
CN108271359B
(zh)
*
|
2015-02-13 |
2021-11-09 |
索伦托药业有限公司 |
结合ctla4的抗体治疗剂
|
|
EP3263599A4
(en)
*
|
2015-02-16 |
2018-12-19 |
Pharma Foods International Co., Ltd. |
Anti-cancer agent and antimetastatic agent using fstl1, and concomitant drug for same
|
|
MA44594B1
(fr)
*
|
2015-05-29 |
2020-09-30 |
Memorial Sloan Kettering Cancer Center |
Anticorps anti-ctla-4 et méthodes d'utilisation de ceux-ci
|
|
NL2014935B1
(en)
*
|
2015-06-08 |
2017-02-03 |
Applied Immune Tech Ltd |
T cell receptor like antibodies having fine specificity.
|
|
RU2711380C2
(ru)
|
2015-07-16 |
2020-01-16 |
Байоксэл Терапьютикс, Инк. |
Новый подход к лечению рака с применением иммуномодуляции
|
|
WO2017040790A1
(en)
|
2015-09-01 |
2017-03-09 |
Agenus Inc. |
Anti-pd-1 antibodies and methods of use thereof
|
|
US11208483B2
(en)
|
2015-11-19 |
2021-12-28 |
Shanghai Kanda Biotechnology Co, Ltd. |
CTLA-4 antibodies and uses thereof
|
|
SG11201804839WA
(en)
|
2015-12-14 |
2018-07-30 |
Macrogenics Inc |
Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
|
|
AU2016370648B2
(en)
*
|
2015-12-15 |
2023-03-09 |
OncoC4, Inc. |
Chimeric and humanized anti-human CTLA4 monoclonal antibodies and uses thereof
|
|
MA43587A
(fr)
|
2016-01-10 |
2018-11-14 |
Modernatx Inc |
Arnm thérapeutiques codant pour des anticorps anti-ctla-4
|
|
US10947317B2
(en)
|
2016-03-15 |
2021-03-16 |
Mersana Therapeutics, Inc. |
NaPi2b-targeted antibody-drug conjugates and methods of use thereof
|
|
WO2017165742A1
(en)
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments
|
|
US11760803B2
(en)
|
2016-03-24 |
2023-09-19 |
Takeda Pharmaceutical Company Limited |
Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments
|
|
US11542332B2
(en)
|
2016-03-26 |
2023-01-03 |
Bioatla, Inc. |
Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
|
|
EA039322B1
(ru)
*
|
2016-04-15 |
2022-01-13 |
Эйдженус Инк. |
Антитела против ctla-4 и способы их применения
|
|
AU2017268399B2
(en)
|
2016-05-18 |
2023-01-12 |
Modernatx, Inc. |
mRNA combination therapy for the treatment of cancer
|
|
NZ789594A
(en)
|
2016-06-20 |
2025-07-25 |
Kymab Ltd |
Anti-PD-L1 antibodies
|
|
CA3029426A1
(en)
|
2016-06-30 |
2018-01-04 |
Oncorus, Inc. |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
KR20190086431A
(ko)
*
|
2016-08-17 |
2019-07-22 |
오르비스 헬스 솔루션즈 엘엘씨 |
종양-표적화 비드 벡터 및 그의 사용 방법
|
|
WO2018035710A1
(en)
|
2016-08-23 |
2018-03-01 |
Akeso Biopharma, Inc. |
Anti-ctla4 antibodies
|
|
CN106977602B
(zh)
|
2016-08-23 |
2018-09-25 |
中山康方生物医药有限公司 |
一种抗pd1单克隆抗体、其药物组合物及其用途
|
|
CN106967172B
(zh)
|
2016-08-23 |
2019-01-08 |
康方药业有限公司 |
抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
|
|
CN107815468B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
CN107815467B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
WO2018041121A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric ctla-4
|
|
CA3037380A1
(en)
|
2016-10-11 |
2018-04-19 |
Agenus Inc. |
Anti-lag-3 antibodies and methods of use thereof
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
IL307242A
(en)
*
|
2016-12-07 |
2023-11-01 |
Agenus Inc |
Anti-CTLA-4 antibodies and methods of using them
|
|
US20200095301A1
(en)
|
2016-12-14 |
2020-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13 superkine: immune cell targeting constructs and methods of use thereof
|
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
|
CA3049656A1
(en)
|
2017-01-10 |
2018-07-19 |
Nodus Therapeutics |
Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
|
|
EP3585430A4
(en)
*
|
2017-02-21 |
2020-12-09 |
REMD Biotherapeutics, Inc. |
TREATMENT OF CANCER WITH ANTIBODIES THAT BIND TO T-CYTOTOXIC T-LYMPHOCYTES ANTIGEN-4 (CTLA-4)
|
|
US20180271996A1
(en)
|
2017-02-28 |
2018-09-27 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
CN116440257A
(zh)
*
|
2017-02-28 |
2023-07-18 |
百时美施贵宝公司 |
具有增强的adcc的抗ctla-4抗体增强对疫苗的免疫应答的用途
|
|
US20220411506A1
(en)
*
|
2017-03-15 |
2022-12-29 |
Suzhou Galaxy Biopharma Co., Ltd. |
Ctla4 antibody, pharmaceutical composition and use thereof
|
|
CN108948194B
(zh)
*
|
2017-05-19 |
2023-02-17 |
上海药明生物技术有限公司 |
一种新的ctla-4单克隆抗体
|
|
US11643463B2
(en)
|
2017-05-19 |
2023-05-09 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
|
|
CN111201035A
(zh)
|
2017-06-19 |
2020-05-26 |
梅迪塞纳医疗股份有限公司 |
Il-2超激动剂、激动剂及其融合体的用途和方法
|
|
TWI799432B
(zh)
*
|
2017-07-27 |
2023-04-21 |
美商再生元醫藥公司 |
抗ctla-4抗體及其用途
|
|
CN111542538A
(zh)
*
|
2017-07-28 |
2020-08-14 |
基因信号国际公司 |
Cd9p-1-靶向抗体及其用途
|
|
WO2019020807A1
(en)
*
|
2017-07-28 |
2019-01-31 |
Gene Signal International Sa |
CD9P-1 TARGETING ANTIBODIES AND USES THEREOF
|
|
KR102543719B1
(ko)
*
|
2017-09-21 |
2023-06-16 |
유큐(베이징) 바이오파마 코., 엘티디 |
항―ctla4 항체 및 그의 용도
|
|
US11638760B2
(en)
|
2017-11-27 |
2023-05-02 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
WO2019120232A1
(en)
*
|
2017-12-20 |
2019-06-27 |
Harbour Biomed (Shanghai) Co., Ltd |
Antibodies binding ctla-4 and uses thereof
|
|
TW201929908A
(zh)
|
2017-12-21 |
2019-08-01 |
美商梅爾莎納醫療公司 |
吡咯并苯并二氮呯抗體共軛物
|
|
WO2019133847A1
(en)
|
2017-12-29 |
2019-07-04 |
Oncorus, Inc. |
Oncolytic viral delivery of therapeutic polypeptides
|
|
CN118108857A
(zh)
|
2018-06-01 |
2024-05-31 |
利兰斯坦福初级大学董事会 |
免疫细胞靶向性构建体
|
|
CA3103629A1
(en)
|
2018-06-15 |
2019-12-19 |
Flagship Pioneering Innovations V, Inc. |
Increasing immune activity through modulation of postcellular signaling factors
|
|
EP3827079A1
(en)
|
2018-07-25 |
2021-06-02 |
Askgene Pharma, Inc. |
Novel il-21 prodrugs and methods of use thereof
|
|
CN110760002A
(zh)
*
|
2018-07-25 |
2020-02-07 |
南京金斯瑞生物科技有限公司 |
人源化抗人ctla4单克隆抗体及其制备方法和用途
|
|
CA3108951A1
(en)
|
2018-08-30 |
2020-03-05 |
HCW Biologics, Inc. |
Single-chain chimeric polypeptides and uses thereof
|
|
WO2020047462A2
(en)
|
2018-08-30 |
2020-03-05 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
US11518792B2
(en)
|
2018-08-30 |
2022-12-06 |
HCW Biologics, Inc. |
Multi-chain chimeric polypeptides and uses thereof
|
|
EP3856763A1
(en)
|
2018-09-28 |
2021-08-04 |
Massachusetts Institute of Technology |
Collagen-localized immunomodulatory molecules and methods thereof
|
|
MX2021004906A
(es)
|
2018-10-29 |
2021-09-10 |
Mersana Therapeutics Inc |
Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos.
|
|
BR112021008060A2
(pt)
*
|
2018-10-31 |
2021-11-23 |
Bioatla Inc |
Polipeptídeo, anticorpo anti-ctla4 ou fragmento de anticorpo, imunoconjugado, composição farmacêutica, dose única de composição farmacêutica, método de tratar câncer, e, kit para diagnóstico ou tratamento
|
|
US20230071889A1
(en)
|
2018-12-21 |
2023-03-09 |
Ose Immunotherapeutics |
Bifunctional anti-pd-1/il-7 molecule
|
|
WO2020139926A2
(en)
|
2018-12-26 |
2020-07-02 |
Akrevia Therapeutics Inc. |
Anti-ctla4 antibodies and methods of use thereof
|
|
AU2019413366B2
(en)
|
2018-12-27 |
2025-06-05 |
Gigagen, Inc. |
Anti-CTLA-4 binding proteins and methods of use thereof
|
|
EP3914289A1
(en)
|
2019-01-23 |
2021-12-01 |
Massachusetts Institute of Technology |
Combination immunotherapy dosing regimen for immune checkpoint blockade
|
|
WO2020165374A1
(en)
|
2019-02-14 |
2020-08-20 |
Ose Immunotherapeutics |
Bifunctional molecule comprising il-15ra
|
|
WO2020227159A2
(en)
|
2019-05-03 |
2020-11-12 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity
|
|
TWI869398B
(zh)
*
|
2019-05-10 |
2025-01-11 |
英商拜西克爾德有限公司 |
治療癌症之方法
|
|
AU2020291012B2
(en)
|
2019-06-12 |
2025-09-25 |
AskGene Pharma, Inc. |
Novel IL-15 prodrugs and methods of use thereof
|
|
CA3143035A1
(en)
|
2019-06-21 |
2020-12-24 |
HCW Biologics, Inc. |
Multi-chain chimeric polypeptides and uses thereof
|
|
JP2022538974A
(ja)
|
2019-06-26 |
2022-09-07 |
マサチューセッツ インスチテュート オブ テクノロジー |
免疫調節融合タンパク質-金属水酸化物錯体およびその方法
|
|
EP3999539A1
(en)
|
2019-07-15 |
2022-05-25 |
Intervet International B.V. |
Caninized antibodies to human and canine ctla-4
|
|
US12435143B2
(en)
|
2019-07-15 |
2025-10-07 |
Intervet Inc. |
Caninized antibodies against canine CTLA-4
|
|
CN110467675B
(zh)
*
|
2019-09-19 |
2020-08-14 |
合源生物科技(天津)有限公司 |
一种ctla-4单克隆抗体6f1及其用于抗肿瘤的用途
|
|
US11459389B2
(en)
|
2019-10-24 |
2022-10-04 |
Massachusetts Institute Of Technology |
Monoclonal antibodies that bind human CD161
|
|
WO2021127217A1
(en)
|
2019-12-17 |
2021-06-24 |
Flagship Pioneering Innovations V, Inc. |
Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
|
|
WO2021122866A1
(en)
|
2019-12-17 |
2021-06-24 |
Ose Immunotherapeutics |
Bifunctional molecules comprising an il-7 variant
|
|
MX2022007840A
(es)
|
2019-12-27 |
2022-07-19 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti antigeno-4 asociado al linfocito t citotoxico (ctla4) y uso del mismo.
|
|
AU2021219720B2
(en)
|
2020-02-11 |
2025-10-02 |
Immunitybio, Inc. |
Chromatography resin and uses thereof
|
|
CA3169231A1
(en)
|
2020-02-11 |
2021-08-19 |
HCW Biologics, Inc. |
Methods of treating age-related and inflammatory diseases
|
|
CN115380045A
(zh)
|
2020-02-11 |
2022-11-22 |
Hcw生物科技公司 |
激活调节性t细胞的方法
|
|
WO2021216572A1
(en)
|
2020-04-20 |
2021-10-28 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
US12159700B2
(en)
|
2020-04-22 |
2024-12-03 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
EP4143231A1
(en)
|
2020-04-29 |
2023-03-08 |
HCW Biologics, Inc. |
Anti-cd26 proteins and uses thereof
|
|
WO2021247003A1
(en)
|
2020-06-01 |
2021-12-09 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
US12024545B2
(en)
|
2020-06-01 |
2024-07-02 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
IL298608A
(en)
|
2020-06-01 |
2023-01-01 |
Hcw Biologics Inc |
Methods of treating aging-related disorders
|
|
WO2021250594A1
(en)
*
|
2020-06-11 |
2021-12-16 |
Nantbio, Inc. |
Anti-ctla4 monoclonal antibodies and chimeric antigen receptors
|
|
EP4172323A1
(en)
|
2020-06-29 |
2023-05-03 |
Flagship Pioneering Innovations V, Inc. |
Viruses engineered to promote thanotransmission and their use in treating cancer
|
|
AU2021299338A1
(en)
*
|
2020-07-02 |
2023-02-23 |
Gigagen, Inc. |
Anti-CTLA-4 binding proteins and methods of use thereof
|
|
WO2022112198A1
(en)
|
2020-11-24 |
2022-06-02 |
Worldwide Innovative Network |
Method to select the optimal immune checkpoint therapies
|
|
EP4263600A1
(en)
|
2020-12-18 |
2023-10-25 |
Century Therapeutics, Inc. |
Chimeric antigen receptor systems with adaptable receptor specificity
|
|
KR20220112208A
(ko)
*
|
2021-02-03 |
2022-08-10 |
주식회사 유틸렉스 |
항 ctla-4 항체 및 이의 용도
|
|
KR20230165276A
(ko)
|
2021-03-31 |
2023-12-05 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도
|
|
WO2022214652A1
(en)
|
2021-04-09 |
2022-10-13 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
US20240182571A1
(en)
|
2021-04-09 |
2024-06-06 |
Ose Immunotherapeutics |
New scaffold for bifunctional molecules with improved properties
|
|
WO2022270612A1
(ja)
|
2021-06-25 |
2022-12-29 |
中外製薬株式会社 |
抗ctla-4抗体の使用
|
|
US12448451B2
(en)
|
2021-06-25 |
2025-10-21 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-CTLA-4 antibody and use thereof
|
|
WO2022270611A1
(ja)
|
2021-06-25 |
2022-12-29 |
中外製薬株式会社 |
抗ctla-4抗体
|
|
JP2024525475A
(ja)
|
2021-06-29 |
2024-07-12 |
フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド |
タノトランスミッションを促進するように操作された免疫細胞及びその使用
|
|
AU2023228683B2
(en)
|
2022-03-02 |
2025-12-04 |
Immunitybio, Inc. |
Method of treating pancreatic cancer
|
|
EP4507704A1
(en)
|
2022-04-15 |
2025-02-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
|
WO2024003360A1
(en)
|
2022-07-01 |
2024-01-04 |
Institut Curie |
Biomarkers and uses thereof for the treatment of neuroblastoma
|
|
CN119907811A
(zh)
|
2022-08-02 |
2025-04-29 |
Ose免疫疗法公司 |
针对cd28的多功能分子
|
|
US20240174732A1
(en)
|
2022-10-05 |
2024-05-30 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer
|
|
KR20250122544A
(ko)
|
2022-11-21 |
2025-08-13 |
이오반스 바이오테라퓨틱스, 인크. |
종양 침윤 림프구의 확장을 위한 2차원 공정 및 이를 통한 요법
|
|
US20240269251A1
(en)
|
2023-01-09 |
2024-08-15 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
|
WO2024200823A1
(en)
|
2023-03-30 |
2024-10-03 |
Ose Immunotherapeutics |
Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
|
|
WO2024200826A1
(en)
|
2023-03-30 |
2024-10-03 |
Ose Immunotherapeutics |
Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell inhibiting molecule and use thereof
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|