|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
EP0171407B1
(en)
|
1984-01-30 |
1993-11-18 |
Imperial Cancer Research Technology Limited |
Improvements relating to growth factors
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5401638A
(en)
|
1986-06-04 |
1995-03-28 |
Oncogene Science, Inc. |
Detection and quantification of neu related proteins in the biological fluids of humans
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US4994560A
(en)
|
1987-06-24 |
1991-02-19 |
The Dow Chemical Company |
Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
|
|
US5489425A
(en)
|
1987-06-24 |
1996-02-06 |
The Dow Chemical Company |
Functionalized polyamine chelants
|
|
DE3850542T2
(de)
|
1987-09-23 |
1994-11-24 |
Bristol Myers Squibb Co |
Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
|
|
CN1033030C
(zh)
|
1988-06-24 |
1996-10-16 |
唐化学原料公司 |
大环双官能螯合剂及其配合物和抗体共轭物的制备方法
|
|
JP2831073B2
(ja)
|
1988-06-24 |
1998-12-02 |
ザ ダウ ケミカル カンパニー |
大環状二官能キレート剤、その錯体及びそれらの抗体接合体
|
|
US5756065A
(en)
|
1988-06-24 |
1998-05-26 |
The Dow Chemical Company |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
|
|
US5274119A
(en)
|
1988-07-01 |
1993-12-28 |
The Dow Chemical Company |
Vicinal diols
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5696239A
(en)
|
1988-10-31 |
1997-12-09 |
The Dow Chemical Company |
Conjugates possessing ortho ligating functionality and complexes thereof
|
|
US5342604A
(en)
|
1988-10-31 |
1994-08-30 |
The Dow Chemical Company |
Complexes possessing ortho ligating functionality
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5808003A
(en)
|
1989-05-26 |
1998-09-15 |
Perimmune Holdings, Inc. |
Polyaminocarboxylate chelators
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
EP0479909B1
(en)
|
1989-06-29 |
1996-10-30 |
Medarex, Inc. |
Bispecific reagents for aids therapy
|
|
EP0494135B1
(en)
|
1989-09-29 |
1996-04-10 |
Oncogene Science, Inc. |
Human "neu" related protein p100 and use of the same for detecting preneoplastic or neoplastic cells in a human
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
ATE204902T1
(de)
|
1990-06-29 |
2001-09-15 |
Large Scale Biology Corp |
Melaninproduktion durch transformierte mikroorganismen
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
DE69233528T2
(de)
|
1991-11-25 |
2006-03-16 |
Enzon, Inc. |
Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
|
|
US5428139A
(en)
|
1991-12-10 |
1995-06-27 |
The Dow Chemical Company |
Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
US5505931A
(en)
|
1993-03-04 |
1996-04-09 |
The Dow Chemical Company |
Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
|
|
DE69303494T2
(de)
|
1992-11-13 |
1997-01-16 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
CA2226575C
(en)
|
1995-07-27 |
2011-10-18 |
Genentech, Inc. |
Stabile isotonic lyophilized protein formulation
|
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
US5994071A
(en)
|
1997-04-04 |
1999-11-30 |
Albany Medical College |
Assessment of prostate cancer
|
|
EP0999853B1
(en)
|
1997-06-13 |
2003-01-02 |
Genentech, Inc. |
Stabilized antibody formulation
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
|
AU3657899A
(en)
|
1998-04-20 |
1999-11-08 |
James E. Bailey |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
|
KR100940380B1
(ko)
|
1999-01-15 |
2010-02-02 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
PT1176195E
(pt)
|
1999-04-09 |
2013-07-18 |
Kyowa Hakko Kirin Co Ltd |
Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
|
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
KR100988949B1
(ko)
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
당단백질 조성물
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
CZ308720B6
(cs)
|
2003-01-22 |
2021-03-24 |
Roche Glycart Ag |
Fúzní konstrukty a jejich použití pro přípravu protilátek se zvýšenou vazebnou afinitou k receptorům Fc a efektorovou funkcí
|
|
EP1648511A1
(en)
|
2003-07-29 |
2006-04-26 |
Morphotek, Inc. |
Antibodies and methods for generating genetically altered antibodies with enhanced effector function
|
|
CN1871259A
(zh)
|
2003-08-22 |
2006-11-29 |
比奥根艾迪克Ma公司 |
具有改变的效应物功能的经改进的抗体和制备它的方法
|
|
AU2004273791A1
(en)
|
2003-09-05 |
2005-03-31 |
Genentech, Inc. |
Antibodies with altered effector functions
|
|
PT1692182E
(pt)
|
2003-11-05 |
2010-05-13 |
Roche Glycart Ag |
Anticorpos de cd20 com uma afinidade de ligação acrescida ao receptor fc e uma função efectora acrescida
|
|
US20110142822A1
(en)
|
2004-06-14 |
2011-06-16 |
Kussie Paul H |
Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof
|
|
WO2007024249A2
(en)
|
2004-11-10 |
2007-03-01 |
Macrogenics, Inc. |
Engineering fc antibody regions to confer effector function
|
|
US8008443B2
(en)
|
2005-04-26 |
2011-08-30 |
Medimmune, Llc |
Modulation of antibody effector function by hinge domain engineering
|
|
CA2605697A1
(en)
|
2005-04-26 |
2006-11-02 |
Bioren, Inc. |
Method of producing human igg antibodies with enhanced effector functions
|
|
RU2482132C2
(ru)
|
2005-08-26 |
2013-05-20 |
Роше Гликарт Аг |
Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью
|
|
ATE461220T1
(de)
*
|
2005-11-12 |
2010-04-15 |
Lilly Co Eli |
Anti-egfr-antikörper
|
|
US7498142B2
(en)
*
|
2006-01-31 |
2009-03-03 |
Yeda Research And Development Co., Ltd. |
Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
|
|
EP2493929B1
(en)
*
|
2009-10-28 |
2017-08-16 |
AbbVie Biotherapeutics Inc. |
Anti-egfr antibodies and their uses
|
|
AU2010318542B2
(en)
*
|
2009-10-29 |
2015-08-27 |
Janssen Biotech Inc. |
Antibody glycosylation variants
|
|
KR20140008308A
(ko)
*
|
2010-10-29 |
2014-01-21 |
이뮤노젠 아이엔씨 |
신규한 egfr-결합 분자 및 이의 면역컨쥬게이트
|
|
AU2012237456B2
(en)
*
|
2011-04-01 |
2017-06-29 |
Universitat Stuttgart |
Recombinant TNF ligand family member polypeptides with antibody binding domain and uses thereof
|
|
US8628773B2
(en)
*
|
2011-04-07 |
2014-01-14 |
Amgen Inc. |
Antigen binding proteins
|
|
AU2013229786B2
(en)
*
|
2012-03-08 |
2017-06-22 |
Halozyme, Inc. |
Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
|
|
WO2013156054A1
(en)
*
|
2012-04-16 |
2013-10-24 |
Universität Stuttgart |
The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity
|
|
CA2902505A1
(en)
*
|
2013-03-06 |
2014-09-12 |
Merrimack Pharmaceuticals, Inc. |
Anti-c-met tandem fc bispecific antibodies
|
|
JP6693872B2
(ja)
|
2013-07-25 |
2020-05-13 |
シトムクス セラピューティクス,インコーポレイティド |
多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法
|
|
TWI689520B
(zh)
|
2014-05-30 |
2020-04-01 |
漢霖生技股份有限公司 |
抗表皮生長因子受體(egfr)抗體
|