JP2018528759A5 - - Google Patents

Info

Publication number

JP2018528759A5

JP2018528759A5 JP2017567294A JP2017567294A JP2018528759A5 JP 2018528759 A5 JP2018528759 A5 JP 2018528759A5 JP 2017567294 A JP2017567294 A JP 2017567294A JP 2017567294 A JP2017567294 A JP 2017567294A JP 2018528759 A5 JP2018528759 A5 JP 2018528759A5

Authority

JP

Japan

Prior art keywords

amino acid

cdr

seq

acid sequence

chain variable

Prior art date

2016-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 94
• 239000000427 antigen Substances 0.000 claims 25
• 102000036639 antigens Human genes 0.000 claims 25
• 108091007433 antigens Proteins 0.000 claims 25
• 239000012634 fragment Substances 0.000 claims 24
• 238000000034 method Methods 0.000 claims 8
• 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
• 230000033115 angiogenesis Effects 0.000 claims 3
• 201000005202 lung cancer Diseases 0.000 claims 3
• 208000020816 lung neoplasm Diseases 0.000 claims 3
• 230000001575 pathological effect Effects 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 230000002137 anti-vascular effect Effects 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 238000012286 ELISA Assay Methods 0.000 claims 1
• 108010041308 Endothelial Growth Factors Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 206010062878 Gastrooesophageal cancer Diseases 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000030533 eye disease Diseases 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 201000006974 gastroesophageal cancer Diseases 0.000 claims 1
• 230000002055 immunohistochemical effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1
• 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 1