JP2017521054A5 - - Google Patents
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- JP2017521054A5 JP2017521054A5 JP2016571061A JP2016571061A JP2017521054A5 JP 2017521054 A5 JP2017521054 A5 JP 2017521054A5 JP 2016571061 A JP2016571061 A JP 2016571061A JP 2016571061 A JP2016571061 A JP 2016571061A JP 2017521054 A5 JP2017521054 A5 JP 2017521054A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 59
- 102000004965 antibodies Human genes 0.000 claims 41
- 108090001123 antibodies Proteins 0.000 claims 41
- 239000000427 antigen Substances 0.000 claims 21
- 102000038129 antigens Human genes 0.000 claims 21
- 108091007172 antigens Proteins 0.000 claims 21
- 102000017256 epidermal growth factor-activated receptor activity proteins Human genes 0.000 claims 3
- 108040009258 epidermal growth factor-activated receptor activity proteins Proteins 0.000 claims 3
- 230000035693 Fab Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 238000004166 bioassay Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 206010043515 Throat cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 230000002055 immunohistochemical Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Claims (28)
- 抗ＥＧＦＲ抗体又はその抗原結合断片であって、（１）配列番号１−３からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｈ１；（２）配列番号５−８からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｈ２；及び（３）配列番号１１−１３からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）配列番号１５−１９からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｌ１；（２）配列番号２１−２３からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｌ２；及び（３）配列番号２６−２９からなる群から選択されるアミノ酸配列を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＮＴＰＦＴＳＲＦ（配列番号５）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＧＴＮＩＨ（配列番号１５）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＡＳＥＳＩＳ（配列番号２１）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＧＴＮＩＨ（配列番号１５）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＡＳＥＳＩＳ（配列番号２１）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＡＴＥＦＴＳＲＦ（配列番号７）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＧＴＮＩＨ（配列番号１５）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＡＳＥＳＩＳ（配列番号２１）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＤＤＫＦＴＳＲＦ（配列番号６）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＧＴＮＩＨ（配列番号１５）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＡＳＥＳＩＳ（配列番号２１）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＴＹＧＶＨ（配列番号３）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＲＴＮＩＨ（配列番号１６）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＧＳＥＳＩＳ（配列番号２２）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＴＹＧＶＨ（配列番号３）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＳＴＮＩＨ（配列番号１９）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＧＳＥＳＩＳ（配列番号２２）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＲＴＮＩＨ（配列番号１６）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＧＳＥＳＩＳ（配列番号２２）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＴＹＧＶＨ（配列番号３）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＧＰＮＩＨ（配列番号１８）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＡＳＥＴＩＲ（配列番号２３）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体が、（１）アミノ酸配列ＮＹＧＶＨ（配列番号１）を含むＣＤＲ−Ｈ１；（２）アミノ酸配列ＹＧＮＥＦＴＳＲＦ（配列番号８）を含むＣＤＲ−Ｈ２；及び（３）アミノ酸配列ＤＹＹＤＹＥＦＡＹ（配列番号１１）を含むＣＤＲ−Ｈ３を含む重鎖可変ドメイン配列；並びに（１）アミノ酸配列ＩＳＴＮＩＨ（配列番号１９）を含むＣＤＲ−Ｌ１；（２）アミノ酸配列ＫＹＧＳＥＳＩＳ（配列番号２２）を含むＣＤＲ−Ｌ２；及び（３）アミノ酸配列ＮＷＰＴＳ（配列番号２７）を含むＣＤＲ−Ｌ３を含む軽鎖可変ドメイン配列を含む、請求項１に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗体がヒトＩｇＧのＦｃ配列を含む、請求項１−１０の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 抗原結合断片が、Ｆａｂ、Ｆａｂ’、Ｆ（ａｂ）’２、一本鎖Ｆｖ（ｓｃＦｖ）、Ｆｖ断片、ダイアボディ、及び線状抗体からなる群から選択される、請求項１−１１の何れか一項に記載の抗ＥＧＦＲ抗体の抗原結合断片。
- 抗体が多重特異性抗体である、請求項１−１１の何れか一項に記載の抗ＥＧＦＲ抗体。
- 抗体がアフコシル化抗体である、請求項１−１３の何れか一項に記載の抗ＥＧＦＲ抗体。
- 治療剤にコンジュゲートした、請求項１−１４の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 標識にコンジュゲートした、請求項１−１４の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片。
- 標識が放射性同位体、蛍光色素、及び酵素からなる群から選択される、請求項１６に記載の抗ＥＧＦＲ抗体。
- 請求項１−１４の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片をコードする単離された核酸分子。
- 請求項１８の核酸分子をコードする発現ベクター。
- 請求項１９の発現ベクターを含む細胞。
- 請求項２０の細胞を培養すること及び細胞培養物から抗体を回収することを含む、抗体を産生する方法。
- 請求項１−１５の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片及び薬学的に許容可能な担体を含む、組成物。
- 請求項１−１０の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片を試料に接触させること、及びＥＧＦＲタンパク質に結合した抗ＥＧＦＲ抗体を検出することにより、患者からの試料中のＥＧＦＲタンパク質を検出する方法。
- 抗ＥＧＦＲ抗体又はその抗原結合断片が免疫組織化学アッセイ（ＩＨＣ）又はＥＬＩＳＡアッセイで使用される、請求項２３に記載の方法。
- 請求項１−１５の何れか一項に記載の抗ＥＧＦＲ抗体又はその抗原結合断片、又は請求項２２に記載の組成物を含む、被験体におけるがんを治療することに使用するための組成物。
- がんが、咽喉がん、結腸直腸がん、肺がん、及び頭頸部がんから選択される、請求項２５に記載の使用のための組成物。
- 抗腫瘍剤、化学療法剤、増殖阻害剤、及び細胞傷害性剤からなる群から選択される更なる治療剤との共投与のために製剤化される、請求項２５に記載の使用のための組成物。
- 放射線療法と組み合わせて投与するために製剤化される、請求項２５に記載の使用のための組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005887P | 2014-05-30 | 2014-05-30 | |
| US62/005,887 | 2014-05-30 | ||
| PCT/US2015/033402 WO2015184403A2 (en) | 2014-05-30 | 2015-05-29 | Anti-epidermal growth factor receptor (egfr) antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521054A JP2017521054A (ja) | 2017-08-03 |
| JP2017521054A5 true JP2017521054A5 (ja) | 2018-07-12 |
| JP6691872B2 JP6691872B2 (ja) | 2020-05-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571061A Active JP6691872B2 (ja) | 2014-05-30 | 2015-05-29 | 抗上皮増殖因子受容体（ｅｇｆｒ）抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10584171B2 (ja) |
| EP (2) | EP3613433B1 (ja) |
| JP (1) | JP6691872B2 (ja) |
| KR (1) | KR102366644B1 (ja) |
| CN (1) | CN106714830B (ja) |
| AU (1) | AU2015266664B2 (ja) |
| CY (1) | CY1122436T1 (ja) |
| DK (1) | DK3148581T3 (ja) |
| ES (2) | ES2761675T3 (ja) |
| HR (1) | HRP20192038T1 (ja) |
| HU (1) | HUE047113T2 (ja) |
| PL (1) | PL3148581T3 (ja) |
| PT (1) | PT3148581T (ja) |
| SG (1) | SG11201609959UA (ja) |
| SI (1) | SI3148581T1 (ja) |
| TW (1) | TWI689520B (ja) |
| WO (1) | WO2015184403A2 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3148581T (pt) | 2014-05-30 | 2020-01-06 | Henlix Biotech Co Ltd | Anticorpos antirrecetor do fator de crescimento epidérmico (egfr) |
| EP3532498A1 (en) | 2016-10-31 | 2019-09-04 | Hexal AG | Antibody preparation |
| WO2019114793A1 (zh) * | 2017-12-13 | 2019-06-20 | 凯惠科技发展(上海)有限公司 | 一种egfr抗体及其制备方法和应用 |
| WO2021170068A1 (en) * | 2020-02-28 | 2021-09-02 | Shanghai Henlius Biotech, Inc. | Anti-cd137 constructs, multispecific antibody and uses thereof |
| US11617767B2 (en) | 2020-11-20 | 2023-04-04 | Simcere Innovation, Inc. | Armed dual CAR-T compositions and methods for cancer immunotherapy |
| WO2024051762A1 (en) * | 2022-09-07 | 2024-03-14 | Xadcera Biopharmaceutical (Suzhou) Co., Ltd. | Anti-trop2/egfr antibodies and uses thereof |
| WO2024061297A1 (en) * | 2022-09-22 | 2024-03-28 | Shanghai Henlius Biotech , Inc. | Anti-b7h3 antibodies, multispecific antibodies and methods of use |
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