AU2015243246B2 - Antibodies, pharmaceutical compositions and uses thereof - Google Patents

Antibodies, pharmaceutical compositions and uses thereof Download PDF

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Publication number
AU2015243246B2
AU2015243246B2 AU2015243246A AU2015243246A AU2015243246B2 AU 2015243246 B2 AU2015243246 B2 AU 2015243246B2 AU 2015243246 A AU2015243246 A AU 2015243246A AU 2015243246 A AU2015243246 A AU 2015243246A AU 2015243246 B2 AU2015243246 B2 AU 2015243246B2
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AU
Australia
Prior art keywords
ser
thr
gly
tyr
leu
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Ceased
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AU2015243246A
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AU2015243246A1 (en
Inventor
I-Ju Chen
Jiann-Shiun Lai
Yi-Chien Tsai
Cheng-Chi Wang
Cheng-Der Tony Yu
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OBI Pharma Inc
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OBI Pharma Inc
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Filing date
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Application filed by OBI Pharma Inc filed Critical OBI Pharma Inc
Publication of AU2015243246A1 publication Critical patent/AU2015243246A1/en
Application granted granted Critical
Publication of AU2015243246B2 publication Critical patent/AU2015243246B2/en
Priority to AU2018253589A priority Critical patent/AU2018253589B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
AU2015243246A 2014-04-10 2015-04-10 Antibodies, pharmaceutical compositions and uses thereof Ceased AU2015243246B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018253589A AU2018253589B2 (en) 2014-04-10 2018-10-26 Antibodies, pharmaceutical compositions and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461977824P 2014-04-10 2014-04-10
US61/977,824 2014-04-10
US201462057381P 2014-09-30 2014-09-30
US62/057,381 2014-09-30
PCT/US2015/025305 WO2015157629A2 (en) 2014-04-10 2015-04-10 Antibodies, pharmaceutical compositions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018253589A Division AU2018253589B2 (en) 2014-04-10 2018-10-26 Antibodies, pharmaceutical compositions and uses thereof

Publications (2)

Publication Number Publication Date
AU2015243246A1 AU2015243246A1 (en) 2016-09-08
AU2015243246B2 true AU2015243246B2 (en) 2018-09-06

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015243246A Ceased AU2015243246B2 (en) 2014-04-10 2015-04-10 Antibodies, pharmaceutical compositions and uses thereof
AU2018253589A Ceased AU2018253589B2 (en) 2014-04-10 2018-10-26 Antibodies, pharmaceutical compositions and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018253589A Ceased AU2018253589B2 (en) 2014-04-10 2018-10-26 Antibodies, pharmaceutical compositions and uses thereof

Country Status (17)

Country Link
US (2) US9902779B2 (enExample)
EP (2) EP3662928A1 (enExample)
JP (1) JP2017512759A (enExample)
KR (1) KR101966408B1 (enExample)
CN (2) CN112390887B (enExample)
AU (2) AU2015243246B2 (enExample)
BR (1) BR112016020009A2 (enExample)
CA (2) CA2941029C (enExample)
CL (1) CL2016002569A1 (enExample)
ES (1) ES2772817T3 (enExample)
IL (2) IL246837B (enExample)
PH (1) PH12016501976A1 (enExample)
RU (1) RU2016138744A (enExample)
SG (1) SG11201607258SA (enExample)
TW (3) TWI697503B (enExample)
WO (1) WO2015157629A2 (enExample)
ZA (1) ZA201605175B (enExample)

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BR112015032713B1 (pt) 2013-09-17 2023-03-21 Obi Pharma, Inc Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
WO2015143123A2 (en) 2014-03-19 2015-09-24 Mackay Memorial Hospital Of Taiwan Presbyterian Church And Mackay Memorial Social Work Foundation Antibodies against immunogenic glycopeptides, composition comprising the same and use thereof
EP3662928A1 (en) 2014-04-10 2020-06-10 OBI Pharma Inc. Antibodies binding to tumour associated carbohydrate antigens, pharmaceutical compositions and uses thereof
JP2018532990A (ja) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド グリカンアレイおよび使用の方法
EP3359193A4 (en) 2015-10-07 2019-05-08 OBI Pharma, Inc. NOVEL CARBOHYDRATIC ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
KR20180121786A (ko) 2016-03-29 2018-11-08 오비아이 파머 인코퍼레이티드 항체, 제약 조성물 및 방법
KR20250048399A (ko) 2016-04-22 2025-04-08 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에 의한 암 면역요법
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JP7121724B2 (ja) 2016-07-29 2022-08-18 オービーアイ ファーマ，インコーポレイテッド ヒト抗体、医薬組成物及び方法
CA3044274A1 (en) * 2016-11-21 2018-05-24 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
TWI714854B (zh) * 2017-05-24 2021-01-01 財團法人生物技術開發中心 抗globo h之人類化抗體及其於治療癌症之用途
JP7386800B2 (ja) * 2018-03-14 2023-11-27 メモリアル スローン－ケタリング キャンサー センター 抗ポリシアル酸抗体およびその使用
AU2019276647A1 (en) * 2018-06-01 2020-12-24 Obi Pharma, Inc. Combination therapy by using anti-Globo H or anti-SSEA-4 antibody with anti-negative immune check points antibody
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
KR20220016044A (ko) * 2019-03-28 2022-02-08 밍-테인 라이 글로보-h 관련 암 치료법을 위한 동반 진단 검정
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Also Published As

Publication number Publication date
TW201738277A (zh) 2017-11-01
JP2017512759A (ja) 2017-05-25
TWI697503B (zh) 2020-07-01
AU2018253589A1 (en) 2018-11-22
US20170029526A1 (en) 2017-02-02
AU2015243246A1 (en) 2016-09-08
EP3129048B1 (en) 2020-01-15
IL276695B (en) 2021-09-30
KR101966408B1 (ko) 2019-04-05
CA3104268A1 (en) 2015-10-15
KR20160137984A (ko) 2016-12-02
US20180134799A1 (en) 2018-05-17
IL246837B (en) 2020-08-31
IL246837A0 (en) 2016-08-31
CN112390887B (zh) 2023-09-26
TWI695013B (zh) 2020-06-01
WO2015157629A2 (en) 2015-10-15
CN112390887A (zh) 2021-02-23
CA2941029A1 (en) 2015-10-15
SG11201607258SA (en) 2016-10-28
RU2016138744A3 (enExample) 2018-05-11
TWI609886B (zh) 2018-01-01
ES2772817T3 (es) 2020-07-08
CN106456727B (zh) 2020-11-27
IL276695A (en) 2020-09-30
CA2941029C (en) 2021-02-16
BR112016020009A2 (pt) 2017-10-17
TW201546092A (zh) 2015-12-16
AU2018253589B2 (en) 2020-04-16
US9902779B2 (en) 2018-02-27
WO2015157629A3 (en) 2015-12-03
RU2016138744A (ru) 2018-05-11
ZA201605175B (en) 2017-09-27
EP3662928A1 (en) 2020-06-10
EP3129048A4 (en) 2017-10-25
TW201738276A (zh) 2017-11-01
CN106456727A (zh) 2017-02-22
PH12016501976A1 (en) 2016-12-19
US10815307B2 (en) 2020-10-27
EP3129048A2 (en) 2017-02-15
CL2016002569A1 (es) 2017-09-08

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