JP2015527318A5 - - Google Patents

Info

Publication number

JP2015527318A5

JP2015527318A5 JP2015521674A JP2015521674A JP2015527318A5 JP 2015527318 A5 JP2015527318 A5 JP 2015527318A5 JP 2015521674 A JP2015521674 A JP 2015521674A JP 2015521674 A JP2015521674 A JP 2015521674A JP 2015527318 A5 JP2015527318 A5 JP 2015527318A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

immune complex

independently selected

Prior art date

2013-07-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 206010028980 Neoplasm Diseases 0.000 claims description 24
• 239000003814 drug Substances 0.000 claims description 15
• 125000003275 alpha amino acid group Chemical group 0.000 claims 13
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 7
• 125000005843 halogen group Chemical group 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• 125000003118 aryl group Chemical group 0.000 claims 4
• 125000005647 linker group Chemical group 0.000 claims 4
• 102100038080 B-cell receptor CD22 Human genes 0.000 claims 3
• 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 3
• 125000000623 heterocyclic group Chemical group 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
• 108010016626 Dipeptides Proteins 0.000 claims 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 238000010276 construction Methods 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 201000009277 hairy cell leukemia Diseases 0.000 claims 2
• 229940127121 immunoconjugate Drugs 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
• ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
• 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
• 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
• FADYJNXDPBKVCA-UHFFFAOYSA-N L-Phenylalanyl-L-lysin Natural products NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 claims 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 125000004980 cyclopropylene group Chemical group 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000002541 furyl group Chemical group 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000001544 thienyl group Chemical group 0.000 claims 1
• 241000699670 Mus sp. Species 0.000 description 22
• 229940079593 drug Drugs 0.000 description 14
• 230000003247 decreasing effect Effects 0.000 description 6
• 230000001747 exhibiting effect Effects 0.000 description 3
• 241001465754 Metazoa Species 0.000 description 2
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 description 2
• 230000000259 anti-tumor effect Effects 0.000 description 2
• 108010044540 auristatin Proteins 0.000 description 2
• 125000000446 sulfanediyl group Chemical group *S* 0.000 description 2
• 0 CC(C)(CCC(C)(C)COc(c(OC)c1)cc(N=C[C@](C2)N3C=C2C=CC)c1C3=O)CCOc(cc(c1c2)N(*C(OCC(C)(*)SC3CCCCCC=CCCCCCC3)=O)*[C@](C)(CC(C=C*)=C3)N3C1=O)c2OC Chemical compound CC(C)(CCC(C)(C)COc(c(OC)c1)cc(N=C[C@](C2)N3C=C2C=CC)c1C3=O)CCOc(cc(c1c2)N(*C(OCC(C)(*)SC3CCCCCC=CCCCCCC3)=O)*[C@](C)(CC(C=C*)=C3)N3C1=O)c2OC 0.000 description 1