JP2012509344A5 - - Google Patents

Download PDF

Info

Publication number
JP2012509344A5
JP2012509344A5 JP2011537608A JP2011537608A JP2012509344A5 JP 2012509344 A5 JP2012509344 A5 JP 2012509344A5 JP 2011537608 A JP2011537608 A JP 2011537608A JP 2011537608 A JP2011537608 A JP 2011537608A JP 2012509344 A5 JP2012509344 A5 JP 2012509344A5
Authority
JP
Japan
Prior art keywords
formulation
amino acid
acid sequence
seq
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011537608A
Other languages
English (en)
Japanese (ja)
Other versions
JP5726085B2 (ja
JP2012509344A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/065084 external-priority patent/WO2010059787A1/en
Publication of JP2012509344A publication Critical patent/JP2012509344A/ja
Publication of JP2012509344A5 publication Critical patent/JP2012509344A5/ja
Application granted granted Critical
Publication of JP5726085B2 publication Critical patent/JP5726085B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011537608A 2008-11-20 2009-11-19 治療用タンパク質製剤 Active JP5726085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11654108P 2008-11-20 2008-11-20
US61/116,541 2008-11-20
PCT/US2009/065084 WO2010059787A1 (en) 2008-11-20 2009-11-19 Therapeutic protein formulations

Publications (3)

Publication Number Publication Date
JP2012509344A JP2012509344A (ja) 2012-04-19
JP2012509344A5 true JP2012509344A5 (enExample) 2015-04-02
JP5726085B2 JP5726085B2 (ja) 2015-05-27

Family

ID=41683048

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011537608A Active JP5726085B2 (ja) 2008-11-20 2009-11-19 治療用タンパク質製剤

Country Status (12)

Country Link
US (2) US20120027772A1 (enExample)
EP (1) EP2358393A1 (enExample)
JP (1) JP5726085B2 (enExample)
KR (1) KR101676887B1 (enExample)
CN (2) CN102281901A (enExample)
AU (1) AU2009316592B2 (enExample)
BR (1) BRPI0921947A2 (enExample)
CA (1) CA2737045C (enExample)
HK (1) HK1244426A1 (enExample)
IL (1) IL211670A (enExample)
MX (1) MX2011004748A (enExample)
WO (1) WO2010059787A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009003938A (es) 2006-10-27 2009-04-24 Genentech Inc Anticuerpos e inmunoconjugados y sus usos.
BR112012031727B1 (pt) * 2010-06-15 2022-03-29 Genmab A/S Conjugado de droga-anticorpo, composição farmacêutica, e, uso do conjugado de droga- anticorpo
EP2399604A1 (en) * 2010-06-25 2011-12-28 F. Hoffmann-La Roche AG Novel antibody formulation
MX354988B (es) 2011-10-25 2018-03-28 Prothena Biosciences Ltd Formulaciones de anticuerpo y metodos.
JP2017516860A (ja) * 2014-05-27 2017-06-22 ナビゲン,インコーポレーテッド Arf6阻害剤並びにそれらの合成方法及び使用
WO2017055388A2 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific t cell activating antigen binding molecules
KR102667951B1 (ko) 2017-04-03 2024-05-22 에프. 호프만-라 로슈 아게 Steap-1에 결합하는 항체
CN116898955A (zh) * 2017-09-22 2023-10-20 旭化成制药株式会社 稳定性优异的含有特立帕肽的液态药物组合物
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法
MX2020010320A (es) * 2018-04-02 2021-01-08 Amgen Inc Composiciones de erenumab y usos de las mismas.
IL278522B2 (en) 2018-05-07 2025-10-01 Genmab As Methods for treating cancer with a combination of anti-PD-1 antibody and always an anti-tissue factor antibody drug
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法
US11634485B2 (en) 2019-02-18 2023-04-25 Eli Lilly And Company Therapeutic antibody formulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054732A1 (en) * 2000-01-27 2001-08-02 Genetics Institute, Llc. Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
EP1314437B1 (en) * 2000-08-11 2014-06-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
JP5052736B2 (ja) * 2001-05-30 2012-10-17 中外製薬株式会社 タンパク質製剤
US20030113316A1 (en) * 2001-07-25 2003-06-19 Kaisheva Elizabet A. Stable lyophilized pharmaceutical formulation of IgG antibodies
JP2003128575A (ja) * 2001-10-25 2003-05-08 Mochida Pharmaceut Co Ltd 脳腫瘍治療剤
NZ534542A (en) * 2002-02-14 2006-08-31 Chugai Pharmaceutical Co Ltd Antibody-containing solutions in which the formation of degradation products and insoluble particles during storage and freeze/thaw cycles is inhibited by adding a sugar and surfactant respectively
EP1558645B1 (en) * 2002-11-08 2011-07-27 Ablynx N.V. Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
NZ550816A (en) * 2004-04-22 2009-12-24 Agensys Inc Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
BRPI0516284A (pt) * 2004-09-23 2008-09-02 Genentech Inc anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
MX2009003938A (es) * 2006-10-27 2009-04-24 Genentech Inc Anticuerpos e inmunoconjugados y sus usos.

Similar Documents

Publication Publication Date Title
JP2012509344A5 (enExample)
JP7472210B2 (ja) 有効性の改善および毒性の減少のための、抗体およびsn-38からなるイムノコンジュゲートの投薬
JP7245239B2 (ja) Ror1抗体免疫複合体
JP2015528818A5 (enExample)
ES2819573T3 (es) Método para producir inmunoconjugados de anticuerpo-SN-38 con un enlazador CL2A
JP2015527318A5 (enExample)
JP2015531750A5 (enExample)
ES2988698T3 (es) Conjugados de fracciones de unión a la camptotecina
ES2945533T3 (es) Inmunoconjugados con un enlace escindible intracelularmente
ES2892525T3 (es) Uso neoadyuvante de conjugados anticuerpo-fármaco
AU2014293670B2 (en) Antibody-SN-38 immunoconjugates with a CL2A linker
JP2019146572A5 (enExample)
JP2017503011A5 (enExample)
JP2017522861A5 (enExample)
JP2015523380A5 (enExample)
JP2015527319A5 (enExample)
AU2014214843A1 (en) Pro-drug form (P2PDox) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
JP2011500725A5 (enExample)
RU2016129894A (ru) Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения
EP3316885A1 (en) Antibody-sn-38 immunoconjugates with a cl2a linker
JP2011505371A5 (enExample)
JP2015529656A5 (enExample)
JP2016537399A5 (enExample)
WO2024145398A1 (en) Antibody drug conjugates
RU2016109247A (ru) Способы применения антител к lgr5