JP2016528882A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016528882A5 JP2016528882A5 JP2016521907A JP2016521907A JP2016528882A5 JP 2016528882 A5 JP2016528882 A5 JP 2016528882A5 JP 2016521907 A JP2016521907 A JP 2016521907A JP 2016521907 A JP2016521907 A JP 2016521907A JP 2016528882 A5 JP2016528882 A5 JP 2016528882A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YCBIWVHDKSQGFJ-UHFFFAOYSA-N C(C1)C11OCCCC1 Chemical compound C(C1)C11OCCCC1 YCBIWVHDKSQGFJ-UHFFFAOYSA-N 0.000 description 2
- BVJWKTOWLQBIRD-UHFFFAOYSA-N C1OC11NCCOC1 Chemical compound C1OC11NCCOC1 BVJWKTOWLQBIRD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838534P | 2013-06-24 | 2013-06-24 | |
| US61/838,534 | 2013-06-24 | ||
| PCT/US2014/043952 WO2014210064A1 (en) | 2013-06-24 | 2014-06-24 | Anti-fcrh5 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192491A Division JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗FcRH5抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528882A JP2016528882A (ja) | 2016-09-23 |
| JP2016528882A5 true JP2016528882A5 (enExample) | 2017-08-10 |
| JP6684208B2 JP6684208B2 (ja) | 2020-04-22 |
Family
ID=51212984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521907A Active JP6684208B2 (ja) | 2013-06-24 | 2014-06-24 | 抗FcRH5抗体 |
| JP2019192491A Pending JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗FcRH5抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192491A Pending JP2020048559A (ja) | 2013-06-24 | 2019-10-23 | 抗FcRH5抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10435471B2 (enExample) |
| EP (3) | EP3013861B1 (enExample) |
| JP (2) | JP6684208B2 (enExample) |
| KR (1) | KR20160022912A (enExample) |
| CN (2) | CN105473618A (enExample) |
| AR (1) | AR096687A1 (enExample) |
| AU (2) | AU2014302617B2 (enExample) |
| BR (1) | BR112015032224B1 (enExample) |
| CA (1) | CA2915480C (enExample) |
| DK (3) | DK3736291T5 (enExample) |
| ES (3) | ES2812243T3 (enExample) |
| FI (1) | FI3736291T3 (enExample) |
| HK (1) | HK1222663A1 (enExample) |
| HR (3) | HRP20231323T1 (enExample) |
| HU (3) | HUE063910T2 (enExample) |
| IL (2) | IL243129B (enExample) |
| LT (3) | LT3736291T (enExample) |
| MX (1) | MX376663B (enExample) |
| MY (2) | MY176285A (enExample) |
| NO (1) | NO2955475T3 (enExample) |
| PL (3) | PL3336106T3 (enExample) |
| PT (3) | PT3013861T (enExample) |
| RS (3) | RS60418B1 (enExample) |
| RU (2) | RU2687132C2 (enExample) |
| SG (2) | SG10201804338PA (enExample) |
| SI (3) | SI3336106T1 (enExample) |
| TW (1) | TWI725931B (enExample) |
| WO (1) | WO2014210064A1 (enExample) |
| ZA (2) | ZA201509261B (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI725931B (zh) | 2013-06-24 | 2021-05-01 | 美商建南德克公司 | 抗fcrh5抗體 |
| MX379030B (es) | 2013-12-17 | 2025-03-10 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| AU2015289644A1 (en) | 2014-07-15 | 2017-02-02 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| MA40579A (fr) | 2014-09-12 | 2016-03-17 | Genentech Inc | Anticorps anti-cll-1 et immunoconjugués |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| WO2016090337A1 (en) | 2014-12-05 | 2016-06-09 | Memorial Sloan-Kettering Cancer Center | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof |
| EP3878861B1 (en) * | 2015-02-16 | 2025-05-07 | Lonza Ltd. | Cl and/or ch1 mutated antibodies for drug conjugation |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN107847568B (zh) | 2015-06-16 | 2022-12-20 | 豪夫迈·罗氏有限公司 | 抗cll-1抗体和使用方法 |
| HRP20231134T1 (hr) * | 2015-06-16 | 2024-01-05 | F. Hoffmann - La Roche Ag | Humanizirana i afinitetno zrela protutijela na fcrh5 i postupci za uporabu |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| CN109071654B (zh) | 2015-12-04 | 2022-09-23 | 纪念斯隆-凯特琳癌症中心 | 靶向Fc受体样5的抗体及使用方法 |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| IL324632A (en) | 2016-12-01 | 2026-01-01 | Regeneron Pharma | Radiolabeled anti-PD-L1 antibodies for immuno-PET imaging |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CN110650974B (zh) | 2017-02-10 | 2024-04-19 | 瑞泽恩制药公司 | 用于免疫-pet成像的放射性标记的抗-lag3抗体 |
| MY197688A (en) | 2017-07-24 | 2023-07-05 | Regeneron Pharma | Anti-cd8 antibodies and uses thereof |
| MA50855A (fr) | 2017-11-01 | 2020-09-09 | Juno Therapeutics Inc | Procédé de génération de compositions thérapeutiques de cellules modifiées |
| MX2020004572A (es) | 2017-11-01 | 2020-10-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos. |
| CA3080904A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| MA50859A (fr) | 2017-11-01 | 2020-09-09 | Celgene Corp | Procédé pour la production d'une composition de lymphocytes t |
| WO2019108900A1 (en) | 2017-11-30 | 2019-06-06 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| CA3084445A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| EP3720480A2 (en) | 2017-12-08 | 2020-10-14 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| AR115360A1 (es) | 2018-02-08 | 2021-01-13 | Genentech Inc | Moléculas de unión al antígeno y métodos de uso |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| AU2019277029C1 (en) | 2018-06-01 | 2024-01-04 | Novartis Ag | Binding molecules against BCMA and uses thereof |
| US20210123075A1 (en) | 2018-06-08 | 2021-04-29 | Novartis Ag | Compositions and methods for immunooncology |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| BR112021002245A2 (pt) | 2018-08-09 | 2021-05-04 | Juno Therapeutics Inc | métodos para avaliar ácidos nucleicos integrados |
| MX2021005022A (es) | 2018-11-01 | 2021-09-08 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d). |
| SG11202104188VA (en) | 2018-11-01 | 2021-05-28 | Juno Therapeutics Inc | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| WO2020128972A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| BR112021015672A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos |
| ES3032659T3 (en) | 2019-02-15 | 2025-07-23 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| MX2021013223A (es) | 2019-05-01 | 2022-02-17 | Juno Therapeutics Inc | Celulas que expresan un receptor quimerico de un locus cd247 modificado, polinucleotidos relacionados y metodos. |
| AU2020265741A1 (en) | 2019-05-01 | 2021-11-25 | Editas Medicine, Inc. | Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods |
| JP7750828B2 (ja) | 2019-09-16 | 2025-10-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 免疫pet撮像のための放射標識されたmet結合タンパク質 |
| KR20220116257A (ko) | 2019-12-20 | 2022-08-22 | 노파르티스 아게 | 골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물 |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| IL297147B1 (en) | 2020-04-10 | 2026-05-01 | Juno Therapeutics Inc | Methods and uses related to engineered cell therapy with a chimeric antigen receptor directed against a B-cell maturation antigen |
| WO2021231657A1 (en) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| WO2021260186A1 (en) | 2020-06-26 | 2021-12-30 | Juno Therapeutics Gmbh | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
| US20230271940A1 (en) | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| AU2021374590A1 (en) | 2020-11-04 | 2023-06-01 | Genentech, Inc. | Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies |
| WO2022098787A1 (en) | 2020-11-04 | 2022-05-12 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
| KR20230095113A (ko) | 2020-11-04 | 2023-06-28 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체들과 항-cd79b 항체 약물 접합체들을 이용한 치료를 위한 투약 |
| TWI874719B (zh) | 2020-11-04 | 2025-03-01 | 美商建南德克公司 | 用抗cd20/抗cd3雙特異性抗體進行治療之給藥 |
| EP4240491A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Cd19 binding molecules and uses thereof |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN116635085A (zh) | 2020-12-23 | 2023-08-22 | 斯迪安生物技术公司 | 肿瘤特异性密蛋白18.2抗体-药物缀合物 |
| WO2022187406A1 (en) | 2021-03-03 | 2022-09-09 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| JP2024515591A (ja) | 2021-04-08 | 2024-04-10 | マレンゴ・セラピューティクス,インコーポレーテッド | Tcrに結合する多機能性分子およびその使用 |
| TW202309294A (zh) | 2021-04-27 | 2023-03-01 | 瑞士商諾華公司 | 病毒載體生產系統 |
| WO2022228705A1 (en) | 2021-04-30 | 2022-11-03 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| KR20240007171A (ko) | 2021-05-14 | 2024-01-16 | 제넨테크, 인크. | 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법 |
| WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
| WO2023159182A1 (en) | 2022-02-18 | 2023-08-24 | Rakuten Medical, Inc. | Anti-programmed death-ligand 1 (pd-l1) antibody molecules, encoding polynucleotides, and methods of use |
| CN119384432A (zh) | 2022-04-13 | 2025-01-28 | 基因泰克公司 | 治疗性蛋白质的药物组合物和使用方法 |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| EP4532695A1 (en) | 2022-05-25 | 2025-04-09 | Celgene Corporation | Methods of manufacturing t cell therapies |
| US20250345432A1 (en) | 2022-05-25 | 2025-11-13 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
| AU2023369684A1 (en) | 2022-10-26 | 2025-04-17 | Novartis Ag | Lentiviral formulations |
| CN117384299B (zh) * | 2022-11-01 | 2024-04-30 | 邦恩泰(山东)生物医药科技集团股份有限公司 | 靶向bcma和/或fcrh5的嵌合抗原受体、car-t细胞及其应用 |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| CN116789849B (zh) * | 2023-04-12 | 2024-03-08 | 南京紫珑生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| TW202525277A (zh) * | 2023-08-10 | 2025-07-01 | 瑞典商阿斯特捷利康公司 | 蒽環黴素衍生物和綴合物及其用途 |
| WO2025213043A1 (en) * | 2024-04-04 | 2025-10-09 | Translational Sciences, Inc. | Matrix metalloproteinase-9 inhibitor and treatment of stroke |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| JP3469580B2 (ja) | 1993-10-01 | 2003-11-25 | 帝国臓器製薬株式会社 | 新規なペプチド誘導体 |
| US6956108B2 (en) | 1997-06-16 | 2005-10-18 | Genentech, Inc. | PRO1184 antibodies |
| US6248564B1 (en) | 1997-08-29 | 2001-06-19 | Harvard University | Mutant MHC class I molecules |
| US7105149B1 (en) | 1999-11-29 | 2006-09-12 | The Trustees Of Columbia University In The City Of New York | Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma |
| CA2393126C (en) | 1999-11-29 | 2016-05-24 | The Trustees Of Columbia University In The City Of New York | Isolation of five novel genes coding for new fc receptors-type melanoma involved in the pathogenesis of lymphoma/melanoma |
| US20040005561A1 (en) | 2000-03-01 | 2004-01-08 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| US20040018194A1 (en) | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| CU23007A1 (es) | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| CA2450793A1 (en) | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| ES2431929T3 (es) | 2001-09-18 | 2013-11-28 | Genentech, Inc. | Composiciones y procedimientos para el diagnóstico y el tratamiento de tumores |
| US7888478B2 (en) | 2002-09-11 | 2011-02-15 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20050226869A1 (en) | 2001-10-19 | 2005-10-13 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US7858330B2 (en) | 2001-10-19 | 2010-12-28 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| JP2005511627A (ja) | 2001-11-20 | 2005-04-28 | シアトル ジェネティクス,インコーポレーテッド | 抗cd30抗体を使用する免疫学的疾患の治療 |
| EP1575514A2 (en) | 2002-07-31 | 2005-09-21 | Seattle Genetics, Inc. | Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders |
| EP1391213A1 (en) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| JP4658967B2 (ja) | 2003-12-24 | 2011-03-23 | ジェネンテック, インコーポレイテッド | 造血系起源の腫瘍の治療のための組成物と方法 |
| EP1718667B1 (en) * | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US7999077B2 (en) * | 2004-09-30 | 2011-08-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | IRTA2 antibodies and methods of use |
| US20070134243A1 (en) | 2004-12-01 | 2007-06-14 | Gazzard Lewis J | Antibody drug conjugates and methods |
| US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| CA2594318A1 (en) | 2005-01-12 | 2006-07-20 | Medarex, Inc. | Irta-2 antibodies and their uses |
| BRPI0613382A8 (pt) | 2005-06-20 | 2018-01-02 | Genentech Inc | anticorpos isolados, anticorpo monoclonal, célula de hibridoma, método de identificação, método de inibição do crescimento de uma célula, método de tratamento terapêutico, método de determinação da presença de uma proteína, métodos de diagnósticos da presença de tumor |
| WO2008109533A2 (en) | 2007-03-02 | 2008-09-12 | Medarex, Inc. | Human antibodies that bind multiple irta family proteins, and uses thereof |
| US8742076B2 (en) * | 2008-02-01 | 2014-06-03 | Genentech, Inc. | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods |
| WO2010009124A2 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
| CA2757382A1 (en) | 2009-04-01 | 2010-10-21 | Kristi Elkins | Anti-fcrh5 antibodies and immunoconjugates |
| BRPI1012560A2 (pt) | 2009-04-01 | 2016-07-26 | Genentech Inc | anticorpos anti-fcrh5 e imunoconjugados e métodos de uso |
| BR112012004777A2 (pt) | 2009-09-03 | 2019-09-24 | Genentech Inc | métodos para tratar diagnósticar e monitorar artrite reumatoide |
| WO2011130598A1 (en) * | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
| TWI725931B (zh) | 2013-06-24 | 2021-05-01 | 美商建南德克公司 | 抗fcrh5抗體 |
| MX379030B (es) | 2013-12-17 | 2025-03-10 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
| HRP20231134T1 (hr) | 2015-06-16 | 2024-01-05 | F. Hoffmann - La Roche Ag | Humanizirana i afinitetno zrela protutijela na fcrh5 i postupci za uporabu |
-
2014
- 2014-06-23 TW TW103121621A patent/TWI725931B/zh active
- 2014-06-23 AR ARP140102352A patent/AR096687A1/es unknown
- 2014-06-24 US US14/313,822 patent/US10435471B2/en active Active
- 2014-06-24 RS RS20200733A patent/RS60418B1/sr unknown
- 2014-06-24 FI FIEP20169942.8T patent/FI3736291T3/fi active
- 2014-06-24 SI SI201431623T patent/SI3336106T1/sl unknown
- 2014-06-24 PL PL17198415T patent/PL3336106T3/pl unknown
- 2014-06-24 ES ES17198415T patent/ES2812243T3/es active Active
- 2014-06-24 SI SI201430602T patent/SI3013861T1/en unknown
- 2014-06-24 EP EP14742047.5A patent/EP3013861B1/en active Active
- 2014-06-24 CA CA2915480A patent/CA2915480C/en active Active
- 2014-06-24 DK DK20169942.8T patent/DK3736291T5/da active
- 2014-06-24 EP EP17198415.6A patent/EP3336106B1/en active Active
- 2014-06-24 RU RU2016101965A patent/RU2687132C2/ru active
- 2014-06-24 DK DK14742047.5T patent/DK3013861T3/da active
- 2014-06-24 SI SI201432050T patent/SI3736291T1/sl unknown
- 2014-06-24 PL PL14742047T patent/PL3013861T3/pl unknown
- 2014-06-24 SG SG10201804338PA patent/SG10201804338PA/en unknown
- 2014-06-24 MX MX2015017331A patent/MX376663B/es active IP Right Grant
- 2014-06-24 JP JP2016521907A patent/JP6684208B2/ja active Active
- 2014-06-24 PT PT147420475T patent/PT3013861T/pt unknown
- 2014-06-24 ES ES14742047.5T patent/ES2659229T3/es active Active
- 2014-06-24 LT LTEP20169942.8T patent/LT3736291T/lt unknown
- 2014-06-24 HR HRP20231323TT patent/HRP20231323T1/hr unknown
- 2014-06-24 KR KR1020167001897A patent/KR20160022912A/ko not_active Ceased
- 2014-06-24 HU HUE20169942A patent/HUE063910T2/hu unknown
- 2014-06-24 ES ES20169942T patent/ES2962874T3/es active Active
- 2014-06-24 SG SG11201510653YA patent/SG11201510653YA/en unknown
- 2014-06-24 PT PT201699428T patent/PT3736291T/pt unknown
- 2014-06-24 LT LTEP17198415.6T patent/LT3336106T/lt unknown
- 2014-06-24 RS RS20180149A patent/RS56878B1/sr unknown
- 2014-06-24 HU HUE14742047A patent/HUE036581T2/hu unknown
- 2014-06-24 HU HUE17198415A patent/HUE049446T2/hu unknown
- 2014-06-24 HR HRP20180352TT patent/HRP20180352T1/hr unknown
- 2014-06-24 BR BR112015032224-7A patent/BR112015032224B1/pt active IP Right Grant
- 2014-06-24 DK DK17198415.6T patent/DK3336106T3/da active
- 2014-06-24 LT LTEP14742047.5T patent/LT3013861T/lt unknown
- 2014-06-24 AU AU2014302617A patent/AU2014302617B2/en active Active
- 2014-06-24 HK HK16110816.3A patent/HK1222663A1/zh unknown
- 2014-06-24 EP EP20169942.8A patent/EP3736291B1/en active Active
- 2014-06-24 RU RU2019109452A patent/RU2019109452A/ru unknown
- 2014-06-24 CN CN201480045475.0A patent/CN105473618A/zh active Pending
- 2014-06-24 RS RS20230745A patent/RS64514B1/sr unknown
- 2014-06-24 CN CN202211286136.4A patent/CN116063515A/zh active Pending
- 2014-06-24 MY MYPI2015704672A patent/MY176285A/en unknown
- 2014-06-24 WO PCT/US2014/043952 patent/WO2014210064A1/en not_active Ceased
- 2014-06-24 PL PL20169942.8T patent/PL3736291T3/pl unknown
- 2014-06-24 PT PT171984156T patent/PT3336106T/pt unknown
-
2015
- 2015-05-08 NO NO15001398A patent/NO2955475T3/no unknown
- 2015-12-15 IL IL243129A patent/IL243129B/en active IP Right Grant
- 2015-12-18 ZA ZA2015/09261A patent/ZA201509261B/en unknown
-
2018
- 2018-12-14 ZA ZA2018/08451A patent/ZA201808451B/en unknown
-
2019
- 2019-01-31 MY MYPI2019000547A patent/MY191169A/en unknown
- 2019-09-23 IL IL26952819A patent/IL269528A/en unknown
- 2019-09-26 US US16/583,584 patent/US11352431B2/en active Active
- 2019-10-23 JP JP2019192491A patent/JP2020048559A/ja active Pending
-
2020
- 2020-03-17 AU AU2020201918A patent/AU2020201918A1/en not_active Abandoned
- 2020-07-15 HR HRP20201111TT patent/HRP20201111T1/hr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2016101965A (ru) | Анти-fcrh5 антитела | |
| JP2019146572A5 (enExample) | ||
| JP2016523810A5 (enExample) | ||
| JP2017522861A5 (enExample) | ||
| JP7401126B2 (ja) | 抗cubドメイン含有タンパク質1(cdcp1)抗体、抗体薬物コンジュゲート、およびその使用方法 | |
| JP2015523961A5 (enExample) | ||
| JP2017534253A5 (enExample) | ||
| JP2017505604A5 (enExample) | ||
| JP6251678B2 (ja) | Cd27l抗原結合タンパク質 | |
| JP2015523380A5 (enExample) | ||
| RU2014148162A (ru) | Анти-pmel17 антитела и их иммуноконъюгаты | |
| JP2017534256A5 (enExample) | ||
| JP2014509835A5 (enExample) | ||
| JP2015528818A5 (enExample) | ||
| RU2016133846A (ru) | Конъюгат лиганд - цитотоксическое лекарственное средство, способ его получения и его применения | |
| JP2017514461A5 (enExample) | ||
| JP2016098233A5 (enExample) | ||
| JP2009536921A5 (enExample) | ||
| KR20160097336A (ko) | 신규 항-dpep3 항체 및 이의 사용 방법 | |
| CN115969970A (zh) | Abcg2抑制剂与sacituzumab govitecan的组合 | |
| JP2017535257A5 (enExample) | ||
| RU2016150370A (ru) | Антитела и иммуноконъюгаты против GPC3 | |
| EP3448260A1 (en) | Efficacy of anti-trop-2-sn-38 antibody drug conjugates for therapy of tumors relapsed/refractory to checkpoint inhibitors | |
| IL278574B2 (en) | Glycan-interacting compounds and methods of use | |
| TW201620553A (zh) | 抗cd98抗體-藥物結合物 |