JP2014509835A5 - - Google Patents

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Publication number

JP2014509835A5

JP2014509835A5 JP2013544871A JP2013544871A JP2014509835A5 JP 2014509835 A5 JP2014509835 A5 JP 2014509835A5 JP 2013544871 A JP2013544871 A JP 2013544871A JP 2013544871 A JP2013544871 A JP 2013544871A JP 2014509835 A5 JP2014509835 A5 JP 2014509835A5

Authority

JP

Japan

Prior art keywords

seq

antibody

hvr

amino acid

acid sequence

Prior art date

2011-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 49
• 102000003735 Mesothelin Human genes 0.000 claims 22
• 108090000015 Mesothelin Proteins 0.000 claims 22
• 229940127121 immunoconjugate Drugs 0.000 claims 20
• 239000003814 drug Substances 0.000 claims 19
• 206010028980 Neoplasm Diseases 0.000 claims 15
• 201000011510 cancer Diseases 0.000 claims 15
• 238000000034 method Methods 0.000 claims 15
• 210000004027 cell Anatomy 0.000 claims 10
• 210000004408 hybridoma Anatomy 0.000 claims 10
• 239000000523 sample Substances 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• 206010014733 Endometrial cancer Diseases 0.000 claims 5
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 5
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
• 206010027406 Mesothelioma Diseases 0.000 claims 5
• 206010033128 Ovarian cancer Diseases 0.000 claims 5
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 5
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
• 239000012472 biological sample Substances 0.000 claims 5
• 201000005202 lung cancer Diseases 0.000 claims 5
• 208000020816 lung neoplasm Diseases 0.000 claims 5
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
• 201000002528 pancreatic cancer Diseases 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 2
• 102100023123 Mucin-16 Human genes 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
• 229960005277 gemcitabine Drugs 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000012308 immunohistochemistry method Methods 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 239000004299 sodium benzoate Substances 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 125000004434 sulfur atom Chemical group 0.000 claims 1
• 239000004108 vegetable carbon Substances 0.000 claims 1