MX2023000958A - Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica. - Google Patents
Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica.Info
- Publication number
- MX2023000958A MX2023000958A MX2023000958A MX2023000958A MX2023000958A MX 2023000958 A MX2023000958 A MX 2023000958A MX 2023000958 A MX2023000958 A MX 2023000958A MX 2023000958 A MX2023000958 A MX 2023000958A MX 2023000958 A MX2023000958 A MX 2023000958A
- Authority
- MX
- Mexico
- Prior art keywords
- muscle
- myotonic dystrophy
- muscle targeting
- molecular payload
- targeting complexes
- Prior art date
Links
- 206010068871 Myotonic dystrophy Diseases 0.000 title 1
- 210000003205 muscle Anatomy 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 102000018658 Myotonin-Protein Kinase Human genes 0.000 abstract 1
- 108010052185 Myotonin-Protein Kinase Proteins 0.000 abstract 1
- 108091030071 RNAI Proteins 0.000 abstract 1
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 1
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 210000000663 muscle cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Los aspectos de la descripción se refieren a complejos que comprenden un agente dirigido al músculo enlazado covalentemente a una carga útil molecular; en algunas modalidades, el agente dirigido al músculo se une específicamente a un receptor de internalización de superficie celular en células musculares; en algunas modalidades, la carga útil molecular inhibe la expresión o la actividad de un alelo DMPK que comprende una repetición asociada a la enfermedad; en algunas modalidades, la carga útil molecular es un oligonucleótido, como un oligonucleótido antisentido o un oligonucleótido de ARNi.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063055749P | 2020-07-23 | 2020-07-23 | |
US202063069075P | 2020-08-23 | 2020-08-23 | |
US202163143827P | 2021-01-30 | 2021-01-30 | |
PCT/US2021/040986 WO2022026152A2 (en) | 2020-07-23 | 2021-07-09 | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023000958A true MX2023000958A (es) | 2023-04-14 |
Family
ID=80038121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023000958A MX2023000958A (es) | 2020-07-23 | 2021-07-09 | Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20240016952A1 (es) |
EP (1) | EP4185383A4 (es) |
JP (1) | JP2023535078A (es) |
KR (1) | KR20230042713A (es) |
CN (1) | CN116438304A (es) |
AU (1) | AU2021318851A1 (es) |
BR (1) | BR112023001126A8 (es) |
CA (1) | CA3186742A1 (es) |
IL (1) | IL299663A (es) |
MX (1) | MX2023000958A (es) |
WO (1) | WO2022026152A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020028864A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
WO2023201332A1 (en) * | 2022-04-15 | 2023-10-19 | Dyne Therapeutics, Inc. | Dosing of muscle targeting complexes for treating myotonic dystrophy |
US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
WO2023201324A1 (en) * | 2022-04-15 | 2023-10-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
WO2023220719A2 (en) * | 2022-05-13 | 2023-11-16 | University Of Washington | Method for treatment of myotonic dystrophy combining protein expression and rna interference vector delivery with tissue detargeting |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140014116A (ko) * | 2010-12-20 | 2014-02-05 | 제넨테크, 인크. | 항-메소텔린 항체 및 면역접합체 |
BR112017027965A2 (pt) * | 2015-06-24 | 2018-08-28 | Japan Chem Res | anticorpo receptor, proteína de fusão, fragmento de dna, vetor de expressão, célula, complexo de anticorpo receptor, usos de um anticorpo receptor e de uma proteína de fusão, e, métodos para tratamento de um distúrbio e de uma doença. |
FR3049951A1 (fr) * | 2016-04-12 | 2017-10-13 | Univ Rabelais Francois | Nouvelles constructions peptidiques et leur utilisation dans le traitement de la toxoplasmose |
PE20190562A1 (es) * | 2016-05-27 | 2019-04-22 | Abbvie Biotherapeutics Inc | Proteinas de union biespecificas que se unen a una proteina inmunomoduladora y un antigeno tumoral |
MX2020005860A (es) * | 2017-12-06 | 2020-09-09 | Avidity Biosciences Inc | Composiciones y metodos de tratamiento de atrofia muscular y distrofia miotonica. |
CN112930193A (zh) * | 2018-08-02 | 2021-06-08 | 达因疗法公司 | 肌肉靶向复合物及其在治疗肌肉萎缩中的用途 |
KR20210081323A (ko) * | 2018-08-02 | 2021-07-01 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 근긴장성 이영양증을 치료하기 위한 그의 용도 |
EP3829594A4 (en) * | 2018-08-02 | 2022-05-11 | Dyne Therapeutics, Inc. | MUSCLE TARGETED COMPLEXES AND THEIR USES IN THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY |
IL280536B1 (en) * | 2018-08-02 | 2024-08-01 | Dyne Therapeutics Inc | Muscle oriented clasps and their uses |
TW202039573A (zh) * | 2018-12-21 | 2020-11-01 | 美商亞維代堤生物科學公司 | 抗轉鐵蛋白受體抗體及其用途 |
-
2021
- 2021-07-09 CA CA3186742A patent/CA3186742A1/en active Pending
- 2021-07-09 MX MX2023000958A patent/MX2023000958A/es unknown
- 2021-07-09 KR KR1020237005830A patent/KR20230042713A/ko active Search and Examination
- 2021-07-09 CN CN202180064935.4A patent/CN116438304A/zh active Pending
- 2021-07-09 WO PCT/US2021/040986 patent/WO2022026152A2/en active Application Filing
- 2021-07-09 EP EP21850418.1A patent/EP4185383A4/en active Pending
- 2021-07-09 IL IL299663A patent/IL299663A/en unknown
- 2021-07-09 BR BR112023001126A patent/BR112023001126A8/pt unknown
- 2021-07-09 AU AU2021318851A patent/AU2021318851A1/en active Pending
- 2021-07-09 JP JP2023504653A patent/JP2023535078A/ja active Pending
- 2021-07-09 US US18/017,170 patent/US20240016952A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4185383A4 (en) | 2024-07-31 |
AU2021318851A1 (en) | 2023-03-16 |
CN116438304A (zh) | 2023-07-14 |
WO2022026152A2 (en) | 2022-02-03 |
JP2023535078A (ja) | 2023-08-15 |
EP4185383A2 (en) | 2023-05-31 |
BR112023001126A2 (pt) | 2023-02-14 |
US20240016952A1 (en) | 2024-01-18 |
BR112023001126A8 (pt) | 2023-03-14 |
KR20230042713A (ko) | 2023-03-29 |
IL299663A (en) | 2023-03-01 |
CA3186742A1 (en) | 2022-02-03 |
WO2022026152A3 (en) | 2022-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022008533A (es) | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de la distrofia miotonica. | |
MX2023000958A (es) | Complejos dirigidos al musculo y usos de estos para el tratamiento de la distrofia miotonica. | |
MX2021001283A (es) | Complejos dirigidos al músculo y sus usos para tratar la distrofia miotónica. | |
MX2022008538A (es) | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de la distrofia muscular facioescapulohumeral. | |
MX2023000961A (es) | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de la distrofia muscular facioescapulohumeral. | |
MX2021001284A (es) | Complejos dirigidos al musculo y sus usos para el tratamiento de distrofia muscular facioescapulohumeral. | |
MX2021001282A (es) | Complejos dirigidos al músculo y sus usos. | |
MX2023007881A (es) | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de la distrofia miotonica. | |
MX2024000488A (es) | Complejos dirigidos al musculo y usos de los mismos para tratar la distrofia miotónica. | |
CA3163608A1 (en) | Muscle-targeting complexes and uses thereof | |
EA202190421A1 (ru) | Мышечно-специфические комплексы и их применение для лечения мышечной атрофии | |
MX2022008540A (es) | Complejos dirigidos a musculos y usos de los mismos para el tratamiento de distrofinopatias. | |
WO2020028831A8 (en) | Muscle targeting complexes and uses thereof for treating fibrodysplasia ossificans progressiva | |
MX2024000493A (es) | Complejos dirigidos a los musculos y sus usos para el tratamiento de distrofinopatías. | |
MX2023000984A (es) | Complejos dirigidos al musculo y usos de los mismos para el tratamiento de distrofinopatias. | |
MX2024000494A (es) | Complejos dirigidos al tratamiento de musculos, y usos de los mismos para tratar distrofinopatías. | |
MX2024000492A (es) | Complejos dirigidos al musculo y usos de los mismos para tratar las distrofinopatías. | |
WO2021142217A8 (en) | Muscle targeting complexes and uses thereof for modulation of milck1 | |
WO2023283619A3 (en) | Muscle targeting complexes and uses thereof for treating dystrophinopathies | |
CA3226298A1 (en) | Muscle targeting complexes and uses thereof for treating dystrophinopathies | |
WO2022271543A3 (en) | Muscle targeting complexes and uses thereof for treating friedreich's ataxia | |
WO2023283531A3 (en) | Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health | |
Lee et al. | Improvement of electrical properties via glucose oxidase-immobilization by actively turning over glucose for an enzyme-based biofuel cell modified with DNA-wrapped single walled nanotubes | |
Yuan et al. | Poly (4-vinylaniline)-polyaniline bilayer-modified stainless steels for the mitigation of biocorrosion by sulfate-reducing bacteria (SRB) in seawater | |
MX2016001006A (es) | Policonjugados para suministro de desencadenantes de acido ribonucleico de interferencia (arni) en celulas tumorales en vivo. |