JP2017512765A5 - - Google Patents

Info

Publication number

JP2017512765A5

JP2017512765A5 JP2016555809A JP2016555809A JP2017512765A5 JP 2017512765 A5 JP2017512765 A5 JP 2017512765A5 JP 2016555809 A JP2016555809 A JP 2016555809A JP 2016555809 A JP2016555809 A JP 2016555809A JP 2017512765 A5 JP2017512765 A5 JP 2017512765A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

polypeptide chain

antibody

her2

Prior art date

2015-04-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 235000001014 amino acid Nutrition 0.000 claims 81
• 108090000765 processed proteins & peptides Proteins 0.000 claims 41
• 150000001413 amino acids Chemical class 0.000 claims 39
• 229920001184 polypeptide Polymers 0.000 claims 39
• 102000004196 processed proteins & peptides Human genes 0.000 claims 39
• 125000003275 alpha amino acid group Chemical group 0.000 claims 28
• 108060003951 Immunoglobulin Proteins 0.000 claims 23
• 239000000427 antigen Substances 0.000 claims 23
• 102000036639 antigens Human genes 0.000 claims 23
• 108091007433 antigens Proteins 0.000 claims 23
• 102000018358 immunoglobulin Human genes 0.000 claims 23
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 21
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 21
• 230000001225 therapeutic effect Effects 0.000 claims 16
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 15
• 235000018417 cysteine Nutrition 0.000 claims 15
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 14
• -1 cysteine amino acid Chemical class 0.000 claims 13
• 238000006467 substitution reaction Methods 0.000 claims 13
• 239000000611 antibody drug conjugate Substances 0.000 claims 12
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 201000011510 cancer Diseases 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 108010032595 Antibody Binding Sites Proteins 0.000 claims 4
• 229960000575 trastuzumab Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 101710112752 Cytotoxin Proteins 0.000 claims 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
• 231100000599 cytotoxic agent Toxicity 0.000 claims 2
• 239000002619 cytotoxin Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• 239000004215 Carbon black (E152) Substances 0.000 claims 1
• 102000019034 Chemokines Human genes 0.000 claims 1
• 108010012236 Chemokines Proteins 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 108700011259 MicroRNAs Proteins 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 108091030071 RNAI Proteins 0.000 claims 1
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 102000004243 Tubulin Human genes 0.000 claims 1
• 108090000704 Tubulin Proteins 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 230000015556 catabolic process Effects 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 239000002738 chelating agent Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000006731 degradation reaction Methods 0.000 claims 1
• 238000006471 dimerization reaction Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000009368 gene silencing by RNA Effects 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000003667 hormone antagonist Substances 0.000 claims 1
• 229930195733 hydrocarbon Natural products 0.000 claims 1
• 150000002430 hydrocarbons Chemical class 0.000 claims 1
• 239000002955 immunomodulating agent Substances 0.000 claims 1
• 229940121354 immunomodulator Drugs 0.000 claims 1
• 230000002584 immunomodulator Effects 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 230000015100 lysosomal transport Effects 0.000 claims 1
• 239000002679 microRNA Substances 0.000 claims 1
• 229960002087 pertuzumab Drugs 0.000 claims 1
• 230000026731 phosphorylation Effects 0.000 claims 1
• 238000006366 phosphorylation reaction Methods 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 230000000861 pro-apoptotic effect Effects 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 102000003390 tumor necrosis factor Human genes 0.000 claims 1