RS64690B1 - Konjugati biparatopskog anti-her2 antitela i leka i postupci za njihovu upotrebu - Google Patents

Konjugati biparatopskog anti-her2 antitela i leka i postupci za njihovu upotrebu

Info

Publication number
RS64690B1
RS64690B1 RS20230943A RSP20230943A RS64690B1 RS 64690 B1 RS64690 B1 RS 64690B1 RS 20230943 A RS20230943 A RS 20230943A RS P20230943 A RSP20230943 A RS P20230943A RS 64690 B1 RS64690 B1 RS 64690B1
Authority
RS
Serbia
Prior art keywords
methods
drug conjugates
biparatopic antibody
her2 biparatopic
her2
Prior art date
Application number
RS20230943A
Other languages
English (en)
Inventor
Kevin Hamblett
Rupert H Davies
James R Rich
Gerald J Rowse
Vincent K C Fung
Stuart D Barnscher
Original Assignee
Zymeworks Bc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Bc Inc filed Critical Zymeworks Bc Inc
Publication of RS64690B1 publication Critical patent/RS64690B1/sr

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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
RS20230943A 2018-03-13 2019-03-12 Konjugati biparatopskog anti-her2 antitela i leka i postupci za njihovu upotrebu RS64690B1 (sr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862642483P 2018-03-13 2018-03-13
US201862658477P 2018-04-16 2018-04-16
US201862743884P 2018-10-10 2018-10-10
PCT/CA2019/050303 WO2019173911A1 (en) 2018-03-13 2019-03-12 Anti-her2 biparatopic antibody-drug conjugates and methods of use
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