BR112015023520A2 - purificação do conjugado de anticorpo-fármaco (adc) - Google Patents

purificação do conjugado de anticorpo-fármaco (adc)

Info

Publication number
BR112015023520A2
BR112015023520A2 BR112015023520A BR112015023520A BR112015023520A2 BR 112015023520 A2 BR112015023520 A2 BR 112015023520A2 BR 112015023520 A BR112015023520 A BR 112015023520A BR 112015023520 A BR112015023520 A BR 112015023520A BR 112015023520 A2 BR112015023520 A2 BR 112015023520A2
Authority
BR
Brazil
Prior art keywords
antibody
drug
adc
purification
adcs
Prior art date
Application number
BR112015023520A
Other languages
English (en)
Inventor
Lawrence Becker Calvin
Robert Leanna Marvin
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of BR112015023520A2 publication Critical patent/BR112015023520A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

resumo “purificação do conjugado de anticorpo-fármaco (adc)” a invenção fornece métodos para obter composições que apresentam conjugados de anticorpo-fármaco (adcs) com razões de fármaco para anticorpo (dars) especificadas. incluído na invenção está um método para purificar uma mistura de adc que apresenta adcs com uma espécie carregada com fármaco de 6 ou mais através do contato da mistura com uma resina hidrofóbica, tal que uma composição compreendendo menos do que 15 % da espécie carregada com fármaco de 6 ou mais é obtida. a invenção também fornece uma composição em que 70 % ou mais do adcs presentes têm uma espécie carregada com fármaco de 4 ou menos, em que o adc compreende um anticorpo anti-egfr e uma auristatina.
BR112015023520A 2013-03-15 2014-03-14 purificação do conjugado de anticorpo-fármaco (adc) BR112015023520A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361792834P 2013-03-15 2013-03-15
PCT/US2014/027062 WO2014152199A1 (en) 2013-03-15 2014-03-14 Antibody drug conjugate (adc) purification

Publications (1)

Publication Number Publication Date
BR112015023520A2 true BR112015023520A2 (pt) 2017-10-24

Family

ID=50686153

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023520A BR112015023520A2 (pt) 2013-03-15 2014-03-14 purificação do conjugado de anticorpo-fármaco (adc)

Country Status (16)

Country Link
US (2) US20140286968A1 (pt)
EP (2) EP4137160A1 (pt)
JP (1) JP2016519070A (pt)
KR (1) KR20150132864A (pt)
CN (1) CN105209076A (pt)
AU (1) AU2014240012A1 (pt)
BR (1) BR112015023520A2 (pt)
CA (1) CA2906022A1 (pt)
HK (2) HK1217643A1 (pt)
IL (1) IL241004A0 (pt)
MX (1) MX2015012562A (pt)
NZ (1) NZ630888A (pt)
RU (1) RU2015144186A (pt)
SG (2) SG11201507432XA (pt)
TW (1) TW201519904A (pt)
WO (1) WO2014152199A1 (pt)

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TW202214691A (zh) 2014-03-21 2022-04-16 美商艾伯維有限公司 抗-egfr抗體及抗體藥物結合物
CN106999606B (zh) * 2015-02-17 2020-06-19 上海美雅珂生物技术有限责任公司 抗体药物偶联物
WO2016144773A1 (en) 2015-03-06 2016-09-15 Abbvie Inc. Arabinosylated glycoproteins
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TWI631958B (zh) * 2016-11-02 2018-08-11 財團法人生物技術開發中心 抗tmcc3免疫共軛物及其用途
WO2018119351A1 (en) * 2016-12-23 2018-06-28 Bluefin Biomedicine, Inc. Anti-sez6l2 antibodies and antibody drug conjugates
CN107375941A (zh) * 2017-07-17 2017-11-24 中国药科大学 一种抗人dll4单克隆抗体与海兔毒素衍生物mmae的偶联物
SG11202008770QA (en) 2018-03-13 2020-10-29 Zymeworks Inc Anti-her2 biparatopic antibody-drug conjugates and methods of use
WO2019183633A1 (en) 2018-03-23 2019-09-26 Case Western Reserve Univeristy Psma targeted conjugate compounds and uses thereof
EP3980073A4 (en) * 2019-06-07 2023-11-01 Dyne Therapeutics, Inc. PROCESSES FOR PREPARING PROTEIN-OLIGONUCLEOTIDE COMPLEXES
CN114502593A (zh) 2019-08-06 2022-05-13 葛兰素史密斯克莱知识产权发展有限公司 生物药物组合物和相关方法
CN112604004B (zh) * 2019-09-19 2022-05-10 中国医学科学院医药生物技术研究所 一类抗人egfr抗体药物偶联物及其制备方法与应用
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
KR20240040786A (ko) 2021-08-03 2024-03-28 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 생물제약 조성물 및 안정한 동위원소 표지 펩티드 맵핑 방법

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Also Published As

Publication number Publication date
HK1217643A1 (zh) 2017-01-20
WO2014152199A1 (en) 2014-09-25
SG11201507432XA (en) 2015-10-29
HK1219056A1 (zh) 2017-03-24
MX2015012562A (es) 2016-06-21
RU2015144186A3 (pt) 2018-03-19
US20140286968A1 (en) 2014-09-25
KR20150132864A (ko) 2015-11-26
SG10201800313UA (en) 2018-02-27
JP2016519070A (ja) 2016-06-30
TW201519904A (zh) 2015-06-01
CN105209076A (zh) 2015-12-30
CA2906022A1 (en) 2014-09-25
NZ630888A (en) 2017-06-30
US20190262417A1 (en) 2019-08-29
EP4137160A1 (en) 2023-02-22
EP2968589A1 (en) 2016-01-20
IL241004A0 (en) 2015-11-30
AU2014240012A1 (en) 2015-09-24
RU2015144186A (ru) 2017-04-24

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B15K Others concerning applications: alteration of classification

Ipc: A61K 47/00 (2006.01), A61P 35/00 (2006.01)

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