PL3765525T3 - Koniugaty biparatopowe przeciwciało anty-her2 – lek i sposoby stosowania - Google Patents

Koniugaty biparatopowe przeciwciało anty-her2 – lek i sposoby stosowania

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Publication number
PL3765525T3
PL3765525T3 PL19766478.2T PL19766478T PL3765525T3 PL 3765525 T3 PL3765525 T3 PL 3765525T3 PL 19766478 T PL19766478 T PL 19766478T PL 3765525 T3 PL3765525 T3 PL 3765525T3
Authority
PL
Poland
Prior art keywords
methods
drug conjugates
biparatopic antibody
her2 biparatopic
her2
Prior art date
Application number
PL19766478.2T
Other languages
English (en)
Inventor
Kevin HAMBLETT
Rupert H. DAVIES
James R. RICH
Gerald J. ROWSE
Vincent K. C. FUNG
Stuart D. Barnscher
Original Assignee
Zymeworks Bc Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Bc Inc. filed Critical Zymeworks Bc Inc.
Publication of PL3765525T3 publication Critical patent/PL3765525T3/pl

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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