JP2013520984A5 - - Google Patents

Info

Publication number

JP2013520984A5

JP2013520984A5 JP2012555532A JP2012555532A JP2013520984A5 JP 2013520984 A5 JP2013520984 A5 JP 2013520984A5 JP 2012555532 A JP2012555532 A JP 2012555532A JP 2012555532 A JP2012555532 A JP 2012555532A JP 2013520984 A5 JP2013520984 A5 JP 2013520984A5

Authority

JP

Japan

Prior art keywords

antibody

seq

cdr3 sequences

light chain

her2

Prior art date

2011-03-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 40
• 239000000203 mixture Substances 0.000 claims 24
• 210000004027 cell Anatomy 0.000 claims 11
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 10
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 238000000034 method Methods 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 238000012258 culturing Methods 0.000 claims 2
• 230000014509 gene expression Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 210000004881 tumor cell Anatomy 0.000 claims 2
• 102000001301 EGF receptor Human genes 0.000 claims 1
• 108060006698 EGF receptor Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 230000003024 amidolytic effect Effects 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 239000000833 heterodimer Substances 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229960000575 trastuzumab Drugs 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1