JP6039428B2 - 抗ｈｅｒ２抗体および組成物 - Google Patents
抗ｈｅｒ２抗体および組成物 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US31055210P | 2010-03-04 | 2010-03-04 | |
| DKPA201070085 | 2010-03-04 | ||
| DKPA201070085 | 2010-03-04 | ||
| US61/310,552 | 2010-03-04 | ||
| US35413310P | 2010-06-11 | 2010-06-11 | |
| US61/354,133 | 2010-06-11 | ||
| US201061428014P | 2010-12-29 | 2010-12-29 | |
| US61/428,014 | 2010-12-29 | ||
| PCT/IB2011/050903 WO2011107957A1 (en) | 2010-03-04 | 2011-03-03 | Anti-her2 antibodies and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2016123623A Division JP2016182135A (ja) | 2010-03-04 | 2016-06-22 | 抗ｈｅｒ２抗体および組成物 |
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| JP2013520984A JP2013520984A (ja) | 2013-06-10 |
| JP2013520984A5 JP2013520984A5 (enExample) | 2014-04-24 |
| JP6039428B2 true JP6039428B2 (ja) | 2016-12-07 |
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| Country | Link |
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| EP (1) | EP2542589A4 (enExample) |
| JP (1) | JP6039428B2 (enExample) |
| CN (1) | CN102884084B (enExample) |
| TW (1) | TW201141519A (enExample) |
| WO (1) | WO2011107957A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2337800B1 (en) | 2008-09-15 | 2013-10-02 | Yeda Research and Development Co. Ltd. | Antibody combinations and use of same for treating cancer |
| JP6033783B2 (ja) | 2010-11-01 | 2016-11-30 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | Ｐａｎ−ｈｅｒ抗体組成物 |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| WO2012156975A1 (en) * | 2011-05-16 | 2012-11-22 | Yeda Research And Development Co. Ltd. | COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER |
| BR112014027291A2 (pt) * | 2012-05-02 | 2017-08-08 | Symphogen As | composições de anticorpos pan-her humanizados |
| WO2014031174A1 (en) | 2012-08-24 | 2014-02-27 | The Regents Of The University Of California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
| ES2879799T3 (es) * | 2013-11-19 | 2021-11-23 | Remegen Co Ltd | Anticuerpo anti-HER2 y conjugado del mismo |
| CN104974261B (zh) * | 2014-04-01 | 2019-06-14 | 三生国健药业（上海）股份有限公司 | 重组抗her2/ps双特异性抗体、其制备方法和应用 |
| KR20170094787A (ko) * | 2014-12-18 | 2017-08-21 | 에프. 호프만-라 로슈 아게 | Cdc 유발 항체를 측정하기 위한 검정 및 방법 |
| CN106831987B (zh) * | 2015-12-04 | 2020-01-21 | 浙江大学 | 一种抗人her2抗体及其编码基因和应用 |
| CN109154600A (zh) * | 2016-06-16 | 2019-01-04 | 豪夫迈·罗氏有限公司 | 用于确定cdc诱导抗体的测定法和方法 |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| CN107137424B (zh) * | 2017-05-15 | 2024-12-17 | 广州领晟医疗科技有限公司 | 一种利用正常小鼠建立her2阳性肿瘤的动物模型的方法 |
| PL3765525T3 (pl) | 2018-03-13 | 2023-12-27 | Zymeworks Bc Inc. | Koniugaty biparatopowe przeciwciało anty-her2 – lek i sposoby stosowania |
| CN109134656A (zh) * | 2018-09-12 | 2019-01-04 | 四川妙和生物科技有限公司 | 一种抗her2多克隆抗体 |
| KR102834768B1 (ko) * | 2019-03-15 | 2025-07-17 | 고에키자이단호진 간겐큐카이 | 항포도플라닌 항체 |
| CN113993902B (zh) * | 2019-03-22 | 2025-03-14 | 瑟缇斯治疗私人有限公司 | 抗her2结合分子 |
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| US7244826B1 (en) * | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| US6794128B2 (en) * | 1998-04-24 | 2004-09-21 | The Regents Of The University Of California | Methods of selecting internalizing antibodies |
| AU2003295798B2 (en) * | 2002-11-21 | 2009-09-10 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-ErbB2 antibodies |
| GB0503546D0 (en) * | 2005-02-21 | 2005-03-30 | Hellenic Pasteur Inst | Antibody |
| US7498142B2 (en) * | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
| KR101706255B1 (ko) * | 2008-08-29 | 2017-02-14 | 심포젠 에이/에스 | 재조합 항-표피 성장 인자 수용체 항체 조성물 |
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2011
- 2011-03-03 CN CN201180022307.6A patent/CN102884084B/zh not_active Expired - Fee Related
- 2011-03-03 JP JP2012555532A patent/JP6039428B2/ja not_active Expired - Fee Related
- 2011-03-03 TW TW100107086A patent/TW201141519A/zh unknown
- 2011-03-03 WO PCT/IB2011/050903 patent/WO2011107957A1/en not_active Ceased
- 2011-03-03 EP EP11750275.7A patent/EP2542589A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| TW201141519A (en) | 2011-12-01 |
| JP2013520984A (ja) | 2013-06-10 |
| CN102884084A (zh) | 2013-01-16 |
| EP2542589A1 (en) | 2013-01-09 |
| EP2542589A4 (en) | 2013-08-07 |
| CN102884084B (zh) | 2016-12-07 |
| WO2011107957A1 (en) | 2011-09-09 |
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