JP2014522843A5 - - Google Patents

Info

Publication number

JP2014522843A5

JP2014522843A5 JP2014519125A JP2014519125A JP2014522843A5 JP 2014522843 A5 JP2014522843 A5 JP 2014522843A5 JP 2014519125 A JP2014519125 A JP 2014519125A JP 2014519125 A JP2014519125 A JP 2014519125A JP 2014522843 A5 JP2014522843 A5 JP 2014522843A5

Authority

JP

Japan

Prior art keywords

pharmaceutical formulation

concentration

present

seq

met antibody

Prior art date

2012-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 34
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 13
• 239000003814 drug Substances 0.000 claims 11
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 239000000872 buffer Substances 0.000 claims 10
• 229920000136 polysorbate Polymers 0.000 claims 9
• 229950008882 polysorbate Drugs 0.000 claims 9
• 150000001720 carbohydrates Chemical class 0.000 claims 8
• 239000012895 dilution Substances 0.000 claims 8
• 238000010790 dilution Methods 0.000 claims 8
• 229950000846 onartuzumab Drugs 0.000 claims 4
• 150000002016 disaccharides Chemical class 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 229920001213 Polysorbate 20 Polymers 0.000 claims 2
• 229930006000 Sucrose Natural products 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 2
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 2
• 229940068977 polysorbate 20 Drugs 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 239000005720 sucrose Substances 0.000 claims 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000008482 dysregulation Effects 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 125000000185 sucrose group Chemical group 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 125000000647 trehalose group Chemical group 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1