MX2013014687A - Formulaciones de anticuerpo anti-c-met. - Google Patents
Formulaciones de anticuerpo anti-c-met.Info
- Publication number
- MX2013014687A MX2013014687A MX2013014687A MX2013014687A MX2013014687A MX 2013014687 A MX2013014687 A MX 2013014687A MX 2013014687 A MX2013014687 A MX 2013014687A MX 2013014687 A MX2013014687 A MX 2013014687A MX 2013014687 A MX2013014687 A MX 2013014687A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- pharmaceutical formulation
- met
- sequence
- seq
- Prior art date
Links
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| MX2012005168A (es) | 2009-11-05 | 2012-06-08 | Genentech Inc | Metodos y composicion para secrecion de polipeptidos heterologos. |
| CA2792125C (en) * | 2010-03-22 | 2019-02-12 | Genentech, Inc. | Compositions and methods useful for stabilizing protein-containing formulations |
| US20130004484A1 (en) | 2011-06-30 | 2013-01-03 | Genentech, Inc. | Anti-c-met antibody formulations |
| CN107880123A (zh) | 2011-10-28 | 2018-04-06 | 普罗典娜生物科学有限公司 | 识别α‑突触核蛋白的人源化抗体 |
| AU2013211874B2 (en) | 2012-01-27 | 2017-11-02 | Prothena Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| JP6254146B2 (ja) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
| CA2883385A1 (en) * | 2012-08-31 | 2014-03-06 | Life Sciences Research Partners Vzw | Modulating transendothelial migration and recruitment of granulocytes by modulating c-met pathway |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| RU2704285C2 (ru) | 2013-01-30 | 2019-10-25 | Нгм Байофармасьютикалз, Инк. | Композиции и способы применения для лечения метаболических расстройств |
| AU2014229282B2 (en) | 2013-03-15 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Low concentration antibody formulations |
| KR20140119396A (ko) | 2013-03-29 | 2014-10-10 | 삼성전자주식회사 | 단백질 약물의 액상 제형 |
| US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| PT3060256T (pt) * | 2013-10-25 | 2019-07-19 | Bayer Pharma AG | Uma nova formulação estável |
| MX2016011637A (es) | 2014-03-14 | 2017-04-13 | Genentech Inc | Metodos y composiciones para secrecion de polipeptidos heterologos. |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| SG10201802098UA (en) | 2014-07-30 | 2018-04-27 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
| CN115043945A (zh) | 2014-10-31 | 2022-09-13 | Ngm生物制药有限公司 | 用于治疗代谢病症的组合物和方法 |
| TWI738632B (zh) * | 2014-11-07 | 2021-09-11 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| US20180057595A1 (en) | 2015-03-16 | 2018-03-01 | Celldex Therapeutics, Inc. | Anti-MET Antibodies and Methods of Use Thereof |
| EP3371223B1 (en) * | 2015-11-03 | 2021-03-10 | Merck Patent GmbH | Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof |
| CN108292989B (zh) * | 2015-12-10 | 2022-08-30 | 索尼公司 | 接收装置与数据处理方法 |
| AU2017241161B2 (en) | 2016-03-31 | 2022-05-26 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| US20200129633A1 (en) | 2017-06-06 | 2020-04-30 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising c-met antibody-drug conjugate and use thereof |
| CN110144325A (zh) * | 2018-02-12 | 2019-08-20 | 深圳宾德生物技术有限公司 | 一种靶向性t淋巴细胞及其制备方法和应用 |
| CN110684113A (zh) * | 2018-07-06 | 2020-01-14 | 复旦大学 | 一种抗PD-1抗原和抗c-Met抗原的双特异性抗体及其构建方法 |
| JOP20210152A1 (ar) | 2018-12-18 | 2023-01-30 | Novartis Ag | صياغة محلول بروتيني محتوية على تركيز عالٍ من جسم مضاد لـ vegf |
| CN120241997A (zh) | 2019-02-18 | 2025-07-04 | 伊莱利利公司 | 治疗性抗体制剂 |
| CN112239506B (zh) * | 2019-07-16 | 2023-09-26 | 复旦大学 | 一种抗PD-1及c-Met抗原的小分子双特异性抗体Diabody |
| CN114340684B (zh) | 2019-09-16 | 2025-09-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
| TW202317635A (zh) | 2021-07-14 | 2023-05-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｈｇｆｒ和ｅｇｆｒ的抗原結合分子及其醫藥用途 |
| EP4624493A1 (en) | 2022-11-24 | 2025-10-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising bispecific antibody specifically binding to hgfr and egfr |
| KR20250156749A (ko) * | 2023-03-08 | 2025-11-03 | 이뮤노반트 사이언시스 게엠베하 | 폴리소르베이트 부형제를 포함하는 고농도 단백질 제제 및 이의 제조 방법 |
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-
2012
- 2012-06-29 US US13/538,901 patent/US20130004484A1/en not_active Abandoned
- 2012-06-29 RU RU2013155695/10A patent/RU2013155695A/ru not_active Application Discontinuation
- 2012-06-29 KR KR1020137034360A patent/KR20140045440A/ko not_active Withdrawn
- 2012-06-29 CN CN201610902236.3A patent/CN107090038A/zh active Pending
- 2012-06-29 CA CA2835242A patent/CA2835242A1/en not_active Abandoned
- 2012-06-29 SG SG2013083985A patent/SG194932A1/en unknown
- 2012-06-29 MX MX2013014687A patent/MX2013014687A/es unknown
- 2012-06-29 AR ARP120102364A patent/AR086823A1/es unknown
- 2012-06-29 AU AU2012275233A patent/AU2012275233A1/en not_active Abandoned
- 2012-06-29 BR BR112013030472A patent/BR112013030472A2/pt not_active IP Right Cessation
- 2012-06-29 JP JP2014519125A patent/JP2014522843A/ja active Pending
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- 2012-06-29 EP EP12735395.1A patent/EP2726098A1/en not_active Ceased
- 2012-06-29 WO PCT/US2012/044829 patent/WO2013003680A1/en not_active Ceased
- 2012-06-29 TW TW101123655A patent/TW201306866A/zh unknown
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2013
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|---|---|
| TW201306866A (zh) | 2013-02-16 |
| JP2014522843A (ja) | 2014-09-08 |
| BR112013030472A2 (pt) | 2019-09-24 |
| KR20140045440A (ko) | 2014-04-16 |
| SG194932A1 (en) | 2013-12-30 |
| WO2013003680A1 (en) | 2013-01-03 |
| WO2013003680A8 (en) | 2013-02-28 |
| EP2726098A1 (en) | 2014-05-07 |
| CN107090038A (zh) | 2017-08-25 |
| US20130004484A1 (en) | 2013-01-03 |
| CA2835242A1 (en) | 2013-01-03 |
| CN103781493A (zh) | 2014-05-07 |
| AR086823A1 (es) | 2014-01-22 |
| RU2013155695A (ru) | 2015-08-10 |
| IL229233A0 (en) | 2014-01-30 |
| AU2012275233A1 (en) | 2013-11-28 |
| US20150064191A1 (en) | 2015-03-05 |
| US9487589B2 (en) | 2016-11-08 |
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