ATE256736T1 - Ein nicht-mitogener kompetitiver hgf-antagonist - Google Patents

Ein nicht-mitogener kompetitiver hgf-antagonist

Info

Publication number
ATE256736T1
ATE256736T1 AT91917603T AT91917603T ATE256736T1 AT E256736 T1 ATE256736 T1 AT E256736T1 AT 91917603 T AT91917603 T AT 91917603T AT 91917603 T AT91917603 T AT 91917603T AT E256736 T1 ATE256736 T1 AT E256736T1
Authority
AT
Austria
Prior art keywords
hgf
present
mitogenic
relates
hgf antagonist
Prior art date
Application number
AT91917603T
Other languages
English (en)
Inventor
Jeffrey S Rubin
Andrew M-L Chan
Stuart A Aaronson
Donald P Bottaro
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE256736T1 publication Critical patent/ATE256736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91917603T 1990-09-14 1991-09-10 Ein nicht-mitogener kompetitiver hgf-antagonist ATE256736T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58206390A 1990-09-14 1990-09-14
US65550291A 1991-02-15 1991-02-15
PCT/US1991/006368 WO1992005184A1 (en) 1990-09-14 1991-09-10 A non-mitogenic competitive hgf antagonist

Publications (1)

Publication Number Publication Date
ATE256736T1 true ATE256736T1 (de) 2004-01-15

Family

ID=27078485

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91917603T ATE256736T1 (de) 1990-09-14 1991-09-10 Ein nicht-mitogener kompetitiver hgf-antagonist

Country Status (7)

Country Link
EP (1) EP0571387B1 (de)
JP (2) JP3438888B2 (de)
AT (1) ATE256736T1 (de)
AU (1) AU650292B2 (de)
CA (1) CA2091700C (de)
DE (1) DE69133349T2 (de)
WO (1) WO1992005184A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871959A (en) * 1989-12-27 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Method of producing hepatocycte growth factor/scatter factor and related cell lines
US6566098B1 (en) 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
US5316921A (en) * 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
JPH07508420A (ja) * 1992-05-18 1995-09-21 ジェネンテク，インコーポレイテッド 肝細胞成長因子変異体
CA2142185A1 (en) * 1992-08-10 1994-02-17 David I. Gwynne Inhibitors of cell proliferation, their preparation and use
EP0805203B1 (de) * 1992-09-18 2007-08-01 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Medizinische Verwendung eines Antikörpers oder eines Antikörperfragments gegen die extrazelluläre Domäne von Met zur Prevention von Metastasen
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
PT847757E (pt) 1995-08-29 2005-06-30 Anges Mg Inc Medicamento que compreende o gene de hgf
US6855685B2 (en) 1995-10-24 2005-02-15 Toshikazu Nakamura Anti-cancer agent
EP0941111A4 (de) * 1996-11-05 2000-09-27 Smithkline Beecham Corp Wachstumsfaktor-antagonisten von hepatozyten
AU784359B2 (en) * 1999-12-15 2006-03-16 Entremed, Inc Compositions and methods for inhibiting endothelial cell proliferation
WO2006015371A2 (en) 2004-08-05 2006-02-09 Genentech, Inc. Humanized anti-cmet antagonists
EP1869070B1 (de) 2005-04-15 2013-11-27 Genentech, Inc. Hgf-beta-kettenvarianten
KR102059663B1 (ko) 2010-03-10 2019-12-26 젠맵 에이/에스 Ｃ―ｍｅｔ에 대한 모노클로날 항체
US20130004484A1 (en) 2011-06-30 2013-01-03 Genentech, Inc. Anti-c-met antibody formulations
CN107002119A (zh) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE108459T1 (de) * 1986-04-22 1994-07-15 Salk Inst For Biological Studi Antagonisten des fibroblasten-wachstumsfaktors.
NZ232813A (en) * 1989-03-10 1992-08-26 Snow Brand Milk Products Co Ltd Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons

Also Published As

Publication number Publication date
DE69133349D1 (de) 2004-01-29
WO1992005184A1 (en) 1992-04-02
AU650292B2 (en) 1994-06-16
AU8659591A (en) 1992-04-15
EP0571387B1 (de) 2003-12-17
JPH06504189A (ja) 1994-05-19
DE69133349T2 (de) 2004-10-07
EP0571387A4 (en) 1994-07-13
CA2091700A1 (en) 1992-03-15
JP2003102488A (ja) 2003-04-08
CA2091700C (en) 2002-11-19
JP3438888B2 (ja) 2003-08-18
EP0571387A1 (de) 1993-12-01

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Legal Events

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